CH312529A - Verfahren zur Herstellung eines neuen Pyridinderivates. - Google Patents
Verfahren zur Herstellung eines neuen Pyridinderivates.Info
- Publication number
- CH312529A CH312529A CH312529DA CH312529A CH 312529 A CH312529 A CH 312529A CH 312529D A CH312529D A CH 312529DA CH 312529 A CH312529 A CH 312529A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- pyridine derivative
- new pyridine
- new
- isonicotinyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title description 3
- 150000003222 pyridines Chemical class 0.000 title description 2
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000000155 melt Substances 0.000 claims 1
- RCFUFEMQNKVAGF-UHFFFAOYSA-N undec-2-enoyl chloride Chemical compound CCCCCCCCC=CC(Cl)=O RCFUFEMQNKVAGF-UHFFFAOYSA-N 0.000 claims 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- -1 1-isonicotinoyl-2-undecenoyl Chemical group 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/86—Hydrazides; Thio or imino analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung eines neuen Pyridinderivates. Gegenstand des vorliegenden Patentes ist ein Verfahren zur Herstellung von 1-Isonico- tinyl-2-dw -undecenoyl-hydrazin, das dadurch gekennzeichnet ist, dass Isonicotinylhydrazin mit df-Undecenoylchlorid umgesetzt wird.
Die neue Verbindung soll als Therapeuti- cum, besonders zur Bekämpfung der Tuberku lose, Verwendung finden. <I>Beispiel:</I> Man setzt tropfenweise 20,2 g dw-Undece- noylchlorid einer Lösung von 13,7 g Isonico- tinylhydrazin in 100 cm3 Siedenein Pyridin in einer solchen Geschwindigkeit zu,
dass die 1VIi- sehung trotz Entfernung der äussern Wärme- quelle unter Rückfluss weitersiedet. Nach be endetem Zusatz wird die Mischung während weiteren 10 Minuten im Sieden gehalten. Man setzt nun 100 em3 Wasser zu, worauf sich beim Abkühlen 1-Isonicotinoyl-2-undecenoyl.- hydrazin abscheidet. Die aus einem Wasser- Propanol=Gemisch umkristallisierten weissen Flocken schmelzen bei 111,5 C.
Claims (1)
- PATENTANSPRUCH: Verfahren zur Herstellung von 1-Isonico- tinyl-2-'w-midecenoyl-hydrazin, dadurch ge kennzeichnet, dass Isonicotinylhydrazin mit Undecenoylchlorid umgesetzt wird. Die neue Verbindung schmilzt bei 111,5 C.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US312529XA | 1951-11-03 | 1951-11-03 | |
| CH309035T | 1952-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH312529A true CH312529A (de) | 1955-12-31 |
Family
ID=25735568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH312529D CH312529A (de) | 1951-11-03 | 1952-10-16 | Verfahren zur Herstellung eines neuen Pyridinderivates. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH312529A (de) |
-
1952
- 1952-10-16 CH CH312529D patent/CH312529A/de unknown
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