DK2205608T3 - Fremstilling af dihydrothieno[3,2-d]pyrimidiner og intermediære anvendt deri - Google Patents
Fremstilling af dihydrothieno[3,2-d]pyrimidiner og intermediære anvendt deriInfo
- Publication number
- DK2205608T3 DK2205608T3 DK08840060.1T DK08840060T DK2205608T3 DK 2205608 T3 DK2205608 T3 DK 2205608T3 DK 08840060 T DK08840060 T DK 08840060T DK 2205608 T3 DK2205608 T3 DK 2205608T3
- Authority
- DK
- Denmark
- Prior art keywords
- dihydrothieno
- pyrimidines
- preparation
- intermediates used
- intermediates
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98110507P | 2007-10-18 | 2007-10-18 | |
| PCT/US2008/079925 WO2009052138A1 (en) | 2007-10-18 | 2008-10-15 | Preparation of dihydrothieno [3, 2-d] pyrimidines and intermediates used therein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2205608T3 true DK2205608T3 (da) | 2013-07-01 |
Family
ID=40158557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08840060.1T DK2205608T3 (da) | 2007-10-18 | 2008-10-15 | Fremstilling af dihydrothieno[3,2-d]pyrimidiner og intermediære anvendt deri |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8653282B2 (da) |
| EP (1) | EP2205608B1 (da) |
| JP (1) | JP5538231B2 (da) |
| KR (1) | KR20100095528A (da) |
| CN (2) | CN103497201A (da) |
| AR (1) | AR069077A1 (da) |
| AU (1) | AU2008312624B2 (da) |
| BR (1) | BRPI0818671A2 (da) |
| CA (1) | CA2702500A1 (da) |
| CL (2) | CL2008003095A1 (da) |
| DK (1) | DK2205608T3 (da) |
| ES (1) | ES2424445T3 (da) |
| IL (1) | IL204854A0 (da) |
| MX (1) | MX2010003826A (da) |
| NZ (2) | NZ592534A (da) |
| PL (1) | PL2205608T3 (da) |
| RU (1) | RU2528340C2 (da) |
| TW (1) | TW200918541A (da) |
| WO (1) | WO2009052138A1 (da) |
| ZA (1) | ZA201002425B (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| EP2474523B1 (en) | 2006-12-26 | 2020-04-08 | Lantheus Medical Imaging, Inc. | Ligands for imaging cardiac innervation |
| CA2702524A1 (en) | 2007-10-19 | 2009-04-23 | Boehringer Ingelheim International Gmbh | Heterocycle-substituted piperazino-dihydrothienopyrimidines |
| CN104069112A (zh) | 2007-10-19 | 2014-10-01 | 贝林格尔.英格海姆国际有限公司 | 取代的哌啶子基-二氢噻吩并嘧啶 |
| CA2702518A1 (en) | 2007-10-19 | 2009-04-23 | Boehringer Ingelheim International Gmbh | New piperazino-dihydrothienopyrimidine derivatives |
| US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| US9840517B2 (en) * | 2013-09-18 | 2017-12-12 | Beijing Hanmi Pharmaceutical Co., Ltd. | Compound inhibiting activities of BTK and/or JAK3 kinases |
| KR20250046278A (ko) * | 2022-08-09 | 2025-04-02 | 시젱 하이스코 파마수티칼 씨오., 엘티디. | Pde4b 억제제 및 이의 용도 |
| JP2025534418A (ja) | 2022-09-29 | 2025-10-15 | 蘇州愛科百発生物医薬技術有限公司 | 含窒素縮合複素環化合物、その調製方法、および医薬におけるその使用 |
| CU20250021A7 (es) * | 2023-02-28 | 2026-03-10 | Innovstone Therapeutics Ltd | Compuesto inhibidor de la pde4b,útil para el tratamiento de enfermedades mediadas por pde4b |
| CN116925099B (zh) * | 2023-07-21 | 2025-06-03 | 厦门大学 | 手性二氢噻吩并嘧啶亚砜的制备方法及其应用与其2、4位取代化合物 |
| WO2025162289A2 (zh) * | 2024-02-04 | 2025-08-07 | 西藏海思科制药有限公司 | 一种pde4b抑制剂的晶型及其在医药上的用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1470336A1 (de) * | 1962-07-04 | 1969-03-20 | Thomae Gmbh Dr K | Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung |
| CH632755A5 (de) * | 1976-04-10 | 1982-10-29 | Basf Ag | Verfahren zur herstellung von thiophenverbindungen. |
| DE2700215A1 (de) * | 1977-01-05 | 1978-07-13 | Basf Ag | Thiophenverbindungen und verfahren zur herstellung von thiophenverbindungen |
| US4974609A (en) * | 1986-08-18 | 1990-12-04 | Philip Morris Incorporated | Tobacco flavorants |
| JP3398152B2 (ja) | 1993-10-12 | 2003-04-21 | ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー | １ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体 |
