CA3045242C - Ligands opioides kappa heteroarylphenoxy benzamide - Google Patents

Ligands opioides kappa heteroarylphenoxy benzamide

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Publication number
CA3045242C
CA3045242C CA3045242A CA3045242A CA3045242C CA 3045242 C CA3045242 C CA 3045242C CA 3045242 A CA3045242 A CA 3045242A CA 3045242 A CA3045242 A CA 3045242A CA 3045242 C CA3045242 C CA 3045242C
Authority
CA
Canada
Prior art keywords
methyl
pyrazol
phenoxy
benzamide
pyrrolidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3045242A
Other languages
English (en)
Other versions
CA3045242A1 (fr
Inventor
Kapildev Kashmirilal Arora
Michael Aaron Brodney
Matthew Francis Dunn
Michael Eric Green
Natasha Mariam Kablaoui
Gregory Wayne Kauffman
Scot Richard Mente
Justin Ian Montgomery
Danica Antonia Rankic
Bruce Nelsen Rogers
Patrick Robert Verhoest
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Priority claimed from PCT/IB2017/057418 external-priority patent/WO2018096510A1/fr
Publication of CA3045242A1 publication Critical patent/CA3045242A1/fr
Application granted granted Critical
Publication of CA3045242C publication Critical patent/CA3045242C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

La présente invention concerne des composés de Formule I: et des sels pharmaceutiquement acceptables de ceux-ci, les variables R1, R2, R3, R4, R9, X, m et n sont tels que définis dans la description; des procédés pour la préparation de; des intermédiaires utilisés dans la préparation de; et des compositions contenant de tels composés ou sels, et leurs utilisations pour traiter des troubles associés aux opioïdes kappa (?-opioïdes) comprenant, par exemple, un trouble neurologique, ou un trouble psychiatrique tel qu'un trouble neurocognitif, un trouble d'abus de substance, un trouble dépressif, un trouble anxieux, un trouble lié à traumatisme et un stress et un trouble lié aux habitudes alimentaires.
CA3045242A 2016-11-28 2017-11-27 Ligands opioides kappa heteroarylphenoxy benzamide Active CA3045242C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662426980P 2016-11-28 2016-11-28
US62/426,980 2016-11-28
US201762576435P 2017-10-24 2017-10-24
US62/576,435 2017-10-24
US201762585016P 2017-11-13 2017-11-13
US62/585,016 2017-11-13
PCT/IB2017/057418 WO2018096510A1 (fr) 2016-11-28 2017-11-27 Ligands opioïdes kappa hétéroarylphénoxy benzamide

Publications (2)

Publication Number Publication Date
CA3045242A1 CA3045242A1 (fr) 2018-05-31
CA3045242C true CA3045242C (fr) 2025-09-23

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