ES2487616T3 - Derivados de benzofurano - Google Patents

Derivados de benzofurano Download PDF

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ES2487616T3
ES2487616T3 ES10710111.5T ES10710111T ES2487616T3 ES 2487616 T3 ES2487616 T3 ES 2487616T3 ES 10710111 T ES10710111 T ES 10710111T ES 2487616 T3 ES2487616 T3 ES 2487616T3
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alkyl
substituted
atom
formula
alkoxy
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Tetsuya Tsukamoto
Takeshi Wakabayashi
Taiichi Ohra
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Takeda Pharmaceutical Co Ltd
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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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Abstract

Compuesto representado por la siguiente Formula (I):**Fórmula** en el que la formula estructural parcial:**Fórmula** de la formula (I) es una de las siguientes formulas:**Fórmula** donde: R8 es: (1) arilo C8_14 que puede sustituirse con 1 a 3 sustituyentes seleccionados de (i) un atomo de halógeno; (ii) alcoxi C1.6 que puede sustituirse con un atomo de halógeno; (iii) alquilo Ci que puede sustituirse con un sustituyente seleccionado de un atomo de halogeno, hidroxi, amino y di(alquilo C1.6)amino; (iv) alquiltio C1.6; (v) alquilsulfonilo Cis; (vi) ciano; (vii) carbamoilo; (viii) alquilsulfinilo C1.6 y (ix) alquilcarbonilo C1.6; o (2) un anillo heterociclico aromatic° de 5 a 10 elementos que contiene de 1 a 4 heteroatomos seleccionados de un atomo de nitrogeno, un atomo de azufre y un atomo de oxIgeno, aparte de un atomo de carbono y que puede sustituirse con 1 a 3 sustituyentes seleccionados de un atomo de halogeno, alquilo C1-e, alcoxi C1.6 y fenilo que puede sustituirse con alcoxi C1-6; es un solo enlace; Ri es un atom° de hidrOgeno o alquilo C1-6 que puede sustituirse con un hidroxi; R2 es: (1) un atom° de hidógeno; o (2) alquilo C1-6 que puede sustituirse con un sustituyente seleccionado de un hidroxi, amino, di(alquilo C1.6) amino, (alquilo Ci.6)(bencipamino, mono(alquilo C1.6)amino, di-benzylamino, alquilo C1.6-carbonilamino, formiloxi, alquilsulfoniloxi C1-8, ciano, carboxi, mono(alquilo C1-6)carbamoilo, alcoxi C1-8 que puede sustituirse con un sustituyente seleccionado de alcoxi C1_6 y fenilo, alquiltio Ci.c, alquilsulfonilo C1-8, morfolina, 1,1-dioxidotiomorfolina, pirazolil, imidazolil sustituido con alquilo Ci.6, pirrolidinilo, piperidinilo sustituido con oxo o hidroxi y 1,4-dioxa-8- azaspiro[4,5]deca-8-il; o IR, y R2forman un anillo ciclopentano o un anillo tetrahidropirano junto con un atom° de carbon° adyacente; R3 es un atom° de hidrOgeno; R4 as tin atom° de hidrogeno;

Description

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Claims (1)

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ES10710111.5T 2009-03-10 2010-03-09 Derivados de benzofurano Active ES2487616T3 (es)

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JP2009056719 2009-03-10
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