CH648754A5 - Pharmaceutical slow release tablet - Google Patents

Pharmaceutical slow release tablet Download PDF

Info

Publication number: CH648754A5
Authority: CH; Switzerland
Prior art keywords: grooves; tablets; tablet; cellulose; release tablet
Prior art date: 1979-08-16

Application number

CH7514/79A

Other languages

German (de)

English (en)

Inventor

Hans Dr Hess

Carlo Dr Voellmy

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-08-16

Filing date

1979-08-16

Publication date

1985-04-15

1979-08-16 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1979-08-16 Priority to CH7514/79A priority Critical patent/CH648754A5/de

1980-08-11 Priority to US06/177,028 priority patent/US4353887A/en

1980-08-13 Priority to BE0/201740A priority patent/BE884760A/fr

1980-08-13 Priority to DE3030622A priority patent/DE3030622C2/de

1980-08-13 Priority to FR8017858A priority patent/FR2462908A1/fr

1980-08-13 Priority to FI802542A priority patent/FI76691C/fi

1980-08-14 Priority to NL8004616A priority patent/NL8004616A/nl

1980-08-14 Priority to PT71706A priority patent/PT71706B/pt

1980-08-14 Priority to GR62678A priority patent/GR69943B/el

1980-08-14 Priority to LU82718A priority patent/LU82718A1/de

1980-08-14 Priority to CA000358243A priority patent/CA1158555A/en

1980-08-14 Priority to IL60839A priority patent/IL60839A/xx

1980-08-14 Priority to ES494274A priority patent/ES494274A0/es

1980-08-14 Priority to GB8026549A priority patent/GB2057878B/en

1980-08-14 Priority to IT49501/80A priority patent/IT1145285B/it

1980-08-15 Priority to IE1727/80A priority patent/IE50108B1/en

1980-08-15 Priority to AU61481/80A priority patent/AU531058B2/en

1980-08-15 Priority to SE8005759A priority patent/SE445802B/sv

1980-08-15 Priority to NZ194681A priority patent/NZ194681A/xx

1980-08-15 Priority to DK354580A priority patent/DK153772C/da

1980-08-15 Priority to JP11186280A priority patent/JPS5659708A/ja

1980-08-15 Priority to ZA00805015A priority patent/ZA805015B/xx

1980-08-15 Priority to NO802447A priority patent/NO156274C/no

1985-04-15 Publication of CH648754A5 publication Critical patent/CH648754A5/de

1987-12-30 Priority to MY198/87A priority patent/MY8700198A/xx

Links

239000013543 active substance Substances 0.000 claims abstract description 9
239000011159 matrix material Substances 0.000 claims abstract description 7
230000000694 effects Effects 0.000 claims abstract description 5
239000003826 tablet Substances 0.000 claims description 49
239000000203 mixture Substances 0.000 claims description 16
239000004480 active ingredient Substances 0.000 claims description 13
229920001577 copolymer Polymers 0.000 claims description 10
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 10
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 10
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 10
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 10
230000000979 retarding effect Effects 0.000 claims description 10
239000000463 material Substances 0.000 claims description 8
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 8
230000002035 prolonged effect Effects 0.000 claims description 8
239000007939 sustained release tablet Substances 0.000 claims description 8
229920002678 cellulose Polymers 0.000 claims description 7
239000001913 cellulose Substances 0.000 claims description 7
235000010980 cellulose Nutrition 0.000 claims description 7
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
229940079593 drug Drugs 0.000 claims description 6
239000003814 drug Substances 0.000 claims description 6
239000012634 fragment Substances 0.000 claims description 6
239000000454 talc Substances 0.000 claims description 5
229910052623 talc Inorganic materials 0.000 claims description 5
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 4
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 4
150000001252 acrylic acid derivatives Chemical class 0.000 claims description 4
150000001875 compounds Chemical class 0.000 claims description 4
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 4
239000008101 lactose Substances 0.000 claims description 4
150000002632 lipids Chemical class 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
150000002734 metacrylic acid derivatives Chemical class 0.000 claims description 4
230000007935 neutral effect Effects 0.000 claims description 4
229920002689 polyvinyl acetate Polymers 0.000 claims description 4
239000011118 polyvinyl acetate Substances 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 4
150000003626 triacylglycerols Chemical class 0.000 claims description 4
239000001993 wax Substances 0.000 claims description 4
JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims description 3
239000001856 Ethyl cellulose Substances 0.000 claims description 3
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 3
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 3
235000019325 ethyl cellulose Nutrition 0.000 claims description 3
