CH101278A - Process for the preparation of a mercury salt of the complex bismuthyltartaric acid. - Google Patents
Process for the preparation of a mercury salt of the complex bismuthyltartaric acid.Info
- Publication number
- CH101278A CH101278A CH101278DA CH101278A CH 101278 A CH101278 A CH 101278A CH 101278D A CH101278D A CH 101278DA CH 101278 A CH101278 A CH 101278A
- Authority
- CH
- Switzerland
- Prior art keywords
- mercury
- acid
- complex
- bismuthyltartaric
- preparation
- Prior art date
Links
- 239000002253 acid Substances 0.000 title claims description 8
- 150000002730 mercury Chemical class 0.000 title claims description 6
- 238000002360 preparation method Methods 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 3
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims description 7
- 229910052753 mercury Inorganic materials 0.000 claims description 7
- 229910052797 bismuth Inorganic materials 0.000 claims description 5
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 2
- 238000002474 experimental method Methods 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 230000001988 toxicity Effects 0.000 claims description 2
- 231100000419 toxicity Toxicity 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- -1 alkali metal salts Chemical class 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 150000001622 bismuth compounds Chemical class 0.000 description 1
- 229910001987 mercury nitrate Inorganic materials 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- DRXYRSRECMWYAV-UHFFFAOYSA-N nitrooxymercury Chemical compound [Hg+].[O-][N+]([O-])=O DRXYRSRECMWYAV-UHFFFAOYSA-N 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Darstellung eines Quecksilbersalzes der komplexen Bismutylweinsäure. Es wurde gefunden, dass eine komplexe Wismutverbindung der Weinsäure mitQueck- silbersalzen zu einer Verbindung zusammen tritt, die als Quecksilbersalz der komplexen Bismutylweinsäure anzusehen ist. Die Dar stellung der neuen Verbindung kann in der Weise geschehen, dass die komplexe Bismutyl- weinsäure in Form ihrer Alkalisalze, wie z. B. das bismutylweinsaure Kalium (Zeit schrift für anorganische Chemie 48, 208 (1906), mit Salzen des Quecksilbers umge setzt werden.
Das Präparat soll bei der Behandlung der Syphilis Verwendung finden. Der Gehalt des Präparates an Wismut und Quecksilber schwankt je nach der Menge der angewand ten Komponenten; seine Giftigkeit ist ge ringer als die der wismutfreien Verbindun gen mit gleichem Gehalt an Quecksilber, anderseits ist im Tierversuch die therapeu tische Wirkung des Wismuts durch die Quecksilberkomponente verstärkt. <I>.
Beispiel:</I> 10 gr bismutylweinsaures Natrium wer den in 500 ccm Wasser gelöst und in eine schwach mit Salpetersäure angesäuerte Lö sung von 6,5 gr Merkuronitrat in 150 ccm Wasser eingegossen. Es fällt ein weisser, gallertiger Niederschlag, der nach dem Aus waschen und Trocknen ein schweres, weisses Pulver mit einem Gehalt von etwa 40 Wismut und 34% Quecksilber bildet.
Process for the preparation of a mercury salt of the complex bismuthyltartaric acid. It has been found that a complex bismuth compound of tartaric acid combines with mercury salts to form a compound which is to be regarded as the mercury salt of the complex bismuthyltartaric acid. The presentation of the new compound can be done in such a way that the complex bismuthyltartaric acid in the form of its alkali salts, such as. B. the bismutyltartaric acid potassium (journal for inorganic chemistry 48, 208 (1906), with salts of mercury is implemented.
The preparation is said to be used in the treatment of syphilis. The bismuth and mercury content of the preparation varies depending on the amount of components used; its toxicity is lower than that of the bismuth-free compounds with the same mercury content; on the other hand, the therapeutic effect of bismuth is enhanced by the mercury component in animal experiments. <I>.
Example: </I> 10 g bismutyltartaric acid sodium are dissolved in 500 ccm water and poured into a solution of 6.5 g mercury nitrate in 150 ccm water that is weakly acidified with nitric acid. A white, gelatinous precipitate falls which, after washing and drying, forms a heavy, white powder with a content of about 40 bismuth and 34% mercury.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE101278X | 1922-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH101278A true CH101278A (en) | 1923-09-17 |
Family
ID=5648842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH101278D CH101278A (en) | 1922-01-25 | 1923-01-22 | Process for the preparation of a mercury salt of the complex bismuthyltartaric acid. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH101278A (en) |
-
1923
- 1923-01-22 CH CH101278D patent/CH101278A/en unknown
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