CH617775A5 - Process for the preparation of antigens from schistosomes - Google Patents

Process for the preparation of antigens from schistosomes Download PDF

Info

Publication number: CH617775A5
Authority: CH; Switzerland
Prior art keywords: schistosomes; antigens; solution; extraction; free
Prior art date: 1974-04-29

Application number

CH540475A

Other languages

German (de)

English (en)

Inventor

Burkhard Dr Enders

Guenther Henke

Original Assignee

Behringwerke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-04-29

Filing date

1975-04-28

Publication date

1980-06-13

1975-04-28 Application filed by Behringwerke Ag filed Critical Behringwerke Ag

1980-06-13 Publication of CH617775A5 publication Critical patent/CH617775A5/de

Links

241000242678 Schistosoma Species 0.000 title claims description 38
239000000427 antigen Substances 0.000 title claims description 38
102000036639 antigens Human genes 0.000 title claims description 38
108091007433 antigens Proteins 0.000 title claims description 38
238000000034 method Methods 0.000 title claims description 15
238000002360 preparation method Methods 0.000 title claims description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 33
239000000243 solution Substances 0.000 claims description 21
201000004409 schistosomiasis Diseases 0.000 claims description 14
235000002639 sodium chloride Nutrition 0.000 claims description 14
238000000605 extraction Methods 0.000 claims description 12
239000011780 sodium chloride Substances 0.000 claims description 12
241001465754 Metazoa Species 0.000 claims description 11
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 6
239000008103 glucose Substances 0.000 claims description 6
238000001514 detection method Methods 0.000 claims description 5
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
229910000397 disodium phosphate Inorganic materials 0.000 claims description 4
238000000338 in vitro Methods 0.000 claims description 4
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
239000001110 calcium chloride Substances 0.000 claims description 3
229910001628 calcium chloride Inorganic materials 0.000 claims description 3
235000011148 calcium chloride Nutrition 0.000 claims description 3
229910052943 magnesium sulfate Inorganic materials 0.000 claims description 3
235000019341 magnesium sulphate Nutrition 0.000 claims description 3
239000001103 potassium chloride Substances 0.000 claims description 3
229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 3
239000002904 solvent Substances 0.000 claims description 3
239000000126 substance Substances 0.000 claims description 3
239000012736 aqueous medium Substances 0.000 claims description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 2
235000019800 disodium phosphate Nutrition 0.000 claims description 2
150000002632 lipids Chemical class 0.000 claims description 2
102000004169 proteins and genes Human genes 0.000 claims description 2
108090000623 proteins and genes Proteins 0.000 claims description 2
239000012266 salt solution Substances 0.000 claims description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
235000001727 glucose Nutrition 0.000 claims 1
235000011164 potassium chloride Nutrition 0.000 claims 1
235000017557 sodium bicarbonate Nutrition 0.000 claims 1
239000001488 sodium phosphate Substances 0.000 claims 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
230000000392 somatic effect Effects 0.000 description 8
238000004519 manufacturing process Methods 0.000 description 7
230000010412 perfusion Effects 0.000 description 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
239000000463 material Substances 0.000 description 5
239000007858 starting material Substances 0.000 description 5
238000012360 testing method Methods 0.000 description 5
239000000284 extract Substances 0.000 description 4
239000007924 injection Substances 0.000 description 4
238000002347 injection Methods 0.000 description 4
210000002966 serum Anatomy 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
241000283984 Rodentia Species 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
238000003745 diagnosis Methods 0.000 description 3
239000000203 mixture Substances 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
235000015097 nutrients Nutrition 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
241000700198 Cavia Species 0.000 description 2
241000735552 Erythroxylum Species 0.000 description 2
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
241000699670 Mus sp. Species 0.000 description 2
208000024780 Urticaria Diseases 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000008280 blood Substances 0.000 description 2
235000008957 cocaer Nutrition 0.000 description 2
ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 2
230000007423 decrease Effects 0.000 description 2
238000011161 development Methods 0.000 description 2
238000002405 diagnostic procedure Methods 0.000 description 2
230000035931 haemagglutination Effects 0.000 description 2
238000011534 incubation Methods 0.000 description 2
230000003108 parasitologic effect Effects 0.000 description 2
244000052769 pathogen Species 0.000 description 2
230000001717 pathogenic effect Effects 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
230000000405 serological effect Effects 0.000 description 2
239000006228 supernatant Substances 0.000 description 2
238000010998 test method Methods 0.000 description 2
210000001519 tissue Anatomy 0.000 description 2
238000002604 ultrasonography Methods 0.000 description 2
206010002198 Anaphylactic reaction Diseases 0.000 description 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
COXVTLYNGOIATD-HVMBLDELSA-N CC1=C(C=CC(=C1)C1=CC(C)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S(O)(=O)=O)S(O)(=O)=O)\N=N\C1=CC=C2C(=CC(=C(N)C2=C1O)S(O)(=O)=O)S(O)(=O)=O Chemical compound CC1=C(C=CC(=C1)C1=CC(C)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S(O)(=O)=O)S(O)(=O)=O)\N=N\C1=CC=C2C(=CC(=C(N)C2=C1O)S(O)(=O)=O)S(O)(=O)=O COXVTLYNGOIATD-HVMBLDELSA-N 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
241000699673 Mesocricetus auratus Species 0.000 description 1
-1 NaHCOj Chemical compound 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
208000030852 Parasitic disease Diseases 0.000 description 1
241000700159 Rattus Species 0.000 description 1
241000242683 Schistosoma haematobium Species 0.000 description 1
241000242680 Schistosoma mansoni Species 0.000 description 1
241000282887 Suidae Species 0.000 description 1
238000003916 acid precipitation Methods 0.000 description 1
238000007792 addition Methods 0.000 description 1
230000036783 anaphylactic response Effects 0.000 description 1
208000003455 anaphylaxis Diseases 0.000 description 1
238000010171 animal model Methods 0.000 description 1
239000006286 aqueous extract Substances 0.000 description 1
229960001230 asparagine Drugs 0.000 description 1
235000009582 asparagine Nutrition 0.000 description 1
238000009739 binding Methods 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
210000004204 blood vessel Anatomy 0.000 description 1
239000003618 borate buffered saline Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000007975 buffered saline Substances 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229910002092 carbon dioxide Inorganic materials 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
230000002596 correlated effect Effects 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
229960003699 evans blue Drugs 0.000 description 1
238000000227 grinding Methods 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
230000003053 immunization Effects 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
238000011835 investigation Methods 0.000 description 1
229910001629 magnesium chloride Inorganic materials 0.000 description 1
210000000713 mesentery Anatomy 0.000 description 1
238000002156 mixing Methods 0.000 description 1
239000004570 mortar (masonry) Substances 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000011403 purification operation Methods 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
239000013049 sediment Substances 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
238000009589 serological test Methods 0.000 description 1
238000007873 sieving Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
238000009210 therapy by ultrasound Methods 0.000 description 1
238000004448 titration Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0003—Invertebrate antigens
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Pathology (AREA)
Cell Biology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
Food Science & Technology (AREA)
General Physics & Mathematics (AREA)
Mycology (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