229920001249 ethyl cellulose Polymers 0.000 claims description 3
239000000945 filler Substances 0.000 claims description 3
239000001863 hydroxypropyl cellulose Substances 0.000 claims description 3
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 3
230000000968 intestinal effect Effects 0.000 claims description 3
229920000609 methyl cellulose Polymers 0.000 claims description 3
239000001923 methylcellulose Substances 0.000 claims description 3
235000010981 methylcellulose Nutrition 0.000 claims description 3
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 3
229920003023 plastic Polymers 0.000 claims description 3
239000004033 plastic Substances 0.000 claims description 3
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
241000416162 Astragalus gummifer Species 0.000 claims description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
229920002907 Guar gum Polymers 0.000 claims description 2
229920000715 Mucilage Polymers 0.000 claims description 2
-1 Polyethylene Polymers 0.000 claims description 2
239000004698 Polyethylene Substances 0.000 claims description 2
229920002125 Sokalan® Polymers 0.000 claims description 2
235000021355 Stearic acid Nutrition 0.000 claims description 2
229920001615 Tragacanth Polymers 0.000 claims description 2
229920002433 Vinyl chloride-vinyl acetate copolymer Polymers 0.000 claims description 2
SMEGJBVQLJJKKX-HOTMZDKISA-N [(2R,3S,4S,5R,6R)-5-acetyloxy-3,4,6-trihydroxyoxan-2-yl]methyl acetate Chemical compound CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)OC(=O)C)O)O SMEGJBVQLJJKKX-HOTMZDKISA-N 0.000 claims description 2
229940081735 acetylcellulose Drugs 0.000 claims description 2
230000002378 acidificating effect Effects 0.000 claims description 2
239000000654 additive Substances 0.000 claims description 2
239000000853 adhesive Substances 0.000 claims description 2
235000010443 alginic acid Nutrition 0.000 claims description 2
239000000783 alginic acid Substances 0.000 claims description 2
229920000615 alginic acid Polymers 0.000 claims description 2
229960001126 alginic acid Drugs 0.000 claims description 2
150000004781 alginic acids Chemical class 0.000 claims description 2
125000000129 anionic group Chemical group 0.000 claims description 2
235000013871 bee wax Nutrition 0.000 claims description 2
239000012166 beeswax Substances 0.000 claims description 2
239000000440 bentonite Substances 0.000 claims description 2
229910000278 bentonite Inorganic materials 0.000 claims description 2
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
230000002146 bilateral effect Effects 0.000 claims description 2
239000002775 capsule Substances 0.000 claims description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
239000004203 carnauba wax Substances 0.000 claims description 2
235000013869 carnauba wax Nutrition 0.000 claims description 2
239000000969 carrier Substances 0.000 claims description 2
239000012876 carrier material Substances 0.000 claims description 2
239000004359 castor oil Substances 0.000 claims description 2
235000019438 castor oil Nutrition 0.000 claims description 2
229920002301 cellulose acetate Polymers 0.000 claims description 2
229940082500 cetostearyl alcohol Drugs 0.000 claims description 2
229960000541 cetyl alcohol Drugs 0.000 claims description 2
LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 claims description 2
230000003111 delayed effect Effects 0.000 claims description 2
235000014113 dietary fatty acids Nutrition 0.000 claims description 2
230000003628 erosive effect Effects 0.000 claims description 2
239000000194 fatty acid Substances 0.000 claims description 2
229930195729 fatty acid Natural products 0.000 claims description 2
150000004665 fatty acids Chemical class 0.000 claims description 2
150000002191 fatty alcohols Chemical class 0.000 claims description 2
230000002496 gastric effect Effects 0.000 claims description 2
125000005456 glyceride group Chemical group 0.000 claims description 2
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 claims description 2
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 claims description 2
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
239000000665 guar gum Substances 0.000 claims description 2
235000010417 guar gum Nutrition 0.000 claims description 2
229960002154 guar gum Drugs 0.000 claims description 2
239000010514 hydrogenated cottonseed oil Substances 0.000 claims description 2
238000011068 loading method Methods 0.000 claims description 2
230000005923 long-lasting effect Effects 0.000 claims description 2
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
239000006186 oral dosage form Substances 0.000 claims description 2
239000012188 paraffin wax Substances 0.000 claims description 2
239000004584 polyacrylic acid Substances 0.000 claims description 2
229920000573 polyethylene Polymers 0.000 claims description 2
229920000642 polymer Polymers 0.000 claims description 2
229920000915 polyvinyl chloride Polymers 0.000 claims description 2
