CA2941466C - Exotoxines de pseudomonas mutees a antigenicite reduite - Google Patents

Exotoxines de pseudomonas mutees a antigenicite reduite Download PDF

Info

Publication number
CA2941466C
CA2941466C CA2941466A CA2941466A CA2941466C CA 2941466 C CA2941466 C CA 2941466C CA 2941466 A CA2941466 A CA 2941466A CA 2941466 A CA2941466 A CA 2941466A CA 2941466 C CA2941466 C CA 2941466C
Authority
CA
Canada
Prior art keywords
amino acid
alanine
seq
glycine
glutamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2941466A
Other languages
English (en)
Other versions
CA2941466A1 (fr
Inventor
Ira H. Pastan
Masanori Onda
Satoshi Nagata
David Fitzgerald
Robert Kreitman
Byungkook Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of CA2941466A1 publication Critical patent/CA2941466A1/fr
Application granted granted Critical
Publication of CA2941466C publication Critical patent/CA2941466C/fr
Anticipated expiration legal-status Critical
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6829—Bacterial toxins, e.g. diphteria toxins or Pseudomonas exotoxin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Linvention concerne des exotoxines de Pseudomonas (PE) qui présentent une immunologie initie réduite par rapport aux PE contenant la séquence native. Les PE de linvention possèdent une ou plusieurs mutations individuelles de positions de la séquence native de PE qui réduit la liaison danticorps à un ou plusieurs épitopes PE. Linvention concerne également des acides nucléiques codant les PE mutés, des molécules chimères les contenant, des compositions contenant ces molécules chimères et des procédés dutilisation de ceux-ci.
CA2941466A 2005-07-29 2006-07-25 Exotoxines de pseudomonas mutees a antigenicite reduite Active CA2941466C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70379805P 2005-07-29 2005-07-29
US60/703,798 2005-07-29
CA2616987A CA2616987C (fr) 2005-07-29 2006-07-25 Exotoxines de pseudomonas mutees a antigenicite reduite

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2616987A Division CA2616987C (fr) 2005-07-29 2006-07-25 Exotoxines de pseudomonas mutees a antigenicite reduite

Publications (2)

Publication Number Publication Date
CA2941466A1 CA2941466A1 (fr) 2007-02-08
CA2941466C true CA2941466C (fr) 2019-12-03

Family

ID=37709138

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2941466A Active CA2941466C (fr) 2005-07-29 2006-07-25 Exotoxines de pseudomonas mutees a antigenicite reduite
CA2616987A Active CA2616987C (fr) 2005-07-29 2006-07-25 Exotoxines de pseudomonas mutees a antigenicite reduite

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2616987A Active CA2616987C (fr) 2005-07-29 2006-07-25 Exotoxines de pseudomonas mutees a antigenicite reduite

Country Status (8)