CH540475A 1974-04-29 1975-04-28 Process for the preparation of antigens from schistosomes CH617775A5 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2420706A DE2420706C3 (de)	1974-04-29	1974-04-29	Verfahren zum Herstellen von spezifischen Antigenen aus Schistosomen und jene enthaltendes Mittel

Publications (1)

Publication Number	Publication Date
CH617775A5 true CH617775A5 (en)	1980-06-13

Family

ID=5914244

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH540475A CH617775A5 (en)	1974-04-29	1975-04-28	Process for the preparation of antigens from schistosomes

Country Status (16)

Country	Link
JP (1)	JPS50145518A (fr)
AT (1)	AT344329B (fr)
BE (1)	BE828565A (fr)
CA (1)	CA1052694A (fr)
CH (1)	CH617775A5 (fr)
DE (1)	DE2420706C3 (fr)
DK (1)	DK140044C (fr)
EG (1)	EG12734A (fr)
ES (1)	ES436866A1 (fr)
FR (1)	FR2268532B1 (fr)
GB (1)	GB1478082A (fr)
IE (1)	IE41024B1 (fr)
IT (1)	IT1049537B (fr)
LU (1)	LU72375A1 (fr)
NL (1)	NL7504853A (fr)
ZA (1)	ZA752717B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2356428A1 (fr) *	1976-06-29	1978-01-27	Inserm Ctre Technologie Biomed	Procede de preparation d'un agent immunologique antiparasitaire, produit obtenu et son application
FR2601037B1 (fr) *	1986-07-03	1988-10-21	Pasteur Institut	Peptide presentant des proprietes antigeniques isole de la proteine 28 kd de s. mansoni et son procede d'isolement, anticorps monoclonaux reconnaissant au moins un epitope dudit peptide et application de celui-ci dans l'induction de la synthese d'anticorps neutralisants
CN117203526A (zh) *	2020-10-27	2023-12-08	默克专利有限公司	用于检测血吸虫感染的蛋白质

