CH201872A - Process for the preparation of 3,6-diamino-10-methylacridinium glycolate. - Google Patents

Process for the preparation of 3,6-diamino-10-methylacridinium glycolate.

Info

Publication number
CH201872A
CH201872A CH201872DA CH201872A CH 201872 A CH201872 A CH 201872A CH 201872D A CH201872D A CH 201872DA CH 201872 A CH201872 A CH 201872A
Authority
CH
Switzerland
Prior art keywords
diamino
preparation
glycolate
methylacridinium
water
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH201872A publication Critical patent/CH201872A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Description

  

  Verfahren zur     Herstellung    von     3,0-Diamino-10-methylacridiniumglykolat.       Die vorliegende Erfindung bezieht sich  auf ein Verfahren zur Herstellung von     3;6-          Diamino-10-m-etllylacridiniumglykol,at,        wel-          ches    .dadurch     gekennzeichnet    ist,     @daZ    man 3,6  Diamino--10     -methylacridiniumzyklohexanon-          verbindung    mit Wasser kocht und     das    so  entstehende     Acridiniumhydroxyd    mit     Glykol-          säure    umsetzt.

    



  Das so     erhältliche        @3,6-Diamino-10-methyl-          acridiniumglykolatstellt        ein    rotbraunes Pul  ver dar, das in Äther, Benzol und Chloroform  unlöslich, in Aceton schwer löslich und in  Äthanol,     Methanol    und Wasser     leicht        1ö    lieh  ist; es soll für     pharmazeutische    Zwecke Ver  wendung finden.  



  <I>Beispiel:</I>  320     ,g        3,6-Di@amino-10-methylaeridinium-          zykloh,exanonverbindung    werden am abstei  genden     Kühler    mit 10 Liter Wasser und  etwas     Tierkohle    :gekocht. Dabei wird durch  Einleiten von Stickstoff die Luft verdrängt,  um     Oxydation        der        Ammoniumbase        ,zu    ver  hindern.

   Wenn     alles        Zyklohexanon        abd        es@til-          liert    ist, gibt man 76     g        Glykolsäure    zu, fil-         triert    und dampft im Vakuum zur     Trockne.     Durch     Aufnehmen    in Alkohol und Fällen  mit     Aceton    und Äther erhält man     ein    rot  braunes Pulver.     Daus        3,6-Diamino-l0-znethyl-          acridiniumglykolat    löst sich in Alkohol und  Essigester.

   In Äther, Aceton und Benzol ist  es unlöslich, in Wasser löst es     sichspielend     leicht.



  Process for the preparation of 3,0-diamino-10-methylacridinium glycolate. The present invention relates to a process for the production of 3; 6- diamino-10-m-ethyllacridiniumglycol, ate, which is characterized by boiling 3.6 diamino-10-methylacridiniumcyclohexanone compound with water and the resulting acridinium hydroxide is reacted with glycolic acid.

    



  The thus obtainable @ 3,6-diamino-10-methyl-acridiniumglykolat is a red-brown powder which is insoluble in ether, benzene and chloroform, sparingly soluble in acetone and easily borrowed in ethanol, methanol and water; it is intended to be used for pharmaceutical purposes.



  <I> Example: </I> 320, g of 3,6-Di @ amino-10-methylaeridinium- cycloh, exanone compound are boiled on the descending cooler with 10 liters of water and some animal charcoal. The air is displaced by introducing nitrogen in order to prevent oxidation of the ammonium base.

   When all the cyclohexanone has been removed, 76 g of glycolic acid are added, the mixture is filtered and evaporated to dryness in vacuo. A red-brown powder is obtained by absorption in alcohol and precipitation with acetone and ether. The 3,6-diamino-10-methyl acridinium glycolate dissolves in alcohol and ethyl acetate.

   It is insoluble in ether, acetone and benzene; in water it dissolves easily.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von 3,6-Di- amino-10-methylacrmdiniumglykolat, dadurch gekennzeichnet, dass man 8; PATENT CLAIM: Process for the preparation of 3,6-di-amino-10-methylacrmdiniumglycolate, characterized in that 8; 6-Diamino-10,-me- thylacridiniumzyklo#hexanonverbindung mit Wasser kocht und das so entstehende Aori- ,diniumhydroxyd mit Glykol@säure umsetzt. Die neue Verbindung stellt ein rotbraunes Pulver dar, das in. Äther, Benzol und: 6-diamino-10, -methylacridiniumcyclohexanone compound boils with water and the resulting aori, dinium hydroxide is reacted with glycolic acid. The new compound is a reddish brown powder that is contained in ether, benzene and: Chloro- form unlöslich, in Aceton schwer löslich. und in Äthanol, Methanol und Wasser leicht lös lich ist; sie soll für pharmazeutische Zwecke Verwendung finden. Chloroform insoluble, sparingly soluble in acetone. and is easily soluble in ethanol, methanol and water; it should be used for pharmaceutical purposes.
CH201872D 1935-04-20 1936-04-18 Process for the preparation of 3,6-diamino-10-methylacridinium glycolate. CH201872A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE201872X 1935-04-20
CH197431T 1936-04-18

Publications (1)

Publication Number Publication Date
CH201872A true CH201872A (en) 1938-12-15

Family

ID=25722988

Family Applications (1)

Application Number Title Priority Date Filing Date
CH201872D CH201872A (en) 1935-04-20 1936-04-18 Process for the preparation of 3,6-diamino-10-methylacridinium glycolate.

Country Status (1)

Country Link
CH (1) CH201872A (en)

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