CA3101880A1 - Dispositifs, systemes et procedes pour mesurer une caracteristique de solution d'un echantillon comprenant des micro-organismes - Google Patents

Dispositifs, systemes et procedes pour mesurer une caracteristique de solution d'un echantillon comprenant des micro-organismes Download PDF

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Publication number
CA3101880A1
CA3101880A1 CA3101880A CA3101880A CA3101880A1 CA 3101880 A1 CA3101880 A1 CA 3101880A1 CA 3101880 A CA3101880 A CA 3101880A CA 3101880 A CA3101880 A CA 3101880A CA 3101880 A1 CA3101880 A1 CA 3101880A1
Authority
CA
Canada
Prior art keywords
sample
conduit
sensor apparatus
active electrode
electrode
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3101880A
Other languages
English (en)
Inventor
Creighton T. BUIE
Hima SHAH
Nitin K. RAJAN
Ashraf M. Wahba
Oren S. KNOPFMACHER
Meike Herget
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avails Medical Inc
Original Assignee
Avails Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avails Medical Inc filed Critical Avails Medical Inc
Publication of CA3101880A1 publication Critical patent/CA3101880A1/fr
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/301—Reference electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/12—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluid; of a solid body in dependence upon reaction with a fluid, for detecting components in the fluid
    • G01N27/125—Composition of the body, e.g. the composition of its sensitive layer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/302—Electrodes, e.g. test electrodes; Half-cells pH sensitive, e.g. quinhydron, antimony or hydrogen electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/4166—Systems measuring a particular property of an electrolyte
    • G01N27/4167—Systems measuring a particular property of an electrolyte pH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/4166—Systems measuring a particular property of an electrolyte
    • G01N27/4168—Oxidation-reduction potential, e.g. for chlorination of water
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La présente invention concerne divers appareils, systèmes et procédés pour mesurer une caractéristique de solution d'un échantillon comprenant des micro-organismes. Dans un mode de réalisation, la présente invention concerne un appareil de capteur comprenant un récipient d'échantillon comprenant une chambre d'échantillon configurée pour recevoir l'échantillon et un composant de capteur de référence comprenant un conduit de référence ayant une cavité de conduit de référence définie à l'intérieur de celui-ci. La cavité de conduit de référence peut être au moins partiellement remplie d'un gel de tampon de référence, d'une solution tampon, ou d'un constituant à effet de mèche. Un segment du conduit de référence peut s'étendre dans la chambre d'échantillon. Un matériau d'électrode de référence peut être positionné au niveau d'une extrémité proximale du constituant à effet de mèche ou s'étendre partiellement dans la cavité de conduit de référence. L'appareil de capteur peut également comprendre un composant de capteur actif ayant une électrode active en contact fluidique avec l'échantillon. L'échantillon dans la chambre d'échantillon peut être aéré par l'intermédiaire d'un orifice d'aération défini le long d'une surface du récipient d'échantillon.
CA3101880A 2018-06-19 2019-06-19 Dispositifs, systemes et procedes pour mesurer une caracteristique de solution d'un echantillon comprenant des micro-organismes Pending CA3101880A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862687167P 2018-06-19 2018-06-19
US62/687,167 2018-06-19
PCT/US2019/037915 WO2019246208A1 (fr) 2018-06-19 2019-06-19 Dispositifs, systèmes et procédés pour mesurer une caractéristique de solution d'un échantillon comprenant des micro-organismes

Publications (1)

Publication Number Publication Date
CA3101880A1 true CA3101880A1 (fr) 2019-12-26

Family

ID=68983929

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3101880A Pending CA3101880A1 (fr) 2018-06-19 2019-06-19 Dispositifs, systemes et procedes pour mesurer une caracteristique de solution d'un echantillon comprenant des micro-organismes

Country Status (6)

Country Link
US (3) US11536682B2 (fr)
EP (1) EP3813646A4 (fr)
JP (2) JP7653261B2 (fr)
CN (2) CN112584754B (fr)
CA (1) CA3101880A1 (fr)
WO (1) WO2019246208A1 (fr)

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CN108350408B (zh) 2015-08-25 2022-12-16 阿威尔斯医疗公司 用于检测流体样品中有活力的微生物的设备、系统和方法
WO2018111234A1 (fr) 2016-12-13 2018-06-21 Avails Medical, Inc. Dispositifs, systèmes et procédés de détection de la présence de bactéries d'hydrolyse d'un antibiotique ss-lactamine dans un échantillon
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JP7209701B2 (ja) 2017-10-03 2023-01-20 アベイルズ メディカル，インコーポレイテッド レドックス反応に基づいて微生物の濃度及び抗感染剤に対する微生物の感受性を決定する装置、システム、及び方法
CN117451472A (zh) 2017-12-05 2024-01-26 阿威尔斯医疗公司 制备用于下游测试的包含确定浓度的感染原的输出样品
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Also Published As

Publication number Publication date
JP2024069327A (ja) 2024-05-21
EP3813646A1 (fr) 2021-05-05
CN112584754A (zh) 2021-03-30
US11536682B2 (en) 2022-12-27
JP2021527821A (ja) 2021-10-14
EP3813646A4 (fr) 2022-03-30
WO2019246208A1 (fr) 2019-12-26
CN112584754B (zh) 2024-10-01
CN119147604A (zh) 2024-12-17
JP7653261B2 (ja) 2025-03-28
US20240288395A1 (en) 2024-08-29
US20210131993A1 (en) 2021-05-06
US12007350B2 (en) 2024-06-11
US20230090007A1 (en) 2023-03-23

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