CL2010000657A1 - Composicion inmunogenica efectiva contra una infeccion por pcv2 que comprende al menos 0,2 ug de proteina recombinante orf2 de pcv2 (divisional solicitud 3475-05). - Google Patents

Composicion inmunogenica efectiva contra una infeccion por pcv2 que comprende al menos 0,2 ug de proteina recombinante orf2 de pcv2 (divisional solicitud 3475-05).

Info

Publication number
CL2010000657A1
CL2010000657A1 CL2010000657A CL2010000657A CL2010000657A1 CL 2010000657 A1 CL2010000657 A1 CL 2010000657A1 CL 2010000657 A CL2010000657 A CL 2010000657A CL 2010000657 A CL2010000657 A CL 2010000657A CL 2010000657 A1 CL2010000657 A1 CL 2010000657A1
Authority
CL
Chile
Prior art keywords
pcv2
immunogenic composition
infection
divisional application
composition against
Prior art date
Application number
CL2010000657A
Other languages
English (en)
Inventor
Mark Eichmeyer
Merrill Schaeffer
Greg Nitzel
Original Assignee
Boehringer Ingelheim Vetmedica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36615566&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2010000657(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Vetmedica Inc filed Critical Boehringer Ingelheim Vetmedica Inc
Publication of CL2010000657A1 publication Critical patent/CL2010000657A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14161—Methods of inactivation or attenuation
    • C12N2710/14163—Methods of inactivation or attenuation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Composición inmunogénica que comprende al menos 0,2 ug de proteína recombinante orf2 pcv2 por dosis y un adyuvante seleccionado de ácido acrílico, ácido metacrílico y cualquier polímero de los mismos (Div. Sol. 3475-05).
CL2010000657A 2004-12-30 2010-06-18 Composicion inmunogenica efectiva contra una infeccion por pcv2 que comprende al menos 0,2 ug de proteina recombinante orf2 de pcv2 (divisional solicitud 3475-05). CL2010000657A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64051004P 2004-12-30 2004-12-30
US11/034,797 US7833707B2 (en) 2004-12-30 2005-01-13 Methods of overexpression and recovery of porcine circovirus type 2 ORF2

Publications (1)

Publication Number Publication Date
CL2010000657A1 true CL2010000657A1 (es) 2010-10-15

Family

ID=36615566

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2010000657A CL2010000657A1 (es) 2004-12-30 2010-06-18 Composicion inmunogenica efectiva contra una infeccion por pcv2 que comprende al menos 0,2 ug de proteina recombinante orf2 de pcv2 (divisional solicitud 3475-05).
CL2010001146A CL2010001146A1 (es) 2004-12-30 2010-10-19 Proteina recombinante de circovirus porcino tipo 2 (pcv2); uso de la proteina recombinante para prevenir una infección por pcv2; un envase que comprende la composición inmunogénica (div exp 3475-2005).
CL2012002431A CL2012002431A1 (es) 2004-12-30 2012-08-31 Composición inmunogénica que comprende al menos 0,2 µg de proteína recombinante orf2 del circovirus porcino de tipo 2 (pcv2) por dosis y un adyuvante seleccionado de ácido acrílico, ácido metacrílico y cualquier polímero de los mismos, la cual es efectiva para disminuir los síntomas clínicos asociados con una infección pcv2.

Family Applications After (2)

Application Number Title Priority Date Filing Date
CL2010001146A CL2010001146A1 (es) 2004-12-30 2010-10-19 Proteina recombinante de circovirus porcino tipo 2 (pcv2); uso de la proteina recombinante para prevenir una infección por pcv2; un envase que comprende la composición inmunogénica (div exp 3475-2005).
CL2012002431A CL2012002431A1 (es) 2004-12-30 2012-08-31 Composición inmunogénica que comprende al menos 0,2 µg de proteína recombinante orf2 del circovirus porcino de tipo 2 (pcv2) por dosis y un adyuvante seleccionado de ácido acrílico, ácido metacrílico y cualquier polímero de los mismos, la cual es efectiva para disminuir los síntomas clínicos asociados con una infección pcv2.

