CA2967385C - Methods of manufacturing treprostinil and treprostinil derivative prodrugs - Google Patents
Methods of manufacturing treprostinil and treprostinil derivative prodrugs Download PDFInfo
- Publication number
- CA2967385C CA2967385C CA2967385A CA2967385A CA2967385C CA 2967385 C CA2967385 C CA 2967385C CA 2967385 A CA2967385 A CA 2967385A CA 2967385 A CA2967385 A CA 2967385A CA 2967385 C CA2967385 C CA 2967385C
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- linear
- branched
- treprostinil
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462081515P | 2014-11-18 | 2014-11-18 | |
| US62/081,515 | 2014-11-18 | ||
| PCT/US2015/061427 WO2016081658A1 (en) | 2014-11-18 | 2015-11-18 | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2967385A1 CA2967385A1 (en) | 2016-05-26 |
| CA2967385C true CA2967385C (en) | 2023-05-16 |
Family
ID=56014536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2967385A Active CA2967385C (en) | 2014-11-18 | 2015-11-18 | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US10343979B2 (2) |
| EP (2) | EP3904326A1 (2) |
| JP (1) | JP6866043B2 (2) |
| AU (1) | AU2015349969B2 (2) |
| CA (1) | CA2967385C (2) |
| ES (1) | ES2873873T3 (2) |
| WO (1) | WO2016081658A1 (2) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| ES2860975T3 (es) | 2013-10-25 | 2021-10-05 | Insmed Inc | Compuestos de prostaciclina |
| AU2015349969B2 (en) | 2014-11-18 | 2020-02-06 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| WO2017223400A1 (en) * | 2016-06-24 | 2017-12-28 | Insmed Incorporated | Prostacyclin compounds and compositions for treating sarcoidosis |
| JP7220650B2 (ja) * | 2016-09-26 | 2023-02-10 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| CN114072136B (zh) | 2019-04-29 | 2024-11-29 | 英斯梅德股份有限公司 | 曲前列素前药的干粉组合物及其使用方法 |
| EP4017588A1 (en) | 2019-08-23 | 2022-06-29 | United Therapeutics Corporation | Treprostinil prodrugs |
| US10781160B1 (en) | 2019-10-04 | 2020-09-22 | Chirogate International Inc. | Hexadecyl Treprostinil crystals and methods for preparation thereof |
| JP2023523557A (ja) | 2020-04-17 | 2023-06-06 | ユナイテッド セラピューティクス コーポレイション | 間質性肺疾患の治療における使用のためのトレプロスチニル |
| IL298591A (en) | 2020-06-09 | 2023-01-01 | United Therapeutics Corp | Pomeryl dictopiperidine prodrugs of treprostinil |
| KR20250133451A (ko) | 2020-12-14 | 2025-09-05 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐 프로드러그로 질환을 치료하는 방법 |
| JP2024510930A (ja) | 2021-03-03 | 2024-03-12 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニル及びそのプロドラッグの乾燥粉末組成物、及び、さらに（ｅ）－３，６－ビス［４－（ｎ－カルボニル－２－プロペニル）アミドブチル］－２，５－ジケトピペラジン（ｆｄｋｐ）を含む乾燥粉末組成物 |
| WO2023154705A1 (en) | 2022-02-08 | 2023-08-17 | United Therapeutics Corporation | Treprostinil iloprost combination therapy |
| EP4652151A1 (en) | 2023-01-19 | 2025-11-26 | United Therapeutics Corporation | Treprostinil analogs |
| US20250197338A1 (en) | 2023-11-09 | 2025-06-19 | United Therapeutics Corporation | Syntheses of compounds useful for producing treprostinil |
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| MX349950B (es) | 2011-08-12 | 2017-08-22 | Ascendis Pharma As | Profarmacos de treprostinil enlazados a un portador. |
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| EP3712142B1 (en) * | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| JP2016517410A (ja) | 2013-03-14 | 2016-06-16 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルの固体形態 |
| CN109608326A (zh) | 2013-03-15 | 2019-04-12 | 联合治疗公司 | 曲前列环素的盐 |
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| ES2908142T3 (es) | 2014-06-13 | 2022-04-27 | United Therapeutics Corp | Formulaciones de treprostinil |
| US9593061B2 (en) | 2014-10-20 | 2017-03-14 | United Therapeutics Corporation | Synthesis of intermediates for producing prostacyclin derivatives |
| AU2015349969B2 (en) | 2014-11-18 | 2020-02-06 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
| US20160318844A1 (en) | 2015-04-29 | 2016-11-03 | Insmed Incorporated | Prostacyclin compounds, compositions and methods of use thereof |
| IL262720B2 (en) | 2016-05-05 | 2024-06-01 | Liquidia Tech Inc | Dry powder treprostinil for the treatment of pulmonary hypertension |
| WO2017223400A1 (en) | 2016-06-24 | 2017-12-28 | Insmed Incorporated | Prostacyclin compounds and compositions for treating sarcoidosis |
| JP7220650B2 (ja) | 2016-09-26 | 2023-02-10 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| EP3673895A1 (en) | 2018-12-28 | 2020-07-01 | Université Libre de Bruxelles | Dry powder inhalation formulation and its use for the therapeutic treatment of lungs |
| CN114072136B (zh) | 2019-04-29 | 2024-11-29 | 英斯梅德股份有限公司 | 曲前列素前药的干粉组合物及其使用方法 |
-
2015
- 2015-11-18 AU AU2015349969A patent/AU2015349969B2/en active Active
- 2015-11-18 US US15/527,811 patent/US10343979B2/en active Active
- 2015-11-18 WO PCT/US2015/061427 patent/WO2016081658A1/en not_active Ceased
- 2015-11-18 JP JP2017526523A patent/JP6866043B2/ja active Active
- 2015-11-18 CA CA2967385A patent/CA2967385C/en active Active
- 2015-11-18 EP EP21164646.8A patent/EP3904326A1/en not_active Withdrawn
- 2015-11-18 ES ES15862092T patent/ES2873873T3/es active Active
- 2015-11-18 EP EP15862092.2A patent/EP3221291B1/en active Active
-
2019
- 2019-05-21 US US16/417,958 patent/US11148997B2/en active Active
-
2021
- 2021-09-09 US US17/470,723 patent/US20220135513A1/en not_active Abandoned
-
2023
- 2023-04-18 US US18/302,682 patent/US20230250051A1/en not_active Abandoned
-
2025
- 2025-01-17 US US19/031,214 patent/US20250162982A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2967385A1 (en) | 2016-05-26 |
| US20250162982A1 (en) | 2025-05-22 |
| EP3221291A1 (en) | 2017-09-27 |
| WO2016081658A1 (en) | 2016-05-26 |
| EP3904326A1 (en) | 2021-11-03 |
| AU2015349969B2 (en) | 2020-02-06 |
| HK1244783A1 (en) | 2018-08-17 |
| AU2015349969A1 (en) | 2017-05-25 |
| US20190337888A1 (en) | 2019-11-07 |
| EP3221291A4 (en) | 2018-06-27 |
| US20170320813A1 (en) | 2017-11-09 |
| US10343979B2 (en) | 2019-07-09 |
| JP6866043B2 (ja) | 2021-04-28 |
| EP3221291B1 (en) | 2021-03-31 |
| US20230250051A1 (en) | 2023-08-10 |
| US20220135513A1 (en) | 2022-05-05 |
| ES2873873T3 (es) | 2021-11-04 |
| US11148997B2 (en) | 2021-10-19 |
| JP2017535555A (ja) | 2017-11-30 |
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