BRPI0513078B8 - anticorpo igg que se liga a il-17 humana e composição líquida - Google Patents

anticorpo igg que se liga a il-17 humana e composição líquida Download PDF

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Publication number
BRPI0513078B8
BRPI0513078B8 BRPI0513078A BRPI0513078A BRPI0513078B8 BR PI0513078 B8 BRPI0513078 B8 BR PI0513078B8 BR PI0513078 A BRPI0513078 A BR PI0513078A BR PI0513078 A BRPI0513078 A BR PI0513078A BR PI0513078 B8 BRPI0513078 B8 BR PI0513078B8
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BR
Brazil
Prior art keywords
human
binds
liquid composition
igg antibody
antibody
Prior art date
Application number
BRPI0513078A
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English (en)
Inventor
E Di Padova Franco
Hofstetter Hans
Gram Hermann
Rondeau Jean-Michel
Jeschke Margit
Van Den Berg Wim
Original Assignee
Novartis Ag
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Application filed by Novartis Ag filed Critical Novartis Ag
Priority to BR122017009404-1A priority Critical patent/BR122017009404B1/pt
Publication of BRPI0513078A publication Critical patent/BRPI0513078A/pt
Publication of BRPI0513078B1 publication Critical patent/BRPI0513078B1/pt
Publication of BRPI0513078B8 publication Critical patent/BRPI0513078B8/pt
Publication of BRPI0513078C1 publication Critical patent/BRPI0513078C1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

anticorpos antagonísticos de il-17. a presente invenção refere-se a uma molécula de ligação de il-17, em particular um anticorpo para il-17 humana, mais preferivelmente um anticorpo humano para il-17 humana é fornecida, em que as regiões hiper-variáveis das cadeias pesadas e leves têm seqüências de aminoácido como definido, para o uso no tratamento de uma doença ou distúrbio mediados por il-17, por exemplo, artrite reumatóide.
BRPI0513078A 2004-08-05 2005-08-04 anticorpo igg que se liga a il-17 humana e composição líquida BRPI0513078C1 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122017009404-1A BR122017009404B1 (pt) 2004-08-05 2005-08-04 Usos de um anticorpo anti-il-17

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0417487.6 2004-08-05
GBGB0417487.6A GB0417487D0 (en) 2004-08-05 2004-08-05 Organic compound
PCT/EP2005/008470 WO2006013107A1 (en) 2004-08-05 2005-08-04 Il-17 antagonistic antibodies

Publications (4)

Publication Number Publication Date
BRPI0513078A BRPI0513078A (pt) 2008-04-22
BRPI0513078B1 BRPI0513078B1 (pt) 2019-02-19
BRPI0513078B8 true BRPI0513078B8 (pt) 2019-08-27
BRPI0513078C1 BRPI0513078C1 (pt) 2021-05-25

Family

ID=32982602

Family Applications (3)

Application Number Title Priority Date Filing Date
BR122017009404-1A BR122017009404B1 (pt) 2004-08-05 2005-08-04 Usos de um anticorpo anti-il-17
BR122018075556-3A BR122018075556B1 (pt) 2004-08-05 2005-08-04 Construção de dna que codifica um anticorpo anti-il-17 e vetor de expressão capaz de replicar em uma linhagem de células eucariótica
BRPI0513078A BRPI0513078C1 (pt) 2004-08-05 2005-08-04 anticorpo igg que se liga a il-17 humana e composição líquida

Family Applications Before (2)

Application Number Title Priority Date Filing Date
BR122017009404-1A BR122017009404B1 (pt) 2004-08-05 2005-08-04 Usos de um anticorpo anti-il-17
BR122018075556-3A BR122018075556B1 (pt) 2004-08-05 2005-08-04 Construção de dna que codifica um anticorpo anti-il-17 e vetor de expressão capaz de replicar em uma linhagem de células eucariótica

Country Status (40)

Country Link
US (9) US7807155B2 (pt)
EP (5) EP2902039B1 (pt)
JP (1) JP4682200B2 (pt)
KR (2) KR100852523B1 (pt)
CN (1) CN101001645B (pt)
AR (1) AR050200A1 (pt)
AT (1) ATE517924T1 (pt)
AU (2) AU2005268857C1 (pt)
BE (1) BE2015C041I2 (pt)
BR (3) BR122017009404B1 (pt)
CA (1) CA2573586C (pt)
CY (6) CY1111963T1 (pt)
DK (4) DK2902039T3 (pt)
EC (1) ECSP077198A (pt)
ES (4) ES2487533T7 (pt)
FR (1) FR15C0048I2 (pt)
GB (1) GB0417487D0 (pt)
HK (1) HK1256639A1 (pt)
HR (3) HRP20110758T4 (pt)
HU (4) HUE038187T2 (pt)
IL (1) IL180717A (pt)
LT (3) LT2902039T (pt)
LU (2) LU92768I2 (pt)
MA (1) MA28982B1 (pt)
MX (1) MX2007001338A (pt)
MY (1) MY144925A (pt)
NL (1) NL300749I2 (pt)
NO (9) NO336279B1 (pt)
NZ (1) NZ552658A (pt)
PE (1) PE20060418A1 (pt)
PL (4) PL2364729T6 (pt)
PT (4) PT1776142E (pt)
RU (2) RU2426741C3 (pt)
SG (1) SG155186A1 (pt)
SI (4) SI2364729T1 (pt)
TN (1) TNSN07034A1 (pt)
TR (1) TR201808057T4 (pt)
TW (1) TWI359153B (pt)
WO (1) WO2006013107A1 (pt)
ZA (1) ZA200700242B (pt)

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WO2006013107A1 (en) 2006-02-09
AU2005268857B2 (en) 2010-01-28
IL180717A (en) 2012-07-31
PT2366405E (pt) 2015-06-30
NZ552658A (en) 2009-11-27
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BE2015C041I2 (pt) 2024-10-08
NO337286B1 (no) 2016-02-29
US20090280131A1 (en) 2009-11-12
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US20140079719A1 (en) 2014-03-20
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NO20150064L (no) 2007-03-30
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US10344084B2 (en) 2019-07-09
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CN101001645A (zh) 2007-07-18
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HK1256639A1 (en) 2019-09-27
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BRPI0513078B1 (pt) 2019-02-19
ES2487533T7 (es) 2015-07-14
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PL2902039T3 (pl) 2018-09-28
LU92768I2 (fr) 2015-11-03
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BR122017009404B1 (pt) 2022-02-22
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HK1101277A1 (en) 2007-10-12
CN101001645B (zh) 2012-09-05
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EP1776142A1 (en) 2007-04-25
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HUS1500037I1 (hu) 2017-10-30
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AR050200A1 (es) 2006-10-04
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PL2366405T3 (pl) 2015-08-31
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SI2364729T1 (sl) 2014-08-29
NO336279B1 (no) 2015-07-06
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US20100215666A1 (en) 2010-08-26

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