CH650498A5 - 1,4-dihydropyridinverbindungen. - Google Patents

1,4-dihydropyridinverbindungen. Download PDF

Info

Publication number
CH650498A5
CH650498A5 CH6058/82A CH605882A CH650498A5 CH 650498 A5 CH650498 A5 CH 650498A5 CH 6058/82 A CH6058/82 A CH 6058/82A CH 605882 A CH605882 A CH 605882A CH 650498 A5 CH650498 A5 CH 650498A5
Authority
CH
Switzerland
Prior art keywords
dihydropyridine
dimethyl
formula
nitrophenyl
dicarboxylate
Prior art date
Application number
CH6058/82A
Other languages
German (de)
English (en)
Inventor
Sachio Ohno
Kiyoshi Mizukoshi
Osamu Komatsu
Kenzi Ichihara
Takashi Morishima
Original Assignee
Maruko Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP16696381A external-priority patent/JPS5867668A/ja
Priority claimed from JP259782A external-priority patent/JPS58121288A/ja
Priority claimed from JP2839182A external-priority patent/JPS58146565A/ja
Application filed by Maruko Pharmaceutical Co filed Critical Maruko Pharmaceutical Co
Publication of CH650498A5 publication Critical patent/CH650498A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH6058/82A 1981-10-19 1982-10-18 1,4-dihydropyridinverbindungen. CH650498A5 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP16696381A JPS5867668A (ja) 1981-10-19 1981-10-19 １，４−ジヒドロピリジン誘導体
JP259782A JPS58121288A (ja) 1982-01-11 1982-01-11 １，４−ジヒドロピリジン誘導体
JP2839182A JPS58146565A (ja) 1982-02-24 1982-02-24 １，４−ジヒドロピリジン誘導体

Publications (1)

Publication Number Publication Date
CH650498A5 true CH650498A5 (de) 1985-07-31

Family

ID=27275435

Family Applications (1)

Application Number Title Priority Date Filing Date
CH6058/82A CH650498A5 (de) 1981-10-19 1982-10-18 1,4-dihydropyridinverbindungen.

Country Status (12)

Country Link
US (1) US4446325A (fr)
KR (1) KR880002704B1 (fr)
AU (1) AU555036B2 (fr)
CA (1) CA1177079A (fr)
CH (1) CH650498A5 (fr)
DE (1) DE3238705A1 (fr)
ES (2) ES517022A0 (fr)
FR (1) FR2514761B1 (fr)
GB (1) GB2111978B (fr)
IT (1) IT1189393B (fr)
NL (1) NL194203C (fr)
SE (1) SE442864B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
FR2577552B1 (fr) * 1985-02-20 1987-09-04 Sori Soc Rech Ind Esters heterocycliques dissymetriques d'acides 1,4-dihydropyridine-3,5-dicarboxyliques, procede de preparation et utilisation en therapeutique
US4833150A (en) * 1985-03-14 1989-05-23 Nelson Research & Development Co. 1,4-dihydropyridines
DE3514865A1 (de) * 1985-04-25 1986-11-06 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridin-derivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US4849436A (en) * 1986-03-11 1989-07-18 Nelson Research & Development Co. 1,4-dihydropyridines
EP0272336B1 (fr) * 1986-12-18 1991-10-23 Kurt H. Prof. Dr. Bauer Concentré de nifédipine stabilisé contre l'influence de la lumière et mode de préparation
TWI246921B (en) * 2000-04-11 2006-01-11 Sankyo Co Stabilized pharmaceutical composition with calcium blocker
AU2003250483A1 (en) 2002-08-19 2004-03-11 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
JP2008507585A (ja) * 2004-07-26 2008-03-13 コセリックス インク 微粒子製剤を用いて吸入したイロプロストによる肺高血圧症の治療
EP2351569B1 (fr) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil dans des thérapies combinées pour le traitement de l'hypertension artérielle pulmonaire
WO2007050783A2 (fr) * 2005-10-26 2007-05-03 Asahi Kasei Pharma Corporation Fasudil en polytherapies pour traiter l'hypertension arterielle pulmonaire
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
WO2012037665A1 (fr) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Oxyde nitrique libérant un ester d'acide aminé pour le traitement de l'hypertension pulmonaire et autres états respiratoires
WO2013030725A1 (fr) 2011-08-26 2013-03-07 Wockhardt Limited Procédés de traitement de troubles cardiovasculaires

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
DE2228363A1 (de) * 1972-06-10 1974-01-03 Bayer Ag 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2747513A1 (de) * 1977-10-22 1979-05-03 Bayer Ag Dihydropyridine mit schwefelhaltigen estergruppierungen
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines

Also Published As

Publication number Publication date
AU555036B2 (en) 1986-09-11
ES8504127A1 (es) 1985-04-16
US4446325A (en) 1984-05-01
IT8249295A0 (it) 1982-10-18
KR840001954A (ko) 1984-06-07
NL194203B (nl) 2001-05-01
NL8204014A (nl) 1983-05-16
DE3238705C2 (fr) 1989-11-09
ES8406439A1 (es) 1984-08-16
IT1189393B (it) 1988-02-04
CA1177079A (fr) 1984-10-30
DE3238705A1 (de) 1983-07-14
KR880002704B1 (ko) 1988-12-26
FR2514761B1 (fr) 1985-09-06
SE442864B (sv) 1986-02-03
ES517022A0 (es) 1984-08-16
FR2514761A1 (fr) 1983-04-22
SE8205905D0 (sv) 1982-10-18
GB2111978A (en) 1983-07-13
AU8931782A (en) 1983-04-28
NL194203C (nl) 2001-09-04
IT8249295A1 (it) 1984-04-18
SE8205905L (sv) 1983-04-20
ES527980A0 (es) 1985-04-16
GB2111978B (en) 1985-05-01

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