CL2011002206A1 - Compuestos derivados de benzofurano sustituidos, moduladores del señalador igf1 o activador de la proteina quinasa b; composicion farmaceutica que los comprende; utiles en el tratamiento de enfermedades del snc, tales como alzheimer, entre otras. - Google Patents

Compuestos derivados de benzofurano sustituidos, moduladores del señalador igf1 o activador de la proteina quinasa b; composicion farmaceutica que los comprende; utiles en el tratamiento de enfermedades del snc, tales como alzheimer, entre otras.

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Publication number
CL2011002206A1
CL2011002206A1 CL2011002206A CL2011002206A CL2011002206A1 CL 2011002206 A1 CL2011002206 A1 CL 2011002206A1 CL 2011002206 A CL2011002206 A CL 2011002206A CL 2011002206 A CL2011002206 A CL 2011002206A CL 2011002206 A1 CL2011002206 A1 CL 2011002206A1
Authority
CL
Chile
Prior art keywords
alzheimer
pharmaceutical composition
cns
modulators
activator
Prior art date
Application number
CL2011002206A
Other languages
English (en)
Inventor
Tetsuya Tsukamoto
Takeshi Wakabayashi
Taiichi Ohra
Original Assignee
Takeda Pharmaceuticals Co
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Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of CL2011002206A1 publication Critical patent/CL2011002206A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

Compuestos derivados de 5-piperazin-benzofurano; composición farmacéutica; método de tratamiento; y su uso para prevenir o tratar una enfermedad del sistema nervioso central, tal como la enfermedad de Alzheimer.
CL2011002206A 2009-03-10 2011-09-08 Compuestos derivados de benzofurano sustituidos, moduladores del señalador igf1 o activador de la proteina quinasa b; composicion farmaceutica que los comprende; utiles en el tratamiento de enfermedades del snc, tales como alzheimer, entre otras. CL2011002206A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009056719 2009-03-10

Publications (1)

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CL2011002206A1 true CL2011002206A1 (es) 2012-02-03

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CL2011002206A CL2011002206A1 (es) 2009-03-10 2011-09-08 Compuestos derivados de benzofurano sustituidos, moduladores del señalador igf1 o activador de la proteina quinasa b; composicion farmaceutica que los comprende; utiles en el tratamiento de enfermedades del snc, tales como alzheimer, entre otras.

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US (4) US8957069B2 (es)
EP (2) EP2406243B1 (es)
JP (2) JP5746631B2 (es)
KR (1) KR20110128913A (es)
CN (2) CN103965147B (es)
AR (1) AR076098A1 (es)
AU (1) AU2010221979A1 (es)
BR (1) BRPI1009252A2 (es)
CA (1) CA2754904A1 (es)
CL (1) CL2011002206A1 (es)
CO (1) CO6420340A2 (es)
CR (1) CR20110474A (es)
CY (1) CY1115469T1 (es)
DK (1) DK2406243T3 (es)
DO (1) DOP2011000281A (es)
EA (1) EA201171020A1 (es)
EC (1) ECSP11011318A (es)
ES (1) ES2487616T3 (es)
HK (1) HK1202293A1 (es)
HR (1) HRP20140687T1 (es)
IL (1) IL214667A0 (es)
MA (1) MA33159B1 (es)
MX (1) MX2011009394A (es)
NZ (1) NZ594847A (es)
PE (1) PE20120357A1 (es)
PL (1) PL2406243T3 (es)
PT (1) PT2406243E (es)
RS (1) RS53416B (es)
SG (1) SG173757A1 (es)
SI (1) SI2406243T1 (es)
SM (1) SMT201500027B (es)
TN (1) TN2011000422A1 (es)
TW (1) TWI477497B (es)
UA (1) UA107657C2 (es)
UY (1) UY32481A (es)
WO (1) WO2010104194A1 (es)
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WO2018235926A1 (ja) 2017-06-23 2018-12-27 協和発酵キリン株式会社 α、β不飽和アミド化合物
CN109580790A (zh) * 2017-09-28 2019-04-05 安徽省庆云医药股份有限公司 一种液相色谱法分离测定西洛多辛及其光学异构体的方法
CN108530405A (zh) * 2018-05-08 2018-09-14 南京晓庄学院 非金属路易斯酸催化烯烃分子内加成c-o键合成苯并呋喃衍生物的方法
CN109879839B (zh) * 2019-03-12 2023-04-25 沈阳大学 6-哌嗪甲基-7-羟基苯并呋喃类化合物及其医药用途
CN113045523B (zh) * 2019-12-27 2022-09-23 上海泓博智源医药股份有限公司 一种咪唑啉吡啶化合物中间体的制备方法
PY2121402A (es) * 2020-03-16 2022-08-09 Norvatis Ag Derivados de biarilo como inhibidores de la interacción proteína-proteína de yap/taz-tead
CN111362965B (zh) * 2020-04-27 2022-05-03 梯尔希（南京）药物研发有限公司 一种莫西菌素杂质的制备方法
CN113219085B (zh) * 2021-03-31 2022-05-13 河北国龙制药有限公司 一种2,3-二甲基溴苯有关物质的检测方法
CN113214205B (zh) * 2021-04-09 2022-06-10 南方海洋科学与工程广东省实验室(湛江) 一种色原酮衍生物的制备方法
CN115260136B (zh) * 2022-08-09 2023-08-15 嘉兴学院 一种苯酞类化合物及其制备方法
CN115724721A (zh) * 2022-12-19 2023-03-03 山东京博石油化工有限公司 一种2-取代基-4-溴苯酚的制备方法

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EP2781513A1 (en) 2014-09-24
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