CH399653A - Verfahren zur Inaktivierung von Poliomyelitisviren - Google Patents

Verfahren zur Inaktivierung von Poliomyelitisviren

Info

Publication number: CH399653A
Authority: CH; Switzerland
Prior art keywords: per; chelating agent; formaldehyde; inactivating; tetraacetate
Prior art date: 1959-12-22

Application number

CH1412560A

Other languages

German (de)

English (en)

Inventor

Haas Richard

Hennessen Walter

Mauler Rudolf

Original Assignee

Behringwerke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1959-12-22

Filing date

1960-12-16

Publication date

1965-09-30

1960-12-16 Application filed by Behringwerke Ag filed Critical Behringwerke Ag

1965-09-30 Publication of CH399653A publication Critical patent/CH399653A/de

Links

241000700605 Viruses Species 0.000 title claims description 19
238000000034 method Methods 0.000 title claims description 14
208000000474 Poliomyelitis Diseases 0.000 title claims description 10
230000000415 inactivating effect Effects 0.000 title claims description 4
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 26
239000002738 chelating agent Substances 0.000 claims description 10
239000000725 suspension Substances 0.000 claims description 10
230000002779 inactivation Effects 0.000 claims description 7
MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 claims description 3
159000000000 sodium salts Chemical class 0.000 claims description 3
238000001556 precipitation Methods 0.000 claims description 2
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims 1
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 8
210000002966 serum Anatomy 0.000 description 6
229960005486 vaccine Drugs 0.000 description 5
238000012360 testing method Methods 0.000 description 3
239000008098 formaldehyde solution Substances 0.000 description 2
239000000463 material Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
RNMCCPMYXUKHAZ-UHFFFAOYSA-N 2-[3,3-diamino-1,2,2-tris(carboxymethyl)cyclohexyl]acetic acid Chemical compound NC1(N)CCCC(CC(O)=O)(CC(O)=O)C1(CC(O)=O)CC(O)=O RNMCCPMYXUKHAZ-UHFFFAOYSA-N 0.000 description 1
QDHGQJQZPJPKJK-UHFFFAOYSA-N 2-[carboxymethyl-(2,4,6-trioxo-1,3-diazinan-5-yl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)C1C(=O)NC(=O)NC1=O QDHGQJQZPJPKJK-UHFFFAOYSA-N 0.000 description 1
WDJHALXBUFZDSR-UHFFFAOYSA-N Acetoacetic acid Natural products CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 description 1
241000700198 Cavia Species 0.000 description 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
102000004407 Lactalbumin Human genes 0.000 description 1
108090000942 Lactalbumin Proteins 0.000 description 1
102000004338 Transferrin Human genes 0.000 description 1
108090000901 Transferrin Proteins 0.000 description 1
-1 acetoacetic acid ester Chemical class 0.000 description 1
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
235000013330 chicken meat Nutrition 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000001914 filtration Methods 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
238000002649 immunization Methods 0.000 description 1
230000003053 immunization Effects 0.000 description 1
230000016784 immunoglobulin production Effects 0.000 description 1
238000009776 industrial production Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
230000005855 radiation Effects 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/125—Picornaviridae, e.g. calicivirus
- A61K39/13—Poliovirus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32661—Methods of inactivation or attenuation
- C12N2770/32663—Methods of inactivation or attenuation by chemical treatment
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Public Health (AREA)
Zoology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Mycology (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

CH1412560A 1959-12-22 1960-12-16 Verfahren zur Inaktivierung von Poliomyelitisviren CH399653A (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DEB55993A DE1131846B (de)	1959-12-22	1959-12-22	Verfahren zur Inaktivierung von Poliomyelitisviren

Publications (1)

Publication Number	Publication Date
CH399653A true CH399653A (de)	1965-09-30

Family

ID=6971173

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH1412560A CH399653A (de)	1959-12-22	1960-12-16	Verfahren zur Inaktivierung von Poliomyelitisviren

Country Status (6)