Country Status (20)

Country Link
US (8) US7833707B2 (es)
EP (4) EP2460817B1 (es)
JP (3) JP5726395B2 (es)
KR (5) KR20130113544A (es)
CN (2) CN107602671B (es)
AR (1) AR051885A1 (es)
AU (1) AU2005321798B2 (es)
BR (1) BRPI0519783A2 (es)
CA (1) CA2592735C (es)
CL (3) CL2010000657A1 (es)
DK (2) DK2460820T3 (es)
MX (1) MX2007007983A (es)
MY (3) MY172287A (es)
PL (2) PL2281829T3 (es)
PT (1) PT1833992E (es)
RU (1) RU2435854C2 (es)
SG (2) SG192442A1 (es)
TW (3) TWI387647B (es)
WO (1) WO2006072065A2 (es)
ZA (1) ZA200706158B (es)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2772047B1 (fr) * 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
US7833707B2 (en) 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
RU2620968C9 (ru) 2004-12-30 2017-08-08 Берингер Ингельгейм Ветмедика, Инк. Иммуногенные композиции pcv2 и способы получения таких композиций
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
DK2275132T3 (da) 2005-12-29 2021-05-17 Boehringer Ingelheim Animal Health Usa Inc Multivalente pcv2-immunogeniske sammensætninger og fremgangsmåder til at fremstille dem
CA2635430A1 (en) 2005-12-29 2007-08-23 Boehringer Ingelheim Vetmedica, Inc. Use of a pcv2 immunogenic composition for lessening clinical symptoms in pigs
WO2008064299A2 (en) * 2006-11-22 2008-05-29 Boehringer Ingelheim Vetmedica, Inc. Methods of reducing porcine circovirus-associated disease outbreaks
WO2008073464A2 (en) 2006-12-11 2008-06-19 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
PT2094872T (pt) 2006-12-15 2017-04-27 Boehringer Ingelheim Vetmedica Inc Tratamento de porcos seropositivos para o anticorpo anti-pcv2 com antigénio de pcv2
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
US7829274B2 (en) * 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
US8138318B2 (en) * 2007-09-13 2012-03-20 Abbott Laboratories Hepatitis B pre-S2 nucleic acid
CN101932336B (zh) * 2007-12-31 2014-07-09 贝林格尔.英格海姆维特梅迪卡有限公司 有外来氨基酸插入的pcv2 orf2病毒样颗粒
KR20100113582A (ko) 2008-01-23 2010-10-21 베링거잉겔하임베트메디카인코퍼레이티드 Ｐｃｖ2 마이코플라즈마 히오뉴모니에 면역원성 조성물 및 당해 조성물의 생산 방법
EP2254595A4 (en) * 2008-02-15 2012-12-05 Boehringer Ingelheim Vetmed METHODS AND COMPOSITIONS FOR REDUCING THE IMPACT OF ENTERIC DISEASES
EP2291194B1 (en) * 2008-06-25 2017-02-22 Braasch Biotech LLC Compositions and methods for enhanced somatostatin immunogenicity
AU2008364200B2 (en) * 2008-11-19 2016-01-28 Laboratorio Avi-Mex, S.A. De C.V. Recombinant inactivated viral vector vaccine
TWI627281B (zh) * 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 降低ｐｃｖ－２組合物殺病毒活性之方法及具有改良免疫原性之ｐｃｖ－２組合物
KR20110090711A (ko) * 2010-02-04 2011-08-10 녹십자수의약품(주) 신규한 돼지 써코바이러스 타입 2 및 그의 용도
