CH564574A5 - - Google Patents

Info

Publication number
CH564574A5
CH564574A5 CH1090772A CH1090772A CH564574A5 CH 564574 A5 CH564574 A5 CH 564574A5 CH 1090772 A CH1090772 A CH 1090772A CH 1090772 A CH1090772 A CH 1090772A CH 564574 A5 CH564574 A5 CH 564574A5
Authority
CH
Switzerland
Application number
CH1090772A
Original Assignee
Hayashibara Biochem Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP8596071A external-priority patent/JPS526346B2/ja
Application filed by Hayashibara Biochem Lab filed Critical Hayashibara Biochem Lab
Publication of CH564574A5 publication Critical patent/CH564574A5/xx

Links

Classifications

    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/269—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of microbial origin, e.g. xanthan or dextran
    • A23L29/274—Pullulan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0018—Pullulan, i.e. (alpha-1,4)(alpha-1,6)-D-glucan; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/05—Alcohols; Metal alcoholates
    • C08K5/053—Polyhydroxylic alcohols
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02—Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08L3/12—Amylose; Amylopectin; Degradation products thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
    • C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C12P19/10—Pullulan

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Textile Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Meat, Egg Or Seafood Products (AREA)
CH1090772A 1971-07-23 1972-07-21 CH564574A5 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5457971 1971-07-23
JP8596071A JPS526346B2 (fr) 1971-10-30 1971-10-30

Publications (1)

Publication Number Publication Date
CH564574A5 true CH564574A5 (fr) 1975-07-31

Family

ID=26395350

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1090772A CH564574A5 (fr) 1971-07-23 1972-07-21

Country Status (16)

