JP6362610B2 - 治療用化合物及び組成物並びにｐｋｍ２調節剤としてのそれらの使用 - Google Patents

治療用化合物及び組成物並びにｐｋｍ２調節剤としてのそれらの使用 Download PDF

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Publication number: JP6362610B2
Authority: JP; Japan
Prior art keywords: compound; pharmaceutically acceptable; acceptable salt; alkyl; composition
Prior art date: 2012-11-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP2015541933A

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English (en)

Japanese (ja)

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JP2016501189A5 (2

JP2016501189A (ja

Inventor

ギオバンニシアンチェッタ，

ジャニータポポビシ−ムラー，

ジェフリーオー．サウンダーズ，

ロバートザーラー，

Original Assignee

アジオスファーマシューティカルズ，インコーポレイテッド

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-11-08

Filing date

2013-11-08

Publication date

2018-07-25

2013-11-08 Application filed by アジオスファーマシューティカルズ，インコーポレイテッド, アジオスファーマシューティカルズ，インコーポレイテッド filed Critical アジオスファーマシューティカルズ，インコーポレイテッド

2016-01-18 Publication of JP2016501189A publication Critical patent/JP2016501189A/ja

2016-12-22 Publication of JP2016501189A5 publication Critical patent/JP2016501189A5/ja

2018-07-25 Application granted granted Critical

2018-07-25 Publication of JP6362610B2 publication Critical patent/JP6362610B2/ja

Status Expired - Fee Related legal-status Critical Current

2033-11-08 Anticipated expiration legal-status Critical

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epidemiology (AREA)
Enzymes And Modification Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

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EP2956138B1 (en)	2013-02-15	2022-06-22	Kala Pharmaceuticals, Inc.	Therapeutic compounds and uses thereof
MX368903B (es)	2013-02-20	2019-10-21	Kala Pharmaceuticals Inc	Compuestos terapéuticos y sus usos en el tratamiento de enfermedades proliferativas.
US9688688B2 (en)	2013-02-20	2017-06-27	Kala Pharmaceuticals, Inc.	Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
US9890173B2 (en)	2013-11-01	2018-02-13	Kala Pharmaceuticals, Inc.	Crystalline forms of therapeutic compounds and uses thereof
US9458169B2 (en)	2013-11-01	2016-10-04	Kala Pharmaceuticals, Inc.	Crystalline forms of therapeutic compounds and uses thereof
CN104817490B (zh) *	2015-05-13	2017-10-13	北京大学	氨基二硫代甲酸酯类化合物及其制备方法与应用
WO2017095751A1 (en)	2015-12-02	2017-06-08	Partikula Llc	Compositions and methods for modulating cancer cell metabolism
CA2968836C (en)	2016-06-13	2025-09-02	Gilead Sciences, Inc.	FXR MODULATING COMPOUNDS (NR1H4)
EP3509423A4 (en)	2016-09-08	2020-05-13	Kala Pharmaceuticals, Inc.	CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
US10336767B2 (en)	2016-09-08	2019-07-02	Kala Pharmaceuticals, Inc.	Crystalline forms of therapeutic compounds and uses thereof
AU2017324713B2 (en)	2016-09-08	2020-08-13	KALA BIO, Inc.	Crystalline forms of therapeutic compounds and uses thereof
LT3483164T (lt)	2017-03-20	2020-05-11	Forma Therapeutics, Inc.	Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai
TWI796353B (zh) *	2017-08-15	2023-03-21	美商阿吉歐斯製藥公司	丙酮酸激酶調節劑及其用途
US20200237766A1 (en)	2017-10-13	2020-07-30	Tolero Pharmaceuticals, Inc.	Pkm2 activators in combination with reactive oxygen species for treatment of cancer
EP3852791B1 (en)	2018-09-19	2024-07-03	Novo Nordisk Health Care AG	Activating pyruvate kinase r
EP3853206B1 (en)	2018-09-19	2024-04-10	Novo Nordisk Health Care AG	Treating sickle cell disease with a pyruvate kinase r activating compound
JP2022519906A (ja)	2019-02-19	2022-03-25	ギリアードサイエンシーズ，インコーポレイテッド	Ｆｘｒアゴニストの固体形態
KR20210141621A (ko)	2019-03-22	2021-11-23	스미토모 다이니폰 파마 온콜로지, 인크.	Pkm2 조정제를 포함하는 조성물 및 그를 사용한 치료 방법
HRP20251148T1 (hr)	2019-09-19	2025-11-21	Novo Nordisk Health Care Ag	Pripravci koji aktiviraju piruvat-kinazu r (pkr)
US11566030B2 (en)	2021-02-08	2023-01-31	Global Blood Therapeutics, Inc.	Substituted 2,6-dihydropyrrolo[3,4-c]pyrazoles as pyruvate kinase activators
US12128035B2 (en)	2021-03-19	2024-10-29	Novo Nordisk Health Care Ag	Activating pyruvate kinase R

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HK1213888A1 (zh)	2016-07-15
MX2015005841A (es)	2016-01-08
KR20150080619A (ko)	2015-07-09
US9458132B2 (en)	2016-10-04
JP2016501189A (ja)	2016-01-18
NZ707778A (en)	2019-03-29
WO2014074848A1 (en)	2014-05-15
CN104822672B (zh)	2018-08-28
CN104822672A (zh)	2015-08-05
EA201590881A1 (ru)	2015-08-31
CA2890664A1 (en)	2014-05-15
AU2013342203A1 (en)	2015-05-21
EA032007B1 (ru)	2019-03-29
EP2917207A1 (en)	2015-09-16
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