CA2890664A1 - Therapeutic compounds and compositions and their use as pkm2 modulators - Google Patents

Therapeutic compounds and compositions and their use as pkm2 modulators Download PDF

Info

Publication number: CA2890664A1
Authority: CA; Canada
Prior art keywords: compound; subject; pharmaceutically acceptable; optionally substituted; acceptable salt
Prior art date: 2012-11-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA2890664A

Other languages

English (en)

French (fr)

Inventor

Janeta Popovici-Muller

Jeffrey O. Saunders

Robert Zahler

Giovanni Cianchetta

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Agios Pharmaceuticals Inc

Original Assignee

Agios Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-11-08

Filing date

2013-11-08

Publication date

2014-05-15

2013-11-08 Application filed by Agios Pharmaceuticals Inc filed Critical Agios Pharmaceuticals Inc

2014-05-15 Publication of CA2890664A1 publication Critical patent/CA2890664A1/en

Status Abandoned legal-status Critical Current

Links

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- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
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Pharmacology & Pharmacy (AREA)
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Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epidemiology (AREA)
Enzymes And Modification Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

CA2890664A 2012-11-08 2013-11-08 Therapeutic compounds and compositions and their use as pkm2 modulators Abandoned CA2890664A1 (en)

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Application Number	Priority Date	Filing Date	Title
US201261724266P	2012-11-08	2012-11-08
US61/724,266		2012-11-08
PCT/US2013/069193 WO2014074848A1 (en)	2012-11-08	2013-11-08	Therapeutic compounds and compositions and their use as pkm2 modulators

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US (1)	US9458132B2 (2)
EP (1)	EP2917207A1 (2)
JP (1)	JP6362610B2 (2)
KR (1)	KR20150080619A (2)
CN (1)	CN104822672B (2)
AU (1)	AU2013342203B2 (2)
CA (1)	CA2890664A1 (2)
EA (1)	EA032007B1 (2)
HK (1)	HK1213888A1 (2)
MX (1)	MX2015005841A (2)
NZ (1)	NZ707778A (2)
WO (1)	WO2014074848A1 (2)

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Publication number	Priority date	Publication date	Assignee	Title
EP2909181B1 (en)	2012-10-16	2017-08-09	Tolero Pharmaceuticals, Inc.	Pkm2 modulators and methods for their use
EP2956138B1 (en)	2013-02-15	2022-06-22	Kala Pharmaceuticals, Inc.	Therapeutic compounds and uses thereof
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HK1213888A1 (zh)	2016-07-15
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KR20150080619A (ko)	2015-07-09
US9458132B2 (en)	2016-10-04
JP2016501189A (ja)	2016-01-18
NZ707778A (en)	2019-03-29
WO2014074848A1 (en)	2014-05-15
CN104822672B (zh)	2018-08-28
CN104822672A (zh)	2015-08-05
EA201590881A1 (ru)	2015-08-31
AU2013342203A1 (en)	2015-05-21
EA032007B1 (ru)	2019-03-29
EP2917207A1 (en)	2015-09-16
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Publication	Publication Date	Title
AU2013342203B2 (en)	2017-11-23	Therapeutic compounds and compositions and their use as PKM2 modulators
EP2970189B1 (en)	2020-05-06	Therapeutic compounds and compositions
EP2651898B1 (en)	2015-12-09	Novel n-(4-(azetidine-1-carbonyl)phenyl)-(hetero-)arylsulfonamide derivatives as pyruvate kinase m2 (pmk2) modulators
DK2448581T3 (en)	2017-03-13	Therapeutic compositions and methods for their applications
DK2922850T3 (en)	2018-10-08	Compounds and Methods for Their Use
HK1190405B (en)	2016-12-02	Novel n- (4- (azetidine - 1 - carbonyl) phenyl) - (hetero - ) arylsulfonamide derivatives as pyruvate kinase m2 (pmk2) modulators
HK1170152A (en)	2013-02-22	Therapeutic compositions and related methods of use
HK1170152B (en)	2018-01-12	Therapeutic compositions and related methods of use
HK1214593B (en)	2019-08-02	Compounds and their methods of use