Country Link
US (1) US8907060B2 (fr)
EP (6) EP3006457B1 (fr)
AT (1) ATE524489T1 (fr)
AU (1) AU2006275865B2 (fr)
CA (2) CA2941466C (fr)
ES (6) ES2564092T3 (fr)
PL (3) PL3006456T3 (fr)
WO (1) WO2007016150A2 (fr)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7989322B2 (en) 2007-02-07 2011-08-02 Micron Technology, Inc. Methods of forming transistors
WO2008109005A2 (fr) * 2007-03-02 2008-09-12 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Utilisation d'immunotoxines anti-cd22 et d'agents chimiothérapeutiques inhibant la synthèse des protéines, dans le traitement du cancer des lymphocytes b
EP2197903B9 (fr) 2007-09-04 2015-04-22 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Délétions dans le domaine ii de l'exotoxine a de pseudomonas qui réduisent la toxicité non spécifique
WO2011031441A1 (fr) 2009-08-28 2011-03-17 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Thérapie avec une molécule chimérique et un agent pro-apoptotique
CA2773665C (fr) * 2009-09-11 2018-02-20 Ira H. Pastan Exotoxine a pseudomonias amelioree a immunogenicite reduite
WO2011100455A1 (fr) 2010-02-12 2011-08-18 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Inhibition des réponses d'anticorps à des protéines étrangères
ES2678204T3 (es) 2010-07-30 2018-08-09 Medimmune, Llc Método para purificar inmunoconjugados
WO2012036746A1 (fr) 2010-09-15 2012-03-22 Randall J Mrsny Systèmes et procédés d'administration d'agents biologiquement actifs par le biais de séquences vectrices dérivées de toxine bactérienne
US11246915B2 (en) 2010-09-15 2022-02-15 Applied Molecular Transport Inc. Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo
WO2012145469A1 (fr) 2011-04-19 2012-10-26 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Anticorps monoclonaux humains spécifiques au glypican-3 et leur utilisation
MX2013012905A (es) 2011-05-06 2014-04-25 Us Gov Health & Human Serv Inmunotoxina recombinante dirigida a la mesotelina.
KR20140033391A (ko) 2011-06-09 2014-03-18 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 면역원성이 보다 낮은 t 세포 및/또는 b 세포 에피토프를 갖는 슈도모나스 외독소 a
US8932586B2 (en) 2011-09-06 2015-01-13 Intrexon Corporation Modified forms of Pseudomonas exotoxin A
WO2013039916A1 (fr) 2011-09-12 2013-03-21 The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services Compositions et méthodes de traitement et de détection améliorée de tumeurs non pituitaires
EP3301110A1 (fr) 2011-09-16 2018-04-04 The USA, as represented by The Secretary, Department of Health and Human Services Exotoxine a de pseudomonas des épitopes de cellules b moins immunogènes
IN2014CN02906A (fr) 2011-10-20 2015-07-03 Us Health
PL397167A1 (pl) 2011-11-28 2013-06-10 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Przeciwnowotworowe bialko fuzyjne
US9409994B2 (en) 2012-06-01 2016-08-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services High-affinity monoclonal antibodies to glypican-3 and use thereof
WO2014031476A1 (fr) 2012-08-21 2014-02-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux spécifiques au domaine de la mésothéline et utilisation de ces derniers
WO2014052064A1 (fr) 2012-09-27 2014-04-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps dirigés contre la mésothéline et procédés d'induction d'une activité anticancéreuse puissante
WO2014072306A1 (fr) 2012-11-08 2014-05-15 F. Hoffmann-La Roche Ag Protéines de liaison à l'antigène her3 se liant à l'épingle à cheveux beta de her3
JP6553515B2 (ja) 2012-12-20 2019-07-31 メディミューン，エルエルシー 免疫複合体の製造方法
CA2926215A1 (fr) * 2013-10-06 2015-04-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Exotoxine a de pseudomonas modifiee
ES2764833T3 (es) 2013-10-11 2020-06-04 The United States Of America Represented By The Sec Dep Of Health And Human Services Anticuerpos contra TEM8 y su uso
EP3066118B1 (fr) 2013-11-06 2020-01-08 The U.S.A. as represented by the Secretary, Department of Health and Human Services Anticorps anti-alk, conjugues, et recepteurs antigeniques chimeriques, et leur utilisation
EP3102245B1 (fr) 2014-02-05 2021-09-08 Molecular Templates, Inc. Procédés de criblage, de sélection et d'identification de polypeptides de recombinaison cytotoxiques fondés sur une diminution provisoire de la ribotoxicité
SG11201610183XA (en) 2014-05-07 2017-01-27 Applied Molecular Transp Llc Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo
WO2016019280A1 (fr) 2014-07-31 2016-02-04 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Anticorps monoclonaux humains dirigés contre l'epha4 et leur utilisation
WO2016146833A1 (fr) 2015-03-19 2016-09-22 F. Hoffmann-La Roche Ag Biomarqueurs de résistance à la nad(+)-diphtamide adp-ribosyltransférase
WO2017049296A1 (fr) 2015-09-20 2017-03-23 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Anticorps monoclonaux spécifiques du récepteur de facteur de croissance des fibroblastes 4 (fgfr4) et leurs procédés d'utilisation
EP3184547A1 (fr) 2015-10-29 2017-06-28 F. Hoffmann-La Roche AG Anticorps anti-tpbg et procédés d'utilisation
AU2016353067B2 (en) 2015-11-13 2023-10-05 Sanford Research Anti-BCMA polypeptides and proteins