1974
- 1974-04-29 DE DE2420706A patent/DE2420706C3/de not_active Expired
1975
- 1975-04-23 ES ES436866A patent/ES436866A1/es not_active Expired
- 1975-04-24 IT IT22763/75A patent/IT1049537B/it active
- 1975-04-24 NL NL7504853A patent/NL7504853A/xx not_active Application Discontinuation
- 1975-04-25 GB GB1734675A patent/GB1478082A/en not_active Expired
- 1975-04-26 EG EG247/75A patent/EG12734A/xx active
- 1975-04-28 AT AT325475A patent/AT344329B/de not_active IP Right Cessation
- 1975-04-28 CH CH540475A patent/CH617775A5/de not_active IP Right Cessation
- 1975-04-28 JP JP50051942A patent/JPS50145518A/ja active Pending
- 1975-04-28 IE IE940/75A patent/IE41024B1/xx unknown
- 1975-04-28 DK DK184575A patent/DK140044C/da active
- 1975-04-28 LU LU72375A patent/LU72375A1/xx unknown
- 1975-04-28 ZA ZA00752717A patent/ZA752717B/xx unknown
- 1975-04-28 CA CA225,850A patent/CA1052694A/fr not_active Expired
- 1975-04-29 FR FR7513347A patent/FR2268532B1/fr not_active Expired
- 1975-04-29 BE BE155933A patent/BE828565A/fr unknown

Also Published As

Publication number	Publication date
DK140044C (da)	1979-11-12
FR2268532B1 (fr)	1980-01-25
CA1052694A (fr)	1979-04-17
DE2420706C3 (de)	1979-11-22
ZA752717B (en)	1976-03-31
IE41024B1 (en)	1979-10-10
GB1478082A (en)	1977-06-29
BE828565A (fr)	1975-10-29
AT344329B (de)	1978-07-10
IT1049537B (it)	1981-02-10
LU72375A1 (fr)	1977-02-03
DK140044B (da)	1979-06-11
JPS50145518A (fr)	1975-11-21
DE2420706A1 (de)	1975-10-30
ES436866A1 (es)	1977-01-01
ATA325475A (de)	1977-11-15
NL7504853A (nl)	1975-10-31
DE2420706B2 (de)	1979-03-22
IE41024L (en)	1975-10-29
FR2268532A1 (fr)	1975-11-21
DK184575A (da)	1975-10-30
EG12734A (en)	1979-06-30

Legal Events

Date	Code	Title	Description
1981-12-31	PL	Patent ceased
2024-10-31	PL	Patent ceased

Publication	Publication Date	Title
DE2029499C3 (de)	1983-12-22	Verfahren zum Nachweis der Anwesenheit von carcinoembryonalen Antigenen im Blut
DE2638762A1 (de)	1977-03-10	Wasserloesliche adjuvantien, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE2049515A1 (de)	1971-04-15	Impfstoff gegen Virushepatitis
DE3750225T2 (de)	1994-11-17	Herstellung und verwendung von anti-helminthischen wirkstoffen und schutzantigenen.
DE2619715A1 (de)	1977-11-24	Tumor-antigen und verfahren zu dessen herstellung
DE2518474A1 (de)	1975-11-20	Mitogenes mittel, verfahren zu seiner herstellung und diese mittel enthaltende arzneimittel und biologische reagenzien
CH617775A5 (en)	1980-06-13	Process for the preparation of antigens from schistosomes
DE3012204A1 (de)	1980-10-23	Antigen, verfahren zu seiner herstellung und seine verwendung
Gillman	1957	Venous Obstruction in the Pathogenesis of Hepatic Bilharziasis a Preliminary Report of Comparative Findings in Rats, Monkeys and Man
CH404858A (de)	1965-12-31	Verfahren zur Herstellung von wachstumfördernde Stoffe enthaltenden Präparaten
Bean	1945	Alterations in CNS associated with chronic motor disabilities induced by O2 at high pressure
US4150107A (en)	1979-04-17	Antigen from schistosomes and process for obtaining same
DE2213709A1 (de)	1972-10-19	Verfahren zur Herstellung eines Interferonerzeugers
DE2728802C2 (de)	1982-04-22	Verfahren zum Herstellen eines antischistosomen immunologischen Mittels
DE2728806A1 (de)	1978-01-05	Auf oralem wege einzunehmender antiparasitaerer impfstoff, verfahren zu dessen herstellung und anwendungsmethode des impfstoffs bei saeugetieren
DE2057544B2 (de)	1978-06-29	Impfstoff gegen ein neonatales Kälberdiarrhoevirus, Verfahren zu seiner Herstellung und seine Verwendung
DE238162C (fr)
DE1902590C2 (de)	1984-04-26	Verwendung einer Immunribonucleinsäure (IRNS) zum Immunisieren lebender Tiere
DE2205897C3 (de)	1980-05-22	Verfahren zur Herstellung von Antithymozytenserum
AT54778B (de)	1912-08-10	Verfahren zur Gewinnung von Immunstoffen.
AT58152B (de)	1913-03-10	Verfahren zur Darstellung eines therapeutisch wirksamen Präparates aus Tuberkelbazillen.
DE2644149A1 (de)	1978-04-06	Neue parasiten-antigene
WO1994006010A1 (fr)	1994-03-17	Procede et dispositif de controle in vitro d'influences sur des structures biologiques
DE239560C (fr)
DE1798170C2 (de)	1976-09-30	Verfahren zur Bestimmung der Anwesenheit von gegen bestimmte Allergene gerichteten Reagin-Immunoglobulinen (Reagin-Ig) in wäßrigen Proben