CL2007003696A1 - Proceso para la obtencion de acido 1-(2-etil-butil)-ciclohexanocarboxilico que comprende hacer reaccionar un derivado de acido ciclohexanocarboxilico con agente alquilante en presencia de una amina secundaria y (alquil c1-c6)-litio, (cicloalquil c3-c - Google Patents

Proceso para la obtencion de acido 1-(2-etil-butil)-ciclohexanocarboxilico que comprende hacer reaccionar un derivado de acido ciclohexanocarboxilico con agente alquilante en presencia de una amina secundaria y (alquil c1-c6)-litio, (cicloalquil c3-c

Info

Publication number
CL2007003696A1
CL2007003696A1 CL200703696A CL2007003696A CL2007003696A1 CL 2007003696 A1 CL2007003696 A1 CL 2007003696A1 CL 200703696 A CL200703696 A CL 200703696A CL 2007003696 A CL2007003696 A CL 2007003696A CL 2007003696 A1 CL2007003696 A1 CL 2007003696A1
Authority
CL
Chile
Prior art keywords
acid
cyclohexanocarboxylic
cyclhexanocarboxyll
reactioning
butil
Prior art date
Application number
CL200703696A
Other languages
English (en)
Inventor
Hoffmann Y Bruno Lohri Ursula
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38121659&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2007003696(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2007003696A1 publication Critical patent/CL2007003696A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C07C319/06—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols from sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/08—Saturated compounds having a carboxyl group bound to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CL200703696A 2006-12-20 2007-12-19 Proceso para la obtencion de acido 1-(2-etil-butil)-ciclohexanocarboxilico que comprende hacer reaccionar un derivado de acido ciclohexanocarboxilico con agente alquilante en presencia de una amina secundaria y (alquil c1-c6)-litio, (cicloalquil c3-c CL2007003696A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06126724A EP1935867A1 (en) 2006-12-20 2006-12-20 Process for preparing 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid

Publications (1)

Publication Number Publication Date
CL2007003696A1 true CL2007003696A1 (es) 2008-07-04

Family

ID=38121659

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200703696A CL2007003696A1 (es) 2006-12-20 2007-12-19 Proceso para la obtencion de acido 1-(2-etil-butil)-ciclohexanocarboxilico que comprende hacer reaccionar un derivado de acido ciclohexanocarboxilico con agente alquilante en presencia de una amina secundaria y (alquil c1-c6)-litio, (cicloalquil c3-c

Country Status (16)