US9932372B2 (en) * 2010-07-08 2018-04-03 United Biomedical, Inc. Designer peptide-based PCV2 vaccine
CN101920012B (zh) * 2010-07-22 2012-12-12 普莱柯生物工程股份有限公司 利用家蚕生物反应器生产猪圆环病毒2型重组衣壳蛋白亚单位疫苗的方法及其产品
CN102115755A (zh) * 2010-10-11 2011-07-06 洛阳普莱柯生物工程有限公司 酵母表达猪圆环病毒2型orf2蛋白与亚单位疫苗
TWI670373B (zh) * 2011-02-08 2019-09-01 淡馬錫生命科學實驗室有限公司 用於有效率地表面呈示抗原蛋白質之新穎表現匣
CN102183650A (zh) * 2011-02-15 2011-09-14 武汉中博生物股份有限公司 猪圆环病毒2型elisa抗体检测试剂盒
WO2012170945A2 (en) 2011-06-10 2012-12-13 Isis Pharmaceuticals, Inc. Methods for modulating kallikrein (klkb1) expression
CN103102397A (zh) * 2011-11-09 2013-05-15 韩健宝 预防和治疗pcv-2病毒的肽核酸及其制剂
UA113192C2 (xx) 2011-12-06 2016-12-26 Імуногенна композиція проти цирковірусу свиней типу 2 (pcv2)
CN102517331A (zh) * 2011-12-26 2012-06-27 武汉中博生物股份有限公司 一种猪圆环病毒2型亚单位疫苗及其制备方法和其应用
CN103033622B (zh) * 2011-12-26 2015-03-25 武汉中博生物股份有限公司 猪圆环病毒2型elisa抗原检测试剂盒及其制备方法和其应用
WO2013104550A1 (de) * 2012-01-13 2013-07-18 Boehringer Ingelheim Vetmedica Gmbh Kit zur herstellung eines impfstoffs
US9474692B2 (en) 2012-01-13 2016-10-25 Boehringer Ingelheim Vetmedica Gmbh Kit for the preparation of a vaccinating agent
US9624527B2 (en) 2013-03-01 2017-04-18 Boehringer Ingelheim Vetmedica, Inc. Quantification of vaccine compositions
CN105246505A (zh) * 2013-04-30 2016-01-13 勃林格殷格翰动物保健公司 PCV2a亚型(PCV2a)的ORF2蛋白用于交叉保护中的用途
HUE060972T2 (hu) 2013-08-23 2023-05-28 Boehringer Ingelheim Animal Health Usa Inc 2-es típusú sertés cirkovírus (PCV) alegység vakcina
CA2925281C (en) 2013-09-25 2022-05-03 Zoetis Services Llc Pcv2b divergent vaccine composition and methods of use
ES2778425T3 (es) 2013-10-02 2020-08-10 Boehringer Ingelheim Animal Health Usa Inc Variante de la proteína ORF2 del PCV2 y partículas similares a virus compuestas por esta
PL3076996T3 (pl) * 2013-12-03 2020-05-18 Intervet International B.V. Szczepionka przeciwko cirkowirusowi świń typu 2
JP2014065741A (ja) * 2014-01-09 2014-04-17 Boehringer Ingelheim Vetmedica Inc ブタのｐｒｄｃの治療
TWI577802B (zh) * 2014-08-01 2017-04-11 豐茂生物科技有限公司 胞外分泌型豬環狀病毒重組外殼蛋白類病毒顆粒（ＰＣＶ２ Ｃａｐ ＶＬＰ），其製備方法及於次單位疫苗之應用
US9328147B2 (en) * 2014-09-05 2016-05-03 Chung Yuan Christian University Recombinant baculovirus vector and uses thereof
CN104388453B (zh) * 2014-11-14 2017-03-22 华中农业大学 一种猪圆环病毒cap蛋白嵌合猪瘟病毒B细胞表位的重组病毒及应用
AU2016226003B2 (en) 2015-03-05 2021-07-29 Boehringer Ingelheim Animal Health USA Inc. Marker system, in particular for baculovirus-expressed subunit antigens
US10555994B2 (en) 2015-03-30 2020-02-11 Boehringer Ingelheim Animal Health USA Inc. PCV2 ORF2 carrier platform
TWI737616B (zh) 2015-06-16 2021-09-01 德商百靈佳殷格翰維美迪加股份有限公司 容器系統、容器系統之用法、連接配置、容器及帽狀蓋罩裝置之用法
