CL2008002565A1 - Anticuerpo aislado o fragmento de unión a antígeno del mismo que se une específicamente al dominio extracelular de cxcr5/receptor de linfoma de burkitt (blr1)/cd185/mdr15/mgc117347 humano; molécula de ácido nucleico aislada que lo codifica; vector que comprende a dicha molécula de ácido nucleico; célula huésped aislada que comprende a dicho vector; uso médico de dicho anticuerpo; y composición farmacéutica que lo comprende. - Google Patents

Anticuerpo aislado o fragmento de unión a antígeno del mismo que se une específicamente al dominio extracelular de cxcr5/receptor de linfoma de burkitt (blr1)/cd185/mdr15/mgc117347 humano; molécula de ácido nucleico aislada que lo codifica; vector que comprende a dicha molécula de ácido nucleico; célula huésped aislada que comprende a dicho vector; uso médico de dicho anticuerpo; y composición farmacéutica que lo comprende.

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Publication number
CL2008002565A1
CL2008002565A1 CL2008002565A CL2008002565A CL2008002565A1 CL 2008002565 A1 CL2008002565 A1 CL 2008002565A1 CL 2008002565 A CL2008002565 A CL 2008002565A CL 2008002565 A CL2008002565 A CL 2008002565A CL 2008002565 A1 CL2008002565 A1 CL 2008002565A1
Authority
CL
Chile
Prior art keywords
isolated
vector
nucleic acid
acid molecule
antibody
Prior art date
Application number
CL2008002565A
Other languages
English (en)
Inventor
Renata Lee
Vincent Mikol
Norman Reutsch
Beatrice Cameron
Thomas Oligino
Nicholas Baurin
Elizabeth Allen
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40429297&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008002565(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CL2008002565A1 publication Critical patent/CL2008002565A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
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    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

LA PRESENTE INVENCIÓN SE REFIERE A ANTICUERPOS HUMANIZADOS QUE SE UNEN ESPECÍFICAMENTE A CXCR5 Y, POR EJEMPLO, PUEDEN INHIBIR LA FUNCIÓN DE CXCR5. LA INVENCIÓN TAMBIÉN INCLUYE USOS DE LOS ANTICUERPOS PARA TRATAR O PREVENIR ENFERMEDADES O TRASTORNOS RELACIONADOS CON CXCR5.
CL2008002565A 2007-08-29 2008-08-29 Anticuerpo aislado o fragmento de unión a antígeno del mismo que se une específicamente al dominio extracelular de cxcr5/receptor de linfoma de burkitt (blr1)/cd185/mdr15/mgc117347 humano; molécula de ácido nucleico aislada que lo codifica; vector que comprende a dicha molécula de ácido nucleico; célula huésped aislada que comprende a dicho vector; uso médico de dicho anticuerpo; y composición farmacéutica que lo comprende. CL2008002565A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96879207P 2007-08-29 2007-08-29

Publications (1)

Publication Number Publication Date
CL2008002565A1 true CL2008002565A1 (es) 2009-01-16

Family

ID=40429297

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008002565A CL2008002565A1 (es) 2007-08-29 2008-08-29 Anticuerpo aislado o fragmento de unión a antígeno del mismo que se une específicamente al dominio extracelular de cxcr5/receptor de linfoma de burkitt (blr1)/cd185/mdr15/mgc117347 humano; molécula de ácido nucleico aislada que lo codifica; vector que comprende a dicha molécula de ácido nucleico; célula huésped aislada que comprende a dicho vector; uso médico de dicho anticuerpo; y composición farmacéutica que lo comprende.

Country Status (44)

Country Link
US (9) US8647622B2 (es)
EP (3) EP2195023B1 (es)
JP (3) JP5743543B2 (es)
KR (4) KR101599704B1 (es)
CN (4) CN101842115B (es)
AR (2) AR068354A1 (es)
AU (1) AU2008296538B2 (es)
BR (1) BRPI0815983A2 (es)
CA (1) CA2698203C (es)
CL (1) CL2008002565A1 (es)
CO (1) CO6270238A2 (es)
CR (2) CR11293A (es)
CY (1) CY1120665T1 (es)
DK (1) DK2195023T3 (es)
DO (1) DOP2010000069A (es)
EC (1) ECSP109985A (es)
ES (1) ES2672769T3 (es)
HR (1) HRP20180873T1 (es)
HU (1) HUE037489T2 (es)
IL (2) IL204173A (es)
LT (1) LT2195023T (es)
MA (1) MA31821B1 (es)
MX (5) MX338397B (es)
MY (1) MY159201A (es)
NI (2) NI201000281A (es)
NO (1) NO2195023T3 (es)
NZ (1) NZ583605A (es)
PA (1) PA8794201A1 (es)
PE (1) PE20090993A1 (es)
PH (1) PH12015500248A1 (es)
PL (1) PL2195023T3 (es)
PT (1) PT2195023T (es)
RS (1) RS57273B1 (es)
RU (2) RU2015147300A (es)
SG (1) SG10201407388XA (es)
SI (1) SI2195023T1 (es)
SV (1) SV2010003494A (es)
TN (1) TN2010000092A1 (es)
TR (1) TR201807983T4 (es)
TW (4) TWI608017B (es)
UA (2) UA117446C2 (es)
UY (1) UY31309A1 (es)
WO (1) WO2009032661A1 (es)
ZA (1) ZA201001514B (es)

