CH632245A5 - Process for preparing novel prostaglandin derivatives possessing a 9-deoxy-6,9-epoxy functionality - Google Patents

Process for preparing novel prostaglandin derivatives possessing a 9-deoxy-6,9-epoxy functionality Download PDF

Info

Publication number
CH632245A5
CH632245A5 CH141677A CH141677A CH632245A5 CH 632245 A5 CH632245 A5 CH 632245A5 CH 141677 A CH141677 A CH 141677A CH 141677 A CH141677 A CH 141677A CH 632245 A5 CH632245 A5 CH 632245A5
Authority
CH
Switzerland
Prior art keywords
formula
radical
carbon atoms
radicals
phenyl
Prior art date
Application number
CH141677A
Other languages
German (de)
English (en)
Inventor
Udo Friedrich Axen
Frank Harris Lincoln
Roy Allen Johnson
Robert Charles Kelly
John Edward Pike
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of CH632245A5 publication Critical patent/CH632245A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
CH141677A 1976-02-04 1977-02-04 Process for preparing novel prostaglandin derivatives possessing a 9-deoxy-6,9-epoxy functionality CH632245A5 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US65511076A 1976-02-04 1976-02-04
US71677076A 1976-08-23 1976-08-23
US71696976A 1976-08-23 1976-08-23
US71677176A 1976-08-23 1976-08-23
US71696076A 1976-08-23 1976-08-23
US71697276A 1976-08-23 1976-08-23
US72554876A 1976-09-22 1976-09-22

Publications (1)

Publication Number Publication Date
CH632245A5 true CH632245A5 (en) 1982-09-30

Family

ID=27569874

Family Applications (2)

Application Number Title Priority Date Filing Date
CH141677A CH632245A5 (en) 1976-02-04 1977-02-04 Process for preparing novel prostaglandin derivatives possessing a 9-deoxy-6,9-epoxy functionality
CH206082A CH637949A5 (en) 1976-02-04 1982-04-02 Process for the preparation of novel sodium salts of prostaglandin derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH206082A CH637949A5 (en) 1976-02-04 1982-04-02 Process for the preparation of novel sodium salts of prostaglandin derivatives

Country Status (13)

