CH297614A - Process for the preparation of a new reaction product. - Google Patents
Process for the preparation of a new reaction product.Info
- Publication number
- CH297614A CH297614A CH297614DA CH297614A CH 297614 A CH297614 A CH 297614A CH 297614D A CH297614D A CH 297614DA CH 297614 A CH297614 A CH 297614A
- Authority
- CH
- Switzerland
- Prior art keywords
- metal salt
- acid
- catalyst
- chloride
- dependent
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 20
- 239000007795 chemical reaction product Substances 0.000 title claims description 9
- 238000002360 preparation method Methods 0.000 title description 2
- 150000003839 salts Chemical class 0.000 claims description 15
- 229910052751 metal Inorganic materials 0.000 claims description 14
- 239000002184 metal Substances 0.000 claims description 14
- 239000002253 acid Substances 0.000 claims description 11
- 239000003054 catalyst Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- 239000001888 Peptone Substances 0.000 claims description 5
- 108010080698 Peptones Proteins 0.000 claims description 5
- 239000012153 distilled water Substances 0.000 claims description 5
- 235000019319 peptone Nutrition 0.000 claims description 5
- 229940100445 wheat starch Drugs 0.000 claims description 5
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 3
- 239000012736 aqueous medium Substances 0.000 claims description 3
- UFMZWBIQTDUYBN-UHFFFAOYSA-N cobalt dinitrate Chemical compound [Co+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O UFMZWBIQTDUYBN-UHFFFAOYSA-N 0.000 claims description 3
- 229910001981 cobalt nitrate Inorganic materials 0.000 claims description 3
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 3
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 claims description 3
- JHXKRIRFYBPWGE-UHFFFAOYSA-K bismuth chloride Chemical compound Cl[Bi](Cl)Cl JHXKRIRFYBPWGE-UHFFFAOYSA-K 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000001419 dependent effect Effects 0.000 claims 3
- FBAFATDZDUQKNH-UHFFFAOYSA-M iron chloride Chemical compound [Cl-].[Fe] FBAFATDZDUQKNH-UHFFFAOYSA-M 0.000 claims 1
- 239000000243 solution Substances 0.000 description 16
- 239000000047 product Substances 0.000 description 5
- YKYOUMDCQGMQQO-UHFFFAOYSA-L cadmium dichloride Chemical compound Cl[Cd]Cl YKYOUMDCQGMQQO-UHFFFAOYSA-L 0.000 description 4
- 230000007062 hydrolysis Effects 0.000 description 4
- 238000006460 hydrolysis reaction Methods 0.000 description 4
- 238000009835 boiling Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000017854 proteolysis Effects 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- 229910021380 Manganese Chloride Inorganic materials 0.000 description 2
- GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229940099607 manganese chloride Drugs 0.000 description 2
- 235000002867 manganese chloride Nutrition 0.000 description 2
- 239000011565 manganese chloride Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 102000008934 Muscle Proteins Human genes 0.000 description 1
- 108010074084 Muscle Proteins Proteins 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 240000000359 Triticum dicoccon Species 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 108010050181 aleurone Proteins 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- -1 blood serum Proteins 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Botany (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Description
Verfahren zur Herstellung eines neuen Reaktionsproduktes. Es wurde gefunden., dass man zu Verbin dungen mit völlig neuen immunbiologischen Eigenschaften: gelangt, wenn man ein Poly- sacclra.rid mit einem Protein bzw.
Protein abbaustoff in Gegenwart. eines Metallsalzes und'oder einer Säure als Katalysator so lange reagieren lä.sst, bis beständige Endprodukte entstanden sind', die sich in chemischer und immunbiologischer Hinsicht von einem blossen Gemenge der Ausgangsmaterialien bzw. ihrer Hydrolvsate unterscheiden und pulverför mige, gelbliche bis dunkelbraune, hy grosko- pisehe Produkte darstellen.
Die wässrigen Lö sungen dieser Produkte sind in sterilem Zu stande unbegrenzt haltbar und besitzen ebenso wie tl'ie Trockensubstanzen besondere therapeutische Eigenschaften. So sind sie beispielsweise imstande, die Antigen-Anti- körper-Reaktion quantitativ zu steigern und eine unspezifische Immunisierung allergischer Organismen hervorzurufen, was mit. den Aus- und Zwischenprodukten allein oder mit. Clemischen nicht möglich ist.
Als Proteine bzw. Proteinabbaustoffe kön nensowohl solche pflanzlicher als auch solche tierischer bat-ur, wie z. B. Pepton, Gelatine, Kleber, Aleuron, Blutserum, Muskeleiweiss, Fleischmehl, Seide, Casein, -Milch usw. ver wendet. werden.