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ZA200900545B (en) 2006-07-18 2010-03-31 Sanofi Aventis Antagonist antibody against EPHA2 for the treatment of cancer
EP2195023B1 (en) 2007-08-29 2018-03-07 Sanofi Humanized anti-cxcr5 antibodies, derivatives thereof and their uses
JP5529869B2 (ja) * 2008-08-14 2014-06-25 メルク・シャープ・アンド・ドーム・コーポレーション プロテインａアフィニティークロマトグラフィーを用いる抗体の精製方法
FR2945538B1 (fr) 2009-05-12 2014-12-26 Sanofi Aventis Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide.
UY32914A (es) 2009-10-02 2011-04-29 Sanofi Aventis Anticuerpos que se usan específicamente al receptor epha2
AU2010323037B2 (en) 2009-11-30 2015-01-29 Biotest Ag Humanized anti-IL-10 antibodies for the treatment of systemic lupus erythematosus (SLE)
EP2397495A1 (en) 2010-06-21 2011-12-21 Sanofi Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof
EP2402371A1 (en) 2010-07-01 2012-01-04 Sanofi Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof
EP2336188A1 (en) 2009-12-18 2011-06-22 Sanofi-Aventis Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof
JP5843783B2 (ja) 2009-12-18 2016-01-13 サノフイ ＧＰＶＩに対する新規アンタゴニスト抗体および該抗体のＦａｂフラグメントならびにこれらの使用
FR2958936A1 (fr) 2010-04-14 2011-10-21 Sanofi Aventis Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs
WO2012010582A1 (en) 2010-07-21 2012-01-26 Roche Glycart Ag Anti-cxcr5 antibodies and methods of use
TWI560199B (en) 2010-08-31 2016-12-01 Sanofi Sa Peptide or peptide complex binding to α2 integrin and methods and uses involving the same
UA112170C2 (uk) 2010-12-10 2016-08-10 Санофі Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб
JP2014505239A (ja) * 2010-12-14 2014-02-27 モアハウス スクール オブ メディスン 癌の治療または検出のための抗ｃｘｃｌ１３および抗ｃｘｃｒ５抗体の使用
AR085302A1 (es) 2011-02-24 2013-09-18 Sanofi Sa Metodo de produccion de anticuerpos sialilados
BR112014017814A8 (pt) 2012-01-20 2017-07-11 Genzyme Corp Anticorpos anti-cxcr3
PT2830658T (pt) * 2012-03-26 2018-12-28 Sanofi Sa Formulações de agente de ligação igg4 estável
JP6265970B2 (ja) * 2012-03-26 2018-01-24 サノフイ 安定なＩｇＧ４に基づく結合剤の製剤
US9592289B2 (en) 2012-03-26 2017-03-14 Sanofi Stable IgG4 based binding agent formulations
WO2013148296A1 (en) 2012-03-28 2013-10-03 Sanofi Antibodies to bradykinin b1 receptor ligands
WO2014003742A1 (en) * 2012-06-27 2014-01-03 Morehouse School Of Medicine Anti-cxcl9, anti-cxcl10, anti-cxcl11, anti-cxcl13, anti-cxcr3 and anti-cxcr5 agents for inhibition of inflammation
CN104870012A (zh) * 2012-06-27 2015-08-26 吉安特科技公司 用于炎性疾病的抗-cxcl9、抗-cxcl10、抗-cxcl11、抗-cxcl13、抗-cxcr3和抗-cxcr5试剂
PT3199552T (pt) 2012-11-20 2020-03-25 Sanofi Sa Anticorpos anti-ceacam5 e suas utilizações
US20150322152A1 (en) 2012-11-30 2015-11-12 Institut Pasteur Use of anti-fcyri and/or anti-fcyriia antibodies for treating arthritis, inflammation, thrombocytopenia and allergic shock
US10342869B2 (en) 2012-12-07 2019-07-09 The Regents Of The University Of California Compositions comprising anti-CD38 antibodies and lenalidomide
SG11201504920SA (en) 2012-12-27 2015-07-30 Sanofi Sa Anti-lamp1 antibodies and antibody drug conjugates, and uses thereof
SG10201913777XA (en) 2013-03-13 2020-03-30 Sanofi Sa Compositions comprising anti-cd38 antibodies and carfilzomib
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