CH610302A5 - Process for the preparation of 11-deoxy- omega -pentanorprostaglandins substituted in position 16 - Google Patents

Process for the preparation of 11-deoxy- omega -pentanorprostaglandins substituted in position 16

Info

Publication number: CH610302A5
Authority: CH; Switzerland
Prior art keywords: phenyl; pentanorprostaglandins; deoxy; omega; substituted
Prior art date: 1974-12-11

Application number

CH1610875A

Other languages

English (en)

Inventor

Michael Ross Johnson

Thomas Ken Schaaf

James Frederick Eggler

Jasjit Singh Bindra

Hans-Jurgen Ernst Hess

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-12-11

Filing date

1975-12-11

Publication date

1979-04-12

1975-12-11 Application filed by Pfizer filed Critical Pfizer

1979-04-12 Publication of CH610302A5 publication Critical patent/CH610302A5/xx

Links

-1 beta -naphthyl Chemical group 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/06—Saturated compounds having a carboxyl group bound to a five-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1896—Compounds having one or more Si-O-acyl linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
- C07F9/4059—Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Epidemiology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Crystallography & Structural Chemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Emergency Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CH1610875A 1974-12-11 1975-12-11 Process for the preparation of 11-deoxy- omega -pentanorprostaglandins substituted in position 16 CH610302A5 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US53167674A	1974-12-11	1974-12-11

Publications (1)

Publication Number	Publication Date
CH610302A5 true CH610302A5 (en)	1979-04-12

Family

ID=24118594

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH1610875A CH610302A5 (en)	1974-12-11	1975-12-11	Process for the preparation of 11-deoxy- omega -pentanorprostaglandins substituted in position 16

Country Status (22)

Country	Link
JP (3)	JPS51125257A (2)
AT (1)	AT351185B (2)
BE (1)	BE836564A (2)
BG (1)	BG27227A3 (2)
CH (1)	CH610302A5 (2)
CS (3)	CS194746B2 (2)
DD (3)	DD129783A5 (2)
DE (1)	DE2555210A1 (2)
DK (1)	DK559975A (2)
ES (1)	ES443421A1 (2)
FI (1)	FI753475A7 (2)
FR (1)	FR2293923A1 (2)
GB (3)	GB1508170A (2)
GR (1)	GR60310B (2)
IE (1)	IE43815B1 (2)
IL (2)	IL48617A0 (2)
LU (1)	LU73997A1 (2)
NL (1)	NL166015C (2)
NO (1)	NO754195L (2)
NZ (1)	NZ179502A (2)
SE (1)	SE7513602L (2)
ZA (1)	ZA747723B (2)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5486540A (en) *	1993-10-28	1996-01-23	Allergan, Inc.	Cyclopentane heptanoic or heptenoic acid, 2-arylalkyl or arylalkenyl and derivatives as therapeutic agents
KR20010074981A (ko) *	1998-09-14	2001-08-09	우에노 도시오	ω치환된 페닐프로스타그란딘 Ｅ 유도체 및 그 유도체를유효 성분으로 하는 약제
US20090291904A1 (en) *	2005-12-07	2009-11-26	Yoel Kashman	Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
US9284274B2 (en)	2005-12-07	2016-03-15	Ramot At Tel-Aviv University Ltd.	Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
US9284252B2 (en)	2009-06-09	2016-03-15	Sepal Pharma Ltd.	Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders
HUE031885T2 (en) *	2012-07-19	2017-08-28	Cayman Chemical Co Inc	Difluoro lactam preparations for EP4-mediated osteo-related diseases and conditions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES416865A1 (es) *	1972-07-13	1976-03-01	Pfizer	Procedimiento para preparar w-pentanorprostaglandinas sus- tituidas en la posicion 15.

1974
- 1974-12-04 ZA ZA747723A patent/ZA747723B/xx unknown
1975
- 1975-11-11 GR GR49337A patent/GR60310B/el unknown
- 1975-12-02 SE SE7513602A patent/SE7513602L/xx unknown
- 1975-12-03 IE IE2635/75A patent/IE43815B1/en unknown
- 1975-12-08 IL IL48617A patent/IL48617A0/xx unknown
- 1975-12-09 DE DE19752555210 patent/DE2555210A1/de active Pending
- 1975-12-10 NZ NZ179502A patent/NZ179502A/xx unknown
- 1975-12-10 GB GB29061/77A patent/GB1508170A/en not_active Expired
- 1975-12-10 DK DK559975A patent/DK559975A/da not_active Application Discontinuation
- 1975-12-10 NO NO754195A patent/NO754195L/no unknown
- 1975-12-10 GB GB29060/77A patent/GB1508169A/en not_active Expired
- 1975-12-10 FI FI753475A patent/FI753475A7/fi not_active Application Discontinuation
- 1975-12-10 GB GB50700/75A patent/GB1508168A/en not_active Expired
- 1975-12-11 AT AT941675A patent/AT351185B/de not_active IP Right Cessation
- 1975-12-11 NL NL7514446.A patent/NL166015C/xx not_active IP Right Cessation
- 1975-12-11 BG BG031757A patent/BG27227A3/bg unknown
- 1975-12-11 LU LU73997A patent/LU73997A1/xx unknown
- 1975-12-11 DD DD7500197925A patent/DD129783A5/xx unknown
- 1975-12-11 CS CS771242A patent/CS194746B2/cs unknown
- 1975-12-11 CS CS771241A patent/CS194745B2/cs unknown
- 1975-12-11 BE BE1007076A patent/BE836564A/xx not_active IP Right Cessation
- 1975-12-11 ES ES443421A patent/ES443421A1/es not_active Expired
- 1975-12-11 JP JP50148319A patent/JPS51125257A/ja active Pending
- 1975-12-11 CH CH1610875A patent/CH610302A5/xx not_active IP Right Cessation
- 1975-12-11 DD DD190054A patent/DD125828A5/xx unknown
- 1975-12-11 FR FR7537944A patent/FR2293923A1/fr active Granted
- 1975-12-11 DD DD7500197926A patent/DD129649A5/xx unknown
- 1975-12-11 CS CS758428A patent/CS194733B2/cs unknown
1977
- 1977-03-11 JP JP2687577A patent/JPS52102258A/ja active Pending
- 1977-03-11 JP JP2687477A patent/JPS52102270A/ja active Pending
1979
- 1979-03-13 IL IL56863A patent/IL56863A0/xx unknown