PL3310318T3 (pl) 2015-06-16 2025-12-08 Boehringer Ingelheim Vetmedica Gmbh System łączący i pojemników
UY40339A (es) 2015-06-16 2023-07-31 Boehringer Ingelheim Vetmedica Gmbh Sistema de conexión y de recipiente
CN105087606A (zh) * 2015-09-23 2015-11-25 天津瑞普生物技术股份有限公司 猪圆环病毒2型cap抗原制备方法
RU2744193C2 (ru) * 2015-10-16 2021-03-03 Канзас Стейт Юниверсити Рисерч Фаундейшн Иммуногенные композиции для иммунизации свиней против цирковируса типа 3 и способы их получения и применения
UA130511C2 (uk) 2016-11-03 2026-03-11 Бьорінгер Інгельхайм Ветмедіка Гмбх Вакцина проти свинячого парвовірусу й вірусу свинячого репродуктивного й респіраторного синдрому та спосіб її одержання
EP4570264A3 (en) 2016-11-03 2026-01-21 Boehringer Ingelheim Vetmedica GmbH Vaccine against porcine parvovirus
AR110370A1 (es) 2016-12-16 2019-03-20 Boehringer Ingelheim Vetmedica Gmbh Sistema de recipientes y método
CN107365362B (zh) * 2017-07-04 2021-02-05 武汉科前生物股份有限公司 一种大规模生产高纯度猪圆环病毒orf2蛋白的方法
EA202090228A1 (ru) 2017-07-11 2020-05-06 Бёрингер Ингельхайм Ветмедика Гмбх Система контейнеров
EP3661548B1 (en) 2017-08-03 2024-06-26 Intervet International B.V. A vaccine comprising a pcv2 orf2 protein of genotype 2b
BR112020002804A2 (pt) 2017-08-24 2020-07-28 Novo Nordisk A/S composição farmacêutica líquida, e, kit
CN107982528A (zh) * 2017-10-16 2018-05-04 北京生科基因科技有限公司 Pcv2重组杆状病毒样颗粒亚单位疫苗及制备方法
PL3697804T3 (pl) 2017-10-17 2024-01-03 Intervet International B.V. Rekombinowana ekspresja białka orf2 pcv2b w komórkach owadzich
CN119488586A (zh) 2018-03-26 2025-02-21 勃林格殷格翰动物保健美国有限公司 制备免疫原性组合物的方法
US20210393696A1 (en) * 2018-11-06 2021-12-23 Kansas State University Research Foundation Compositions for improving vaccine safety and efficacy and methods of use thereof
CN114222579A (zh) 2019-04-04 2022-03-22 勃林格殷格翰动物保健美国有限公司 猪圆环病毒3型（pcv3）疫苗及其生产和用途
WO2021033420A1 (ja) 2019-08-20 2021-02-25 株式会社ジェクタス・イノベーターズ ブタサーコウイルス２型ｖｌｐワクチン
IL294521A (en) 2020-02-18 2022-09-01 Novo Nordisk As glp-1 compounds and their uses
US20230241198A1 (en) 2020-07-24 2023-08-03 Boehringer Ingelheim Animal Health USA Inc. Combination porcine vaccine
EP4704977A1 (en) 2023-05-03 2026-03-11 Boehringer Ingelheim Vetmedica GmbH Immunogenic composition useful for self-administration by pigs
AR132582A1 (es) 2023-05-03 2025-07-16 Boehringer Ingelheim Vetmedica Gmbh Método para inducir una respuesta inmunitaria
WO2026099754A1 (en) 2024-11-06 2026-05-15 Boehringer Ingelheim Vetmedica Gmbh Method for reducing virus shedding, tissue colonization, and lymphoid depletion caused by or associated with pcv2 infection