Als Polysaecharide kommen owohl solche, die ein einziges als auch sol che, die verschied,#erre Saecharide als Bau steine enthalten, in Frage, wie z, B.
Weizen- oder Reisstärke und andere Stärkesorten, Traganth, Gummi arabicum usw, Gegenstand des vorliegenden Patentes ist ein Verfahren zur Herstellung eines neuen Reaktionsproduktes, welches dadurch gekenn- zeichnet ist, dass man Weizenstärke mit Pep ton in wässrigem Medium in Gegenwart min destens eines Katalysators reagieren lässt.
Das nach diesem Verfahren erhaltene Endprodukt stellt einen hygroskopischen pulverförmigen Körper dar, der sich in Was ser leicht löst, wärme- und kältebeständig ist. und sich für therapeutische Zwecke eignet.
Als Katalysator kommen sowohl Metall salze als auch Säuren in Frage. Als Metall salz kann man beispielsweise Aluminium chlorid, Cadmiumchlorid, Manganchlorid, Kupfersulfat, Cobaltnitrat, Zinnchlorid, Wis- muthchlorid usw. verwenden, während als Säu ren z. B. Salzsäure, Phosphorsäure, Milch säure usw., verwendet werden können. Man kann auch das Metallsalz und die Säure zu sammen verwenden.
Die Umsetzung wird zweckmässig in sau rem wässrigem Medium ausgeführt, Es ist anzunehmen, dass dabei zunächst Hydrolyse sowohl der Weizenstärke als auch des Peptons eintritt, wie sich auf Grund des Auftretens freier Aldehyd- bzw.
Aminogruppen nachwei sen lässt.Jm weiteren Verlauf der Reaktion dürfte dieses Hydrolysenzwischenprodukt mit den noch unveränderten Anteilen der Aus- gangsmater#ialien über die aktiven Gruppen unter Bildung eines Endproduktes, das keine freien AMehydgruppen mehr enthält, reagieren.
Die Ausführung des erfindungsgemässen Verfahrens kann so erfolgen, dass man zuerst wässrige Lösungen der Ausgangsmaterialien herstellt, nämlich eine Lösung der Weizen stärke in destilliertem Wasser, und eine Lö sung des Peptons in destilliertem Wasser, die beiden Lösungen vereinigt und vorsichtig zum Sieden erhitzt und schliesslich eine Lösung des Katalysators, d. h. des Metallsalzes und/oder der Säure, in kleinen Portionen allmählich in die siedende Lösung einträgt.
Das Gemisch wird so lange im Sieden gehalten bis die Hydrolyse beendet .ist, was beispielsweise aus der Kon stanz des Aminostickstoffgehaltes von Pro ben der klar filtrierten Lösung ersichtlich ist. Das Reaktionsgemiseh wird dann durch Filtrieren von unlöslichen Niedersehläg-en be freit und im Vakuum zur Trockne einge dampft. -Man erhält auf diese Weise ein pul verförmiges, hygroskopisches Endprodukt, das in Wasser unter Bildung einer klaren Lö sung löslich ist.
<I>Beispiel:</I> 5 Gewichtsteile Pepton werden in 500 CTe- wichtsteilen destilliertem 'Vfasser gelöst (Lö sung a). Durch Erwärmen wird eine Lösung von 2 Gewichtsteilen Weizenstärke in 500 Ge wichtsteilen destilliertem Wasser hergestellt (Lösung<B>b).</B> Die beiden. Lösungen werden ver einigt und vorsichtig zum Sieden erhitzt. Hierauf wird in kleinen Portionen allmählich eine Lösung von 5 bis 10 Gewichtsteilen eines Metallsalzes (z.
B. Ahuniniumchlorid, Cad- miumchlorid, Manganehlorrid, Kupfersulfat, Kobaltnitrat, Zinnchlorid, Wismuthchlorid) (Lösung c) zugesetzt. Das Gemisch wird so lange im Sieden gehalten, bis die Hydrolyse beendet. ist. Man kann dies daran erkennen, dass Proben der klar filtrierten Lösung einen konstanten Aminostickstoffgehalt aufweisen.
Das Reaktionsgemisch wird zur Beseitigung des ausgeschiedenen \iedersehlages und der Hauptmenge des Katalysators filtriert und das Spuren von höchstens<B>3"</B> kolloidal gelö stem Katalysator pro cm3 Substanz enthal tende Filtrat im Vakuum zur Trockne ein gedampft. Man erhält ein pulverförmiges, hygroskopisehes Produkt, das in Wasser klar löslich ist.