Also Published As

Publication number	Publication date
NL166015B (nl)	1981-01-15
BE836564A (fr)	1976-06-11
JPS52102258A (en)	1977-08-27
CS194745B2 (en)	1979-12-31
ES443421A1 (es)	1977-04-16
FR2293923B1 (2)	1979-02-23
SE7513602L (sv)	1976-06-14
CS194733B2 (en)	1979-12-31
DE2555210A1 (de)	1976-06-16
GB1508170A (en)	1978-04-19
GB1508169A (en)	1978-04-19
DD129649A5 (de)	1978-02-01
JPS52102270A (en)	1977-08-27
IL48617A0 (en)	1976-02-29
DD125828A5 (2)	1977-05-18
GR60310B (en)	1978-05-08
LU73997A1 (2)	1976-11-11
CS194746B2 (en)	1979-12-31
NO754195L (2)	1976-06-14
FI753475A7 (2)	1976-06-12
FR2293923A1 (fr)	1976-07-09
JPS51125257A (en)	1976-11-01
NZ179502A (en)	1979-01-11
BG27227A3 (bg)	1979-09-14
NL7514446A (nl)	1976-06-15
AT351185B (de)	1979-07-10
IE43815B1 (en)	1981-06-03
DK559975A (da)	1976-06-12
AU8736275A (en)	1977-10-13
DD129783A5 (de)	1978-02-08
NL166015C (nl)	1981-06-15
IL56863A0 (en)	1979-05-31
GB1508168A (en)	1978-04-19
ATA941675A (de)	1978-12-15
ZA747723B (en)	1976-11-24
IE43815L (en)	1976-06-11

Legal Events

Date	Code	Title	Description
1980-08-29	PL	Patent ceased
2024-10-31	PL	Patent ceased

Publication	Publication Date	Title
NL7505375A (nl)	1975-11-11	Nieuwe penicilline en cefalosporinederivaten en werkwijze voor de bereiding daarvan.
GB1456221A (en)	1976-11-24	3-hydroxy cephalosporins their ether derivatives and methods for their preparation
ES412859A1 (es)	1976-06-01	Un procedimiento para la preparacion de un derivado de 7- (alfa hidroxi-alfa-fenil) acetamido - 3 - (1 - metil - 1h - tetrazol - 5 - iltiometil) cefalosporina.
ES438314A1 (es)	1977-01-16	Un procedimiento para preparar los compuestos de decahi- droisoquinolina.
JPS54138590A (en)	1979-10-27	7-methoxycephalosporin compound, its preparation, and anti-bacterial agent containing the same
ES463783A1 (es)	1979-07-16	Un procedimiento para la preparacion de cis-4a-aril-octahi- dro-1h-2-pirindinas 2-sustituidas.
JPS5227791A (en)	1977-03-02	Synthesis of cephalosporins
JPS5271492A (en)	1977-06-14	Synthesis of 9-substituted-2-substituted thioadenines
ES443421A1 (es)	1977-04-16	Un procedimiento para la preparacion de una composicion far-macologica que contiene una 11-desoxi-gamma-pentanorprosta- glandina.
JPS5246093A (en)	1977-04-12	2-alkyl-7-substituted-2, or 3-cephem-4-carboxylic compounds, their sal ts, and preparation thereof
JPS5225740A (en)	1977-02-25	Preparation of o-acyl-amidinophenols or acid addition salts thereof
SE8703623D0 (sv)	1987-09-18	Komposition innefattande ett stannoreduceringsmedel och n-substituerade iminodiettiksyror
GB2111056A (en)	1983-06-29	Derivatives of 1, 4-thiazane-carboxylic acid preparation and utilization thereof and compositions containing same
GB1507723A (en)	1978-04-19	Acyloxymethyl cephalosporin esters
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