WO2017196847A1 (fr) 2016-05-10 2017-11-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps anti-nouveau récepteur variable d'antigène (vnar) et conjugués d'anticorps ciblant des antigènes tumoraux et viraux
WO2017214182A1 (fr) 2016-06-07 2017-12-14 The United States Of America. As Represented By The Secretary, Department Of Health & Human Services Anticorps entièrement humain ciblant pdi pour l'immunothérapie anticancéreuse
US11066479B2 (en) 2016-08-02 2021-07-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Monoclonal antibodies targeting glypican-2 (GPC2) and use thereof
AU2017382883B2 (en) 2016-12-21 2024-07-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies specific for FLT3 and uses thereof
US11390683B2 (en) 2017-05-18 2022-07-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-mesothelin polypeptides and proteins
WO2018213064A1 (fr) 2017-05-19 2018-11-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonal humain ciblant tnfer2 en immunothérapie anticancéreuse
CA3066953A1 (fr) 2017-06-30 2019-01-03 Lentigen Technology, Inc. Anticorps monoclonaux humains specifiques de cd33 et leurs procedes d'utilisation
WO2019005208A1 (fr) 2017-06-30 2019-01-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps de la mésothéline humaine et utilisations dans une thérapie anticancéreuse
WO2019055955A1 (fr) 2017-09-18 2019-03-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunotoxines avec domaine de liaison à l'albumine
KR20250174998A (ko) 2018-03-08 2025-12-15 어플라이드 몰레큘라 트랜스포트 인크. 경구 전달용 독소-유래 전달 구조체
WO2020014482A1 (fr) 2018-07-12 2020-01-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonal spécifique pour cd22 à maturation par affinité et utilisations associées
EP3833684A1 (fr) 2018-08-08 2021-06-16 The United States of America, as represented by the Secretary, Department of Health and Human Services Anticorps monoclonaux à haute affinité ciblant le glypicane-2 et leurs utilisations
JP7487193B2 (ja) 2018-11-07 2024-05-20 アプライド モレキュラー トランスポート インコーポレイテッド 異種ペイロードの経口送達のためのコリックス由来担体
AU2020206308B2 (en) 2019-01-08 2026-02-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cross-species single domain antibodies targeting mesothelin for treating solid tumors
CA3125033A1 (fr) 2019-01-22 2020-07-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux a haute affinite ciblant le glypicane-1 et procedes d'utilisation
AU2020299382A1 (en) 2019-07-02 2022-01-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Monoclonal antibodies that bind EGFRvIII and their use
CN114599665A (zh) 2019-08-16 2022-06-07 应用分子转运公司 组合物、制剂及白细胞介素产生和纯化
US12552865B2 (en) 2019-10-22 2026-02-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services High affinity nanobodies targeting B7-H3 (CD276) for treating multiple solid tumors
WO2021097289A1 (fr) 2019-11-15 2021-05-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunotoxines recombinantes pegylées
US20230391852A1 (en) 2020-10-26 2023-12-07 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Single domain antibodies targeting sars coronavirus spike protein and uses thereof
US20240075158A1 (en) 2020-12-22 2024-03-07 Jiangsu Hengrui Pharmaceutical Co., Ltd. Complex of anti-il-4r antibody or antigen-binding fragment thereof and medical use thereof
WO2022232612A1 (fr) 2021-04-29 2022-11-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nanocorps spécifiques du virus de lassa et leurs méthodes d'utilisation
AU2022291120A1 (en) 2021-06-09 2023-11-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cross species single domain antibodies targeting pd-l1 for treating solid tumors
US20240417446A1 (en) 2021-10-26 2024-12-19 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Single domain antibodies targeting the s2 subunit of sars-cov-2 spike protein
EP4448566A1 (fr) 2021-12-17 2024-10-23 The United States of America, as represented by the Secretary, Department of Health and Human Services Polypeptides anti-mésothéline, protéines et récepteurs antigéniques chimériques
WO2024050399A1 (fr) 2022-09-01 2024-03-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps à domaine unique ciblant des complexes peptide/cmh oncogènes hpv e6/e7
WO2024104584A1 (fr) 2022-11-17 2024-05-23 University Of Cape Town Exotoxine a de pseudomonas désimmunisée
WO2024238346A1 (fr) 2023-05-12 2024-11-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps à domaine unique se liant de manière spécifique à la sous-unité s2 de la protéine de spicule du sars-cov-2, compositions et utilisations associées
CN121986113A (zh) 2023-07-07 2026-05-05 美国政府(由卫生和人类服务部的部长所代表) 人源化40h3抗体
AU2024295016A1 (en) 2023-07-20 2026-02-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Fully human monoclonal antibodies and chimeric antigen receptors against cd276 for the treatment of solid tumors
WO2025106427A1 (fr) 2023-11-14 2025-05-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux neutralisants et protecteurs contre le virus respiratoire syncytial (vrs)
WO2025171238A1 (fr) 2024-02-07 2025-08-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux qui se lient à la région juxtamembranaire de la mésothéline et leurs utilisations