| DE19540737A1 (de) * | 1995-11-02 | 1997-05-07 | Bayer Ag | Substituierte Sulfonylamino(thio)carbonylverbindungen |
| WO1999024440A1 (en) * | 1997-11-11 | 1999-05-20 | Pfizer Products Inc. | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents |
| TW564247B (en) * | 1999-04-08 | 2003-12-01 | Akzo Nobel Nv | Bicyclic heteraromatic compound |
| CN101163706A (zh) | 2005-04-21 | 2008-04-16 | 贝林格尔·英格海姆国际有限公司 | 用于治疗炎性疾病的二氢噻吩并嘧啶 |
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| ES2383249T3 (es) | 2007-09-25 | 2012-06-19 | Actimis Pharmaceuticals, Inc. | Alquiltiopirimidinas como antagonistas de CRTH2 |
| CN104069112A (zh) | 2007-10-19 | 2014-10-01 | 贝林格尔.英格海姆国际有限公司 | 取代的哌啶子基-二氢噻吩并嘧啶 |
| CA2702524A1 (en) * | 2007-10-19 | 2009-04-23 | Boehringer Ingelheim International Gmbh | Heterocycle-substituted piperazino-dihydrothienopyrimidines |
-
2008
- 2008-10-15 MX MX2010003826A patent/MX2010003826A/es active IP Right Grant
- 2008-10-15 CN CN201310480418.2A patent/CN103497201A/zh active Pending
- 2008-10-15 NZ NZ592534A patent/NZ592534A/xx not_active IP Right Cessation
- 2008-10-15 BR BRPI0818671A patent/BRPI0818671A2/pt not_active IP Right Cessation
- 2008-10-15 RU RU2010119647/04A patent/RU2528340C2/ru not_active IP Right Cessation
- 2008-10-15 KR KR1020107010903A patent/KR20100095528A/ko not_active Ceased
- 2008-10-15 US US12/738,152 patent/US8653282B2/en active Active
- 2008-10-15 EP EP08840060.1A patent/EP2205608B1/en active Active
- 2008-10-15 PL PL08840060T patent/PL2205608T3/pl unknown
- 2008-10-15 CA CA2702500A patent/CA2702500A1/en not_active Abandoned
- 2008-10-15 AU AU2008312624A patent/AU2008312624B2/en not_active Ceased
- 2008-10-15 JP JP2010530073A patent/JP5538231B2/ja active Active
- 2008-10-15 WO PCT/US2008/079925 patent/WO2009052138A1/en not_active Ceased
- 2008-10-15 NZ NZ584962A patent/NZ584962A/en not_active IP Right Cessation
- 2008-10-15 ES ES08840060T patent/ES2424445T3/es active Active
- 2008-10-15 CN CN2008801215484A patent/CN101903394B/zh not_active Expired - Fee Related
- 2008-10-15 DK DK08840060.1T patent/DK2205608T3/da active
- 2008-10-17 TW TW097140018A patent/TW200918541A/zh unknown
- 2008-10-17 AR ARP080104562A patent/AR069077A1/es unknown
- 2008-10-17 CL CL2008003095A patent/CL2008003095A1/es unknown
-
2010
- 2010-04-06 IL IL204854A patent/IL204854A0/en unknown
- 2010-04-07 ZA ZA2010/02425A patent/ZA201002425B/en unknown
-
2012
- 2012-03-01 CL CL2012000560A patent/CL2012000560A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2012000560A1 (es) | 2012-09-14 |
| EP2205608A1 (en) | 2010-07-14 |
| NZ592534A (en) | 2013-03-28 |
| TW200918541A (en) | 2009-05-01 |
| CN103497201A (zh) | 2014-01-08 |
| ZA201002425B (en) | 2011-02-23 |
| JP5538231B2 (ja) | 2014-07-02 |
| BRPI0818671A2 (pt) | 2015-09-15 |
| CL2008003095A1 (es) | 2010-01-22 |
| WO2009052138A1 (en) | 2009-04-23 |
| AU2008312624B2 (en) | 2014-07-10 |
| EP2205608B1 (en) | 2013-05-08 |
| CN101903394A (zh) | 2010-12-01 |
| IL204854A0 (en) | 2010-11-30 |
| RU2010119647A (ru) | 2011-11-27 |
| KR20100095528A (ko) | 2010-08-31 |
| CN101903394B (zh) | 2013-12-25 |
| WO2009052138A8 (en) | 2012-11-15 |
| ES2424445T3 (es) | 2013-10-02 |
| US8653282B2 (en) | 2014-02-18 |
| NZ584962A (en) | 2011-07-29 |
| JP2011500701A (ja) | 2011-01-06 |
| AU2008312624A1 (en) | 2009-04-23 |
| US20100222585A1 (en) | 2010-09-02 |
| MX2010003826A (es) | 2010-04-21 |
| PL2205608T3 (pl) | 2013-09-30 |
| CA2702500A1 (en) | 2009-04-23 |
| AR069077A1 (es) | 2009-12-30 |
| RU2528340C2 (ru) | 2014-09-10 |
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