230000000750 progressive effect Effects 0.000 claims description 2
239000000377 silicon dioxide Substances 0.000 claims description 2
235000002639 sodium chloride Nutrition 0.000 claims description 2
239000008117 stearic acid Substances 0.000 claims description 2
229940012831 stearyl alcohol Drugs 0.000 claims description 2
210000002784 stomach Anatomy 0.000 claims description 2
239000012730 sustained-release form Substances 0.000 claims description 2
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 2
235000010487 tragacanth Nutrition 0.000 claims description 2
239000000196 tragacanth Substances 0.000 claims description 2
229940116362 tragacanth Drugs 0.000 claims description 2
LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 claims description 2
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
235000019731 tricalcium phosphate Nutrition 0.000 claims description 2
235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
239000008158 vegetable oil Substances 0.000 claims description 2
229920002554 vinyl polymer Polymers 0.000 claims description 2
239000000230 xanthan gum Substances 0.000 claims description 2
235000010493 xanthan gum Nutrition 0.000 claims description 2
229920001285 xanthan gum Polymers 0.000 claims description 2
229940082509 xanthan gum Drugs 0.000 claims description 2
239000007916 tablet composition Substances 0.000 abstract 1
239000008187 granular material Substances 0.000 description 9
238000000576 coating method Methods 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
239000001267 polyvinylpyrrolidone Substances 0.000 description 4
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
229920001800 Shellac Polymers 0.000 description 3
239000011248 coating agent Substances 0.000 description 3
229960002237 metoprolol Drugs 0.000 description 3
IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 3
229960001300 metoprolol tartrate Drugs 0.000 description 3
235000013874 shellac Nutrition 0.000 description 3
239000004208 shellac Substances 0.000 description 3
229940113147 shellac Drugs 0.000 description 3
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 3
239000000243 solution Substances 0.000 description 3
WUBVEMGCQRSBBT-UHFFFAOYSA-N tert-butyl 4-(trifluoromethylsulfonyloxy)-3,6-dihydro-2h-pyridine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(OS(=O)(=O)C(F)(F)F)=CC1 WUBVEMGCQRSBBT-UHFFFAOYSA-N 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
229920002261 Corn starch Polymers 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
229920000168 Microcrystalline cellulose Polymers 0.000 description 2
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
229940075614 colloidal silicon dioxide Drugs 0.000 description 2
239000008120 corn starch Substances 0.000 description 2
239000006185 dispersion Substances 0.000 description 2
239000007941 film coated tablet Substances 0.000 description 2
239000007888 film coating Substances 0.000 description 2
238000009501 film coating Methods 0.000 description 2
210000004051 gastric juice Anatomy 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
238000000034 method Methods 0.000 description 2
229940016286 microcrystalline cellulose Drugs 0.000 description 2
235000019813 microcrystalline cellulose Nutrition 0.000 description 2
239000008108 microcrystalline cellulose Substances 0.000 description 2
238000002156 mixing Methods 0.000 description 2
239000002245 particle Substances 0.000 description 2
239000008188 pellet Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
235000019658 bitter taste Nutrition 0.000 description 1
FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
229940081734 cellulose acetate phthalate Drugs 0.000 description 1
229960001523 chlortalidone Drugs 0.000 description 1
JIVPVXMEBJLZRO-UHFFFAOYSA-N chlorthalidone Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C2(O)C3=CC=CC=C3C(=O)N2)=C1 JIVPVXMEBJLZRO-UHFFFAOYSA-N 0.000 description 1
238000001816 cooling Methods 0.000 description 1
235000019700 dicalcium phosphate Nutrition 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
238000009826 distribution Methods 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
238000011049 filling Methods 0.000 description 1
235000011389 fruit/vegetable juice Nutrition 0.000 description 1
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
239000004922 lacquer Substances 0.000 description 1
239000007942 layered tablet Substances 0.000 description 1
238000010422 painting Methods 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000000049 pigment Substances 0.000 description 1
229940068196 placebo Drugs 0.000 description 1
239000000902 placebo Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000003825 pressing Methods 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000005507 spraying Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
235000019640 taste Nutrition 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Medicinal Preparation (AREA)