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909462A (en) 1955-12-08 1959-10-20 Bristol Myers Co Acrylic acid polymer laxative compositions
US3479705A (en) 1966-12-15 1969-11-25 Miami Brick & Stone Inc Of Mia Molding apparatus
US5069901A (en) 1988-02-03 1991-12-03 Jones Elaine V Preparation of a recombinant subunit vaccine against pseudorabies infection
DE69027112T2 (de) 1989-01-23 1997-01-09 Auspharm International Ltd 4Th Impfstoffzusammensetzung
US5202430A (en) 1990-01-16 1993-04-13 University Of Tennessee Transmissible gastroenteritis virus genes
AU657907B2 (en) 1990-05-29 1995-03-30 Wyeth Holdings Corporation Mycoplasma hyopneumoniae vaccine
US5565205A (en) 1990-08-16 1996-10-15 Solvay Animal Health, Inc. Inactivated Mycoplasma hypopneumoniae bacterin and method of use thereof
GB9023111D0 (en) * 1990-10-24 1990-12-05 Wellcome Found Expression system
WO1992007934A1 (en) 1990-11-01 1992-05-14 Iowa State University Research Foundation, Inc. Bacterial attenuation method and vaccine
US6042830A (en) 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
US5580557A (en) * 1991-10-09 1996-12-03 Iowa State University Research Foundation, Inc. Live, avirulent salmonella choleraesuis vaccine used for inducing an immune response in animals
US5338543A (en) 1992-02-27 1994-08-16 Ambico, Inc. Thimerosal inactivated mycoplasma hyopneumoniae vaccine
EP1820512B1 (en) 1994-05-10 2013-07-03 Boehringer Ingelheim Vetmedica, Inc. Improved modified live brsv vaccine
US5885823A (en) 1995-06-05 1999-03-23 Nobl Laboratories, Inc. Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents
ES2157522T3 (es) * 1996-10-09 2001-08-16 Akzo Nobel Nv Cepas de vacunas europeas del virus del sindrome respiratorio reproductor porcino (prrsv).
UA78180C2 (uk) 1997-10-03 2007-03-15 Меріаль Кільцевий вірус свині типу ii, вакцини та діагностичні реагенти
FR2781159B1 (fr) * 1998-07-06 2000-10-06 Merial Sas Vaccin circovirus et parvovirus porcin
US6391314B1 (en) * 1997-10-03 2002-05-21 Merial Porcine circoviruses vaccines diagnostic reagents
US20060029617A1 (en) 1997-10-03 2006-02-09 Charreyre Catherine E Porcine circovirus and Helicobacter combination vaccines and methods of use
US7211379B2 (en) 1997-10-03 2007-05-01 Merial Sas Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2
US7192594B2 (en) 1997-10-03 2007-03-20 Merial Limited Postweaning multisystemic wasting syndrome and porcine circovirus from pigs
US6517843B1 (en) 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
US20040062775A1 (en) 1997-12-05 2004-04-01 Agence Francaise De Securite Sanitaire Des Aliments Circovirus sequences associated with piglet weight loss disease (PWD)
FR2772047B1 (fr) 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
JP3795751B2 (ja) * 1997-12-11 2006-07-12 ユニバーシティ オブ サスカッチェワン ブタからの離乳後多全身系消耗症候群ウイルス
WO1999045956A1 (en) 1998-03-13 1999-09-16 University Of Georgia Research Foundation, Inc. Vaccines against circovirus infections
US6294176B1 (en) * 1998-07-10 2001-09-25 Schering-Plough Veterinary Corp. Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species
EP1050584B1 (en) 1998-11-19 2006-10-18 Azwell Inc. Recombinant lysophosphatidic acid phosphatase
FR2789695B1 (fr) * 1999-02-11 2003-03-07 Merial Sas Vecteurs et vaccins viraux a base d'adenovirus porcins recombines et replicatifs
US6943152B1 (en) 1999-06-10 2005-09-13 Merial DNA vaccine-PCV
US6497883B1 (en) * 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
CA2376361A1 (en) 1999-08-19 2001-03-01 Genset S.A. Prostate cancer-related gene 3 (pg-3) and biallelic markers thereof
WO2001017556A1 (fr) 1999-09-07 2001-03-15 Shionogi & Co., Ltd. Préparations vaccinales administrables par les muqueuses
GB9921146D0 (en) 1999-09-07 1999-11-10 Smithkline Beecham Biolog Novel composition
GB9921147D0 (en) 1999-09-07 1999-11-10 Smithkline Beecham Biolog Novel composition
US6656478B1 (en) 1999-11-12 2003-12-02 Samuel D. Charles Cross-protective salmonella vaccines
DE60038048T2 (de) 1999-12-21 2009-07-09 Merial Mindestens ein cryptosporidium parvum-antigen und mindestens ein antigen eines anderen darmkrankheitserregers enthaltende zusammensetzungen und impfstoffe
US6808900B2 (en) 2000-06-15 2004-10-26 Manitoba, University Of Cryptosporidium parvum antigens, antibodies thereto and diagnostic and therapeutic compositions thereof
WO2001096377A2 (en) 2000-06-15 2001-12-20 Purdue Research Foundation Vaccine for congenital tremors in pigs
MY129765A (en) 2000-12-19 2007-04-30 Wyeth Corp Improved mycoplasma hyopneumoniae bacterin vaccine
US7018638B2 (en) * 2000-12-19 2006-03-28 Wyeth Mycoplasma hyopneumoniae bacterin vaccine