Country Link
US (1) US3784390A (fr)
AR (1) AR200845A1 (fr)
AU (1) AU468995B2 (fr)
BE (1) BE786574A (fr)
CA (1) CA1007415A (fr)
CH (1) CH564574A5 (fr)
DE (1) DE2235991C3 (fr)
ES (1) ES405103A1 (fr)
FI (1) FI54133C (fr)
FR (1) FR2147112B1 (fr)
GB (1) GB1374199A (fr)
IT (1) IT1048891B (fr)
NL (1) NL170428C (fr)
NO (1) NO138662C (fr)
PH (1) PH9411A (fr)
SE (1) SE384517B (fr)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3871892A (en) * 1972-12-18 1975-03-18 Hayashibara Biochem Lab Shaped bodies of pullulan esters and their use
JPS5224054B2 (fr) * 1973-01-23 1977-06-29
JPS5315542B2 (fr) * 1973-03-01 1978-05-25
JPS5551080B2 (fr) 1973-09-05 1980-12-22
JPS5060530A (fr) * 1973-09-29 1975-05-24
JPS5247042B2 (fr) * 1973-09-29 1977-11-30
JPS5411358B2 (fr) * 1974-02-01 1979-05-14
US4018233A (en) * 1974-02-05 1977-04-19 Sumitomo Chemical Company Limited Shaped matters of tobaccos and process for producing the same
JPS50117592A (fr) * 1974-02-27 1975-09-13
US4045388A (en) * 1974-02-28 1977-08-30 Sumitomo Chemical Company, Limited Resin composition of hydrophilic pullulan, hydrophobic thermoplastic resin, and plasticizer
JPS5345822B2 (fr) * 1974-03-15 1978-12-09
JPS543707B2 (fr) * 1974-03-29 1979-02-26
JPS514272A (fr) * 1974-06-29 1976-01-14 Sumitomo Chemical Co
JPS51139969A (en) * 1975-05-29 1976-12-02 Hayashibara Biochem Lab New bonding method for unwoven fabrics
JPS5256603A (en) * 1975-10-31 1977-05-10 Sumitomo Chemical Co Liquid of forming protection film for lithographic press plate
JPS6054322B2 (ja) * 1977-09-30 1985-11-29 株式会社林原生物化学研究所 成形物の製法
JPS58213076A (ja) * 1982-06-05 1983-12-10 Hayashibara Biochem Lab Inc 摺動部シ−ル剤
US4562020A (en) * 1982-12-11 1985-12-31 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Process for producing self-supporting glucan film
GB8302676D0 (en) * 1983-02-01 1983-03-02 Spontex Ltd Protection and identification of bulbs & c
JPS6049080A (ja) * 1983-08-27 1985-03-18 Hayashibara Biochem Lab Inc 摺動部シ−ル剤
US4650666A (en) * 1983-11-30 1987-03-17 Dainippon Pharmaceutical Co., Ltd. Pullulan and sugar coated pharmaceutical composition
JPS60219238A (ja) * 1984-04-14 1985-11-01 Hayashibara Biochem Lab Inc 徐崩性プルラン含有成形物とその製法
JPS60258125A (ja) * 1984-06-06 1985-12-20 Hayashibara Biochem Lab Inc 蛋白性生理活性物質を含有する水溶性乾燥物
EP0256611A1 (fr) * 1986-08-08 1988-02-24 Squibb Japan Inc. Systèmes d'apport de médicaments oraux
CA2049524A1 (fr) * 1990-08-30 1992-03-01 Jakob Silbiger Compositions comprenant un polymere hydrophile et un second produit hydrophile qui est different
US5871679A (en) * 1991-04-10 1999-02-16 Isolyser Company, Inc. Method of producing hot water soluble garments and like fabrics
US6048410A (en) * 1991-04-10 2000-04-11 Isolyser Company, Inc. Method of disposal of hot water soluble garments and like fabrics
US5181967A (en) * 1991-04-10 1993-01-26 Isolyser Company, Inc. Method of disposal of hot water soluble utensils
USRE36399E (en) * 1991-04-10 1999-11-23 Isolyser Company, Inc. Method of Disposal of hot water soluble utensils
GB2267711A (en) * 1991-04-10 1993-12-15 Isolyser Co Hot - water soluble polyvinyl alcohol fabric articles and method of disposal thereof
US5650219A (en) * 1991-04-10 1997-07-22 Isolyser Co. Inc. Method of disposal of hot water soluble garments and like fabrics
JPH06228508A (ja) * 1993-02-04 1994-08-16 Nitto Denko Corp 粘着テープ
US5620786A (en) * 1993-04-29 1997-04-15 Isolyser Co. Inc. Hot water soluble towels, sponges and gauzes
US5885907A (en) * 1993-04-29 1999-03-23 Isolyser Company, Inc. Method of disposal of hot water soluble garments and like fabrics
US5470653A (en) * 1994-08-05 1995-11-28 Isolyser Company, Inc. Disposable mop heads
