CH147040A - Process for the preparation of a carbazole derivative. - Google Patents
Process for the preparation of a carbazole derivative.Info
- Publication number
- CH147040A CH147040A CH147040DA CH147040A CH 147040 A CH147040 A CH 147040A CH 147040D A CH147040D A CH 147040DA CH 147040 A CH147040 A CH 147040A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- carbazole derivative
- oxycarbazole
- heating
- converted
- Prior art date
Links
- 125000000609 carbazolyl group Chemical class C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title claims description 5
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 3
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 3
- 235000011116 calcium hydroxide Nutrition 0.000 claims description 3
- 239000000920 calcium hydroxide Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000000975 dye Substances 0.000 claims description 2
- 239000007858 starting material Substances 0.000 claims description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
Landscapes
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Darstellung eines Karbazolderivates. Im Hauptpatent ist ein Verfahren zur Darstellung eines Karbazolderivates beschrie ben, das dadurch gekennzeichnet ist, dass man 1-Oxykai#bazol-2-earbotisäure durch-Er- hitzen in das 1-Oxykarbazol überführt.
Geuenstand vorlie ender Erfindung ist nun <B>0 9</B> ein Verfahren zur Darstellung eines Karbazol- derivates, dadurch gekennzeichnet, dass man 1-Oxykarbazol-8-earbotisaures Calcium. in Mi schung mit gelöschtem Kalk durch Erhitzen in das 1-Oxykarbazol überführt.
<I>Beispiel:</I> <B>100</B> Gewichtsteile 1-Oxykarbazol-8-ear- bonsatires Caleium werden mit etwa der doppelten Gewichtsmenge von trockenem gelöschtem Kalk verrieben und etwa 1-11/2 Stunden auf 270-280' erhitzt.
Nach Er kalten wird das Reaktionsgemisch fein pul verisiert und zwecks Abtrennung des 1-Oxy- karbazols mit einem organischen Lösungs- mittel, beispielsweise Aceton, extrabiert. Nach Abdestillieren des Acetons erhält inan das 1-Oxykarbazol, das nach Umkristallieren aus verdünntem Alkohol die in der Literatur angegebenen Eigenschaften zeigt. Es soll als Ausgangsmaterial<B>für</B> Farbstoffe und Arznei mittel dienen.
Process for the preparation of a carbazole derivative. The main patent describes a process for the preparation of a carbazole derivative which is characterized in that 1-oxycarbazole-2-earbotic acid is converted into 1-oxycarbazole by heating.
The current status of the present invention is now a process for the preparation of a carbazole derivative, characterized in that 1-oxycarbazole-8-earbotisate calcium is used. in a mixture with slaked lime converted into 1-oxycarbazole by heating.
<I> Example: </I> <B> 100 </B> parts by weight of 1-Oxykarbazol-8-ear- bonsatires Caleium are rubbed with about twice the weight of dry slaked lime and for about 1-11 / 2 hours at 270- 280 'heated.
After cooling, the reaction mixture is finely pulverized and extracted with an organic solvent, for example acetone, for the purpose of separating off the 1-oxycarbazole. After the acetone has been distilled off, 1-oxycarbazole is obtained, which after recrystallization from dilute alcohol shows the properties given in the literature. It is intended to serve as the starting material <B> for </B> dyes and drugs.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE147040X | 1928-01-02 | ||
| CH143702T | 1928-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH147040A true CH147040A (en) | 1931-05-15 |
Family
ID=25714321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH147040D CH147040A (en) | 1928-01-02 | 1928-08-30 | Process for the preparation of a carbazole derivative. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH147040A (en) |
-
1928
- 1928-08-30 CH CH147040D patent/CH147040A/en unknown
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