CA2914606C - Benzothiophene compound - Google Patents

Benzothiophene compound Download PDF

Info

Publication number
CA2914606C
CA2914606C CA2914606A CA2914606A CA2914606C CA 2914606 C CA2914606 C CA 2914606C CA 2914606 A CA2914606 A CA 2914606A CA 2914606 A CA2914606 A CA 2914606A CA 2914606 C CA2914606 C CA 2914606C
Authority
CA
Canada
Prior art keywords
compound
salt
pain
methyl
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2914606A
Other languages
English (en)
French (fr)
Other versions
CA2914606A1 (en
Inventor
Tsukasa Ishihara
Kazuhiro Ikegai
Ikumi Kuriwaki
Hiroyuki Hisamichi
Nobuaki Takeshita
Ryuichi Takezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of CA2914606A1 publication Critical patent/CA2914606A1/en
Application granted granted Critical
Publication of CA2914606C publication Critical patent/CA2914606C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2914606A 2013-06-06 2014-06-06 Benzothiophene compound Active CA2914606C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013-119416 2013-06-06
JP2013119416 2013-06-06
PCT/JP2014/065141 WO2014196644A1 (ja) 2013-06-06 2014-06-06 ベンゾチオフェン化合物

Publications (2)

Publication Number Publication Date
CA2914606A1 CA2914606A1 (en) 2014-12-11
CA2914606C true CA2914606C (en) 2021-03-23

Family

ID=52005968

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2914606A Active CA2914606C (en) 2013-06-06 2014-06-06 Benzothiophene compound

Country Status (32)

Country Link
US (2) US8981119B2 (2)
EP (1) EP3006443B1 (2)
JP (1) JP6314978B2 (2)
KR (1) KR102253721B1 (2)
CN (1) CN105263926B (2)
AR (1) AR096544A1 (2)
AU (1) AU2014275768B2 (2)
BR (1) BR112015030533B1 (2)
CA (1) CA2914606C (2)
CY (1) CY1120341T1 (2)
DK (1) DK3006443T3 (2)
ES (1) ES2671818T3 (2)
HR (1) HRP20180722T1 (2)
HU (1) HUE038920T2 (2)
IL (1) IL242800B (2)
LT (1) LT3006443T (2)
MX (1) MX2015016743A (2)
MY (1) MY199155A (2)
NO (1) NO3006443T3 (2)
PH (1) PH12015502637B1 (2)
PL (1) PL3006443T3 (2)
PT (1) PT3006443T (2)
RS (1) RS57250B1 (2)
RU (1) RU2667507C2 (2)
SG (1) SG11201509989VA (2)
SI (1) SI3006443T1 (2)
SM (1) SMT201800306T1 (2)
TR (1) TR201808724T4 (2)
TW (1) TWI624466B (2)
UA (1) UA117484C2 (2)
WO (1) WO2014196644A1 (2)
ZA (1) ZA201508866B (2)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114144183A (zh) * 2019-07-23 2022-03-04 阿斯特拉斯制药全球发展有限公司 治疗与疼痛相关的睡眠障碍的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614639A (en) * 1995-03-31 1997-03-25 Eli Lilly And Company Process for preparing 2-substituted benzo[b]thiophene compounds and intermediates thereof
US20040116405A1 (en) 2001-02-06 2004-06-17 Brian Cox Use of bicyclic esters or amides for the treatment of diseases responsive to enhanced potassium channel activity
WO2003005025A1 (en) * 2001-07-03 2003-01-16 Biovitrum Ab Methods for identifying compounds modulating the activity of ppar-gamma
JP2006522130A (ja) 2003-04-03 2006-09-28 メルク　エンド　カムパニー　インコーポレーテッド ナトリウムチャンネル遮断薬としてのビアリール置換ピラゾール
CN1852906A (zh) 2003-07-15 2006-10-25 史密丝克莱恩比彻姆公司 新化合物
WO2008054435A2 (en) * 2006-01-09 2008-05-08 The Regents Of The University Of California Use of sk channel activators to prevent relapse/reinstatement of drugs of abuse
WO2009035671A1 (en) * 2007-09-12 2009-03-19 Janssen Pharmaceutica N.V. Substituted nitrogen-containing heteroaryl derivatives useful as modulators of the histamine h4 receptor
EP2358750B1 (en) 2008-11-10 2017-01-11 Boehringer Ingelheim International GmbH Compositions and methods for modulating cell-cell fusion via intermediate-conductance calcium-activated potassium channels
AR090037A1 (es) 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio

