CA3084582C - Dinucleotides 2'3' cycliques ayant une liaison phosphonate activant la proteine adaptatrice de sting - Google Patents

Dinucleotides 2'3' cycliques ayant une liaison phosphonate activant la proteine adaptatrice de sting

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Publication number
CA3084582C
CA3084582C CA3084582A CA3084582A CA3084582C CA 3084582 C CA3084582 C CA 3084582C CA 3084582 A CA3084582 A CA 3084582A CA 3084582 A CA3084582 A CA 3084582A CA 3084582 C CA3084582 C CA 3084582C
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Canada
Prior art keywords
compound
pharmaceutically acceptable
inhibitors
acceptable salt
independently
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CA3084582A
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English (en)
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CA3084582A1 (fr
Inventor
Gabriel Birkus
Ondrej Pav
Tomas Jandusik
Ivan Rosenberg
Radim Nencka
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Institute of Organic Chemistry and Biochemistry of ASCR vvi
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Application filed by Institute of Organic Chemistry and Biochemistry of ASCR vvi filed Critical Institute of Organic Chemistry and Biochemistry of ASCR vvi
Priority claimed from PCT/IB2018/060382 external-priority patent/WO2019123339A1/fr
Publication of CA3084582A1 publication Critical patent/CA3084582A1/fr
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Publication of CA3084582C publication Critical patent/CA3084582C/fr
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Abstract

La présente invention concerne des dinucléotides phosphonates 2'3' cycliques de formule générale (J), leurs sels pharmaceutiquement acceptables, leur composition pharmaceutique et des combinaisons desdites substances et d'autres médicaments ou produits pharmaceutiques. L'invention concerne également l'utilisation desdits composés pour le traitement ou la prévention de maladies ou d'états pathologiques modifiables par la modulation protéique de STING, tels que le cancer ou des maladies virales, allergiques et inflammatoires. L'invention concerne en outre, l'utilisation de ces substances en tant qu'adjuvants dans des vaccins.
CA3084582A 2017-12-20 2018-12-19 Dinucleotides 2'3' cycliques ayant une liaison phosphonate activant la proteine adaptatrice de sting Active CA3084582C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762608372P 2017-12-20 2017-12-20
US62/608,372 2017-12-20
US201862725856P 2018-08-31 2018-08-31
US62/725,856 2018-08-31
PCT/IB2018/060382 WO2019123339A1 (fr) 2017-12-20 2018-12-19 Dinucléotides 2'3' cycliques ayant une liaison phosphonate activant la protéine adaptatrice de sting

Publications (2)

Publication Number Publication Date
CA3084582A1 CA3084582A1 (fr) 2019-06-27
CA3084582C true CA3084582C (fr) 2025-11-25

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