Es ist zweel>>riäss-i#, der Lösung des i1fe- tallsalzes (Lösung c), eine Säure zuzusetzen, beispielsweise Salzsäure, Phosphorsäure, Milch säure usw.
Process for the preparation of a new reaction product. It has been found that compounds with completely new immunobiological properties are obtained: if a polysaccharide is used with a protein or
Protein degradation in the presence. a metal salt and 'or an acid as a catalyst lets react until stable end products are formed' which differ chemically and immunobiologically from a mere mixture of the starting materials or their hydrolysates and are powdery, yellowish to dark brown, hy represent groscopic products.
The aqueous solutions of these products can be kept indefinitely in their sterile condition and, like the dry substances, have special therapeutic properties. For example, they are able to increase the antigen-antibody reaction quantitatively and to induce a non-specific immunization of allergic organisms, which with. the final and intermediate products alone or with. Clemic is not possible.
Proteins or protein degradation substances that can be used are those of both vegetable and animal species, such as B. peptone, gelatin, glue, aleurone, blood serum, muscle protein, meat meal, silk, casein, milk, etc. are used. will.
As polysaccharides, those that contain a single as well as those that contain various saecharides as building blocks come into question, e.g.
Wheat or rice starch and other types of starch, tragacanth, gum arabic, etc., the subject of the present patent is a process for the production of a new reaction product, which is characterized in that wheat starch is reacted with pep ton in an aqueous medium in the presence of at least one catalyst leaves.
The end product obtained by this process is a hygroscopic powdery body that dissolves easily in what water, is heat and cold resistant. and is suitable for therapeutic purposes.
Both metal salts and acids are suitable as catalysts. The metal salt can be, for example, aluminum chloride, cadmium chloride, manganese chloride, copper sulfate, cobalt nitrate, tin chloride, wis- muthchlorid, etc., while the acid ren z. B. hydrochloric acid, phosphoric acid, lactic acid, etc., can be used. You can also use the metal salt and the acid together.
The reaction is expediently carried out in an acidic aqueous medium. It can be assumed that hydrolysis of both the wheat starch and the peptone initially occurs, as occurs due to the occurrence of free aldehyde or aldehyde.
Amino groups can be detected. In the further course of the reaction, this intermediate hydrolysis product is likely to react with the still unchanged proportions of the starting materials via the active groups to form an end product which no longer contains any free Amehydgroups.
The method according to the invention can be carried out by first preparing aqueous solutions of the starting materials, namely a solution of the wheat starch in distilled water, and a solution of the peptone in distilled water, combining the two solutions and carefully heating them to the boil, and finally one Solution of the catalyst, d. H. of the metal salt and / or the acid, gradually enters the boiling solution in small portions.
The mixture is kept boiling until the hydrolysis has ended, which can be seen, for example, from the constancy of the amino nitrogen content of samples of the clear, filtered solution. The reaction mixture is then freed from insoluble residues by filtration and evaporated to dryness in vacuo. In this way, a powdery, hygroscopic end product is obtained that is soluble in water to form a clear solution.
<I> Example: </I> 5 parts by weight of peptone are dissolved in 500 parts by weight of distilled water (solution a). A solution of 2 parts by weight of wheat starch in 500 parts by weight of distilled water is prepared by heating (solution <B> b). </B> The two. Solutions are combined and carefully heated to the boil. A solution of 5 to 10 parts by weight of a metal salt (e.g.
B. ammonium chloride, cadmium chloride, manganese chloride, copper sulfate, cobalt nitrate, tin chloride, bismuth chloride) (solution c) are added. The mixture is kept boiling until the hydrolysis has ended. is. This can be seen from the fact that samples of the clear, filtered solution have a constant amino nitrogen content.
The reaction mixture is filtered to remove the precipitated precipitate and most of the catalyst and the filtrate containing traces of at most <B> 3 "</B> colloidally dissolved catalyst per cm3 of substance is evaporated to dryness in vacuo. A powdery product is obtained , hygroscopic product that is clearly soluble in water.
It is twice as important to add an acid to the solution of the metallic salt (solution c), for example hydrochloric acid, phosphoric acid, lactic acid, etc.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH297614T | 1950-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH297614A true CH297614A (en) | 1954-03-31 |
Family
ID=4489679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH297614D CH297614A (en) | 1950-06-10 | 1950-06-10 | Process for the preparation of a new reaction product. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH297614A (en) |
-
1950
- 1950-06-10 CH CH297614D patent/CH297614A/en unknown
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