CH201871A - Process for the preparation of 3,6-diamino-10-methylacridinium lactate. - Google Patents

Process for the preparation of 3,6-diamino-10-methylacridinium lactate.

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Publication number
CH201871A
CH201871A CH201871DA CH201871A CH 201871 A CH201871 A CH 201871A CH 201871D A CH201871D A CH 201871DA CH 201871 A CH201871 A CH 201871A
Authority
CH
Switzerland
Prior art keywords
sep
diamino
methylacridinium
lactate
water
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH201871A publication Critical patent/CH201871A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung von     3,6-Diamino-10-methylacridiniumlactat.     
EMI0001.0002     
  
    Die <SEP> vorliegende <SEP> Erfindung <SEP> bezieht <SEP> sich
<tb>  auf <SEP> ein <SEP> Verfahren <SEP> zur <SEP> Herstellung <SEP> von <SEP> 3,6  Diamino-10-metliylaeridiniumla.etat, <SEP> welches
<tb>  dadurch: <SEP> :gekennzeichnet <SEP> ist, <SEP> :dass <SEP> man <SEP> 3,6-Di  amino-10-methylacridiniumacetonverbin.dung
<tb>  mit <SEP> Wasser <SEP> kocht <SEP> und <SEP> das <SEP> so <SEP> entstehende
<tb>  Aeri:diniumliydro.-"yd <SEP> mit <SEP> Milchsäure <SEP> umsetzt.
<tb>  



  Das <SEP> so <SEP> erhältliche <SEP> 3,6-T@iamino-10-ni:etliyl  aeridiniumla.ctat <SEP> stellt <SEP> ein <SEP> rotbraunes <SEP> Kristall  pillverdar, <SEP> das <SEP> in <SEP> Äther, <SEP> Benzol <SEP> und <SEP> Chloro  form <SEP> itnlöslicli, <SEP> in <SEP> Aceton <SEP> schwer <SEP> löslich <SEP> und
<tb>  in <SEP> Äthanol, <SEP> Methanol <SEP> und <SEP> Wasser <SEP> leicht <SEP> lös  lich <SEP> ist; <SEP> :es <SEP> soll <SEP> für <SEP> ph <SEP> arma.zeutisehe <SEP> Zwecke
<tb>  Verwendung <SEP> finden.
<tb>  



  <I>Beispiel:</I>
<tb>  280 <SEP> g <SEP> 3;6-Diamino-l0-methylacridinium  riec <SEP> toiiverbindung <SEP> werden <SEP> mit <SEP> 10 <SEP> Liter <SEP> Wasser
<tb>  und <SEP> etwas <SEP> Tierkohle <SEP> erhitzt. <SEP> Das <SEP> entwei  chende <SEP> Aceton <SEP> wird <SEP> mit <SEP> einem <SEP> Teil <SEP> des
<tb>  Was#ers <SEP> zusammen <SEP> ab,destilliert. <SEP> Da <SEP> :das <SEP> ent-     
EMI0001.0003     
  
    stehende <SEP> Acridiniumhy.drogyd <SEP> sehr <SEP> ogydabel
<tb>  ist, <SEP> leitet <SEP> man <SEP> einen <SEP> Stiekstoffstro@m <SEP> :durch
<tb>  den <SEP> Kolben. <SEP> Man <SEP> :destilliert <SEP> das <SEP> Wasser <SEP> bis
<tb>  zu <SEP> dem <SEP> gewünschten: <SEP> Volumen <SEP> ab, <SEP> versetzt.
<tb>  mit <SEP> 100 <SEP> .g <SEP> 90 <SEP> 9o"iger <SEP> Milchsäure <SEP> und <SEP> filti:

   <SEP> ert.
<tb>  Die <SEP> erhaltene <SEP> Lösung <SEP> des <SEP> 3;6-Diamino-10  methylacri@diniumla,ctat6 <SEP> wird <SEP> auf <SEP> den <SEP> ge  \i,ünschten <SEP> Gehalt <SEP> einbestellt <SEP> und <SEP> ist <SEP> sofort
<tb>  gebrauchsfertig. <SEP> Durch <SEP> <B>Ei</B> <SEP> inda,mpfen <SEP> der <SEP> U  sung, <SEP> Aufnehmen: <SEP> ,des <SEP> Rückstandes <SEP> in <SEP> Al  kohol <SEP> und <SEP> Fällen <SEP> mit <SEP> Äther <SEP> lässt <SEP> sich <SEP> das
<tb>  Lactat <SEP> als <SEP> rotbraunes <SEP> Kristallpulver <SEP> gewin  nen, <SEP> .das <SEP> in <SEP> den <SEP> meisten <SEP> organischen <SEP> Lösungs  mitteln <SEP> mehr <SEP> oder <SEP> weniger <SEP> leicht, <SEP> in <SEP> Wasser
<tb>  fast <SEP> unbeschränkt <SEP> löslich <SEP> ist.