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4957735A (en) 1984-06-12 1990-09-18 The University Of Tennessee Research Corporation Target-sensitive immunoliposomes- preparation and characterization
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4892827A (en) 1986-09-24 1990-01-09 The United States Of America As Represented By The Department Of Health And Human Services Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
US5055303A (en) 1989-01-31 1991-10-08 Kv Pharmaceutical Company Solid controlled release bioadherent emulsions
US5621078A (en) * 1989-03-22 1997-04-15 Merck & Co., Inc. Modified pseudomonas exotoxin PE40
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
EP0531434B1 (fr) 1990-05-11 1999-07-14 THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE Exotoxines de pseudomonas ameliorees ayant une toxicite animale faible et une forte activite cytocide
US5608039A (en) 1990-10-12 1997-03-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Single chain B3 antibody fusion proteins and their uses
US5254342A (en) 1991-09-30 1993-10-19 University Of Southern California Compositions and methods for enhanced transepithelial and transendothelial transport or active agents
DE69233528T2 (de) 1991-11-25 2006-03-16 Enzon, Inc. Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
EP0630234B1 (fr) 1992-03-12 1997-06-11 Alkermes Controlled Therapeutics, Inc. Microspheres a liberation regulee contenant l'hormone adrenocorticotrope (acth)
AU675440B2 (en) 1992-06-18 1997-02-06 United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Recombinant (pseudomonas) exotoxin with increased activity
US5534496A (en) 1992-07-07 1996-07-09 University Of Southern California Methods and compositions to enhance epithelial drug transport
US5747654A (en) 1993-06-14 1998-05-05 The United States Of America As Represented By The Department Of Health And Human Services Recombinant disulfide-stabilized polypeptide fragments having binding specificity
US5514670A (en) 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
US5888773A (en) 1994-08-17 1999-03-30 The United States Of America As Represented By The Department Of Health And Human Services Method of producing single-chain Fv molecules
US6518061B1 (en) 1995-03-15 2003-02-11 The United States Of America As Represented By The Department Of Health And Human Services IL-13 receptor specific chimeric proteins and uses thereof
JPH11515013A (ja) 1995-10-27 1999-12-21 メルク エンド カンパニー インコーポレーテッド 合成複合ワクチンの免疫原性担体としてのシュードモナスエクソトキシン
JP2001504334A (ja) * 1996-11-06 2001-04-03 アメリカ合衆国 プロテアーゼ活性化可能なＰｓｅｕｄｏｍｏｎａｓ体外毒素Ａ様プロタンパク質
US6296843B1 (en) 1998-04-03 2001-10-02 The Penn State Research Foundation Mutagenized IL 13-based chimeric molecules
US20020142000A1 (en) * 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor
DE60039510D1 (de) * 1999-05-27 2008-08-28 Us Gov Health & Human Serv Immunokonjugate mit hoher bindungsaffinität
CA2404763A1 (fr) 1999-11-11 2001-05-17 Raj K. Puri Modulation de l'activite de il-13 au moyen de molecules il-13 qui sont des antagonistes ou des agonistes de il-13
CA2415902A1 (fr) * 2000-07-10 2002-01-17 Xencor Automatisation de conception de proteines pour la conception de bibliotheques de proteines a antigenicite modifiee
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
US20030113350A1 (en) * 2001-09-19 2003-06-19 Fattom Ali I. Glycoconjugate vaccines for use in immune-compromised populations
CA2461351C (fr) 2001-09-26 2014-08-05 Ira H. Pastan Anticorps anti-cd22 mutes a forte affinite pour les cellules leucemiques exprimant des cd22
CA2466443A1 (fr) 2001-11-09 2003-05-15 Neopharm, Inc. Traitement selectif des tumeurs exprimant l'interleukine 13
ES2343965T3 (es) 2003-11-25 2010-08-13 The Government Of The United States, As Represented By The Secretary Of Health And Human Services Anticuerpos anti-cd22 e inmunocongujados mutados.
WO2009014650A2 (fr) * 2007-07-20 2009-01-29 The General Hospital Corporation Exotoxines recombinantes de vibrio cholerae
EP2197903B9 (fr) * 2007-09-04 2015-04-22 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Délétions dans le domaine ii de l'exotoxine a de pseudomonas qui réduisent la toxicité non spécifique
AU2010230063B2 (en) * 2009-03-24 2015-06-25 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Anti-mesothelin antibodies
WO2011031441A1 (fr) * 2009-08-28 2011-03-17 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Thérapie avec une molécule chimérique et un agent pro-apoptotique
CA2773665C (fr) * 2009-09-11 2018-02-20 Ira H. Pastan Exotoxine a pseudomonias amelioree a immunogenicite reduite
EP2576620A1 (fr) * 2010-05-26 2013-04-10 Regents Of The University Of Minnesota Anticorps anti-cd133 à fragments monocaténaires variables et leurs utilisations
KR20140033391A (ko) * 2011-06-09 2014-03-18 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 면역원성이 보다 낮은 t 세포 및/또는 b 세포 에피토프를 갖는 슈도모나스 외독소 a

