CH626253A5 - Process for the production of a labelling unit - Google Patents
Process for the production of a labelling unit Download PDFInfo
- Publication number
- CH626253A5 CH626253A5 CH190777A CH190777A CH626253A5 CH 626253 A5 CH626253 A5 CH 626253A5 CH 190777 A CH190777 A CH 190777A CH 190777 A CH190777 A CH 190777A CH 626253 A5 CH626253 A5 CH 626253A5
- Authority
- CH
- Switzerland
- Prior art keywords
- tin
- technetium
- solution
- torr
- generator
- Prior art date
Links
- 238000002372 labelling Methods 0.000 title claims 7
- 238000000034 method Methods 0.000 title claims 6
- 238000004519 manufacturing process Methods 0.000 title claims 3
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 claims 15
- 229940056501 technetium 99m Drugs 0.000 claims 15
- 239000000243 solution Substances 0.000 claims 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 229910001868 water Inorganic materials 0.000 claims 8
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 6
- 210000000988 bone and bone Anatomy 0.000 claims 5
- 210000000056 organ Anatomy 0.000 claims 5
- IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical class [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 claims 5
- 210000004185 liver Anatomy 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- GEZAUFNYMZVOFV-UHFFFAOYSA-J 2-[(2-oxo-1,3,2$l^{5},4$l^{2}-dioxaphosphastannetan-2-yl)oxy]-1,3,2$l^{5},4$l^{2}-dioxaphosphastannetane 2-oxide Chemical compound [Sn+2].[Sn+2].[O-]P([O-])(=O)OP([O-])([O-])=O GEZAUFNYMZVOFV-UHFFFAOYSA-J 0.000 claims 3
- 229910021626 Tin(II) chloride Inorganic materials 0.000 claims 3
- 239000000032 diagnostic agent Substances 0.000 claims 3
- 229940039227 diagnostic agent Drugs 0.000 claims 3
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 3
- 235000011180 diphosphates Nutrition 0.000 claims 3
- 238000001035 drying Methods 0.000 claims 3
- 238000002844 melting Methods 0.000 claims 3
- 230000008018 melting Effects 0.000 claims 3
- 229940048084 pyrophosphate Drugs 0.000 claims 3
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims 3
- 210000000952 spleen Anatomy 0.000 claims 3
- 235000011150 stannous chloride Nutrition 0.000 claims 3
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 claims 3
- 239000011261 inert gas Substances 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 229940048086 sodium pyrophosphate Drugs 0.000 claims 2
- 238000003860 storage Methods 0.000 claims 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims 2
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims 2
- 229920000388 Polyphosphate Polymers 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 238000007469 bone scintigraphy Methods 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000012154 double-distilled water Substances 0.000 claims 1
- 238000002474 experimental method Methods 0.000 claims 1
- 230000002349 favourable effect Effects 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 239000007789 gas Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 238000009206 nuclear medicine Methods 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000002504 physiological saline solution Substances 0.000 claims 1
- 239000001205 polyphosphate Substances 0.000 claims 1
- 235000011176 polyphosphates Nutrition 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- SYRHIZPPCHMRIT-UHFFFAOYSA-N tin(4+) Chemical class [Sn+4] SYRHIZPPCHMRIT-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762606561 DE2606561C3 (de) | 1976-02-19 | 1976-02-19 | Verfahren zur Herstellung eines Technetium-99m-markierten Knochendiagnostikums |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH626253A5 true CH626253A5 (en) | 1981-11-13 |
Family
ID=5970237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH190777A CH626253A5 (en) | 1976-02-19 | 1977-02-16 | Process for the production of a labelling unit |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | AT357271B (da) |
| BE (1) | BE851656A (da) |
| CH (1) | CH626253A5 (da) |
| DE (1) | DE2606561C3 (da) |
| DK (1) | DK71277A (da) |
| FR (1) | FR2341306A1 (da) |
| GB (1) | GB1565865A (da) |
| IE (1) | IE44699B1 (da) |
| IT (1) | IT1074322B (da) |
| LU (1) | LU76794A1 (da) |
| NL (1) | NL7701532A (da) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020258282B2 (en) * | 2019-04-18 | 2023-01-19 | Colgate-Palmolive Company | Improved methods for synthesizing stannous pyrophosphate |
-
1976
- 1976-02-19 DE DE19762606561 patent/DE2606561C3/de not_active Expired
-
1977
- 1977-02-14 NL NL7701532A patent/NL7701532A/xx not_active Application Discontinuation
- 1977-02-16 CH CH190777A patent/CH626253A5/de not_active IP Right Cessation
- 1977-02-17 LU LU76794A patent/LU76794A1/xx unknown
- 1977-02-17 IT IT2041677A patent/IT1074322B/it active
- 1977-02-18 GB GB695877A patent/GB1565865A/en not_active Expired
- 1977-02-18 IE IE35077A patent/IE44699B1/en unknown
- 1977-02-18 AT AT111077A patent/AT357271B/de not_active IP Right Cessation
- 1977-02-18 DK DK71277A patent/DK71277A/da unknown
- 1977-02-21 FR FR7704935A patent/FR2341306A1/fr active Granted
- 1977-02-21 BE BE175111A patent/BE851656A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK71277A (da) | 1977-08-20 |
| FR2341306B1 (da) | 1980-02-01 |
| NL7701532A (nl) | 1977-08-23 |
| DE2606561A1 (de) | 1977-09-01 |
| AT357271B (de) | 1980-06-25 |
| DE2606561C3 (de) | 1981-02-05 |
| LU76794A1 (da) | 1977-09-12 |
| BE851656A (fr) | 1977-08-22 |
| ATA111077A (de) | 1979-11-15 |
| GB1565865A (en) | 1980-04-23 |
| DE2606561B2 (de) | 1980-05-14 |
| FR2341306A1 (fr) | 1977-09-16 |
| IT1074322B (it) | 1985-04-20 |
| IE44699L (en) | 1977-08-19 |
| IE44699B1 (en) | 1982-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |