IE44699B1 - Process for the manufacture of a technetium-99m labelled diagnostic agent for bone scanning - Google Patents

Process for the manufacture of a technetium-99m labelled diagnostic agent for bone scanning

Info

Publication number: IE44699B1
Authority: IE; Ireland
Prior art keywords: tin; technetium; pyrophosphate; salt; weight
Prior art date: 1976-02-19

Application number

IE35077A

Other languages

English (en)

Other versions

IE44699L (en

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-02-19

Filing date

1977-02-18

Publication date

1982-02-24

1977-02-18 Application filed by Hoechst Ag filed Critical Hoechst Ag

1977-08-19 Publication of IE44699L publication Critical patent/IE44699L/xx

1982-02-24 Publication of IE44699B1 publication Critical patent/IE44699B1/en

Links

GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 title claims abstract description 16
229940056501 technetium 99m Drugs 0.000 title claims abstract description 15
210000000988 bone and bone Anatomy 0.000 title claims abstract description 8
238000000034 method Methods 0.000 title claims description 16
229940039227 diagnostic agent Drugs 0.000 title claims description 8
239000000032 diagnostic agent Substances 0.000 title claims description 8
238000004519 manufacturing process Methods 0.000 title claims description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
229910021626 Tin(II) chloride Inorganic materials 0.000 claims abstract description 4
235000011150 stannous chloride Nutrition 0.000 claims abstract description 4
AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 claims abstract description 4
FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims abstract description 3
229940048086 sodium pyrophosphate Drugs 0.000 claims abstract description 3
235000019818 tetrasodium diphosphate Nutrition 0.000 claims abstract description 3
239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims abstract description 3
235000011180 diphosphates Nutrition 0.000 claims description 11
229940048084 pyrophosphate Drugs 0.000 claims description 11
IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical class [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 claims description 10
-1 alkali metal pyrophosphate Chemical class 0.000 claims description 9
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims description 8
ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 6
230000008018 melting Effects 0.000 claims description 4
238000002844 melting Methods 0.000 claims description 4
239000000203 mixture Substances 0.000 claims description 4
229910052783 alkali metal Inorganic materials 0.000 claims description 3
238000001035 drying Methods 0.000 claims description 3
150000003839 salts Chemical class 0.000 claims description 3
239000012298 atmosphere Substances 0.000 claims description 2
238000007710 freezing Methods 0.000 claims description 2
230000008014 freezing Effects 0.000 claims description 2
238000002372 labelling Methods 0.000 abstract description 8
238000003745 diagnosis Methods 0.000 abstract description 2
239000003795 chemical substances by application Substances 0.000 abstract 1
230000004927 fusion Effects 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000000243 solution Substances 0.000 description 10
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
210000004185 liver Anatomy 0.000 description 5
239000000126 substance Substances 0.000 description 5
210000000952 spleen Anatomy 0.000 description 4
229910052757 nitrogen Inorganic materials 0.000 description 3
230000002035 prolonged effect Effects 0.000 description 3
230000005855 radiation Effects 0.000 description 3
239000011261 inert gas Substances 0.000 description 2
210000000056 organ Anatomy 0.000 description 2
241001465754 Metazoa Species 0.000 description 1
229920000388 Polyphosphate Polymers 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
210000001185 bone marrow Anatomy 0.000 description 1
238000007469 bone scintigraphy Methods 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
239000007788 liquid Substances 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
238000000968 medical method and process Methods 0.000 description 1
239000012528 membrane Substances 0.000 description 1
239000011859 microparticle Substances 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000012299 nitrogen atmosphere Substances 0.000 description 1
125000000962 organic group Chemical group 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
239000001205 polyphosphate Substances 0.000 description 1
235000011176 polyphosphates Nutrition 0.000 description 1
210000001685 thyroid gland Anatomy 0.000 description 1
SYRHIZPPCHMRIT-UHFFFAOYSA-N tin(4+) Chemical class [Sn+4] SYRHIZPPCHMRIT-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Optics & Photonics (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Physics & Mathematics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

IE35077A 1976-02-19 1977-02-18 Process for the manufacture of a technetium-99m labelled diagnostic agent for bone scanning IE44699B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19762606561 DE2606561C3 (de)	1976-02-19	1976-02-19	Verfahren zur Herstellung eines Technetium-99m-markierten Knochendiagnostikums

Publications (2)

Publication Number	Publication Date
IE44699L IE44699L (en)	1977-08-19
IE44699B1 true IE44699B1 (en)	1982-02-24

Family

ID=5970237

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE35077A IE44699B1 (en)	1976-02-19	1977-02-18	Process for the manufacture of a technetium-99m labelled diagnostic agent for bone scanning

Country Status (11)

