CH176252A - Process for the preparation of 2-ethylmercury mercaptobenzimidazole-5-arsenic acid sodium. - Google Patents
Process for the preparation of 2-ethylmercury mercaptobenzimidazole-5-arsenic acid sodium.Info
- Publication number
- CH176252A CH176252A CH176252DA CH176252A CH 176252 A CH176252 A CH 176252A CH 176252D A CH176252D A CH 176252DA CH 176252 A CH176252 A CH 176252A
- Authority
- CH
- Switzerland
- Prior art keywords
- mercaptobenzimidazole
- ethylmercury
- preparation
- acid
- acid sodium
- Prior art date
Links
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title claims description 5
- 229910052708 sodium Inorganic materials 0.000 title claims description 5
- 239000011734 sodium Substances 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 4
- PJDVOLYULHZZAG-UHFFFAOYSA-N ethylmercury Chemical compound CC[Hg] PJDVOLYULHZZAG-UHFFFAOYSA-N 0.000 title claims 2
- 229940000488 arsenic acid Drugs 0.000 title description 3
- 238000002360 preparation method Methods 0.000 title description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- QWUGXIXRFGEYBD-UHFFFAOYSA-M ethylmercuric chloride Chemical compound CC[Hg]Cl QWUGXIXRFGEYBD-UHFFFAOYSA-M 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 235000019441 ethanol Nutrition 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 230000002378 acidificating effect Effects 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- -1 2-ethylmercury mercaptobenzimidazole- Chemical compound 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung von 2-äthylquecksilbermercaptobenzimidazol-ö-arsensaurem Natrium. Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Herstellung von 2-äthyl quecksilbermercaptobenzimidazol-5-arsensau- rem Natrium, das dadurch gekennzeichnet ist, dass man Äthylquecksilberchlorid mit 2-Mer- captobenzimidazol-5-arsinsäure umsetzt und die so erhaltene Säure in das Natriumsalz überführt.
Die entstandene neue Verbindung ist leicht löslich in Wasser und Methylalkohol, schwe rer in Äthylalkohol und unlöslich in Äther und Aceton. Sie soll als Arzneimittel und Antiseptioum verwandt werden.
Beispiel: 8,63 gr 2-Mercaptobenzimidazol-5-arsin- säure (erhalten nach Beispiel 1 der deutschen Patentschrift Nr. 531801) werden in über schüssiger Natronlauge gelöst und in eine wässerige alkoholische Aufschwemmung von 7,93 gr Äthylquecksilberchlorid eingerührt Es tritt völlige Lösung ein und beim An säuern scheidet sich die quecksilberhaltige Säure ab. Der Niederschlag wird abgesaugt, gewaschen und mit Natronlauge vorsichtig curcumaalkalisch gemacht. Nach Filtrieren wird die Lösung in Äther eingerührt.
Das sich hierbei abscheidende farblose 2-äthyl- quecksilbermercaptobenzimidazol- 5-arsinsaure Natrium von der Formel:
EMI0001.0020
zeigt dieselben Eigenschaften in bezug auf Löslichkeit wie die entsprechende Sulfonsäure- verbindung.
Process for the preparation of 2-ethylmercury mercaptobenzimidazole-ö-arsenic acid sodium. The present invention relates to a process for the preparation of 2-ethylmercaptobenzimidazole-5-arsenic acid rem sodium, which is characterized in that ethylmercury chloride is reacted with 2-mercaptobenzimidazole-5-arsic acid and the acid thus obtained is converted into the sodium salt .
The resulting new compound is easily soluble in water and methyl alcohol, more difficult in ethyl alcohol and insoluble in ether and acetone. It should be used as a medicine and an antiseptic.
Example: 8.63 grams of 2-mercaptobenzimidazole-5-arsinic acid (obtained according to Example 1 of German Patent No. 531801) are dissolved in excess sodium hydroxide solution and stirred into an aqueous alcoholic suspension of 7.93 grams of ethyl mercury chloride. Complete solution occurs on and when acidifying, the mercury-containing acid separates out. The precipitate is filtered off with suction, washed and carefully made curcuma-alkaline with sodium hydroxide solution. After filtering, the solution is stirred into ether.
The colorless 2-ethyl-mercury-mercaptobenzimidazole-5-arsinic acid sodium which separates out has the formula:
EMI0001.0020
shows the same properties in terms of solubility as the corresponding sulfonic acid compound.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE176252X | 1932-04-16 | ||
| CH167320T | 1933-04-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH176252A true CH176252A (en) | 1935-03-31 |
Family
ID=25718405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH176252D CH176252A (en) | 1932-04-16 | 1933-04-13 | Process for the preparation of 2-ethylmercury mercaptobenzimidazole-5-arsenic acid sodium. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH176252A (en) |
-
1933
- 1933-04-13 CH CH176252D patent/CH176252A/en unknown
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