  Process for the preparation of 3,6-diamino-10-methylacridinium lactate.
EMI0001.0002
  
    The <SEP> present <SEP> invention <SEP> relates <SEP>
<tb> on <SEP> a <SEP> process <SEP> for the <SEP> production <SEP> of <SEP> 3,6 diamino-10-metliylaeridiniumla.etat, <SEP> which
<tb> characterized by: <SEP>: marked <SEP>, <SEP>: that <SEP> one <SEP> 3,6-diamino-10-methylacridinium acetone compound
<tb> with <SEP> water <SEP> boils <SEP> and <SEP> the <SEP> so <SEP> resulting
<tb> Aeri: diniumliydro .- "yd <SEP> reacts with <SEP> lactic acid <SEP>.
<tb>



  The <SEP> <SEP> available <SEP> 3,6-T @ iamino-10-ni: etliyl aeridiniumla.ctat <SEP> represents <SEP> a <SEP> red-brown <SEP> crystal pillver, <SEP> that <SEP> in <SEP> ether, <SEP> benzene <SEP> and <SEP> chloroform <SEP> insoluble, <SEP> in <SEP> acetone <SEP> difficultly soluble <SEP> <SEP> and
<tb> in <SEP> ethanol, <SEP> methanol <SEP> and <SEP> water <SEP> is slightly <SEP> soluble <SEP>; <SEP>: it <SEP> should <SEP> for <SEP> ph <SEP> arma.zeutisehe <SEP> purposes
<tb> Find use <SEP>.
<tb>



  <I> Example: </I>
<tb> 280 <SEP> g <SEP> 3; 6-diamino-10-methylacridinium riec <SEP> toiiverbverbindungen <SEP> become <SEP> with <SEP> 10 <SEP> liters <SEP> water
<tb> and <SEP> a little <SEP> animal charcoal <SEP> heated. <SEP> The <SEP> escaping <SEP> acetone <SEP> becomes <SEP> with <SEP> a <SEP> part <SEP> of the
<tb> Was # ers <SEP> together <SEP> from, distilled. <SEP> Since <SEP>: the <SEP>
EMI0001.0003
  
    standing <SEP> acridinium hy.drogyd <SEP> very <SEP> ogydabel
<tb> is, <SEP> passes <SEP> man <SEP> a <SEP> Stiekstoffstro @ m <SEP>: through
<tb> the <SEP> piston. <SEP> Man <SEP>: <SEP> distills the <SEP> water <SEP> until
<tb> to <SEP> the <SEP> desired: <SEP> volume <SEP> down, <SEP> offset.
<tb> with <SEP> 100 <SEP> .g <SEP> 90 <SEP> 9o "iger <SEP> lactic acid <SEP> and <SEP> filti:

   <SEP> ert.
<tb> The <SEP> received <SEP> solution <SEP> of the <SEP> 3; 6-Diamino-10 methylacri @ diniumla, ctat6 <SEP> is <SEP> on <SEP> the <SEP> \ i, Desired <SEP> salary <SEP> ordered <SEP> and <SEP> is <SEP> immediately
<tb> ready to use. <SEP> Through <SEP> <B> Ei </B> <SEP> inda, <SEP> the <SEP> solution, <SEP> record: <SEP>, the <SEP> residue <SEP> in < SEP> Alcohol <SEP> and <SEP> Cases <SEP> with <SEP> ether <SEP> <SEP> can <SEP> that
<tb> Lactate <SEP> as <SEP> red-brown <SEP> crystal powder <SEP>, <SEP>. the <SEP> in <SEP> the <SEP> most <SEP> organic <SEP> solvents <SEP > more <SEP> or <SEP> less <SEP> light, <SEP> in <SEP> water
<tb> almost <SEP> is <SEP> soluble <SEP> without restriction.

Claims (1)

EMI0001.0004 <B>PATENTA</B> <SEP> 1\TSPRÜCH <tb> Verfahren <SEP> zur <SEP> Herstellung <SEP> von <SEP> 3,6-Di amino-1@0-methylacridiniumlactat, <SEP> dadurch <tb> bekennze:ichnet, <SEP> dass <SEP> man <SEP> 3;6-Diamino 10 <SEP> - <SEP> methylacri@diniumacetonverbindunä <SEP> mit Wasser kocht und das so entstehende Acri- diniumhydroayd mit Milchsiq.ure umsetzt. Die neue Verbindung stellt ein rotbraunes Pulver dar, das in Äther, Benzol und Chloro form unlöslich, in Aceton schwer läslich und in Äthanol, Methanol und Wasser leicht lös- lieh ist; sie soll für pharmazeutische Zwecke Verwendung finden. EMI0001.0004 <B> PATENTA </B> <SEP> 1 \ TSPRÜCH <tb> Process <SEP> for the <SEP> production <SEP> of <SEP> 3,6-diamino-1 @ 0-methylacridinium lactate, <SEP> thereby <tb> confess: Ichnet, <SEP> that <SEP> man <SEP> 3; 6-Diamino 10 <SEP> - <SEP> methylacri @ diniumacetonverbindunä <SEP> boils with water and the resulting acridinium hydroxide with milk Siq. ure implements. The new compound is a red-brown powder that is insoluble in ether, benzene and chloroform, difficult to dissolve in acetone and easily soluble in ethanol, methanol and water; it should be used for pharmaceutical purposes.
CH201871D 1935-04-20 1936-04-18 Process for the preparation of 3,6-diamino-10-methylacridinium lactate. CH201871A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE201871X 1935-04-20
CH197431T 1936-04-18

Publications (1)

Publication Number Publication Date
CH201871A true CH201871A (en) 1938-12-15

Family

ID=25722987

Family Applications (1)

Application Number Title Priority Date Filing Date
CH201871D CH201871A (en) 1935-04-20 1936-04-18 Process for the preparation of 3,6-diamino-10-methylacridinium lactate.

Country Status (1)

Country Link
CH (1) CH201871A (en)

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