CH393359A - Verfahren zur Herstellung von Chromenderivaten - Google Patents

Verfahren zur Herstellung von Chromenderivaten

Info

Publication number: CH393359A
Authority: CH; Switzerland
Prior art keywords: condensation; benzene; monoacyl; formula; hydrocarbon radical
Prior art date: 1959-07-15

Application number

CH7578959A

Other languages

German (de)

English (en)

Inventor

Hrishikesh Dr Pendse

Rudolf Dr Rueegg

Ryser Gottlieb

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1959-07-15

Filing date

1959-07-15

Publication date

1965-06-15

1959-07-15 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1959-07-15 Priority to CH7578959A priority Critical patent/CH393359A/de

1960-04-27 Priority to BE590186A priority patent/BE590186A/fr

1960-08-23 Priority to FR836476A priority patent/FR265M/fr

1965-06-15 Publication of CH393359A publication Critical patent/CH393359A/de

Links

238000000034 method Methods 0.000 title claims description 8
150000008371 chromenes Chemical class 0.000 title claims description 4
238000004519 manufacturing process Methods 0.000 title description 2
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 10
238000009833 condensation Methods 0.000 claims description 9
230000005494 condensation Effects 0.000 claims description 9
230000002378 acidificating effect Effects 0.000 claims description 5
239000003795 chemical substances by application Substances 0.000 claims description 5
239000011592 zinc chloride Substances 0.000 claims description 5
235000005074 zinc chloride Nutrition 0.000 claims description 5
239000004215 Carbon black (E152) Substances 0.000 claims description 4
229930195733 hydrocarbon Natural products 0.000 claims description 4
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
125000004423 acyloxy group Chemical group 0.000 claims description 3
150000001875 compounds Chemical class 0.000 claims description 3
125000005843 halogen group Chemical group 0.000 claims description 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
239000011203 carbon fibre reinforced carbon Substances 0.000 claims description 2
239000007859 condensation product Substances 0.000 claims description 2
229910052739 hydrogen Inorganic materials 0.000 claims description 2
239000001257 hydrogen Substances 0.000 claims description 2
238000002360 preparation method Methods 0.000 claims description 2
230000001419 dependent effect Effects 0.000 claims 1
229910052736 halogen Inorganic materials 0.000 claims 1
229910017053 inorganic salt Inorganic materials 0.000 claims 1
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 33
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 15
238000006243 chemical reaction Methods 0.000 description 4
-1 hydrocarbon radical Chemical class 0.000 description 4
239000003208 petroleum Substances 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
230000000694 effects Effects 0.000 description 3
239000000203 mixture Substances 0.000 description 3
238000010992 reflux Methods 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
MULUCORRSAVKOA-UHFFFAOYSA-N 3,7,11,15-tetramethylhexadec-1-yn-3-ol Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)(O)C#C MULUCORRSAVKOA-UHFFFAOYSA-N 0.000 description 2
RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
239000002253 acid Substances 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
150000001721 carbon Chemical group 0.000 description 2
229910052799 carbon Inorganic materials 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 2
239000000047 product Substances 0.000 description 2
238000007127 saponification reaction Methods 0.000 description 2
DSBZYDDWLLIJJS-UHFFFAOYSA-N ubiquinol-0 Chemical compound COC1=C(O)C=C(C)C(O)=C1OC DSBZYDDWLLIJJS-UHFFFAOYSA-N 0.000 description 2
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
ZUWSLVRIPJIHTA-UHFFFAOYSA-N 7,8-dimethoxy-2,2,5-trimethylchromen-6-ol Chemical compound C1=CC(C)(C)OC2=C(OC)C(OC)=C(O)C(C)=C21 ZUWSLVRIPJIHTA-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
102100030497 Cytochrome c Human genes 0.000 description 1
108010075031 Cytochromes c Proteins 0.000 description 1
ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
241001342522 Vampyrum spectrum Species 0.000 description 1
150000001242 acetic acid derivatives Chemical class 0.000 description 1
125000002252 acyl group Chemical group 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
229910052804 chromium Inorganic materials 0.000 description 1
239000011651 chromium Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000032050 esterification Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
150000003254 radicals Chemical class 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000002211 ultraviolet spectrum Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pyrane Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CH7578959A 1959-07-15 1959-07-15 Verfahren zur Herstellung von Chromenderivaten CH393359A (de)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
CH7578959A CH393359A (de)	1959-07-15	1959-07-15	Verfahren zur Herstellung von Chromenderivaten
BE590186A BE590186A (fr)	1959-07-15	1960-04-27	Dérivés de chromène et procédé pour la préparation de ces derniers.
FR836476A FR265M (fr)	1959-07-15	1960-08-23	Dérivés de chromene.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH7578959A CH393359A (de)	1959-07-15	1959-07-15	Verfahren zur Herstellung von Chromenderivaten

