CH235478A - Process for the production of a preparation from the blood sugar lowering hormone of the pancreas. - Google Patents
Process for the production of a preparation from the blood sugar lowering hormone of the pancreas.Info
- Publication number
- CH235478A CH235478A CH235478DA CH235478A CH 235478 A CH235478 A CH 235478A CH 235478D A CH235478D A CH 235478DA CH 235478 A CH235478 A CH 235478A
- Authority
- CH
- Switzerland
- Prior art keywords
- solution
- preparation
- production
- blood sugar
- sugar lowering
- Prior art date
Links
- 239000008280 blood Substances 0.000 title claims description 7
- 210000004369 blood Anatomy 0.000 title claims description 7
- 229940088597 hormone Drugs 0.000 title claims description 7
- 239000005556 hormone Substances 0.000 title claims description 7
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- 238000000034 method Methods 0.000 title claims description 7
- 210000000496 pancreas Anatomy 0.000 title claims description 5
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 20
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 12
- 102000004877 Insulin Human genes 0.000 claims description 10
- 108090001061 Insulin Proteins 0.000 claims description 10
- 229940125396 insulin Drugs 0.000 claims description 10
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 6
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 239000003518 caustics Substances 0.000 claims description 4
- 239000002244 precipitate Substances 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- -1 trichlorobutyl alcohol Chemical compound 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Description
Verfahren zur Herstellung eines Präparates aus dem blutzuckersenkenden Hormon der Bauchspeicheldr se.
Gegenstand des vorliegenden Zusatz- patentes ist ein Verfahren zur Herstellung eines PrÏparates aus dem blutzuckersenken denHormonderBauchspeicheldrüse,welches dadurch gekennzeichnet ist, da? man ds nach dem Schweizer Patent Nr. 219800 erhaltene InsulinprÏparat mit Magnesiumchlorid, welches in Wasser gelöst ist, umsetzt.
Beispiel :
10 g eines nach dem Schweizer Patent Nr. 219800 erhaltenen InsulinprÏparates werden in 2 Liter 0,5%iger Trichlorbutylalkohollösung durch Zusatz von 12, 5 cm3 n-Salzsäure in L¯sung gebracht. Man gibt 1, 3 g Magnesiumchlorid und 15 g Kochsalz zu und versetzt dann mit 500 cm3 einer L¯sung, die 14, 4 g sekundares Natriumphos- phat + 8 cm3 n-Natronlauge in 0, 5 % iger Trichlorbutylalkohollosung enthält. Man erhält eine Suspension, die in 1 cm3 40 Einheiten Insulin enthält und ein pu von zirka 7 aufweist.
Das so erhaltene protrahierend wirkende Insulinpräparat l¯st sich auf Zusatz von Salzsäure. Aus dieser Losung fällt Natron- lauge einen Niederschlag aus, der bei weiterem Zusatz von Lauge wieder in Lösung geht.
PATENTANSPRUCH :
Verfahren zur Herstellung eines PrÏparates aus dem blutzuckersenkenden Hormon der Bauspeiohel'drüse,dadurch gekennzeichnet, dass man das nach dem Schweizer Patent Nr. 219800 erhaltene Insulinpräparat mit Magnesiumehlorid, welches in Wasser gelât ist, umsetzt.
Die so erhaltene Suspension lost sich auf Zusatz von Salzsaure. Aus dieser Losung fällt Natronlauge einen Niederschlag aus, der bei weiterem Zusatz von Lauge wieder in Lösung geht.
**WARNUNG** Ende DESC Feld konnte Anfang CLMS uberlappen**.
Process for the production of a preparation from the blood sugar lowering hormone of the pancreas.
The subject of the present additional patent is a process for the production of a preparation from the blood sugar lowering hormone pancreas, which is characterized by the fact that? the insulin preparation obtained according to Swiss Patent No. 219800 is reacted with magnesium chloride, which is dissolved in water.
Example:
10 g of an insulin preparation obtained according to Swiss Patent No. 219800 are dissolved in 2 liters of 0.5% trichlorobutyl alcohol solution by adding 12.5 cm3 of normal hydrochloric acid. 1.3 g of magnesium chloride and 15 g of sodium chloride are added and then 500 cm3 of a solution containing 14.4 g of secondary sodium phosphate + 8 cm3 of sodium hydroxide solution in 0.5% trichlorobutyl alcohol are added. A suspension is obtained which contains 40 units of insulin in 1 cm3 and has a pu of approximately 7.
The protracting insulin preparation obtained in this way can be obtained by adding hydrochloric acid. A precipitate separates out of this solution, caustic soda, which goes back into solution with further addition of caustic.
PATENT CLAIM:
Process for the production of a preparation from the blood sugar lowering hormone of the Bauspeiohel'drüse, characterized in that the insulin preparation obtained according to Swiss Patent No. 219800 is reacted with magnesium chloride, which is dissolved in water.
The suspension thus obtained dissolves on the addition of hydrochloric acid. From this solution, sodium hydroxide solution separates out a precipitate, which goes back into solution with further addition of caustic solution.
** WARNING ** End of DESC field could overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE235478X | 1938-06-29 | ||
| CH227032T | 1939-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH235478A true CH235478A (en) | 1944-11-30 |
Family
ID=25727052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH235478D CH235478A (en) | 1938-06-29 | 1939-06-29 | Process for the production of a preparation from the blood sugar lowering hormone of the pancreas. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH235478A (en) |
-
1939
- 1939-06-29 CH CH235478D patent/CH235478A/en unknown
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