EA032007B1 - Терапевтические соединения и композиции и их использование в качестве модуляторов пк-m2 - Google Patents

Терапевтические соединения и композиции и их использование в качестве модуляторов пк-m2 Download PDF

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Publication number: EA032007B1
Authority: EA; Eurasian Patent Office
Prior art keywords: compound; pharmaceutically acceptable; acceptable salt; subject; pyruvate kinase
Prior art date: 2012-11-08

Application number

EA201590881A

Other languages

English (en)

Russian (ru)

Other versions

EA201590881A1 (ru

Inventor

Джанета Поповичи-Мюллер

Джеффри О. Сондерз

Роберт Захлер

Джованни Чианкетта

Original Assignee

Аджиос Фармасьютикалз, Инк.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-11-08

Filing date

2013-11-08

Publication date

2019-03-29

2013-11-08 Application filed by Аджиос Фармасьютикалз, Инк. filed Critical Аджиос Фармасьютикалз, Инк.

2015-08-31 Publication of EA201590881A1 publication Critical patent/EA201590881A1/ru

2019-03-29 Publication of EA032007B1 publication Critical patent/EA032007B1/ru

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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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EA201590881A 2012-11-08 2013-11-08 Терапевтические соединения и композиции и их использование в качестве модуляторов пк-m2 EA032007B1 (ru)

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JP (1)	JP6362610B2 (2)
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CN (1)	CN104822672B (2)
AU (1)	AU2013342203B2 (2)
CA (1)	CA2890664A1 (2)
EA (1)	EA032007B1 (2)
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MX (1)	MX2015005841A (2)
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EP2956138B1 (en)	2013-02-15	2022-06-22	Kala Pharmaceuticals, Inc.	Therapeutic compounds and uses thereof
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US9890173B2 (en)	2013-11-01	2018-02-13	Kala Pharmaceuticals, Inc.	Crystalline forms of therapeutic compounds and uses thereof
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CN104817490B (zh) *	2015-05-13	2017-10-13	北京大学	氨基二硫代甲酸酯类化合物及其制备方法与应用
WO2017095751A1 (en)	2015-12-02	2017-06-08	Partikula Llc	Compositions and methods for modulating cancer cell metabolism
CA2968836C (en)	2016-06-13	2025-09-02	Gilead Sciences, Inc.	FXR MODULATING COMPOUNDS (NR1H4)
EP3509423A4 (en)	2016-09-08	2020-05-13	Kala Pharmaceuticals, Inc.	CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
US10336767B2 (en)	2016-09-08	2019-07-02	Kala Pharmaceuticals, Inc.	Crystalline forms of therapeutic compounds and uses thereof
AU2017324713B2 (en)	2016-09-08	2020-08-13	KALA BIO, Inc.	Crystalline forms of therapeutic compounds and uses thereof
LT3483164T (lt)	2017-03-20	2020-05-11	Forma Therapeutics, Inc.	Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai
TWI796353B (zh) *	2017-08-15	2023-03-21	美商阿吉歐斯製藥公司	丙酮酸激酶調節劑及其用途
US20200237766A1 (en)	2017-10-13	2020-07-30	Tolero Pharmaceuticals, Inc.	Pkm2 activators in combination with reactive oxygen species for treatment of cancer
EP3852791B1 (en)	2018-09-19	2024-07-03	Novo Nordisk Health Care AG	Activating pyruvate kinase r
EP3853206B1 (en)	2018-09-19	2024-04-10	Novo Nordisk Health Care AG	Treating sickle cell disease with a pyruvate kinase r activating compound
JP2022519906A (ja)	2019-02-19	2022-03-25	ギリアードサイエンシーズ，インコーポレイテッド	Ｆｘｒアゴニストの固体形態
KR20210141621A (ko)	2019-03-22	2021-11-23	스미토모 다이니폰 파마 온콜로지, 인크.	Pkm2 조정제를 포함하는 조성물 및 그를 사용한 치료 방법
HRP20251148T1 (hr)	2019-09-19	2025-11-21	Novo Nordisk Health Care Ag	Pripravci koji aktiviraju piruvat-kinazu r (pkr)
US11566030B2 (en)	2021-02-08	2023-01-31	Global Blood Therapeutics, Inc.	Substituted 2,6-dihydropyrrolo[3,4-c]pyrazoles as pyruvate kinase activators
US12128035B2 (en)	2021-03-19	2024-10-29	Novo Nordisk Health Care Ag	Activating pyruvate kinase R

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JP6362610B2 (ja)	2018-07-25
HK1213888A1 (zh)	2016-07-15
MX2015005841A (es)	2016-01-08
KR20150080619A (ko)	2015-07-09
US9458132B2 (en)	2016-10-04
JP2016501189A (ja)	2016-01-18
NZ707778A (en)	2019-03-29
WO2014074848A1 (en)	2014-05-15
CN104822672B (zh)	2018-08-28
CN104822672A (zh)	2015-08-05
EA201590881A1 (ru)	2015-08-31
CA2890664A1 (en)	2014-05-15
AU2013342203A1 (en)	2015-05-21
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