Publications (1)

Publication Number	Publication Date
CH393359A true CH393359A (de)	1965-06-15

Family

ID=4534435

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH7578959A CH393359A (de)	1959-07-15	1959-07-15	Verfahren zur Herstellung von Chromenderivaten

Country Status (3)

Country	Link
BE (1)	BE590186A (fr)
CH (1)	CH393359A (fr)
FR (1)	FR265M (fr)

1959
- 1959-07-15 CH CH7578959A patent/CH393359A/de unknown
1960
- 1960-04-27 BE BE590186A patent/BE590186A/fr unknown
- 1960-08-23 FR FR836476A patent/FR265M/fr not_active Expired

Also Published As

Publication number	Publication date
FR265M (fr)	1961-03-06
BE590186A (fr)	1960-10-27

Publication	Publication Date	Title
DE2337813C3 (de)	1981-11-19	Verfahren zur Herstellung von Monoacetalen aromatischer 1,2-Diketone
DE1468529B2 (de)	1979-03-08	Rechtsdrehendes !,S-Dioxo^-ir-carboxyäthyl)-7aß-methyl-5,6,7,7a-tetrahydroindan und Verfahren zu seiner Her-
CH620453A5 (fr)	1980-11-28
CH434225A (de)	1967-04-30	Verfahren zur Herstellung von Carbonsäuresalzen
DE2545511A1 (de)	1976-04-22	Verfahren zur herstellung von 1,4- benzohydrochinonderivaten
CH393359A (de)	1965-06-15	Verfahren zur Herstellung von Chromenderivaten
CH591415A5 (en)	1977-09-15	3-(Tri-substd. benzoyl) propionic acids - as relaxants or spasmolytics for the gall bladder
DE873240C (de)	1953-04-13	Verfahren zur Herstellung von Vitamin A und chemisch aehnlich gebauten Verbindungen
AT261109B (de)	1968-04-10	Verfahren zur Gewinnung von therapeutisch wirksamen Verbindungen aus Valerianaceae
AT215995B (de)	1961-07-10	Verfahren zur Herstellung von neuen Chromanderivaten
DE1001258C2 (de)	1957-07-04	Verfahren zur Herstellung von konjugierten Polyenen der Vitamin-A-Reihe
AT246747B (de)	1966-05-10	Verfahren zur Herstellung eines L-Lyxopyranosylhalogenids
DE2129652A1 (de)	1972-02-10	5,9-Dioxodecansaeuren und ihre Herstellung
AT216156B (de)	1961-07-10	Verfahren zur Herstellung von Polyhydrophenanthren-Verbindungen
DE839495C (de)	1952-05-19	Verfahren zur Darstellung von Pentaenen (Vitamin A-Alkohol bzw. dessen Ester)
AT248622B (de)	1966-08-10	Verfahren zur Herstellung neuer 2-Cyano-3-oxo-steroide
CH530979A (de)	1972-11-30	Verfahren zur Gewinnung von therapeutisch wirksamen Verbindungen aus Valerianaceae
AT242690B (de)	1965-09-27	Verfahren zur Herstellung von Derivaten des 2,3-Dimethoxy-5-methyl-benzohydrochinons-(1,4) und den zugehörigen Chinonen
AT319207B (de)	1974-12-10	Vzh von neuen 3-(2',4',5'-trisubst.benzoyl)-propionsaeuren
AT278261B (de)	1970-01-26	Verfahren zur Herstellung von in 4- bzw. 6-Stellung acylierten Δ<4>-3-Ketosteroiden
CH428703A (de)	1967-01-31	Verfahren zur Herstellung von ungesättigten Verbindungen
AT239971B (de)	1965-05-10	Verfahren zur Herstellung von neuen Steroid-3-enolacylaten
AT335433B (de)	1977-03-10	Verfahren zur herstellung neuer 3-(4-biphenylyl)-buttersauren, deren estern, amiden und salzen
AT272541B (de)	1969-07-10	Verfahren zur Herstellung von Benzindenen
DE935364C (de)	1955-11-17	Verfahren zur Herstellung von Polyenverbindungen