Country	Link
BE (1)	BE598471A (cs)
CH (1)	CH399653A (cs)
DE (1)	DE1131846B (cs)
FR (1)	FR1023M (cs)
GB (1)	GB949684A (cs)
SE (1)	SE309826B (cs)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1042179B (de) *	1957-07-11	1958-10-30	Pasteur Institut	Verfahren zur Herstellung antigenhaltiger Impfstoffe

1959
- 1959-12-22 DE DEB55993A patent/DE1131846B/de active Pending
1960
- 1960-12-16 CH CH1412560A patent/CH399653A/de unknown
- 1960-12-20 GB GB43811/60A patent/GB949684A/en not_active Expired
- 1960-12-22 BE BE598471A patent/BE598471A/fr unknown
- 1960-12-22 SE SE12424/60A patent/SE309826B/xx unknown
1961
- 1961-03-21 FR FR856343A patent/FR1023M/fr not_active Expired

Also Published As

Publication number	Publication date
FR1023M (cs)	1961-12-26
SE309826B (cs)	1969-04-08
DE1131846B (de)	1962-06-20
BE598471A (fr)	1961-06-22
GB949684A (en)	1964-02-19

Publication	Publication Date	Title
DE1924303A1 (de)	1970-12-17	AEthylaethylenimin als Inaktivierungsmittel
DE1924304C3 (de)	1980-07-17	Diäthylaminoäthyldextran (DEAE-D) als Adjuvans für Impfstoffe zur aktiven Immunisierung von Säugetieren
DE1076888B (de)	1960-03-03	Verfahren zur Gewinnung atmungsfoerdernder Wirkstoffe fuer therapeutische Zwecke
DE2262427C3 (de)	1980-04-24	Immunostimulierendes Mittel
AT222274B (cs)	1962-07-10
CH423095A (de)	1966-10-31	Verfahren zur Herstellung eines Tollwutimpfstoffes
DE1492243C3 (de)	1979-08-16	Injizierbare Impfstoffe
EP0022426B1 (de)	1986-09-10	Nasalpräparate und Verfahren zu deren Herstellung
DE2528584A1 (de)	1976-03-11	Verfahren zur inaktivierung der virusinfektiositaet unter gleichzeitiger stabilisierung von virusantigenen
DE2034118A1 (en)	1972-01-13	Xenogenic nucleic acids for enhancing antigenicity - of peptides and proteins
DE1131846B (de)	1962-06-20	Verfahren zur Inaktivierung von Poliomyelitisviren
DE1960713C3 (de)	1981-12-17	Mehrfach-Vaccine zur gleichzeitigen Immunisierung gegen Maul- und Klauenseuche und Brucellose und gegebenenfalls gegen Tollwut
DE3877015T2 (de)	1993-05-06	Antikoerper enthaltende stabilisierte waesserige zusammensetzung.
DE2225548C3 (de)	1980-05-29	Intravenös verträglicher Impfstoff gegen Staupe- und Hepatite contagiosa canis
DE1246167B (de)	1967-08-03	Verfahren zur Herstellung von Influenza-Vaccinen
DE543604C (de)	1932-02-08	Verfahren zur Dauersterilisierung von Heilseren
DE940315C (de)	1956-03-15	Verfahren zur Herstellung von Lymphe gegen Schweinepest
DE2340911A1 (de)	1975-05-07	Tetanus-antigen und verfahren zu seiner herstellung
DE1007473B (de)	1957-05-02	Verfahren zur Herstellung eines Poliomyelitis-Impfstoffes
AT216142B (de)	1961-07-10	Verfahren zur Herstellung von Depotimpfstoffen
CH430052A (de)	1967-02-15	Verfahren zur Herstellung eines inaktivierten Pockenimpfstoffes
AT200257B (cs)	1958-10-25
AT234902B (de)	1964-07-27	Verfahren zur Herstellung einer Vaccine gegen Staupe
AT234275B (de)	1964-06-25	Verfahren zur Herstellung von Vaccinen aus Toxoiden bzw. Toxinen von Clostridium perfringens
DE1667908B1 (de)	1970-12-03	Polyvalenter Impfstoff gegen Pseudomonas aeruginosa Infektionen