CH297280A - Process for the preparation of a diammonium compound. - Google Patents

Process for the preparation of a diammonium compound.

Info

Publication number
CH297280A
CH297280A CH297280DA CH297280A CH 297280 A CH297280 A CH 297280A CH 297280D A CH297280D A CH 297280DA CH 297280 A CH297280 A CH 297280A
Authority
CH
Switzerland
Prior art keywords
preparation
diammonium compound
bis
compound
diammonium
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH297280A publication Critical patent/CH297280A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

      Verfahren    zur Herstellung einer     Diammoniumverbindung.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur Herstellung einer     Diammo-          niumverbindung.    Das Verfahren ist dadurch  gekennzeichnet, dass man     auf    1     Mol        1,12-Bis-          (3'-        dimethylamino    -     propylmercapto)    -     dodekan          '?        11o1        Methyljodid    einwirken lässt.  



  Die erhaltene neue     Verbindung,    das     1,12-          Bis    -     [3'-        (trimethyl    -     ammonium)    -     propylmer-          eapto]-dodekaii-dijodid,    schmilzt bei 155 . Sie  soll therapeutische Verwendung finden.  



  <I>Beispiel:</I>  2,08 Teile     1,12-Bis-(3'-diinetliylamino-pro-          pylmercapto)-dodekan    in 40     Volumteilen        trok-          keneni    Aceton werden unter Eiskühlung trop  fenweise mit 2,6     Volumteilen        Methyljodid    ver  setzt.     Unter    Selbsterwärmung fällt. das Pro-         dukt    aus und kristallisiert rasch. Man bringt  durch Erwärmen und Zugabe von     abs.    Metha  nol wieder in Lösung und lässt bei Zimmer  temperatur kristallisieren. Das Produkt wird  abgesaugt, mit trockenem Aceton gut gewa  schen und bei 50 bis 60  im Vakuum getrock  net.

   Es zeigt einen Schmelzpunkt von 155 .



      Process for the preparation of a diammonium compound. The present patent relates to a process for the preparation of a diammonium compound. The process is characterized in that 1 mole of 1,12-bis (3'-dimethylamino-propylmercapto) -dodecane '? Let 11o1 methyl iodide act.



  The resulting new compound, the 1,12-bis- [3'- (trimethyl-ammonium) -propylmereapto] -dodecai-diiodide, melts at 155. It should find therapeutic use.



  <I> Example: </I> 2.08 parts of 1,12-bis- (3'-diinetliylamino-propylmercapto) -dodecane in 40 parts by volume of dry acetone are mixed dropwise with 2.6 parts by volume of methyl iodide while cooling with ice puts. It falls under self-heating. the product and quickly crystallizes. One brings by heating and adding abs. Metha nol back in solution and lets crystallize at room temperature. The product is filtered off with suction, washed well with dry acetone and net getrock at 50 to 60 in a vacuum.

   It shows a melting point of 155.

Claims (1)

PATENTANSPRUCIH Verfahren zur Herstellung einer Diammo- niumverbindung, dadurch gekennzeichnet, dass man auf 1 Mol 1,12-Bis-(3'-dimethylamino- propylmercapto)-dodekan 2 Mol Methyljodid einwirken lässt. Die erhaltene neue Verbindung, das 1,12- Bis -<B>[X-</B> (trimethyl - ammonium) - propylmer- eapto]-dodekan-dijodid, schmilzt bei 1.55 . A method for the production of a diammonium compound, characterized in that 2 mol of methyl iodide are allowed to act on 1 mol of 1,12-bis (3'-dimethylaminopropylmercapto) -dodecane. The new compound obtained, the 1,12-bis- <B> [X- </B> (trimethyl-ammonium) -propylmer-eapto] -dodecane-diiodide, melts at 1.55.
CH297280D 1950-12-12 1950-12-12 Process for the preparation of a diammonium compound. CH297280A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH293565T 1950-12-12
CH297280T 1950-12-12

Publications (1)

Publication Number Publication Date
CH297280A true CH297280A (en) 1954-03-15

Family

ID=25733378

Family Applications (1)

Application Number Title Priority Date Filing Date
CH297280D CH297280A (en) 1950-12-12 1950-12-12 Process for the preparation of a diammonium compound.

Country Status (1)

Country Link
CH (1) CH297280A (en)

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