Country Link
JP (1) JPS5936911B2 (fr)
BE (1) BE851122A (fr)
CA (3) CA1160627A (fr)
CH (2) CH632245A5 (fr)
DE (1) DE2702553C2 (fr)
FR (3) FR2359125B1 (fr)
GB (1) GB1554044A (fr)
HK (1) HK9385A (fr)
IL (1) IL51189A (fr)
MX (1) MX4811E (fr)
NL (2) NL185515C (fr)
NZ (1) NZ183050A (fr)
SE (1) SE435281B (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351113A1 (fr) * 1976-05-11 1977-12-09 Wellcome Found Derives de prostaglandines et medicaments contenant ces derives
GB1583961A (en) * 1976-05-11 1981-02-04 Wellcome Found Prostacyclin and derivatives thereof
GB1595056A (en) * 1976-10-12 1981-08-05 Wellcome Found Pharmaceutical combination
AU511711B2 (en) * 1976-12-30 1980-09-04 Upjohn Company, The 6-Oxo and 5, 6-Dihalo prostaglandin analogues
FI71138C (fi) * 1976-12-31 1986-11-24 Erba Farmitalia Foerfarande foer framstaellning av terapeutiskt aktiva bisykliska prostaglandiner
US4178367A (en) 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
AU524786B2 (en) * 1977-03-07 1982-10-07 The Upjohn Company Prostacyclins
JPS53136513A (en) * 1977-05-06 1978-11-29 Ono Pharmaceut Co Ltd Stabilization of prostaglandin-x-related compounds
US4219647A (en) 1977-09-22 1980-08-26 Josef Fried Certain amides of prostacyclin and related compounds
JPS6022710B2 (ja) * 1977-09-16 1985-06-03 小野薬品工業株式会社 プロスタグランジン類似化合物
DE2743283A1 (de) * 1977-09-27 1979-04-05 Hoechst Ag Neue prostacyclin-analoga
IT1088036B (it) 1977-11-25 1985-06-04 Erba Carlo Spa 15-epi-prostaciclina e prostaciclina analoghi
US4705806A (en) * 1978-02-13 1987-11-10 Morton Jr Douglas R Prostacyclin analogs
DE2811950A1 (de) * 1978-03-18 1979-12-13 Hoechst Ag Neue analoga von prostacyclin
HU179001B (en) 1978-05-29 1982-08-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 5-halo-6,9alpha-oxido-prostaglandin derivatives
IT1099575B (it) * 1978-07-20 1985-09-18 Erba Carlo Spa 20-metil-13,14-deidro-pgi2' suoi sali e suoi 16s- e 16r-metil derivati
DE2834248A1 (de) * 1978-08-04 1980-02-28 Hoechst Ag Neue prostaglandinderivate in der delta 2-pgf tief 2 und delta 2-pge tief 2 -reihe
US4180657A (en) * 1978-08-14 1979-12-25 The Upjohn Company Acyl-substituted phenyl esters of prostacyclin-type compounds
JPS56122372A (en) * 1980-03-03 1981-09-25 Toray Ind Inc Prostaglandin i2 derivative
DE3029984C2 (de) * 1980-08-08 1983-12-15 Grünenthal GmbH, 5190 Stolberg 2-Oxabicyclo [3.3.0] octanderivate und diese enthaltende Arzneimittel
CH651033A5 (de) * 1981-03-11 1985-08-30 Hoffmann La Roche Fluorprostacycline.
AT381309B (de) * 1982-05-27 1986-09-25 Gruenenthal Gmbh Verfahren zur herstellung von 5z-formen von 2,3,4 -trinor-1,5-inter-m-phenylen-prostacyclinderiva en
JPS595155A (ja) * 1982-06-30 1984-01-12 Ono Pharmaceut Co Ltd プロスタグランジンｄ類似化合物
CA1324129C (fr) * 1987-04-30 1993-11-09 Ryuzo Ueno Prostaglandines de la serie f
US5221763A (en) * 1987-04-30 1993-06-22 R-Tech Ueno, Ltd. Prostaglandins of the F series
US5591887A (en) * 1987-04-30 1997-01-07 R-Tech Ueno, Ltd. Prostaglandins of the F series
US5185374A (en) * 1988-05-11 1993-02-09 K.K. Ueno Seiyaku Oyo Kenkyujo Use of 15-ketoprostaglandin E or F compounds for uterine contraction
AU619543B2 (en) * 1988-05-11 1992-01-30 Sucampo Ag Use of 15-ketoprostaglandin e or f compounds for uterine contraction
RU2540330C2 (ru) 2009-07-28 2015-02-10 Оно Фармасьютикал Ко., Лтд. Бициклическое соединение и его применение для медицинских целей
JP5835236B2 (ja) 2011-01-27 2015-12-24 小野薬品工業株式会社 二環式化合物およびその医薬用途
CN116143742B (zh) * 2023-02-27 2024-10-18 广州楷石生物科技有限公司 依前列醇一氧化氮供体药物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351112A1 (fr) * 1975-10-21 1977-12-09 Wellcome Found Derive de prostaglandine et medicament contenant ce derive
FR2351113A1 (fr) * 1976-05-11 1977-12-09 Wellcome Found Derives de prostaglandines et medicaments contenant ces derives
MX4813E (es) * 1976-06-01 1982-10-19 Upjohn Co Procedimiento para preparar analogos de prostaglandinas
AU511711B2 (en) * 1976-12-30 1980-09-04 Upjohn Company, The 6-Oxo and 5, 6-Dihalo prostaglandin analogues

