CH389608A - Verfahren zur Herstellung von neuen Äthern - Google Patents
Verfahren zur Herstellung von neuen ÄthernInfo
- Publication number
- CH389608A CH389608A CH880760A CH880760A CH389608A CH 389608 A CH389608 A CH 389608A CH 880760 A CH880760 A CH 880760A CH 880760 A CH880760 A CH 880760A CH 389608 A CH389608 A CH 389608A
- Authority
- CH
- Switzerland
- Prior art keywords
- methyl
- sep
- general formula
- ethyl
- production
- Prior art date
Links
- 150000002170 ethers Chemical class 0.000 title claims description 4
- 238000000034 method Methods 0.000 title claims description 4
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 6
- -1 diphenylmethyl compound Chemical class 0.000 claims description 5
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 4
- 239000000460 chlorine Chemical group 0.000 claims description 4
- 229910052801 chlorine Inorganic materials 0.000 claims description 4
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 229960003750 ethyl chloride Drugs 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- HRYZWHHZPQKTII-UHFFFAOYSA-N chloroethane Chemical compound CCCl HRYZWHHZPQKTII-UHFFFAOYSA-N 0.000 claims description 2
- 229910052731 fluorine Chemical group 0.000 claims description 2
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- MHJLXHJZQCHSIT-UHFFFAOYSA-N 1-(4-chlorophenyl)-1-phenylethanol Chemical compound C=1C=C(Cl)C=CC=1C(O)(C)C1=CC=CC=C1 MHJLXHJZQCHSIT-UHFFFAOYSA-N 0.000 claims 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 229960004217 benzyl alcohol Drugs 0.000 description 3
- 235000019445 benzyl alcohol Nutrition 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- QILSFLSDHQAZET-UHFFFAOYSA-N diphenylmethanol Chemical compound C=1C=CC=CC=1C(O)C1=CC=CC=C1 QILSFLSDHQAZET-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- XTEGVFVZDVNBPF-UHFFFAOYSA-L naphthalene-1,5-disulfonate(2-) Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1S([O-])(=O)=O XTEGVFVZDVNBPF-UHFFFAOYSA-L 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH880760A CH389608A (de) | 1960-01-19 | 1960-08-03 | Verfahren zur Herstellung von neuen Äthern |
| GB43068/60A GB942152A (en) | 1960-01-19 | 1960-12-14 | Improvements in or relating to benzhydryl ethers |
| FR849932A FR1279691A (fr) | 1960-01-19 | 1961-01-17 | Nouveaux éthers benzhydryliques et leur préparation |
| DES72107A DE1228262B (de) | 1960-01-19 | 1961-01-18 | Verfahren zur Herstellung von neuen Pyrrolidinderivaten und ihren Salzen |
| ES0264077A ES264077A1 (es) | 1960-01-19 | 1961-01-18 | Un procedimiento de obtenciën de derivados de piperidina y pirrolidina y de sus sales acidas de adiciën |
| BR125965/61A BR6125965D0 (pt) | 1960-01-19 | 1961-01-18 | Processo para a preparacao de novos esteres |
| OA50776A OA00698A (fr) | 1960-01-19 | 1964-12-08 | Nouveaux éthers benzhydryliques et leur préparation. |
| CY37967A CY379A (en) | 1960-01-19 | 1967-03-04 | Improvements in or relating to benzhydryl ethers |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH53760A CH382164A (de) | 1960-01-19 | 1960-01-19 | Verfahren zur Herstellung von neuen Äthern |
| CH880760A CH389608A (de) | 1960-01-19 | 1960-08-03 | Verfahren zur Herstellung von neuen Äthern |
| CH1089760 | 1960-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH389608A true CH389608A (de) | 1965-03-31 |
Family
ID=27172192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH880760A CH389608A (de) | 1960-01-19 | 1960-08-03 | Verfahren zur Herstellung von neuen Äthern |
Country Status (8)
| Country | Link |
|---|---|
| BR (1) | BR6125965D0 (fr) |
| CH (1) | CH389608A (fr) |
| CY (1) | CY379A (fr) |
| DE (1) | DE1228262B (fr) |
| ES (1) | ES264077A1 (fr) |
| FR (1) | FR1279691A (fr) |
| GB (1) | GB942152A (fr) |
| OA (1) | OA00698A (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1307255A (en) * | 1970-09-12 | 1973-02-14 | Pfizer Ltd | Substituted basic benzhydryl ethers |
| JPS5223068A (en) * | 1975-08-13 | 1977-02-21 | Nippon Kayaku Co Ltd | Preparation of optically active 1-methyl -2-(2'-(alpha-methyl-p-chlorobenz hydryloxy) ethtyl) pyrrolidine fumarates |
| US4835164A (en) * | 1987-02-20 | 1989-05-30 | A. H. Robins Company, Incorporated | Aryloxymethyl derivatives of nitrogenous heterocyclic methanols and ethers thereof |
| SI1583542T1 (sl) | 2003-01-14 | 2008-12-31 | Gilead Sciences Inc | Sestavki in postopki za kombinacijsko antivirusnoterapijo |
| TWI375560B (en) | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
| TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
| CN107011228B (zh) * | 2017-05-24 | 2019-08-09 | 浙江诚意药业股份有限公司 | 一种富马酸氯马斯汀的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE934890C (de) * | 1951-10-07 | 1955-11-10 | Chem Fab Promonta Ges Mit Besc | Verfahren zur Herstellung von basischen Benzhydrylaethern |
-
1960
- 1960-08-03 CH CH880760A patent/CH389608A/de unknown
- 1960-12-14 GB GB43068/60A patent/GB942152A/en not_active Expired
-
1961
- 1961-01-17 FR FR849932A patent/FR1279691A/fr not_active Expired
- 1961-01-18 ES ES0264077A patent/ES264077A1/es not_active Expired
- 1961-01-18 DE DES72107A patent/DE1228262B/de active Pending
- 1961-01-18 BR BR125965/61A patent/BR6125965D0/pt unknown
-
1964
- 1964-12-08 OA OA50776A patent/OA00698A/fr unknown
-
1967
- 1967-03-04 CY CY37967A patent/CY379A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR6125965D0 (pt) | 1973-06-28 |
| DE1228262B (de) | 1966-11-10 |
| CY379A (en) | 1967-03-04 |
| FR1279691A (fr) | 1961-12-22 |
| ES264077A1 (es) | 1961-07-16 |
| GB942152A (en) | 1963-11-20 |
| OA00698A (fr) | 1967-07-15 |
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