US5661217A (en) * 1994-08-05 1997-08-26 Isolyser Company, Inc. Method of manufacturing monolithic structures from polyvinyl alcohol
US5707731A (en) * 1996-05-09 1998-01-13 Isolyser Company, Inc. Disposable cleaning articles
US5891812A (en) * 1996-10-11 1999-04-06 Isolyser Company, Inc. Liquid absorbable non-permeable fabrics and methods of making, using, and disposing thereof
US6096328A (en) * 1997-06-06 2000-08-01 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness
US20020018754A1 (en) * 1999-03-15 2002-02-14 Paul Albert Sagel Shapes for tooth whitening strips
FR2775979A1 (fr) * 1998-03-11 1999-09-17 Warner Lambert Co Compositions filmogenes a base d'alcool polyvinylique
EP1062274B1 (fr) * 1998-03-11 2007-11-14 Warner-Lambert Company LLC Compositions a base d'alcool polyvinylique
US6596298B2 (en) 1998-09-25 2003-07-22 Warner-Lambert Company Fast dissolving orally comsumable films
DK1139793T3 (da) 1998-12-23 2010-03-01 Sinai School Medicine Inhibitorer af bittert smagsrespons
EP1196137B1 (fr) 1999-07-02 2004-12-22 The Procter & Gamble Company Systeme comprenant des resines d'organosiloxanes permettant d'administrer des substances destinees a l'hygiene buccale et de prolonger cette administration
EP1072633A1 (fr) * 1999-07-22 2001-01-31 Warner-Lambert Company Compositions filmogènes à base de pullulane
EP1157691A1 (fr) * 2000-05-16 2001-11-28 Warner-Lambert Company Compositions de film à base de pullulan possédant des propriétés de surface améliorées
JP4065691B2 (ja) * 1999-07-22 2008-03-26 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー プルラン膜組成物
US7314716B2 (en) * 1999-11-19 2008-01-01 Mount Sinai School Of Medicine Gustducin γ subunit materials and methods
US7067116B1 (en) 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
US20020131990A1 (en) * 2000-11-30 2002-09-19 Barkalow David G. Pullulan free edible film compositions and methods of making the same
US6656493B2 (en) 2001-07-30 2003-12-02 Wm. Wrigley Jr. Company Edible film formulations containing maltodextrin
EP1438033B1 (fr) * 2001-10-23 2008-06-11 InnoGEL AG Capsules dures a base de gel d'amidon et procede permettant de les utiliser
US20030099691A1 (en) * 2001-11-16 2003-05-29 Susan Lydzinski Films containing starch
JP2003313125A (ja) * 2002-04-24 2003-11-06 Capsugel Japan Inc カプセル剤
US6949240B2 (en) * 2002-05-23 2005-09-27 The Procter & Gamble Company Tooth whitening products
US8524200B2 (en) 2002-09-11 2013-09-03 The Procter & Gamble Company Tooth whitening products
US20050019277A1 (en) * 2002-09-11 2005-01-27 The Procter & Gamble Company Tooth whitening products
US20040202698A1 (en) * 2003-04-02 2004-10-14 The Procter & Gamble Company Drug delivery systems comprising an encapsulated active ingredient
EP1648362A4 (fr) * 2003-07-01 2012-01-11 Todd Maibach Film renfermant des agents therapeutiques
EP1580229A1 (fr) * 2004-03-22 2005-09-28 Warner-Lambert Company Llc Compositions à base de biopolymères et produits fabriqués à partir de celles-ci
EP1593376A1 (fr) * 2004-05-04 2005-11-09 Warner-Lambert Company LLC Gélules de pullulane ameliorées
CN100462394C (zh) * 2006-02-13 2009-02-18 林玉惠 一种可食用食品包装膜及其制备方法
FR2897267A1 (fr) * 2006-02-16 2007-08-17 Flamel Technologies Sa Formes pharmaceutiques multimicroparticulaires pour administration per os
US20070264346A1 (en) * 2006-02-16 2007-11-15 Flamel Technologies Multimicroparticulate pharmaceutical forms for oral administration
EP2100606A4 (fr) * 2006-12-07 2009-12-30 Daiichi Sankyo Co Ltd Préparation revêtue d'un film ayant une stabilité améliorée
US20090198262A1 (en) * 2006-12-26 2009-08-06 Discus Dental, Llc Disposable tongue scraper