CH7514/79A 1979-08-16 1979-08-16 Pharmaceutical slow release tablet CH648754A5 (en)

Priority Applications (24)

Application Number	Priority Date	Filing Date	Title
CH7514/79A CH648754A5 (en)	1979-08-16	1979-08-16	Pharmaceutical slow release tablet
US06/177,028 US4353887A (en)	1979-08-16	1980-08-11	Divisible tablet having controlled and delayed release of the active substance
BE0/201740A BE884760A (fr)	1979-08-16	1980-08-13	Comprime secable permettant une liberation controlee et retardee de la substance active
DE3030622A DE3030622C2 (de)	1979-08-16	1980-08-13	Teilbare Tablette mit Retardeffekt für die Abgabe von Metoprolol oder Oxprenolol
FR8017858A FR2462908A1 (fr)	1979-08-16	1980-08-13	Comprime secable permettant une liberation controlee et retardee de la substance active
FI802542A FI76691C (fi)	1979-08-16	1980-08-13	Delbar tablett med kontrollerad och foerdroejd aktivaemnesavgivning.
IL60839A IL60839A (en)	1979-08-16	1980-08-14	Divisible tablet having controlled and delayed release of a pharmaceutically active substance
PT71706A PT71706B (en)	1979-08-16	1980-08-14	Divisible tablet having controlled and delayed release of the active substance
GR62678A GR69943B (cs)	1979-08-16	1980-08-14
LU82718A LU82718A1 (de)	1979-08-16	1980-08-14	Teilbare tablette mit kontrollierter und verzoegerter wirkstoffabgabe
CA000358243A CA1158555A (en)	1979-08-16	1980-08-14	Divisible tablet having controlled and delayed release of the active substance
NL8004616A NL8004616A (nl)	1979-08-16	1980-08-14	Deelbaar tablet met gecontroleerde en vertraagde afgifte van werkzame stof.
ES494274A ES494274A0 (es)	1979-08-16	1980-08-14	Procedimiento para la obtencion de una tableta divisible concesion controlada y retardada de la sustancia activa
GB8026549A GB2057878B (en)	1979-08-16	1980-08-14	Controlled and delayed release divisible tablet
IT49501/80A IT1145285B (it)	1979-08-16	1980-08-14	Compressa divisibile con erogazione controllata e ritardata di sostanza attiva
IE1727/80A IE50108B1 (en)	1979-08-16	1980-08-15	Divisible tablet having controlled and delayed release of the active substance
AU61481/80A AU531058B2 (en)	1979-08-16	1980-08-15	Delayed release divisible tablet
SE8005759A SE445802B (sv)	1979-08-16	1980-08-15	Delbar tablett med kontrollerad och fordrojd avgivning av verksamt emne
NZ194681A NZ194681A (en)	1979-08-16	1980-08-15	Divisible tablets having delayed and controlled release of active substance
DK354580A DK153772C (da)	1979-08-16	1980-08-15	Delbar tablet med retardvirkning
JP11186280A JPS5659708A (en)	1979-08-16	1980-08-15	Dividable medicine controlling and delaying active substance release
ZA00805015A ZA805015B (en)	1979-08-16	1980-08-15	Divisible tablet having controlled and delayed release of the active substance
NO802447A NO156274C (no)	1979-08-16	1980-08-15	Fremgangsmaate til fremstilling av en delbar tablett med kontrollert og forsinket avgivelse av virksomt stoff.
MY198/87A MY8700198A (en)	1979-08-16	1987-12-30	Divisible tablet having controlled and delayed release of the active substance