Country Link
US (2) US20080154059A1 (es)
EP (2) EP1935867A1 (es)
JP (1) JP5236659B2 (es)
KR (2) KR101412908B1 (es)
CN (1) CN101573319B (es)
AR (1) AR064422A1 (es)
AU (1) AU2007336349B2 (es)
BR (1) BRPI0720848B1 (es)
CA (1) CA2672505C (es)
CL (1) CL2007003696A1 (es)
ES (1) ES2392898T3 (es)
IL (1) IL198971A (es)
MX (1) MX2009006207A (es)
PE (1) PE20081387A1 (es)
TW (1) TW200833657A (es)
WO (1) WO2008074677A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2684067A1 (en) * 2007-04-25 2008-11-06 F. Hoffmann-La Roche Ag Novel process for the preparation of acid chlorides
CN101952236B (zh) * 2008-04-04 2014-07-02 弗·哈夫曼-拉罗切有限公司 通过相应的环己烷羧酰胺衍生物制备环己烷羧酸衍生物的新工艺
AU2009231423B2 (en) * 2008-04-04 2014-01-30 F. Hoffmann-La Roche Ag New process for the preparation of cyclohexanecarboxylic acid derivatives
JP5325980B2 (ja) 2008-06-17 2013-10-23 エフ．ホフマン−ラ ロシュ アーゲー 薬学的に活性なアミドの製造における中間体としての１−（２−エチル−ブチル）−シクロヘキサンカルボン酸エステル
US20110004011A1 (en) * 2009-07-01 2011-01-06 Declan Costello Novel process
KR101113584B1 (ko) 2009-09-07 2012-02-22 현대자동차주식회사 변속케이블의 노이즈 저감장치
GB201008047D0 (en) * 2010-05-14 2010-06-30 Ge Healthcare Ltd Method of synthesis
JP5676005B2 (ja) 2010-11-04 2015-02-25 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｓ−［２−（［［１−（２−エチルブチル）シクロヘキシル］カルボニル］アミノ）フェニル］２−メチルプロパンチオアート及びクロスカルメロースナトリウムを含む組成物
BR112013014291A2 (pt) 2010-12-08 2016-09-20 Hoffmann La Roche formulação lipossômica de calcetrapib
EP2651882B1 (en) 2010-12-16 2018-11-14 F.Hoffmann-La Roche Ag Process for the preparation of aromatic thiol derivatives by hydrogenation of disulfides
EP2675434A1 (en) 2011-02-17 2013-12-25 F.Hoffmann-La Roche Ag A process for controlled crystallization of an active pharmaceutical ingredient from supercooled liquid state by hot melt extrusion
MX2014012349A (es) 2012-04-30 2015-01-12 Hoffmann La Roche Nueva formulacion.
PT2978859T (pt) 2013-03-27 2018-10-04 Hoffmann La Roche Marcadores genéticos para previsão da capacidade de resposta à terapêutica
MX2016005505A (es) 2013-12-19 2016-07-22 Hoffmann La Roche Modulador de la proteina de transferencia de ester de colesterilo (cetp) para usarse en el tratamiento de enfermedades oculares.
RU2703192C2 (ru) 2014-07-30 2019-10-15 Ф. Хоффманн-Ля Рош Аг Генетические маркеры для прогнозирования ответа на терапию поднимающими уровень hdl или имитирующими hdl агентами
CN112892485B (zh) * 2020-12-29 2023-03-28 生态环境部土壤与农业农村生态环境监管技术中心 一种土壤气被动采样用吸附剂及其制备和使用方法
WO2025093129A1 (en) 2023-11-01 2025-05-08 Newamsterdam Pharma B.V. Treatment and prevention of age-related macular degeneration using a cetp inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH641756A5 (fr) * 1978-04-27 1984-03-15 Sanofi Sa Composes derives de l'acide cyclohexylcarboxylique, et medicaments les contenant.
JPH0269432A (ja) * 1988-09-05 1990-03-08 Wako Pure Chem Ind Ltd α−分枝長鎖脂肪酸の製造法
JP2894445B2 (ja) * 1997-02-12 1999-05-24 日本たばこ産業株式会社 Ｃｅｔｐ活性阻害剤として有効な化合物

Also Published As

Publication number Publication date
WO2008074677A1 (en) 2008-06-26
JP2010513371A (ja) 2010-04-30
MX2009006207A (es) 2009-06-22
EP2094636B1 (en) 2012-10-24
PE20081387A1 (es) 2008-10-17
TW200833657A (en) 2008-08-16
CA2672505A1 (en) 2008-06-26
US20080154059A1 (en) 2008-06-26
AR064422A1 (es) 2009-04-01
CN101573319B (zh) 2013-04-03
BRPI0720848A2 (pt) 2014-03-04
EP1935867A1 (en) 2008-06-25
US20090240080A1 (en) 2009-09-24
AU2007336349B2 (en) 2012-03-08
CN101573319A (zh) 2009-11-04
US7863474B2 (en) 2011-01-04
IL198971A0 (en) 2010-02-17
BRPI0720848B1 (pt) 2018-12-18
CA2672505C (en) 2015-01-27
ES2392898T3 (es) 2012-12-14
JP5236659B2 (ja) 2013-07-17
EP2094636A1 (en) 2009-09-02
IL198971A (en) 2012-10-31
KR20090083934A (ko) 2009-08-04
KR20120057660A (ko) 2012-06-05
KR101412908B1 (ko) 2014-06-26
AU2007336349A1 (en) 2008-06-26

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