JP2002247979A (ja) * 2001-02-23 2002-09-03 Nippon Biologicals Inc マレック病ワクチンおよびその製造方法
MY146518A (en) 2001-03-27 2012-08-15 Univ Saskatchewan Methods to culture circovirus.
US20030096377A1 (en) 2001-06-28 2003-05-22 Virginia Tech Intellectual Properties, Inc. Differential PCR-RFLP assay for detecting and distinguishing between nonpathogenic PCV-1 and pathogenic PCV-2
JP2005515162A (ja) 2001-07-02 2005-05-26 ファイザー・プロダクツ・インク マイコプラズマ・ハイオニューモニエ（Ｍｙｃｏｐｌａｓｍａｈｙｏｐｎｅｕｍｏｎｉａｅ）を用いた単回ワクチン接種
US7361352B2 (en) 2001-08-15 2008-04-22 Acambis, Inc. Influenza immunogen and vaccine
US7279166B2 (en) 2001-12-12 2007-10-09 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US7276353B2 (en) 2001-12-12 2007-10-02 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US6841364B2 (en) * 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
WO2003077860A2 (en) 2002-03-13 2003-09-25 Biophysica, Inc. BOSWELLIN COMPOSITIONS ENHANCED WITH 3-β-ACETYL-11-KETO-β-BOSWELLIC ACID (“AKBA”), INDUSTRIAL MANUFACTURE AND THEIR USES
US20030215455A1 (en) 2002-05-14 2003-11-20 Bailey Reynolds Vaccine stabilizer and method of use
US7335362B2 (en) * 2002-07-19 2008-02-26 Beth Israel Deaconess Medical Center Methods of treating pre-eclampsia or eclampsia
US7223207B1 (en) 2002-09-13 2007-05-29 Simon Basyuk Exercise and massage device
AU2002951692A0 (en) 2002-09-23 2002-10-17 Vital Biotech (Hong Kong) Limited Improvements in or relating to vaccines
EP1599164B1 (en) 2003-02-03 2015-04-08 Cerebus Biologicals, Inc. Methods for treating, preventing and detecting helicobacter infection
US7563449B2 (en) 2003-04-21 2009-07-21 Pfizer Inc, Methods for reducing cattle reproductive diseases
CN1458167A (zh) * 2003-06-02 2003-11-26 中国农业科学院哈尔滨兽医研究所 截短表达的猪圆环病毒ⅱ型衣壳蛋白抗原及其应用
US7335361B2 (en) 2003-06-09 2008-02-26 Animal Technology Institute Taiwan Fusion antigen used as vaccine
PL1651265T3 (pl) 2003-07-24 2008-10-31 Merial Ltd Formulacje szczepionek zawierających emulsję olej w wodzie
CA2533559C (en) 2003-07-25 2013-07-02 Boehringer Ingelheim Vetmedica, Inc. Lawsonia intracellularis of european origin and vaccines, diagnostic agents and methods of use thereof
FR2861731B1 (fr) 2003-10-30 2006-02-24 Centre Nat Rech Scient Nouvelle proteine de fixation du phosphate, compositions pharmaceutiques la contenant et ses utilisations
CN1942204A (zh) 2004-04-26 2007-04-04 株式会社中央疫苗研究所 用于猪呼吸病的灭活混合疫苗及其制备方法
CN1579553A (zh) 2004-05-18 2005-02-16 浙江大学 Ii型猪圆环病毒核酸疫苗的制备方法及其应用
US7833707B2 (en) 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
US7700285B1 (en) * 2005-12-29 2010-04-20 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
CA2587321A1 (en) 2005-01-13 2006-07-20 Boehringer Ingelheim Vetmedica Gmbh Improved prrs vaccines
US7300785B2 (en) 2005-02-03 2007-11-27 Universiteit Ghent Culturing circular ssDNA viruses for the production of vaccines
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
MX2007012786A (es) * 2005-04-13 2008-01-11 Merial Ltd Ensayo para produccion de circovirus porcino.
US7691368B2 (en) 2005-04-15 2010-04-06 Merial Limited Vaccine formulations
CN101277717A (zh) 2005-09-09 2008-10-01 英特威国际有限公司 Pcv-2疫苗
CA2635430A1 (en) 2005-12-29 2007-08-23 Boehringer Ingelheim Vetmedica, Inc. Use of a pcv2 immunogenic composition for lessening clinical symptoms in pigs
DK2275132T3 (da) 2005-12-29 2021-05-17 Boehringer Ingelheim Animal Health Usa Inc Multivalente pcv2-immunogeniske sammensætninger og fremgangsmåder til at fremstille dem
WO2008064299A2 (en) 2006-11-22 2008-05-29 Boehringer Ingelheim Vetmedica, Inc. Methods of reducing porcine circovirus-associated disease outbreaks
PT2094872T (pt) 2006-12-15 2017-04-27 Boehringer Ingelheim Vetmedica Inc Tratamento de porcos seropositivos para o anticorpo anti-pcv2 com antigénio de pcv2
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) * 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
GB0712160D0 (en) 2007-06-22 2007-08-01 Univ Ghent Methods and compositions in the treatment of procine circoviral infection
US20090017064A1 (en) 2007-07-10 2009-01-15 Wyeth Methods and Compositions for Immunizing Pigs Against Porcine Circovirus
US7829274B2 (en) 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
EP2254595A4 (en) 2008-02-15 2012-12-05 Boehringer Ingelheim Vetmed METHODS AND COMPOSITIONS FOR REDUCING THE IMPACT OF ENTERIC DISEASES
TWI627281B (zh) 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 降低ｐｃｖ－２組合物殺病毒活性之方法及具有改良免疫原性之ｐｃｖ－２組合物
HUE047972T2 (hu) 2010-03-16 2020-05-28 Virginia Tech Intellectual Properties Inc Gyengített, élõ kiméra sertés cirkovírus vakcina
CN103122352B (zh) 2012-09-27 2015-02-11 华中农业大学 一种猪圆环病毒2型重组杆状病毒及制备方法和应用

