CL2008003095A1 - Procedeimiento de preparacion de dihidrotienopirimidas; uno de los compuestos intermediarios considerados; y el procedimiento de preparacion de dicho compuesto intermediario. - Google Patents

Procedeimiento de preparacion de dihidrotienopirimidas; uno de los compuestos intermediarios considerados; y el procedimiento de preparacion de dicho compuesto intermediario.

Info

Publication number
CL2008003095A1
CL2008003095A1 CL2008003095A CL2008003095A CL2008003095A1 CL 2008003095 A1 CL2008003095 A1 CL 2008003095A1 CL 2008003095 A CL2008003095 A CL 2008003095A CL 2008003095 A CL2008003095 A CL 2008003095A CL 2008003095 A1 CL2008003095 A1 CL 2008003095A1
Authority
CL
Chile
Prior art keywords
preparation
dihydrothienopyrimides
procedure
compounds considered
intermediate compound
Prior art date
Application number
CL2008003095A
Other languages
English (en)
Inventor
Rogelio Frutos
Dhileepkumar Krishnamurthy
Jason Mulder
Sonia Rodriguez
Chris Hugh Senanayake
Thomas G Tampone
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40158557&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008003095(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2008003095A1 publication Critical patent/CL2008003095A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Método para preparar compuestos derivados de dihidrotienopirimidina y los intermediarios utilizados en el proceso.
CL2008003095A 2007-10-18 2008-10-17 Procedeimiento de preparacion de dihidrotienopirimidas; uno de los compuestos intermediarios considerados; y el procedimiento de preparacion de dicho compuesto intermediario. CL2008003095A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98110507P 2007-10-18 2007-10-18

Publications (1)

Publication Number Publication Date
CL2008003095A1 true CL2008003095A1 (es) 2010-01-22

Family

ID=40158557

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2008003095A CL2008003095A1 (es) 2007-10-18 2008-10-17 Procedeimiento de preparacion de dihidrotienopirimidas; uno de los compuestos intermediarios considerados; y el procedimiento de preparacion de dicho compuesto intermediario.
CL2012000560A CL2012000560A1 (es) 2007-10-18 2012-03-01 Procedimiento de preparacion del compuesto intermediario acido 3-oxo-tetrahidrotiofeno-2-carboxilico, utiles en la preparacion de dihidrotienopirimidinas (divisional de la solicitud 3095-08).

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2012000560A CL2012000560A1 (es) 2007-10-18 2012-03-01 Procedimiento de preparacion del compuesto intermediario acido 3-oxo-tetrahidrotiofeno-2-carboxilico, utiles en la preparacion de dihidrotienopirimidinas (divisional de la solicitud 3095-08).

Country Status (20)

Country Link
US (1) US8653282B2 (es)
EP (1) EP2205608B1 (es)
JP (1) JP5538231B2 (es)
KR (1) KR20100095528A (es)
CN (2) CN101903394B (es)
AR (1) AR069077A1 (es)
AU (1) AU2008312624B2 (es)
BR (1) BRPI0818671A2 (es)
CA (1) CA2702500A1 (es)
CL (2) CL2008003095A1 (es)
DK (1) DK2205608T3 (es)
ES (1) ES2424445T3 (es)
IL (1) IL204854A0 (es)
MX (1) MX2010003826A (es)
NZ (2) NZ592534A (es)
PL (1) PL2205608T3 (es)
RU (1) RU2528340C2 (es)
TW (1) TW200918541A (es)
WO (1) WO2009052138A1 (es)
ZA (1) ZA201002425B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
TWI618544B (zh) 2006-12-26 2018-03-21 藍瑟斯醫學影像公司 使心臟神經分布顯像之配位體
AU2008313660B2 (en) 2007-10-19 2013-11-07 Boehringer Ingelheim International Gmbh Substituted piperidino-dihydrothienopyrimidines
EP2205609B1 (de) 2007-10-19 2017-03-29 Boehringer Ingelheim International GmbH Heterocyclus-substituierte piperazino-dihydrothienopyrimidine
WO2009050236A1 (de) 2007-10-19 2009-04-23 Boehringer Ingelheim International Gmbh Neue piperazino-dihydrothienopyrimidin-derivate
US9802954B2 (en) 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
KR101879422B1 (ko) * 2013-09-18 2018-07-17 베이징 한미 파마슈티컬 컴퍼니 리미티드 Btk 및/또는 jak3 키나제의 활성을 억제하는 화합물
EP4570804A1 (en) * 2022-08-09 2025-06-18 Xizang Haisco Pharmaceutical Co., Ltd. Pde4b inhibitor and use thereof
US20260008788A1 (en) 2022-09-29 2026-01-08 Suzhou Ark Biopharmaceutical Co., Ltd. Aza-fused ring compound, preparation method therefor, and use thereof in medicine
JP2026510292A (ja) * 2023-02-28 2026-04-02 上海翊石医薬科技有限公司 ジヒドロチエノピリミジン誘導体の製造方法および使用
CN116925099B (zh) * 2023-07-21 2025-06-03 厦门大学 手性二氢噻吩并嘧啶亚砜的制备方法及其应用与其2、4位取代化合物
WO2025162289A2 (zh) * 2024-02-04 2025-08-07 西藏海思科制药有限公司 一种pde4b抑制剂的晶型及其在医药上的用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470336A1 (de) * 1962-07-04 1969-03-20 Thomae Gmbh Dr K Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung
DE2700215A1 (de) * 1977-01-05 1978-07-13 Basf Ag Thiophenverbindungen und verfahren zur herstellung von thiophenverbindungen
CH632755A5 (de) * 1976-04-10 1982-10-29 Basf Ag Verfahren zur herstellung von thiophenverbindungen.
US4974609A (en) * 1986-08-18 1990-12-04 Philip Morris Incorporated Tobacco flavorants
RU2153494C2 (ru) 1993-10-12 2000-07-27 Дзе Дюпон Мерк Фармасьютикал Компани 1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция
DE19540737A1 (de) * 1995-11-02 1997-05-07 Bayer Ag Substituierte Sulfonylamino(thio)carbonylverbindungen
CA2309690A1 (en) * 1997-11-11 1999-05-20 Pfizer Products Inc. Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
TW564247B (en) * 1999-04-08 2003-12-01 Akzo Nobel Nv Bicyclic heteraromatic compound
MX2007012313A (es) 2006-04-19 2007-11-21 Boehringer Ingelheim Int Dihidrotienopirimidinas para el tratamiento de enfermedades inflamatorias.
EP1847543A1 (de) * 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
ATE547407T1 (de) * 2007-09-25 2012-03-15 Actimis Pharmaceuticals Inc Alkylthiopyrimidine als crth2-antagonisten
EP2205609B1 (de) * 2007-10-19 2017-03-29 Boehringer Ingelheim International GmbH Heterocyclus-substituierte piperazino-dihydrothienopyrimidine
AU2008313660B2 (en) * 2007-10-19 2013-11-07 Boehringer Ingelheim International Gmbh Substituted piperidino-dihydrothienopyrimidines

