CH223224A

CH223224A - Process for the production of a protracted preparation from the blood sugar lowering hormone of the pancreas.

Info

Publication number: CH223224A
Authority: CH
Inventors: Aktiengesellsc Farbenindustrie
Original assignee: Ig Farbenindustrie Ag
Priority date: 1937-10-11
Filing date: 1938-10-11
Publication date: 1942-08-31

Description

  

  
 



  Verfahren zur Rerstellung eines   protrahiert    wirkenden Präparates aus dem   blutzuckersenkenden    Hormon der Bauchspeicheldrüse.



   Gegenstand des vorliegenden Zusatzpatentes ist ein Verfahren zur Herstellung eines neuen, protrahiert wirkenden Präparates aus    dem bintzuckersenkenden : Hormon der Bauch-    speicheldrüse, welches dadurch   giekennzeich-    net ist, dass man das Hormon mit 2-n-Pro  pyloxy-6 . 9-diaminoacridin,    welches als Salz in Wasser gelöst ist, umsetzt. Nach den Feststellungen der Anmelderin tritt das Anion dieses Salzes im Endprodukt nicht auf.



   Das erhaltene Produkt ist zur Verwendung für pharmazeutische Zwecke bestimmt und stellt ein fast farbloses, amorphes, in Wasser sehr schwer lösliches Pulver dar, welches sich auf Zusatz von Säuren löst. Aus dieser Lösung fällt Natronlauge einen Niederschlag aus, welcher bei weiterem Zusatz von Lauge wieder in   Lösung    geht.



   Beispiel:
400   internationaTe    Einheiten des blutzuckersenkenden Hormons der   Bauchspeichel-    drüse werden in 0,5 cm3 n/10 Salzsäure gelöst und 10 mg 2-n-Propyloxy-6. 9-diaminoacridinchlorhydrat in wenig Wasser gelöst zugegeben. Darauf wird mit Wasser auf 8 cm3 aufgefüllt und mit sekundärem Natriumphosphat auf   pn    7 eingestellt und schliesslich mit Wasser auf ein Volumen von 10 cm3 gebracht.  



      PATETANSPRTJCH:   
Verfahren zur Herstellung eines protrahiert wirkenden Präparates aus dem blutzuckersenkenden Hormon der Bauchspeicheldrüse, dadurch gekennzeichnet, dass man das Hormon mit 2-n-Propyloxy-6. 9-diaminoacridin, welches als Salz in Wasser gelöst ist, umsetzt. 

**WARNUNG** Ende DESC Feld konnte Anfang CLMS uberlappen**.



   



  
 



  Process for the creation of a protracted preparation from the blood sugar lowering hormone of the pancreas.



   The subject of the present additional patent is a process for the production of a new, protracted preparation from the sugar-lowering hormone of the pancreas, which is characterized by the fact that the hormone is treated with 2-n-propyloxy-6. 9-diaminoacridine, which is dissolved as a salt in water, is converted. According to the applicant's findings, the anion of this salt does not appear in the end product.



   The product obtained is intended for use for pharmaceutical purposes and is an almost colorless, amorphous powder which is very sparingly soluble in water and which dissolves when acids are added. A precipitate separates out of this solution, sodium hydroxide solution, which goes back into solution with further addition of caustic solution.



   Example:
400 international units of the blood sugar lowering hormone of the pancreas are dissolved in 0.5 cm3 n / 10 hydrochloric acid and 10 mg 2-n-propyloxy-6. 9-diaminoacridine chlorohydrate dissolved in a little water was added. It is then made up to 8 cm3 with water and adjusted to pn 7 with secondary sodium phosphate and finally brought to a volume of 10 cm3 with water.



      PATENTED:
Process for the production of a protracted preparation from the blood sugar lowering hormone of the pancreas, characterized in that the hormone is mixed with 2-n-propyloxy-6. 9-diaminoacridine, which is dissolved as a salt in water, is converted.

** WARNING ** End of DESC field could overlap beginning of CLMS **.

Claims

** WARNING ** Beginning of CLMS field could overlap end of DESC **.

Process for the creation of a protracted preparation from the blood sugar lowering hormone of the pancreas.

The subject of the present additional patent is a process for the production of a new, protracted preparation from the sugar-lowering hormone of the pancreas, which is characterized by the fact that the hormone is treated with 2-n-propyloxy-6. 9-diaminoacridine, which is dissolved as a salt in water, is converted. According to the applicant's findings, the anion of this salt does not appear in the end product.

The product obtained is intended for use for pharmaceutical purposes and is an almost colorless, amorphous powder which is very sparingly soluble in water and which dissolves when acids are added. A precipitate separates out of this solution, sodium hydroxide solution, which goes back into solution with further addition of caustic solution.

Example: 400 international units of the blood sugar lowering hormone of the pancreas are dissolved in 0.5 cm3 n / 10 hydrochloric acid and 10 mg 2-n-propyloxy-6. 9-diaminoacridine chlorohydrate dissolved in a little water was added. It is then made up to 8 cm3 with water and adjusted to pn 7 with secondary sodium phosphate and finally brought to a volume of 10 cm3 with water.

PATENTED: Process for the production of a protracted preparation from the blood sugar lowering hormone of the pancreas, characterized in that the hormone is mixed with 2-n-propyloxy-6. 9-diaminoacridine, which is dissolved as a salt in water, is converted.

The product obtained is an almost colorless, amorphous powder which is very sparingly soluble in water and which dissolves when acids are added. A precipitate separates out of this solution, sodium hydroxide solution, which goes back into solution with further addition of caustic solution.

SUBClaim: Process according to patent claim, characterized in that the reaction is carried out in an acidic medium.