Also Published As

Publication number Publication date
BE851122A (fr) 1977-08-04
FR2362834B1 (fr) 1980-08-08
NL185515B (nl) 1989-12-01
SE435281B (sv) 1984-09-17
NL8300921A (nl) 1983-07-01
NL7700896A (nl) 1977-08-08
FR2362833A1 (fr) 1978-03-24
HK9385A (en) 1985-02-08
CA1160628A (fr) 1984-01-17
NZ183050A (en) 1979-06-08
CA1160627A (fr) 1984-01-17
FR2362833B1 (fr) 1980-08-08
SE7701045L (sv) 1977-08-05
CA1179335A (fr) 1984-12-11
CH637949A5 (en) 1983-08-31
IL51189A0 (en) 1977-02-28
FR2359125A1 (fr) 1978-02-17
FR2362834A1 (fr) 1978-03-24
NL185515C (nl) 1990-05-01
JPS5295644A (en) 1977-08-11
IL51189A (en) 1985-08-30
MX4811E (es) 1982-10-19
GB1554044A (en) 1979-10-17
DE2702553C2 (de) 1986-02-20
JPS5936911B2 (ja) 1984-09-06
DE2702553A1 (de) 1977-08-18
FR2359125B1 (fr) 1985-11-15

Similar Documents

Publication Publication Date Title
CH632245A5 (en) Process for preparing novel prostaglandin derivatives possessing a 9-deoxy-6,9-epoxy functionality
EP0299914B1 (fr) Dérivés de prostaglandines 9-halogène (Z), leur procédé de préparation et leur application thérapeutique
DE2355731C3 (de) Derivate von w -nor-Prostaglandinen- E2IUId -F2 a , Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen Pfizer Ine, New York, N.Y. (YStA.)
DE2826096A1 (de) Prostaglandinanaloga
DE2753986C2 (de) 6-Oxo-PGE↓1↓-derivate und Verfahren zu deren Herstellung
DE2627671A1 (de) Arzneimittel, enthaltend ein lacton eines prostaglandins oder prostaglandinanalogen
DE2641823A1 (de) Neue prostaglandin-analoga
CH638773A5 (en) Prostane derivatives and process for their preparation
DE2638827A1 (de) Neue 11-deoxy-prostaglandine e, f tief alpha und f tief beta
DE2850304A1 (de) Prostacyclinzwischenprodukte und -analoge
DE2746932C2 (fr)
CH636353A5 (de) Enolaether und verfahren zu deren herstellung.
CH640847A5 (en) Process for preparing analogues of 5,6-dihydroprostacyclin
CH642063A5 (de) Verfahren zur herstellung von prostaglandin-analoga, bei welchen die carbonylgruppe am c-9 durch eine methylengruppe ersetzt ist.
DE3116386C2 (de) Prostaglandinanaloge, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
CH639378A5 (de) Prostaglandin-derivate und verfahren zu deren herstellung.
CH624100A5 (fr)
DE2320552A1 (de) 4,5-dihehydro-prostaglandine und verfahren zu ihrer herstellung
DE2542686A1 (de) 2a,2b-dihomo-15-methyl- und -15- aethyl-pgf-und pge-verbindungen und verfahren zu deren herstellung
CH630898A5 (de) Verfahren zur herstellung neuer prostaglandin-analoga mit dreifachbindung zwischen c-13 und c-14.
CH632743A5 (de) Verfahren zur herstellung neuer prostaglandin-analoga mit einer 4,5-doppelbindung.
CH631719A5 (de) Verfahren zur herstellung von prostacyclin-analogen.
DE2736446A1 (de) Neue prostaglandin-analoge
CH630352A5 (de) Verfahren zur herstellung neuer prostaglandin-analoga mit dreifachbindung zwischen c-13 und c-14.
WO1985002187A1 (fr) Derives de 20-alkyle-7-oxoprostacycline et leur procede de fabrication

Legal Events

Date Code Title Description
PL Patent ceased
PL Patent ceased