Also Published As

Publication number Publication date
RU2010119647A (ru) 2011-11-27
BRPI0818671A2 (pt) 2015-09-15
MX2010003826A (es) 2010-04-21
DK2205608T3 (da) 2013-07-01
ES2424445T3 (es) 2013-10-02
JP5538231B2 (ja) 2014-07-02
EP2205608B1 (en) 2013-05-08
CN101903394A (zh) 2010-12-01
US20100222585A1 (en) 2010-09-02
RU2528340C2 (ru) 2014-09-10
PL2205608T3 (pl) 2013-09-30
JP2011500701A (ja) 2011-01-06
WO2009052138A1 (en) 2009-04-23
EP2205608A1 (en) 2010-07-14
AU2008312624B2 (en) 2014-07-10
US8653282B2 (en) 2014-02-18
WO2009052138A8 (en) 2012-11-15
CN103497201A (zh) 2014-01-08
TW200918541A (en) 2009-05-01
AR069077A1 (es) 2009-12-30
NZ592534A (en) 2013-03-28
CL2012000560A1 (es) 2012-09-14
KR20100095528A (ko) 2010-08-31
AU2008312624A1 (en) 2009-04-23
ZA201002425B (en) 2011-02-23
NZ584962A (en) 2011-07-29
IL204854A0 (en) 2010-11-30
CN101903394B (zh) 2013-12-25
CA2702500A1 (en) 2009-04-23

Similar Documents

Publication Publication Date Title
CL2008003095A1 (es) Procedeimiento de preparacion de dihidrotienopirimidas; uno de los compuestos intermediarios considerados; y el procedimiento de preparacion de dicho compuesto intermediario.
UY32049A (es) Inhibidores de cmet
MX2012012527A (es) Compuestos quimicos.
CL2011000846A1 (es) Compuestos heterociclicos sustituidos; composicion farmaceutica; y su uso para el tratamiento de la hepatitis c.
CR11776A (es) Inhibidores de bace
CL2009000426A1 (es) Compuestos derivados de carbociclil/heterociclil-piridin-2-il-urea, inhibidores de topoisomerasa iv bacteriana; composicion farmaceutica; y su uso para el tratamiento de infecciones bacterianas
EA201391313A1 (ru) C4-монометилтритерпеноидные производные и способы их применения
ECSP10010722A (es) Compuestos orgánicos
UY32863A (es) COMPUESTOS DE HEXAHIDROOXAZINOPTERINA PARA USO COMO INHIBIDORES DE mTOR
CR20120334A (es) Derivados de imidazopiridina como inhibidores de jak
CR20120295A (es) Triazolopiridinas
SV2016005149A (es) Polimorfo de los inhibidores de la syk
EA201270149A1 (ru) Ингибиторы bace
CL2011000527A1 (es) Compuestos derivados de benzofurano; composicion farmaceutica que los comprende;y su uso en el tratamiento de la hepatitis c.
CL2008002295A1 (es) Compuestos derivados de tiazolida sustituidos con alquilsulfonilos; composicion farmaceutica; y uso para el tratamiento de la hepatitis c.
EA201490567A1 (ru) Новые бициклические производные дигидрохинолин-2-она
UY34365A (es) Compuestos heterociclicos
CR20140275A (es) Triazolopiridinas sustituidas
CU20130044A7 (es) Proceso para la preparación de inhibidores de pan-cdk de fórmula (i), e intermediarios de la preparación
CL2012000278A1 (es) Proceso para la obtencion de derivados de 5-trifluorometil-pirimidinas; y uno de los compuestos intermediarios considerados.
CL2011001331A1 (es) Clorhidrato de nalmefeno dihidratado; métodos para su preparación; composición farmacéutica que lo comprende; y uso para el tratamiento del alcoholismo.
UY32077A (es) Inhibidores de quinasa tipo polo
CL2009001686A1 (es) Procedimiento de preparacion de agomelatina; y los compuestos intermediarios considerados.
CL2013003056A1 (es) Compuestos derivados de (fenil o piridin)-etinil-(piridin o pirimidin) sustituido; composición farmacéutica que los comprende; proceso de preparación de esto; y su uso en el tratamiento de la esquizofrenia o enfermedades cognitivas.
EA201200820A1 (ru) Способ синтеза промежуточных продуктов, применимых для получения замещенных индазолов и азаиндазолов