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH7514/79A CH648754A5 (en)	1979-08-16	1979-08-16	Pharmaceutical slow release tablet

Publications (1)

Publication Number	Publication Date
CH648754A5 true CH648754A5 (en)	1985-04-15

Family

ID=4326338

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH7514/79A CH648754A5 (en)	1979-08-16	1979-08-16	Pharmaceutical slow release tablet

Country Status (4)

Country	Link
JP (1)	JPS5659708A (cs)
BE (1)	BE884760A (cs)
CH (1)	CH648754A5 (cs)
ZA (1)	ZA805015B (cs)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006038916A2 (en)	2004-05-21	2006-04-13	Accu-Break Technologies, Inc.	Scored pharmaceutical tablets comprising a plurality of segments
JP2009515955A (ja) *	2005-11-18	2009-04-16	エーシーシーユー−ブレイクテクノロジーズ，インク．	セグメント化した薬の剤形
JP2009541341A (ja) *	2006-06-19	2009-11-26	エーシーシーユー−ブレイクテクノロジーズ，インク．	セグメント状の薬剤の剤形

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT207980Z2 (it) *	1986-02-24	1988-03-14	Smithkline Beckman Corp	Pastiglia farmaceutica avente corpo discoidale con contrapposte facce bombate.
JP2577080Y2 (ja) *	1991-09-10	1998-07-23	武田薬品工業株式会社	分割自在固形体
UA67802C2 (uk) *	1998-10-23	2004-07-15	Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А.	Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції
GB0030340D0 (en) *	2000-12-13	2001-01-24	Sorex Ltd	Briquettes
US7776314B2 (en)	2002-06-17	2010-08-17	Grunenthal Gmbh	Abuse-proofed dosage system
DE102005005446A1 (de)	2005-02-04	2006-08-10	Grünenthal GmbH	Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en)	2003-08-06	2007-03-01	Elisabeth Arkenau-Maric	Abuse-proofed dosage form
DE10336400A1 (de)	2003-08-06	2005-03-24	Grünenthal GmbH	Gegen Missbrauch gesicherte Darreichungsform
DE10361596A1 (de)	2003-12-24	2005-09-29	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102004032049A1 (de)	2004-07-01	2006-01-19	Grünenthal GmbH	Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de)	2005-02-04	2006-08-10	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
WO2009092601A1 (en) *	2008-01-25	2009-07-30	Grünenthal GmbH	Pharmaceutical dosage form
FR2928836B1 (fr) *	2008-03-21	2011-08-26	Servier Lab	Forme galenique secable permettant une liberation modifiee du principe actif
CA2723438C (en)	2008-05-09	2016-10-11	Gruenenthal Gmbh	Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
WO2011009602A1 (en)	2009-07-22	2011-01-27	Grünenthal GmbH	Hot-melt extruded controlled release dosage form
PE20120572A1 (es)	2009-07-22	2012-06-06	Gruenenthal Chemie	Forma de dosificacion de oxidacion estabilizada resistente a la manipulacion
PE20131102A1 (es)	2010-09-02	2013-10-12	Gruenenthal Chemie	Forma de dosificacion resistente a manipulacion que comprende una sal inorganica
TWI516286B (zh)	2010-09-02	2016-01-11	歌林達股份有限公司	含陰離子聚合物之抗破碎劑型
DK2736497T3 (da)	2011-07-29	2017-11-13	Gruenenthal Gmbh	Stød-resistent tablet, der tilvejebringer en øjeblikkelig frigivelse af et lægemiddel.
LT2736495T (lt)	2011-07-29	2017-11-10	Grünenthal GmbH	Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu
CA2864949A1 (en)	2012-02-28	2013-09-06	Grunenthal Gmbh	Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
RS57913B1 (sr)	2012-04-18	2019-01-31	Gruenenthal Gmbh	Farmaceutske dozne forme otporne na neovlašćenu upotrebu i naglo oslobađanje celokupne doze
US10064945B2 (en)	2012-05-11	2018-09-04	Gruenenthal Gmbh	Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
TW201402155A (zh) *	2012-06-12	2014-01-16	Daiichi Sankyo Co Ltd	具有容易服用性與分割性之錠劑
AR096438A1 (es)	2013-05-29	2015-12-30	Gruenenthal Gmbh	Forma de dosificación resistente al uso indebido con perfil de liberación bimodal, proceso
US10154966B2 (en)	2013-05-29	2018-12-18	Grünenthal GmbH	Tamper-resistant dosage form containing one or more particles
MX368846B (es)	2013-07-12	2019-10-18	Gruenenthal Gmbh	Forma de dosificación resistente a la alteración que contiene polímero de acetato de etilen-vinilo.
EP3073994A1 (en)	2013-11-26	2016-10-05	Grünenthal GmbH	Preparation of a powdery pharmaceutical composition by means of cryo-milling
JP5719479B1 (ja) *	2013-12-09	2015-05-20	第一三共株式会社	容易な分割性を有する錠剤
WO2015087561A1 (ja) *	2013-12-09	2015-06-18	第一三共株式会社	容易な分割性を有する錠剤
JP2017518980A (ja)	2014-05-12	2017-07-13	グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	タペンタドールを含む、改変防止即時放出カプセル製剤
US9872835B2 (en)	2014-05-26	2018-01-23	Grünenthal GmbH	Multiparticles safeguarded against ethanolic dose-dumping
JP2018517676A (ja)	2015-04-24	2018-07-05	グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	即時放出および溶媒抽出に対する耐性を有する改変防止製剤
US10842750B2 (en)	2015-09-10	2020-11-24	Grünenthal GmbH	Protecting oral overdose with abuse deterrent immediate release formulations

