UA117484C2 - Бензотіофенова сполука - Google Patents

Бензотіофенова сполука

Info

Publication number
UA117484C2
UA117484C2 UAA201512058A UAA201512058A UA117484C2 UA 117484 C2 UA117484 C2 UA 117484C2 UA A201512058 A UAA201512058 A UA A201512058A UA A201512058 A UAA201512058 A UA A201512058A UA 117484 C2 UA117484 C2 UA 117484C2
Authority
UA
Ukraine
Prior art keywords
pain
fibromyalgia
osteoarthritic
channel
inflammatory
Prior art date
Application number
UAA201512058A
Other languages
English (en)
Ukrainian (uk)
Inventor
Цукаса Ісіхара
Казухіро Ікегаі
Ікумі Куривакі
Хіроюкі Хісаміті
Нобуакі Такесіта
Руіті Такедзава
Original Assignee
Астеллас Фарма Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астеллас Фарма Інк. filed Critical Астеллас Фарма Інк.
Publication of UA117484C2 publication Critical patent/UA117484C2/uk

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
UAA201512058A 2013-06-06 2014-06-06 Бензотіофенова сполука UA117484C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013119416 2013-06-06
PCT/JP2014/065141 WO2014196644A1 (ja) 2013-06-06 2014-06-06 ベンゾチオフェン化合物

Publications (1)

Publication Number Publication Date
UA117484C2 true UA117484C2 (uk) 2018-08-10

Family

ID=52005968

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201512058A UA117484C2 (uk) 2013-06-06 2014-06-06 Бензотіофенова сполука

Country Status (32)

Country Link
US (2) US8981119B2 (2)
EP (1) EP3006443B1 (2)
JP (1) JP6314978B2 (2)
KR (1) KR102253721B1 (2)
CN (1) CN105263926B (2)
AR (1) AR096544A1 (2)
AU (1) AU2014275768B2 (2)
BR (1) BR112015030533B1 (2)
CA (1) CA2914606C (2)
CY (1) CY1120341T1 (2)
DK (1) DK3006443T3 (2)
ES (1) ES2671818T3 (2)
HR (1) HRP20180722T1 (2)
HU (1) HUE038920T2 (2)
IL (1) IL242800B (2)
LT (1) LT3006443T (2)
MX (1) MX2015016743A (2)
MY (1) MY199155A (2)
NO (1) NO3006443T3 (2)
PH (1) PH12015502637B1 (2)
PL (1) PL3006443T3 (2)
PT (1) PT3006443T (2)
RS (1) RS57250B1 (2)
RU (1) RU2667507C2 (2)
SG (1) SG11201509989VA (2)
SI (1) SI3006443T1 (2)
SM (1) SMT201800306T1 (2)
TR (1) TR201808724T4 (2)
TW (1) TWI624466B (2)
UA (1) UA117484C2 (2)
WO (1) WO2014196644A1 (2)
ZA (1) ZA201508866B (2)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114144183A (zh) * 2019-07-23 2022-03-04 阿斯特拉斯制药全球发展有限公司 治疗与疼痛相关的睡眠障碍的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614639A (en) * 1995-03-31 1997-03-25 Eli Lilly And Company Process for preparing 2-substituted benzo[b]thiophene compounds and intermediates thereof
US20040116405A1 (en) 2001-02-06 2004-06-17 Brian Cox Use of bicyclic esters or amides for the treatment of diseases responsive to enhanced potassium channel activity
WO2003005025A1 (en) * 2001-07-03 2003-01-16 Biovitrum Ab Methods for identifying compounds modulating the activity of ppar-gamma
JP2006522130A (ja) 2003-04-03 2006-09-28 メルク エンド カムパニー インコーポレーテッド ナトリウムチャンネル遮断薬としてのビアリール置換ピラゾール
CN1852906A (zh) 2003-07-15 2006-10-25 史密丝克莱恩比彻姆公司 新化合物
WO2008054435A2 (en) * 2006-01-09 2008-05-08 The Regents Of The University Of California Use of sk channel activators to prevent relapse/reinstatement of drugs of abuse
WO2009035671A1 (en) * 2007-09-12 2009-03-19 Janssen Pharmaceutica N.V. Substituted nitrogen-containing heteroaryl derivatives useful as modulators of the histamine h4 receptor
EP2358750B1 (en) 2008-11-10 2017-01-11 Boehringer Ingelheim International GmbH Compositions and methods for modulating cell-cell fusion via intermediate-conductance calcium-activated potassium channels
AR090037A1 (es) 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio

Also Published As

Publication number Publication date
MX2015016743A (es) 2016-03-21
PL3006443T3 (pl) 2018-09-28
EP3006443A1 (en) 2016-04-13
NO3006443T3 (2) 2018-09-22
US8981119B2 (en) 2015-03-17
LT3006443T (lt) 2018-07-10
IL242800B (en) 2019-06-30
MY199155A (en) 2023-10-18
AU2014275768A1 (en) 2015-12-17
AR096544A1 (es) 2016-01-13
TW201536775A (zh) 2015-10-01
BR112015030533B1 (pt) 2023-02-28
RU2667507C2 (ru) 2018-09-21
US20150133433A1 (en) 2015-05-14
WO2014196644A1 (ja) 2014-12-11
US9399038B2 (en) 2016-07-26
TR201808724T4 (tr) 2018-07-23
CA2914606A1 (en) 2014-12-11
US20140364421A1 (en) 2014-12-11
ES2671818T3 (es) 2018-06-08
PH12015502637B1 (en) 2019-02-08
CN105263926B (zh) 2018-05-11
HUE038920T2 (hu) 2018-12-28
ZA201508866B (en) 2017-11-29
HK1215570A1 (zh) 2016-09-02
AU2014275768B2 (en) 2017-12-14
TWI624466B (zh) 2018-05-21
HRP20180722T1 (hr) 2018-06-15
KR102253721B1 (ko) 2021-05-18
IL242800A0 (en) 2016-02-01
PT3006443T (pt) 2018-06-07
CN105263926A (zh) 2016-01-20
RU2015152150A (ru) 2017-07-13
RS57250B1 (sr) 2018-07-31
DK3006443T3 (en) 2018-06-25
CA2914606C (en) 2021-03-23
SMT201800306T1 (it) 2018-07-17
CY1120341T1 (el) 2019-07-10
EP3006443A4 (en) 2016-12-21
PH12015502637A1 (en) 2016-03-07
EP3006443B1 (en) 2018-04-25
SG11201509989VA (en) 2016-01-28
KR20160015281A (ko) 2016-02-12
SI3006443T1 (en) 2018-08-31
JP6314978B2 (ja) 2018-04-25
BR112015030533A2 (pt) 2020-10-20
JPWO2014196644A1 (ja) 2017-02-23

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