CL2004000963A1 - Compuestos derivados de 2-hidroxi-2-(4-hidroxi-3-hidroximetilfenil)-3-etilamino)-propilfenilo, procedimiento de preparacion; composicion farmaceutica, utiles en el tratamiento de enfermedades que esta implicado el receptor b2, asma,, obstructivas o i - Google Patents
Compuestos derivados de 2-hidroxi-2-(4-hidroxi-3-hidroximetilfenil)-3-etilamino)-propilfenilo, procedimiento de preparacion; composicion farmaceutica, utiles en el tratamiento de enfermedades que esta implicado el receptor b2, asma,, obstructivas o iInfo
- Publication number
- CL2004000963A1 CL2004000963A1 CL200400963A CL2004000963A CL2004000963A1 CL 2004000963 A1 CL2004000963 A1 CL 2004000963A1 CL 200400963 A CL200400963 A CL 200400963A CL 2004000963 A CL2004000963 A CL 2004000963A CL 2004000963 A1 CL2004000963 A1 CL 2004000963A1
- Authority
- CL
- Chile
- Prior art keywords
- hydroxy
- phenyllene
- hydroxymethylphenyl
- ethylamine
- obstructive
- Prior art date
Links
- -1 4-HYDROXY-3-HYDROXYMETHYLPHENYL Chemical class 0.000 title 1
- 208000006673 asthma Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000000414 obstructive effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03010944A EP1477167A1 (en) | 2003-05-15 | 2003-05-15 | [(2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)-ethylamino)-propyl] phenyl derivatives as beta2 agonists |
| GBGB0329874.2A GB0329874D0 (en) | 2003-05-15 | 2003-12-23 | Compounds useful for the treatment of diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2004000963A1 true CL2004000963A1 (es) | 2005-03-18 |
Family
ID=33454327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200400963A CL2004000963A1 (es) | 2003-05-15 | 2004-05-05 | Compuestos derivados de 2-hidroxi-2-(4-hidroxi-3-hidroximetilfenil)-3-etilamino)-propilfenilo, procedimiento de preparacion; composicion farmaceutica, utiles en el tratamiento de enfermedades que esta implicado el receptor b2, asma,, obstructivas o i |
Country Status (29)
| Country | Link |
|---|---|
| EP (2) | EP1477167A1 (is) |
| JP (1) | JP3966897B2 (is) |
| KR (1) | KR100749990B1 (is) |
| CN (1) | CN1791407A (is) |
| AP (1) | AP2005003443A0 (is) |
| AR (1) | AR044335A1 (is) |
| AT (1) | ATE413879T1 (is) |
| AU (1) | AU2004237952A1 (is) |
| BR (1) | BRPI0410391A (is) |
| CA (1) | CA2525006A1 (is) |
| CL (1) | CL2004000963A1 (is) |
| CO (1) | CO5700776A2 (is) |
| DE (1) | DE602004017710D1 (is) |
| DK (1) | DK1624868T3 (is) |
| EA (1) | EA200501615A1 (is) |
| EC (1) | ECSP056164A (is) |
| ES (1) | ES2314395T3 (is) |
| GB (1) | GB0329874D0 (is) |
| IS (1) | IS8080A (is) |
| MA (1) | MA27840A1 (is) |
| MX (1) | MXPA05012329A (is) |
| NL (1) | NL1026203C2 (is) |
| NO (1) | NO20055854L (is) |
| OA (1) | OA13165A (is) |
| PA (1) | PA8603001A1 (is) |
| PE (1) | PE20060095A1 (is) |
| TW (1) | TW200505865A (is) |
| UY (1) | UY28317A1 (is) |
| WO (1) | WO2004100950A1 (is) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1708992E (pt) | 2004-01-22 | 2007-11-16 | Pfizer | Derivados de sulfonamida para o tratamento de doenças |
| EP1708991B1 (en) | 2004-01-22 | 2007-10-17 | Pfizer Limited | Sulfonamide derivatives for the treatment of diseases |
| EA200601510A1 (ru) * | 2004-03-17 | 2007-04-27 | Пфайзер Инк. | Производные фенилэтаноламина в качестве бета-2-агонистов |
| WO2005092860A1 (en) * | 2004-03-23 | 2005-10-06 | Pfizer Limited | Compounds for the treatment of diseases |
| ATE432278T1 (de) * | 2004-03-23 | 2009-06-15 | Pfizer | Verbindungen zur behandlung von krankheiten |
| AR049384A1 (es) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| GB0516313D0 (en) | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
| BRPI0614290A2 (pt) | 2005-08-08 | 2011-03-22 | Argenta Discovery Ltd | derivados de biciclo [ 2.2.1 ] hept-7-ilamina e seus usos |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| CN101522682A (zh) | 2006-10-30 | 2009-09-02 | 诺瓦提斯公司 | 作为抗炎剂的杂环化合物 |
