CH141420A - Process for the preparation of a detoxified agaric acid preparation. - Google Patents

Process for the preparation of a detoxified agaric acid preparation.

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Publication number
CH141420A
CH141420A CH141420DA CH141420A CH 141420 A CH141420 A CH 141420A CH 141420D A CH141420D A CH 141420DA CH 141420 A CH141420 A CH 141420A
Authority
CH
Switzerland
Prior art keywords
preparation
detoxified
agaric acid
parts
agaric
Prior art date
Application number
Other languages
German (de)
Inventor
Ludwig Dr Hofbauer
Original Assignee
Ludwig Dr Hofbauer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Dr Hofbauer filed Critical Ludwig Dr Hofbauer
Publication of CH141420A publication Critical patent/CH141420A/en

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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Darstellung eines entgifteten     Agaricinsäurepr        äpar        ates.       Die     Agaricinsäure,    der Träger der pharma  kologischen Wirkung des Lärchenschwamms,  hat sich als wertvolles Heilmittel erwiesen.  Ihrer therapeutischen Verwendung steht in  dessen entgegen, dass zuweilen äusserst un  erwünschte Nebenwirkungen     hämolytischer     Natur auftreten.  



  Es wurde nun gefunden, dass die für den  Körper bedrohlichen Eigenschaften der     Aga-          ricinsäure    aufgehoben werden, wenn man sie  mit     Theophyllin    und     Coffein    kombiniert. In  ausgedehnten Versuchen wurde festgestellt,  dass derartige Kombinationen nur noch die  günstigen Wirkungen der     Agaricinsäure    ohne  deren schädliche Nebenwirkungen zeigen.

    Eine besondere Bedeutung gewinnen die  neuen Produkte weiterhin dadurch, dass sie  sich bei der Behandlung von Asthma als  Mittel erwiesen haben, die sie andern bisher  auf diesem Indikationsgebiet gebrauchten  Mitteln     gegenüber    hinsichtlich Zuverlässig-         keit,    Wirksamkeit und Verträglichkeit als  weit überlegen erscheinen lassen.  



  <I>Beispiel:</I>  8,86     gr        Agaricinsäure,    7,92     gr        Theophyl-          lin    und 4,32     gr        Coffein    werden gemeinsam  in zum Sieden erhitztem Alkohol gelöst,  worauf die Lösung im Vakuum zur Trockne.  eingedampft wird. Das erhaltene Produkt  stellt eine farblose Substanz vor, die bei  <B>1030</B> zu schmelzen beginnt, in kaltem Was  ser fast unlöslich ist, sich aber in heissem  Wasser leicht löst. Bei etwa 201 löst sich  ein Teil der Substanz in etwa 25 Teilen  90     o/oigen    Alkohols. Die Löslichkeit im Äther  und in Chloroform ist gering.



  Process for the preparation of a detoxified agaric acid preparation. Agaricic acid, the carrier of the pharmacological effects of the larch sponge, has proven to be a valuable remedy. Their therapeutic use is opposed to the fact that sometimes extremely undesirable side effects of a hemolytic nature occur.



  It has now been found that the properties of agaricic acid which are threatening to the body are canceled out if it is combined with theophylline and caffeine. In extensive experiments it was found that such combinations only show the beneficial effects of agaric acid without its harmful side effects.

    The new products continue to gain particular importance because they have proven to be agents in the treatment of asthma which make them appear far superior to other agents previously used in this area of indication in terms of reliability, effectiveness and tolerability.



  <I> Example: </I> 8.86 grams of agaric acid, 7.92 grams of theophylline and 4.32 grams of caffeine are dissolved together in boiling alcohol, whereupon the solution is dried to dryness in a vacuum. is evaporated. The product obtained is a colorless substance that begins to melt at <B> 1030 </B>, is almost insoluble in cold water, but dissolves easily in hot water. At around 201, part of the substance dissolves in around 25 parts of 90% alcohol. The solubility in ether and in chloroform is low.

Claims (1)

<B>PATENTANSPRUCH:</B> Verfahren zur Darstellung eines entgif teten Agaricinsäurepräparates, dadurch ge kennzeichnet, dass Agaricinsäure mit Theo- phyllin und Coffein kombiniert wird, wodurch ein Präparat gewonnen wird, das ein farb loses Pulver darstellt, welches bei 103 zu schmelzen beginnt, in kaltem Wasser fast unlöslich, in heissem Wasser leicht löslich ist und sich bei 20 in etwa 25 Teilen eines Gemisches von 90 Volum-Teilen Alkohol und 10 Teilen Wasser lösen lässt. <B> PATENT CLAIM: </B> Method for the preparation of a detoxified agaric acid preparation, characterized in that agaric acid is combined with theophylline and caffeine, whereby a preparation is obtained which is a colorless powder which melts at 103 begins, is almost insoluble in cold water, is easily soluble in hot water and can be dissolved at 20 in about 25 parts of a mixture of 90 parts by volume of alcohol and 10 parts of water.
CH141420D 1927-10-11 1928-10-08 Process for the preparation of a detoxified agaric acid preparation. CH141420A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT141420X 1927-10-11

Publications (1)

Publication Number Publication Date
CH141420A true CH141420A (en) 1930-07-31

Family

ID=3641664

Family Applications (1)

Application Number Title Priority Date Filing Date
CH141420D CH141420A (en) 1927-10-11 1928-10-08 Process for the preparation of a detoxified agaric acid preparation.

Country Status (1)

Country Link
CH (1) CH141420A (en)

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