CA2974449A1 - Procede pour la production de 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile - Google Patents

Procede pour la production de 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile Download PDF

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Publication number
CA2974449A1
CA2974449A1 CA2974449A CA2974449A CA2974449A1 CA 2974449 A1 CA2974449 A1 CA 2974449A1 CA 2974449 A CA2974449 A CA 2974449A CA 2974449 A CA2974449 A CA 2974449A CA 2974449 A1 CA2974449 A1 CA 2974449A1
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Canada
Prior art keywords
formula
compound
peg
process according
added
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Granted
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CA2974449A
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English (en)
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CA2974449C (fr
Inventor
Hermut Wehlan
Kai Rossen
Alexander Schaefer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euroapi Germany GmbH
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Sanofi Aventis Deutschland GmbH
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Publication of CA2974449A1 publication Critical patent/CA2974449A1/fr
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne un nouveau procédé pour la production de 2-[4-(cyclopropanecarbonyl)phényl]-2-méthyl-propanenitrile. Ce composé peut être utilisé pour la production de médicaments, tels que la Fexofénadine.
CA2974449A 2015-01-22 2016-01-21 Procede pour la production de 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile Active CA2974449C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15152101.0 2015-01-22
EP15152101 2015-01-22
PCT/EP2016/051223 WO2016116555A1 (fr) 2015-01-22 2016-01-21 Procédé pour la production de 2-[4-(cyclopropanecarbonyl)phényl]-2-méthyl-propanenitrile

Publications (2)

Publication Number Publication Date
CA2974449A1 true CA2974449A1 (fr) 2016-07-28
CA2974449C CA2974449C (fr) 2023-08-29

Family

ID=52394944

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2974449A Active CA2974449C (fr) 2015-01-22 2016-01-21 Procede pour la production de 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile

Country Status (12)

Country Link
US (1) US10336698B2 (fr)
EP (1) EP3247699B1 (fr)
CN (1) CN107428678B (fr)
CA (1) CA2974449C (fr)
DK (1) DK3247699T3 (fr)
ES (1) ES2738630T3 (fr)
HR (1) HRP20191146T1 (fr)
HU (1) HUE044642T2 (fr)
PL (1) PL3247699T3 (fr)
PT (1) PT3247699T (fr)
RS (1) RS58961B1 (fr)
WO (1) WO2016116555A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3365327T (pt) * 2015-10-22 2020-02-06 Sanofi Aventis Deutschland Processo para a preparação de fexofenadina e de intermediários usados no mesmo
US11708283B2 (en) * 2018-06-01 2023-07-25 Cornell University Metal-chelating compositions and their use in methods of removing or inhibiting barium scale

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254129A (en) 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
JPS60130561A (ja) 1983-12-16 1985-07-12 Torii Yakuhin Kk アミジン誘導体およびそれを含む強心剤
DE3839170A1 (de) 1988-11-19 1990-05-31 Bayer Ag Cyclopropyl-substituierte azolylmethylcarbinole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DK0705245T3 (da) 1993-06-25 2003-04-14 Merrell Pharma Inc Nye mellemprodukter til fremstilling af antihistaminiske 4-diphenylmethyl/diphenylmethoxy-piperidinforbindelser
US5420322A (en) 1994-08-31 1995-05-30 Mine Safety Appliances Company Preparation of alkali-metal hexamethydisilazanes
US6303782B1 (en) * 1999-04-20 2001-10-16 Pfizer Inc Process for preparing benzylnitriles
GB0018691D0 (en) 2000-07-28 2000-09-20 Rolabo Sl Process
US20050222154A1 (en) 2004-04-05 2005-10-06 Hartmut Rehwinkel Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
JP4814228B2 (ja) 2004-05-18 2011-11-16 エフ．ホフマン−ラ ロシュ アーゲー 新規ｃｉｓ−イミダゾリン
CA2603818A1 (fr) 2005-04-29 2006-11-09 Wyeth Procede pour preparer des oxindoles 3,3-disubstitues et des thio-oxindoles
DE102005045132A1 (de) 2005-09-22 2007-03-29 Archimica Gmbh Verfahren zur Herstellung von 2-Arylcarbonylverbindungen, 2-Arylestern und 2-Arylnitrilen sowie ihrer heteroaromatischen Analoga
GB0705656D0 (en) 2007-03-23 2007-05-02 Addex Pharmaceuticals Sa Novel compounds E1
WO2009001127A1 (fr) 2007-06-26 2008-12-31 Astrazeneca Ab Cyanocyclopropylcarboxamides en tant qu'inhibiteurs de cathepsine
ES2682303T3 (es) 2010-08-05 2018-09-19 Zoetis Services Llc Derivados de isoxazolina como agentes antiparasitarios
CA2841801A1 (fr) 2011-08-17 2013-02-21 F.Hoffmann-La Roche Ag Inhibiteurs de la tyrosine kinase de bruton
MX2015006457A (es) 2012-11-30 2015-08-14 Hoffmann La Roche Inhibidores de la tirosina cinasa de bruton.

Also Published As

Publication number Publication date
WO2016116555A1 (fr) 2016-07-28
PT3247699T (pt) 2019-08-06
PL3247699T3 (pl) 2019-11-29
EP3247699A1 (fr) 2017-11-29
US10336698B2 (en) 2019-07-02
ES2738630T3 (es) 2020-01-24
CN107428678B (zh) 2021-01-01
EP3247699B1 (fr) 2019-05-15
CA2974449C (fr) 2023-08-29
HUE044642T2 (hu) 2019-11-28
HRP20191146T1 (hr) 2019-10-04
CN107428678A (zh) 2017-12-01
DK3247699T3 (da) 2019-08-12
US20170369440A1 (en) 2017-12-28
RS58961B1 (sr) 2019-08-30

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