Also Published As

Publication number Publication date
MX2015016743A (es) 2016-03-21
PL3006443T3 (pl) 2018-09-28
EP3006443A1 (en) 2016-04-13
NO3006443T3 (2) 2018-09-22
US8981119B2 (en) 2015-03-17
LT3006443T (lt) 2018-07-10
IL242800B (en) 2019-06-30
UA117484C2 (uk) 2018-08-10
MY199155A (en) 2023-10-18
AU2014275768A1 (en) 2015-12-17
AR096544A1 (es) 2016-01-13
TW201536775A (zh) 2015-10-01
BR112015030533B1 (pt) 2023-02-28
RU2667507C2 (ru) 2018-09-21
US20150133433A1 (en) 2015-05-14
WO2014196644A1 (ja) 2014-12-11
US9399038B2 (en) 2016-07-26
TR201808724T4 (tr) 2018-07-23
CA2914606A1 (en) 2014-12-11
US20140364421A1 (en) 2014-12-11
ES2671818T3 (es) 2018-06-08
PH12015502637B1 (en) 2019-02-08
CN105263926B (zh) 2018-05-11
HUE038920T2 (hu) 2018-12-28
ZA201508866B (en) 2017-11-29
HK1215570A1 (zh) 2016-09-02
AU2014275768B2 (en) 2017-12-14
TWI624466B (zh) 2018-05-21
HRP20180722T1 (hr) 2018-06-15
KR102253721B1 (ko) 2021-05-18
IL242800A0 (en) 2016-02-01
PT3006443T (pt) 2018-06-07
CN105263926A (zh) 2016-01-20
RU2015152150A (ru) 2017-07-13
RS57250B1 (sr) 2018-07-31
DK3006443T3 (en) 2018-06-25
SMT201800306T1 (it) 2018-07-17
CY1120341T1 (el) 2019-07-10
EP3006443A4 (en) 2016-12-21
PH12015502637A1 (en) 2016-03-07
EP3006443B1 (en) 2018-04-25
SG11201509989VA (en) 2016-01-28
KR20160015281A (ko) 2016-02-12
SI3006443T1 (en) 2018-08-31
JP6314978B2 (ja) 2018-04-25
BR112015030533A2 (pt) 2020-10-20
JPWO2014196644A1 (ja) 2017-02-23

Similar Documents

Publication Publication Date Title
AU2011246072B2 (en) Tetrahydrobenzothiophene compound
TW200815377A (en) Oxadiazolidinedione compound
MX2011005954A (es) Compuesto de 2h-cromeno y su derivado.
WO2000068203A1 (en) Cyclic compounds and uses thereof
NZ584811A (en) Oxadiazolidinedione compound
AU2012337781A1 (en) Dihydroxy aromatic heterocyclic compound
CA2645712A1 (en) Triazole derivative or salt thereof
CN104125956A (zh) 作为11-β-羟基类固醇脱氢酶的抑制剂的环酰胺及其用途
KR20090114439A (ko) 아실구아니딘 유도체
CA2909783C (en) Heterocyclic acetic acid amide compound
WO2009138338A1 (en) Novel n-(2-amino-phenyl)-acrylamides
CA2914606C (en) Benzothiophene compound
CA2792918A1 (en) Benzazepine compound
HK1215570B (en) Bensothiophene compound

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20190319

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20251211

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20251224

H13 Ip right lapsed

Free format text: ST27 STATUS EVENT CODE: N-4-6-H10-H13-H100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE AND LATE FEE NOT PAID BY DEADLINE OF NOTICE

Effective date: 20260325

H13 Ip right lapsed

Free format text: ST27 STATUS EVENT CODE: N-6-6-H10-H13-H100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE AND LATE FEE NOT PAID BY DEADLINE OF NOTICE

Effective date: 20260407