Also Published As

Publication number Publication date
EP2311854A1 (fr) 2011-04-20
EP2311854B1 (fr) 2013-04-17
EP2332970A2 (fr) 2011-06-15
PL3006458T3 (pl) 2018-05-30
CA2616987C (fr) 2016-10-11
US20090142341A1 (en) 2009-06-04
EP3006456B1 (fr) 2018-09-19
EP3006457B1 (fr) 2017-11-22
EP3006457A1 (fr) 2016-04-13
EP2332970A3 (fr) 2011-09-14
ES2372537T3 (es) 2012-01-23
ES2410783T3 (es) 2013-07-03
EP3006458A1 (fr) 2016-04-13
PL3006456T3 (pl) 2019-05-31
EP1910407A2 (fr) 2008-04-16
US8907060B2 (en) 2014-12-09
AU2006275865B2 (en) 2012-06-28
EP2332970B1 (fr) 2015-12-23
CA2616987A1 (fr) 2007-02-08
EP1910407B1 (fr) 2011-09-14
ES2660026T3 (es) 2018-03-20
EP3006458B1 (fr) 2017-11-22
EP3006456A1 (fr) 2016-04-13
AU2006275865A1 (en) 2007-02-08
CA2941466A1 (fr) 2007-02-08
ES2702650T3 (es) 2019-03-04
ES2564092T3 (es) 2016-03-17
PL3006457T3 (pl) 2018-05-30
WO2007016150A3 (fr) 2007-08-09
WO2007016150A2 (fr) 2007-02-08
ATE524489T1 (de) 2011-09-15
ES2659039T3 (es) 2018-03-13

Similar Documents

Publication Publication Date Title
CA2616987C (fr) Exotoxines de pseudomonas mutees a antigenicite reduite
JP5795765B2 (ja) 低減した免疫原性を有する改良型シュードモナス（Ｐｓｅｕｄｏｍｏｎａｓ）外毒素Ａ
AU2008296194B2 (en) Deletions in domain II of Pseudomonas exotoxin A that reduce non-specific toxicity
US7777019B2 (en) Mutated Anti-CD22 antibodies with increased affinity to CD22-expressing leukemia cells
US10683362B2 (en) Recombinant immunotoxin targeting mesothelin
EP1180123B1 (fr) Immunoconjuges a affinite de liaison elevee
US7470775B2 (en) Anti-CD30 stalk and anti-CD30 antibodies suitable for use in immunotoxins
AU2016202754B2 (en) Mutated pseudomonas exotoxins with reduced antigenicity
AU2014208269B2 (en) Mutated pseudomonas exotoxins with reduced antigenicity
AU2012216642B2 (en) Mutated pseudomonas exotoxins with reduced antigenicity

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160908