Also Published As

Publication number Publication date
ZA200706158B (en) 2008-12-31
WO2006072065A3 (en) 2006-12-07
TWI387647B (zh) 2013-03-01
KR20140120944A (ko) 2014-10-14
JP5726395B2 (ja) 2015-05-27
EP2281829A3 (en) 2011-05-04
US7829101B2 (en) 2010-11-09
TWI582231B (zh) 2017-05-11
KR101629360B1 (ko) 2016-06-13
US8025888B2 (en) 2011-09-27
KR101798838B1 (ko) 2017-11-17
PT1833992E (pt) 2015-06-05
US9011872B2 (en) 2015-04-21
US20110274710A1 (en) 2011-11-10
CA2592735C (en) 2017-02-14
US20090016992A1 (en) 2009-01-15
AU2005321798A1 (en) 2006-07-06
EP2460816A2 (en) 2012-06-06
EP2460817A3 (en) 2013-01-09
DK2460820T3 (da) 2019-07-15
US20090022749A1 (en) 2009-01-22
SG158188A1 (en) 2010-01-29
JP2012016357A (ja) 2012-01-26
CL2012002431A1 (es) 2012-12-14
MY172287A (en) 2019-11-20
KR20130113544A (ko) 2013-10-15
TW200634152A (en) 2006-10-01
EP2281829A2 (en) 2011-02-09
JP5701191B2 (ja) 2015-04-15
MY147801A (en) 2013-01-31
AU2005321798B2 (en) 2012-03-15
KR20080005911A (ko) 2008-01-15
US20130101621A1 (en) 2013-04-25
TW201300531A (zh) 2013-01-01
EP1833992B1 (en) 2015-03-04
MY174830A (en) 2020-05-18
EP1833992A2 (en) 2007-09-19
WO2006072065A2 (en) 2006-07-06
US7833707B2 (en) 2010-11-16
CN107602671B (zh) 2021-11-16
US7910306B2 (en) 2011-03-22
US20090022750A1 (en) 2009-01-22
TWI479021B (zh) 2015-04-01
RU2007128943A (ru) 2009-02-10
EP1833992A4 (en) 2010-01-20
JP2015091264A (ja) 2015-05-14
PL2281829T3 (pl) 2015-05-29
EP2460817A2 (en) 2012-06-06
CN107602671A (zh) 2018-01-19
US20090022751A1 (en) 2009-01-22
JP2008526212A (ja) 2008-07-24
AR051885A1 (es) 2007-02-14
US20090042245A1 (en) 2009-02-12
EP2281829B1 (en) 2014-12-17
PL1833992T3 (pl) 2015-07-31
US20090022752A1 (en) 2009-01-22
BRPI0519783A2 (pt) 2009-03-17
CA2592735A1 (en) 2006-07-06
CN101180406A (zh) 2008-05-14
TW201510219A (zh) 2015-03-16
CN101180406B (zh) 2013-06-19
EP2460817B1 (en) 2017-03-29
KR20150085134A (ko) 2015-07-22
DK2460817T3 (en) 2017-07-03
CL2010001146A1 (es) 2011-03-18
KR20130024978A (ko) 2013-03-08
SG192442A1 (en) 2013-08-30
EP2460816A3 (en) 2014-01-01
MX2007007983A (es) 2007-11-09
RU2435854C2 (ru) 2011-12-10

