CA3014842A1 - Antibodies for il-17c - Google Patents

Antibodies for il-17c Download PDF

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Publication number
CA3014842A1
CA3014842A1 CA3014842A CA3014842A CA3014842A1 CA 3014842 A1 CA3014842 A1 CA 3014842A1 CA 3014842 A CA3014842 A CA 3014842A CA 3014842 A CA3014842 A CA 3014842A CA 3014842 A1 CA3014842 A1 CA 3014842A1
Authority
CA
Canada
Prior art keywords
seq
antibody
region
antibody fragment
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3014842A
Other languages
English (en)
French (fr)
Inventor
Jan Dominik HAAS
Jurgen Klattig
Nick Ernest Rene Vandeghinste
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galapagos NV
Morphosys GmbH
Original Assignee
Galapagos NV
Morphosys GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galapagos NV, Morphosys GmbH filed Critical Galapagos NV
Publication of CA3014842A1 publication Critical patent/CA3014842A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3014842A 2016-02-19 2017-02-17 Antibodies for il-17c Pending CA3014842A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP16156582.5 2016-02-19
EP16156582 2016-02-19
EP16156651.8 2016-02-22
EP16156651 2016-02-22
PCT/EP2017/053592 WO2017140831A1 (en) 2016-02-19 2017-02-17 Antibodies for il-17c

Publications (1)

Publication Number Publication Date
CA3014842A1 true CA3014842A1 (en) 2017-08-24

Family

ID=58057136

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3014842A Pending CA3014842A1 (en) 2016-02-19 2017-02-17 Antibodies for il-17c

Country Status (33)

Country Link
US (5) US20190048071A1 (sr)
EP (1) EP3416983B1 (sr)
JP (2) JP6535139B2 (sr)
KR (1) KR102715157B1 (sr)
CN (1) CN108699143B (sr)
AU (1) AU2017219837B2 (sr)
BR (1) BR112018016798A2 (sr)
CA (1) CA3014842A1 (sr)
CL (1) CL2018002340A1 (sr)
CO (1) CO2018008724A2 (sr)
CU (1) CU20180087A7 (sr)
CY (1) CY1124296T1 (sr)
DK (1) DK3416983T3 (sr)
EA (1) EA037813B1 (sr)
EC (1) ECSP18070641A (sr)
ES (1) ES2877376T3 (sr)
HR (1) HRP20211059T1 (sr)
HU (1) HUE054755T2 (sr)
IL (1) IL260733B2 (sr)
LT (1) LT3416983T (sr)
MA (2) MA44227B1 (sr)
MD (1) MD3416983T2 (sr)
MX (1) MX2018009860A (sr)
PH (1) PH12018501739A1 (sr)
PL (1) PL3416983T3 (sr)
RS (1) RS62012B1 (sr)
SG (1) SG11201806161TA (sr)
SI (1) SI3416983T1 (sr)
SM (1) SMT202100361T1 (sr)
TN (1) TN2018000289A1 (sr)
TW (1) TW201734041A (sr)
WO (1) WO2017140831A1 (sr)
ZA (1) ZA201806249B (sr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018529704A (ja) * 2015-10-05 2018-10-11 モルフォシス・アーゲー アトピー性皮膚炎の治療および/または予防のためのil−17cの拮抗剤
SG11201806161TA (en) * 2016-02-19 2018-08-30 Morphosys Ag Antibodies for il-17c
EP3688031A1 (en) * 2017-09-25 2020-08-05 MorphoSys AG Treatment of atopic dermatitis
GB201803563D0 (en) 2018-03-06 2018-04-18 Galapagos Nv Antibodies and pharmaceutical compositions thereof for the treatment of autoimmune skin diseases
TW202011995A (zh) 2018-07-03 2020-04-01 比利時商葛萊伯格有限公司 高濃度液體抗體配製物
EP4061825A1 (en) * 2019-11-22 2022-09-28 MorphoSys AG Method to increase antibody yield during ion exchange chromatography
IL292940A (en) * 2019-11-22 2022-07-01 Morphosys Ag Collection of extractant during antibody chromatography

