CH381246A - Verfahren zur Herstellung von Acetylsalicylsäure - Google Patents
Verfahren zur Herstellung von AcetylsalicylsäureInfo
- Publication number
- CH381246A CH381246A CH667460A CH667460A CH381246A CH 381246 A CH381246 A CH 381246A CH 667460 A CH667460 A CH 667460A CH 667460 A CH667460 A CH 667460A CH 381246 A CH381246 A CH 381246A
- Authority
- CH
- Switzerland
- Prior art keywords
- pressure
- reaction vessel
- abs
- distillation
- hours
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 19
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 title claims description 8
- 229960001138 acetylsalicylic acid Drugs 0.000 title claims description 8
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims description 36
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 18
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 9
- 229960004889 salicylic acid Drugs 0.000 claims description 9
- 238000004821 distillation Methods 0.000 claims description 8
- 239000011541 reaction mixture Substances 0.000 claims description 8
- 239000007795 chemical reaction product Substances 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000013078 crystal Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000000047 product Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 5
- 239000000463 material Substances 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000005292 vacuum distillation Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
- C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81923659A | 1959-06-10 | 1959-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH381246A true CH381246A (de) | 1964-08-31 |
Family
ID=25227568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH667460A CH381246A (de) | 1959-06-10 | 1960-06-10 | Verfahren zur Herstellung von Acetylsalicylsäure |
Country Status (3)
| Country | Link |
|---|---|
| CH (1) | CH381246A (da) |
| DK (1) | DK110056C (da) |
| ES (1) | ES258560A1 (da) |
-
1960
- 1960-06-01 ES ES0258560A patent/ES258560A1/es not_active Expired
- 1960-06-10 CH CH667460A patent/CH381246A/de unknown
- 1960-06-10 DK DK226860A patent/DK110056C/da active
Also Published As
| Publication number | Publication date |
|---|---|
| ES258560A1 (es) | 1960-09-01 |
| DK110056C (da) | 1968-09-09 |
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