CH192302A - Process for the preparation of an aqueous solution of 1-phenyl-2,3-dimethyl-4-methylamino-5-pyrazolone-4-methanesulfonic acid morphine. - Google Patents
Process for the preparation of an aqueous solution of 1-phenyl-2,3-dimethyl-4-methylamino-5-pyrazolone-4-methanesulfonic acid morphine.Info
- Publication number
- CH192302A CH192302A CH192302DA CH192302A CH 192302 A CH192302 A CH 192302A CH 192302D A CH192302D A CH 192302DA CH 192302 A CH192302 A CH 192302A
- Authority
- CH
- Switzerland
- Prior art keywords
- phenyl
- dimethyl
- methylamino
- pyrazolone
- methanesulfonic acid
- Prior art date
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title claims description 14
- 229940098779 methanesulfonic acid Drugs 0.000 title claims description 8
- AFVFQIVMOAPDHO-UHFFFAOYSA-N methanesulfonic acid Substances CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 title claims description 8
- 229960005181 morphine Drugs 0.000 title claims description 7
- 239000007864 aqueous solution Substances 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 4
- 235000001258 Cinchona calisaya Nutrition 0.000 description 2
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 2
- 229960000948 quinine Drugs 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Description
Verfahren zur Herstellung einer wässerigen Lösung von 1-phenyl-2,3-dimethyl-4- methylamino-6-pyrazolon-4-methansulfosaur em Norphin. Das Hauptpatent betrifft ein Verfahren zur Herstellung von 1-phenyl-2,3-dimethyl 4-methylamino-5-pyrazolori-4-methansulfosau- rem Chinin, welches dadurch gekennzeichnet ist, dass man 1-Phenyl-2,3-dimethyl-4-methyl- amirio. 5-pyrazolon-4-inethansulfonsäure mit Chininbase zur Umsetzung biegt.
Es wurde nun gefunden, dass man zu einer wässerigen Lösung von 1-phenyl-2,3-di methyl-4-methylamino-5-pyrazolon-4-methan- sulfonsaurem Morphin gelangen kann, wenn man Morphinbase in ein wenig Wasser ver teilt und darauf 1-Phenyl-2,3-dimethyl-4- methylamino-5-pyrazoloci-4-methansulfonsäure einwirken lässt. Die so gebildete wässerige Lösung von 1-pheriyl-2,3-dimethyl-4-methyl- amirio-5-pyrazolon-4-methansulfosaurem Mor phin stellt ein wertvolles, für Injektions zwecke geeignetes Heilmittel dar.
<I>Beispiel:</I> 0,38 g Morphinbase (wasserfrei) werden in wenig Wasser verteilt und darauf 0,415 g 1-Phenyl-2,3-dimethyl- 4 -methylamino- 5 -pyr- azolon-4-methansulfonsäure einwirken gelas= sen. Die so gebildete 1-phenyl-2,3-dimethyl-4- methylamino-5-pyrazolon-4.methansulfonsaure Norphinlösung wird z.
B. mit 500 g 1-phenyl- 2, 3 - dimethyl - 4 - methyl ami no- 5 - pyrazolo n-4 methansulfonsanrem Natrium versetzt und das Ganze mit Wasser auf 1000 cms aufge füllt. Nachdem vollständige Lösung ent standen ist, wird die Flüssigkeit zweckmässig in Ampullen abgefüllt.
Process for the preparation of an aqueous solution of 1-phenyl-2,3-dimethyl-4-methylamino-6-pyrazolone-4-methanesulfosaur em norphin. The main patent relates to a process for the preparation of 1-phenyl-2,3-dimethyl-4-methylamino-5-pyrazolori-4-methanesulfonic acid rem quinine, which is characterized in that 1-phenyl-2,3-dimethyl-4 -methyl- amirio. 5-pyrazolon-4-ynethanesulfonic acid with quinine base to react bends.
It has now been found that an aqueous solution of 1-phenyl-2,3-dimethyl-4-methylamino-5-pyrazolone-4-methanesulfonic acid morphine can be obtained if the morphine base is divided into a little water and ver then 1-phenyl-2,3-dimethyl-4-methylamino-5-pyrazoloci-4-methanesulfonic acid to act. The aqueous solution of 1-pheriyl-2,3-dimethyl-4-methyl-amirio-5-pyrazolon-4-methanesulfonic acid morphine thus formed is a valuable remedy suitable for injection purposes.
<I> Example: </I> 0.38 g of morphine base (anhydrous) are distributed in a little water and 0.415 g of 1-phenyl-2,3-dimethyl-4-methylamino-5-pyrazolone-4-methanesulfonic acid act on it let = sen. The 1-phenyl-2,3-dimethyl-4-methylamino-5-pyrazolon-4.methanesulfonsaure norphin solution thus formed is z.
B. with 500 g of 1-phenyl- 2, 3 - dimethyl - 4 - methyl ami no- 5 - pyrazolo n-4 methanesulfonsanrem sodium and the whole thing filled up with water to 1000 cms. When the solution is complete, the liquid is conveniently filled into ampoules.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE192302X | 1934-03-03 | ||
| CH186957T | 1935-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH192302A true CH192302A (en) | 1937-07-31 |
Family
ID=25721461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH192302D CH192302A (en) | 1934-03-03 | 1935-02-25 | Process for the preparation of an aqueous solution of 1-phenyl-2,3-dimethyl-4-methylamino-5-pyrazolone-4-methanesulfonic acid morphine. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH192302A (en) |
-
1935
- 1935-02-25 CH CH192302D patent/CH192302A/en unknown
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