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1247080A (en) 1983-03-08 1988-12-20 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
JP3614866B2 (ja) 1997-06-12 2005-01-26 リサーチ コーポレイション テクノロジーズ,インコーポレイティド 人工抗体ポリペプチド
AU740405B2 (en) * 1998-05-15 2001-11-01 Genentech Inc. IL-17 homologous polypeptides and therapeutic uses thereof
EP1990409A3 (en) 1999-07-20 2011-05-18 MorphoSys AG Bacteriophage
DE60226641D1 (de) 2001-12-03 2008-06-26 Amgen Fremont Inc Antikörperkategorisierung auf der grundlage von bindungseigenschaften
MX2007004597A (es) 2004-10-18 2007-06-22 Zymogenetics Inc Zcytor21 soluble, anticuerpos anti-zcytor21 y moleculas de enlace y metodos de uso en inflamacion.
CA2624763A1 (en) * 2005-10-18 2007-04-26 Zymogenetics, Inc. Il-17c antagonists and methods of using the same
CA2666842A1 (en) 2006-10-18 2008-04-24 Zymogenetics, Inc. Il-17c antagonists and methods of using the same
US20120201821A1 (en) * 2010-10-25 2012-08-09 Gonzalez Jr Lino Treatment of Gastrointestinal Inflammation and Psoriasis and Asthma
HRP20181811T1 (hr) 2010-11-19 2018-12-28 Morphosys Ag Zbirka sljedova protutijela i njezina upotreba
US20140234330A1 (en) 2011-07-22 2014-08-21 Amgen Inc. Il-17 receptor a is required for il-17c biology
SG11201401202YA (en) * 2011-10-19 2014-06-27 Morphosys Ag Antagonists of il17c for the treatment of inflammatory disorders
ES2685553T3 (es) 2012-06-12 2018-10-09 Orega Biotech Antagonistas de isoformas de IL-17 y sus usos
WO2016096896A1 (en) * 2014-12-15 2016-06-23 Morphosys Ag Antibodies for il-17c
SG11201806161TA (en) * 2016-02-19 2018-08-30 Morphosys Ag Antibodies for il-17c

Also Published As

Publication number Publication date
US10259869B2 (en) 2019-04-16
JP2019511910A (ja) 2019-05-09
US20200216529A1 (en) 2020-07-09
CU20180087A7 (es) 2019-03-04
MD3416983T2 (ro) 2021-08-31
CO2018008724A2 (es) 2018-08-31
PH12018501739A1 (en) 2019-06-10
PL3416983T3 (pl) 2021-10-25
EA201891594A1 (ru) 2019-01-31
ECSP18070641A (es) 2018-10-31
MA44227B1 (fr) 2021-06-30
US20180340024A1 (en) 2018-11-29
US20190048071A1 (en) 2019-02-14
CN108699143B (zh) 2021-11-09
US11987621B2 (en) 2024-05-21
CL2018002340A1 (es) 2018-11-23
US10633439B2 (en) 2020-04-28
IL260733B1 (en) 2023-11-01
HUE054755T2 (hu) 2021-09-28
MA43088B1 (fr) 2020-10-28
SMT202100361T1 (it) 2021-07-12
ZA201806249B (en) 2020-02-26
EA037813B1 (ru) 2021-05-24
CN108699143A (zh) 2018-10-23
TW201734041A (zh) 2017-10-01
TN2018000289A1 (en) 2020-01-16
AU2017219837A1 (en) 2018-08-09
US20190202906A1 (en) 2019-07-04
MA43088A1 (fr) 2019-05-31
KR20180109977A (ko) 2018-10-08
HRP20211059T1 (hr) 2021-10-01
AU2017219837B2 (en) 2023-08-17
JP6916834B2 (ja) 2021-08-11
LT3416983T (lt) 2021-07-12
CY1124296T1 (el) 2022-11-25
WO2017140831A1 (en) 2017-08-24
IL260733B2 (en) 2024-03-01
JP6535139B2 (ja) 2019-06-26
JP2019162119A (ja) 2019-09-26
ES2877376T3 (es) 2021-11-16
EP3416983A1 (en) 2018-12-26
SG11201806161TA (en) 2018-08-30
MA44227A (fr) 2018-12-26
RS62012B1 (sr) 2021-07-30
KR102715157B1 (ko) 2024-10-10
SI3416983T1 (sl) 2021-08-31
MX2018009860A (es) 2019-03-28
DK3416983T3 (en) 2021-06-21
BR112018016798A2 (en) 2018-12-26
EP3416983B1 (en) 2021-04-07
IL260733A (sr) 2018-09-20
US20250074978A1 (en) 2025-03-06

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