| MX2010007604A (es) | 2008-01-11 | 2010-08-02 | Novartis Ag | Pirimidinas como inhibidores de cinasa. |
| US8236786B2 (en) | 2008-08-07 | 2012-08-07 | Pulmagen Therapeutics (Inflammation) Limited | Respiratory disease treatment |
| ES2442343T3 (es) | 2008-12-30 | 2014-02-11 | Pulmagen Therapeutics (Inflammation) Limited | Compuestos de sulfonamida para el tratamiento de trastornos respiratorios |
| WO2010150014A1 (en) | 2009-06-24 | 2010-12-29 | Pulmagen Therapeutics (Inflammation) Limited | 5r- 5 -deuterated glitazones for respiratory disease treatment |
| GB201002224D0 (en) | 2010-02-10 | 2010-03-31 | Argenta Therapeutics Ltd | Respiratory disease treatment |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
| WO2012116217A1 (en) | 2011-02-25 | 2012-08-30 | Irm Llc | Compounds and compositions as trk inhibitors |
| GB201601301D0 (en) * | 2016-01-25 | 2016-03-09 | Takeda Pharmaceutical | Novel compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8528633D0 (en) * | 1985-11-21 | 1985-12-24 | Beecham Group Plc | Compounds |
| US5629200A (en) * | 1993-11-18 | 1997-05-13 | Daicel Chemical Industries, Ltd. | Production of optically active 2-amino-1-phenylethanol derivatives by asymetrical assimilation |
| US5561142A (en) * | 1994-04-26 | 1996-10-01 | Merck & Co., Inc. | Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity |
| CA2220399A1 (en) * | 1995-05-10 | 1996-11-14 | Pfizer Inc. | .beta.-adrenergic agonists |
| US6090942A (en) * | 1998-10-15 | 2000-07-18 | Pfizer Inc. | Process and intermediates for a β3 -adrenergic receptor agonist |
-
2003
- 2003-05-15 EP EP03010944A patent/EP1477167A1/en not_active Withdrawn
- 2003-12-23 GB GBGB0329874.2A patent/GB0329874D0/en not_active Ceased
-
2004
- 2004-04-29 BR BRPI0410391-2A patent/BRPI0410391A/pt not_active IP Right Cessation
- 2004-04-29 CN CNA2004800132433A patent/CN1791407A/zh active Pending
- 2004-04-29 WO PCT/IB2004/001519 patent/WO2004100950A1/en not_active Ceased
- 2004-04-29 OA OA1200500317A patent/OA13165A/en unknown
- 2004-04-29 EA EA200501615A patent/EA200501615A1/ru unknown
- 2004-04-29 AP AP2005003443A patent/AP2005003443A0/xx unknown
- 2004-04-29 KR KR1020057021707A patent/KR100749990B1/ko not_active Expired - Fee Related
- 2004-04-29 JP JP2006530636A patent/JP3966897B2/ja not_active Expired - Fee Related
- 2004-04-29 DE DE602004017710T patent/DE602004017710D1/de not_active Expired - Fee Related
- 2004-04-29 DK DK04730338T patent/DK1624868T3/da active
- 2004-04-29 AT AT04730338T patent/ATE413879T1/de not_active IP Right Cessation
- 2004-04-29 MX MXPA05012329A patent/MXPA05012329A/es unknown
- 2004-04-29 CA CA002525006A patent/CA2525006A1/en not_active Abandoned
- 2004-04-29 ES ES04730338T patent/ES2314395T3/es not_active Expired - Lifetime
- 2004-04-29 AU AU2004237952A patent/AU2004237952A1/en not_active Abandoned
- 2004-04-29 EP EP04730338A patent/EP1624868B9/en not_active Expired - Lifetime
- 2004-05-05 CL CL200400963A patent/CL2004000963A1/es unknown
- 2004-05-11 PE PE2004000483A patent/PE20060095A1/es not_active Application Discontinuation
- 2004-05-12 UY UY28317A patent/UY28317A1/es not_active Application Discontinuation
- 2004-05-13 PA PA20048603001A patent/PA8603001A1/es unknown
- 2004-05-14 TW TW093113677A patent/TW200505865A/zh unknown
- 2004-05-14 NL NL1026203A patent/NL1026203C2/nl active Search and Examination
- 2004-05-14 AR ARP040101650A patent/AR044335A1/es not_active Application Discontinuation
-
2005
- 2005-10-20 IS IS8080A patent/IS8080A/is unknown
- 2005-11-09 CO CO05113616A patent/CO5700776A2/es not_active Application Discontinuation
- 2005-11-15 MA MA28609A patent/MA27840A1/fr unknown
- 2005-11-15 EC EC2005006164A patent/ECSP056164A/es unknown
- 2005-12-09 NO NO20055854A patent/NO20055854L/no not_active Application Discontinuation
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