Similar Documents

Publication Publication Date Title
CL2012002431A1 (es) Composición inmunogénica que comprende al menos 0,2 µg de proteína recombinante orf2 del circovirus porcino de tipo 2 (pcv2) por dosis y un adyuvante seleccionado de ácido acrílico, ácido metacrílico y cualquier polímero de los mismos, la cual es efectiva para disminuir los síntomas clínicos asociados con una infección pcv2.
RU2384580C2 (ru) Ингибиторы фосфатидилинозитол-3-киназы
CY1120347T1 (el) Εμβολιο ιου ερπητα ζωστηρα
EA200800413A1 (ru) Новые макроциклические ингибиторы репликации вируса гепатита с
BR9911870A (pt) Vacina de parvovìrus e circovìrus de suìno
MXPA02012443A (es) Profarmaco en 3'' de 2'-desoxi-beta-l-nucleosidos.
EA200970013A1 (ru) Вакцинация против гриппа по схеме многократного введения с использованием безадъювантной дозы
UY26724A1 (es) Métodos y composiciones para tratar el virus de la hepatitis c
CR10101A (es) Nueva composición
MX2007004783A (es) Inhibidores de la proteasa del virus de la hepatitis c, y composiciones y tratamientos que los usan.
BR0204470A (pt) Uso de flavivirus para a expressão de epitopos de proteìna e para o desenvolvimento de um novo virus vacinal vivo atenuado para imunização contra flavivirus e outros agentes infecciosos
PT1187629E (pt) Composicao adjuvante que compreende saponina e um oligonucleotido imunoestimulador
BRPI0214794B8 (pt) sistema para melhorar a saúde da pele de usuários de artigo absorvente.
MA30716B1 (fr) Vaccin
BRPI0418251B8 (pt) fosfonatos, monofosfonamidatos, bisfosfonamidatos, e, composição farmacêutica os compreendendo
DE60236541D1 (de) Inhibitoren von 11-beta-hydroxysteroiddehydrogenase typ 1
WO2001089559A3 (en) Porcine reproductive and respiratory syndrome virus (prrsv) recombinant avipoxvirus vaccine
MY152149A (en) Prevention and treatment of sub-clinical pcvd
MXPA05012827A (es) Composiciones y metodo para el tratamiento de infecciones en ganado vacuno y porcino.
ECSP024257A (es) Proteinas antigenas del virus de la enfermedad de la mancha blanca en el camaron y usos de las mismas
JP2015091835A (ja) シリコーンハイドロゲルコンタクトレンズ用眼科組成物
NZ592713A (en) Adjuvanted influenza vaccines including a cytokine-inducing agents other than an agonist of Toll-Like Receptor 9
ATE341319T1 (de) Esmolol-enthaltende zubereitungen
AR031679A1 (es) Una composicion farmaceutica
TW200509863A (en) Irradiation device for medical use