Country	Link
AT (1)	AT357271B (da)
BE (1)	BE851656A (da)
CH (1)	CH626253A5 (da)
DE (1)	DE2606561C3 (da)
DK (1)	DK71277A (da)
FR (1)	FR2341306A1 (da)
GB (1)	GB1565865A (da)
IE (1)	IE44699B1 (da)
IT (1)	IT1074322B (da)
LU (1)	LU76794A1 (da)
NL (1)	NL7701532A (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US11110042B2 (en)	2019-04-18	2021-09-07	Colgate-Palmolive Company	Methods for synthesizing stannous pyrophosphate

1976
- 1976-02-19 DE DE19762606561 patent/DE2606561C3/de not_active Expired
1977
- 1977-02-14 NL NL7701532A patent/NL7701532A/xx not_active Application Discontinuation
- 1977-02-16 CH CH190777A patent/CH626253A5/de not_active IP Right Cessation
- 1977-02-17 LU LU76794A patent/LU76794A1/xx unknown
- 1977-02-17 IT IT2041677A patent/IT1074322B/it active
- 1977-02-18 DK DK71277A patent/DK71277A/da unknown
- 1977-02-18 IE IE35077A patent/IE44699B1/en unknown
- 1977-02-18 AT AT111077A patent/AT357271B/de not_active IP Right Cessation
- 1977-02-18 GB GB695877A patent/GB1565865A/en not_active Expired
- 1977-02-21 BE BE175111A patent/BE851656A/xx not_active IP Right Cessation
- 1977-02-21 FR FR7704935A patent/FR2341306A1/fr active Granted

Also Published As

Publication number	Publication date
ATA111077A (de)	1979-11-15
DK71277A (da)	1977-08-20
DE2606561A1 (de)	1977-09-01
CH626253A5 (en)	1981-11-13
DE2606561B2 (de)	1980-05-14
IE44699L (en)	1977-08-19
FR2341306B1 (da)	1980-02-01
LU76794A1 (da)	1977-09-12
BE851656A (fr)	1977-08-22
IT1074322B (it)	1985-04-20
DE2606561C3 (de)	1981-02-05
FR2341306A1 (fr)	1977-09-16
AT357271B (de)	1980-06-25
NL7701532A (nl)	1977-08-23
GB1565865A (en)	1980-04-23

Publication	Publication Date	Title
EP0038756B1 (en)	1985-10-16	Cationic lipophilic complexes of 99m tc useful for myocardial and hepatobiliary imaging
CA1173828A (en)	1984-09-04	Diagnostic composition for radiologic imaging of neoplasms in the body and method of preparation
CA1111765A (en)	1981-11-03	Reductant composition for technetium-99m and method for making technetium-99m labelled ligands
JP2502601B2 (ja)	1996-05-29	放射性配位レニウム薬剤の単離および精製方法
US3961038A (en)	1976-06-01	Process for the manufacture of injectable preparations of Tc99m and/or In113m and apparatus for carrying out the process
NO159342B (no)	1988-09-12	Radiofarmasoeytisk blanding, samt middel for fremstilling av denne.
KR100650506B1 (ko)	2006-11-30	방사성 의약품용 레늄-트리카보닐 착물 및 그 전구체의제조방법
JPS6126887B2 (da)	1986-06-23
RU2403067C2 (ru)	2010-11-10	СТАБИЛИЗИРОВАННЫЕ КОМПОЗИЦИИ ТЕХНЕЦИЯ-99m (99mTc)
US4057615A (en)	1977-11-08	Method of tagging excipients with 99M technetium
CA1324317C (en)	1993-11-16	Stable radiodiagnostic products, and the preparation thereof
EP0096933A2 (en)	1983-12-28	Process for making a lyophilized product for use in skeletal imaging
EP0169232B1 (en)	1990-04-25	Composition for technetium-99m labelling of proteinaceous material
US4489054A (en)	1984-12-18	Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging
DE2617895C3 (de)	1980-07-10	Dispersion zur Herstellung eines injizierbaren radiopharmazeutischen Scanning-Mittels
EP0179481B1 (en)	1991-10-23	Stable stannous chloride composition for labeling with radioactive technetium
IE44699B1 (en)	1982-02-24	Process for the manufacture of a technetium-99m labelled diagnostic agent for bone scanning
JPS6315248B2 (da)	1988-04-04
US4291012A (en)	1981-09-22	Technetium-labelled diagnostic agent for the examination of the RES
US4427647A (en)	1984-01-24	Method and reagent for making a radiopharmaceutical composition based on pertechnetate
US4118468A (en)	1978-10-03	Technetium-99m-labelled diagnostic agent for kidney scanning and process for its manufacture
JPS6236393A (ja)	1987-02-17	テクネチウム−アレ−ン複合体および方法
CA1067403A (en)	1979-12-04	Technetium-99m labeled radiodiagnostic agents for liver and bone marrow scanning and method of preparation
US20050186134A1 (en)	2005-08-25	Method for preparing technetium-labeled antimony sulfide nanocolloid
EP0960623A2 (en)	1999-12-01	Kit for the single step preparation of pentavalent technetium 99mTc(V)-DMSA