1979
- 1979-08-16 CH CH7514/79A patent/CH648754A5/de not_active IP Right Cessation
1980
- 1980-08-13 BE BE0/201740A patent/BE884760A/fr not_active IP Right Cessation
- 1980-08-15 JP JP11186280A patent/JPS5659708A/ja active Granted
- 1980-08-15 ZA ZA00805015A patent/ZA805015B/xx unknown

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006038916A2 (en)	2004-05-21	2006-04-13	Accu-Break Technologies, Inc.	Scored pharmaceutical tablets comprising a plurality of segments
EP1755563A4 (en) *	2004-05-21	2007-07-04	Accu Break Technologies Inc	PHARMACEUTICAL TABLETS WITH TWO OR MORE UNIFORM SEGMENTS
EP1746979A4 (en) *	2004-05-21	2007-07-04	Accu Break Pharmaceuticals Inc	CARED PHARMACEUTICAL TABLETS WITH SEVERAL SEGMENTS
JP2008500401A (ja) *	2004-05-21	2008-01-10	アキュ−ブレイクテクノロジーズインコーポレーテッド	複数のセグメントを含む、刻み目のある医薬錠剤
JP2008500400A (ja) *	2004-05-21	2008-01-10	アキュ−ブレイクテクノロジーズインコーポレーテッド	２個またはそれ以上の単位セグメントを含む医薬錠剤
AU2005245025B2 (en) *	2004-05-21	2010-06-03	Accu-Break Technologies, Inc.	Pharmaceutical tablets comprising two or more unitary segments
US8158148B2 (en)	2004-05-21	2012-04-17	Accu-Break Technologies, Inc.	Pharmaceutical tablets comprising two or more unitary segments
JP2009515955A (ja) *	2005-11-18	2009-04-16	エーシーシーユー−ブレイクテクノロジーズ，インク．	セグメント化した薬の剤形
US8231902B2 (en)	2005-11-18	2012-07-31	Accu-Break Technologies, Inc.	Segmented pharmaceutical dosage forms
JP2009541341A (ja) *	2006-06-19	2009-11-26	エーシーシーユー−ブレイクテクノロジーズ，インク．	セグメント状の薬剤の剤形