US20100215774A1 (en) * 2007-02-09 2010-08-26 Todd Maibach Film comprising nitroglycerin
CA2682752C (fr) * 2007-04-05 2015-07-07 University Of Kansas Compositions pharmaceutiques a dissolution rapide comportant du pullulane
US8900629B2 (en) 2007-04-05 2014-12-02 University Of Kansas Rapidly dissolving pharmaceutical compositions comprising pullulan
US20090004254A1 (en) * 2007-06-19 2009-01-01 Todd Maibach Film comprising active drugs
CN101096236B (zh) * 2007-07-05 2010-05-19 江南大学 一种可食用的方便面辅料包装袋的制备方法
ITMO20070323A1 (it) * 2007-10-22 2009-04-23 Illycaffe Spa Contenitore
WO2009095294A1 (fr) * 2008-02-01 2009-08-06 Unilever Plc Véhicule soluble dans l’eau
US20090247644A1 (en) * 2008-03-28 2009-10-01 Forest Laboratories Holdings Limited Memantine formulations
US8715715B2 (en) 2008-11-03 2014-05-06 Nal Pharmaceuticals Ltd. Dosage form for insertion into the mouth
WO2012053006A2 (fr) 2010-10-18 2012-04-26 Panacea Biotec Ltd Films à dissolution rapide améliorés pour l'administration par voie orale comprenant une combinaison de polymères, procédé de préparation de ces derniers
ES2556985T3 (es) 2011-01-11 2016-01-21 Capsugel Belgium Nv Nuevas cápsulas duras que comprenden pululano
US20130266685A1 (en) * 2012-04-06 2013-10-10 Jose Santiago Drink sample apparatus and method of use
MX361101B (es) 2012-10-17 2018-11-27 Procter & Gamble Tira para el suministro de un activo para el cuidado bucal y métodos para aplicar activos para el cuidado bucal.
JP6043693B2 (ja) * 2012-10-19 2016-12-14 富士フイルム株式会社 保護膜形成用の樹脂組成物、保護膜、パターン形成方法、電子デバイスの製造方法及び電子デバイス
ES2797484T3 (es) * 2013-03-15 2020-12-02 Toray Industries Película laminada que utiliza resina basada en ácido poliláctico
US9278050B2 (en) 2013-04-01 2016-03-08 Trevor Anderson Dissolvable medication administration bag and method of using the same
ES2793530T3 (es) * 2014-05-19 2020-11-16 Tillotts Pharma Ag Cápsulas revestidas de liberación modificada
US9579292B1 (en) 2016-11-21 2017-02-28 Karl Wei Cao Film forming hard capsule solution
US9700518B1 (en) 2016-11-21 2017-07-11 Karl Wei Cao Dip molding process for the manufacture of hard capsule shells
WO2018189587A1 (fr) 2017-04-14 2018-10-18 Capsugel Belgium Nv Procédé de fabrication de pullulane
CA3059527A1 (fr) 2017-04-14 2018-10-18 Capsugel Belgium Nv Capsules de pullulane
CN114957810B (zh) * 2022-05-05 2023-04-18 中国科学院天津工业生物技术研究所 一种普鲁兰多糖形状记忆材料的制备方法及其4d打印方法及制品
CN116327723A (zh) * 2023-03-22 2023-06-27 江苏力凡胶囊有限公司 普鲁兰多糖硬胶囊封口胶液配方及封口方法
US20260000543A1 (en) * 2024-06-28 2026-01-01 Starch Medical, Inc. Method and Apparatus for Treating Topical Wounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3054689A (en) * 1959-12-30 1962-09-18 Allene R Jeanes Atypically salt-responsive alkali-deacetylated polysaccharide produced by xanthomonas campestris
US3406114A (en) * 1964-07-20 1968-10-15 Kerr Mc Gee Oil Ind Inc Process for flocculating finely divided solids suspended in an aqueous medium with amicrobial polysaccharide

Also Published As

Publication number Publication date
DE2235991B2 (de) 1980-03-06
AU468995B2 (en) 1976-01-29
FI54133C (fi) 1978-10-10
DE2235991C3 (de) 1980-10-23
NL170428B (nl) 1982-06-01
BE786574A (fr) 1972-11-16
DE2235991A1 (de) 1973-02-08
AU4457672A (en) 1974-01-17
US3784390A (en) 1974-01-08
NL170428C (nl) 1982-11-01
CA1007415A (en) 1977-03-29
NL7210152A (fr) 1973-01-25
GB1374199A (en) 1974-11-20
ES405103A1 (es) 1975-11-16
SE384517B (sv) 1976-05-10
NO138662B (no) 1978-07-10
NO138662C (no) 1978-10-18
FR2147112B1 (fr) 1976-08-06
FI54133B (fi) 1978-06-30
IT1048891B (it) 1980-12-20
PH9411A (en) 1975-11-11
FR2147112A1 (fr) 1973-03-09
AR200845A1 (es) 1974-12-27

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