Also Published As

Publication number	Publication date
JPS6361928B2 (cs)	1988-11-30
JPS5659708A (en)	1981-05-23
BE884760A (fr)	1981-02-13
ZA805015B (en)	1981-08-26

Legal Events

Date	Code	Title	Description
1997-02-14	PFA	Name/firm changed	Owner name: CIBA-GEIGY AG TRANSFER- NOVARTIS AG
1999-09-15	PL	Patent ceased

Publication	Publication Date	Title
CH648754A5 (en)	1985-04-15	Pharmaceutical slow release tablet
DE3030622C2 (de)	1996-05-30	Teilbare Tablette mit Retardeffekt für die Abgabe von Metoprolol oder Oxprenolol
DE69428862T2 (de)	2002-06-20	Linsenförmig pharmazeutische Tablette mit verzögerter Freigabe
AT394310B (de)	1992-03-10	Verfahren zur herstellung lagerstabiler, schnellzerfallender pharmazeutischer wirkstoff-presslinge
DE69620606T2 (de)	2002-10-24	Feste oral anzuwendende arzeneiform
DE3586600T2 (de)	1993-02-18	Dosierungsform eine vielzahl mit einer diffusionshuelle ueberzogener einheiten enthaltend.
DE69420087T2 (de)	2000-03-23	Pharmazeutische Tablette geeignet zur gestuften Freisetzung von Wirkstoffen
DE3587274T2 (de)	1993-09-09	Dosierungsform eine vielzahl mit einer diffusionshuelle ueberzogener einheiten enthaltend.
DE69704712T2 (de)	2001-11-29	Tablette mit gesteuerter freisetzung von alfuzosinhydrochlorid
DE69729134T2 (de)	2005-05-12	Pharmazeutische Tablette geeignet zur Wirkstofffreisetzung in aufeinanderfolgenden und vorherbestimmbaren Zeiträumen
DE69003568T2 (de)	1994-02-10	Arzneimittel mit verzögerter Freigabe.
DE69326163T2 (de)	2000-05-04	Verfahren zur herstellung von arzneiformen und kontrollierte freigabe und die soerhaltenen arzneiformen
DE1258548C2 (de)	1973-04-19	Verfahren zur Herstellung von Arzneimitteltabletten unter Verwendung von Kunstharzen als die Wirkstoffabgabe verzoegernde Einbettungsmassen
DE1492107C3 (de)	1973-12-06	Verfahren zur Herstellung einer Acetylsalicylsauretablette
DE68908297T2 (de)	1994-03-31	Formgepresste Zusammensetzungen.
DE19940944A1 (de)	2001-03-15	Retardierte, orale, pharmazeutische Darreichungsformen
DE10029201A1 (de)	2001-12-20	Verfahren zur Herstellung fester oraler Darreichungsformen mit retardierender Wirkstoffreisetzung
EP0052076B1 (de)	1985-05-29	Schnellzerfallende Arzneimittel-Presslinge
EP1110544A2 (de)	2001-06-27	Verwendung eines Filmüberzuges als geschmacksmaskierendes Coating von oralen Darreichungsformen
DD292837A5 (de)	1991-08-14	Verfahren zur herstellung von cholestyramin-tabletten
CH634748A5 (de)	1983-02-28	Ueberzugsmaterial zur geregelten wirkstoffabgabe von arzneimitteln sowie verfahren zu dessen herstellung.
EP2863891B1 (de)	2020-08-26	Arzneiform zur verlängerten freisetzung von wirkstoffen
DE602006000819T2 (de)	2009-04-09	Dipyridamol enthaltende Zusammensetzungen mit verlängerter Freisetzung und Verfahren zu deren Herstellung
EP2679216B1 (de)	2015-05-27	Arzneiform zur modifizierten Freisetzung von Betahistin
EP0208144B1 (de)	1989-09-20	Ambroxol oder bromhexin enthaltendes arzneimittelgranulat