CL2012001938A1 - Compuestos derivados de oxazol sustituidos, como inhibidores potentes y selectivos de flt-3 y/o inhibidores de syk; composicion farmaceutica que los comprende; y uso en el tratamiento de las malignidades hematologicas, trastorno mieloproliferativo, otros trastornos proliferativos, autoinmunes, entre otros. - Google Patents
Compuestos derivados de oxazol sustituidos, como inhibidores potentes y selectivos de flt-3 y/o inhibidores de syk; composicion farmaceutica que los comprende; y uso en el tratamiento de las malignidades hematologicas, trastorno mieloproliferativo, otros trastornos proliferativos, autoinmunes, entre otros.Info
- Publication number
- CL2012001938A1 CL2012001938A1 CL2012001938A CL2012001938A CL2012001938A1 CL 2012001938 A1 CL2012001938 A1 CL 2012001938A1 CL 2012001938 A CL2012001938 A CL 2012001938A CL 2012001938 A CL2012001938 A CL 2012001938A CL 2012001938 A1 CL2012001938 A1 CL 2012001938A1
- Authority
- CL
- Chile
- Prior art keywords
- inhibitors
- flt
- autoimmune
- potent
- treatment
- Prior art date
Links
- 208000002250 Hematologic Neoplasms Diseases 0.000 title 1
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 title 1
- 208000014767 Myeloproliferative disease Diseases 0.000 title 1
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 title 1
- 229940124639 Selective inhibitor Drugs 0.000 title 1
- 230000001363 autoimmune Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000002916 oxazoles Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000003389 potentiating effect Effects 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29422610P | 2010-01-12 | 2010-01-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2012001938A1 true CL2012001938A1 (es) | 2014-03-07 |
Family
ID=43827464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012001938A CL2012001938A1 (es) | 2010-01-12 | 2012-07-11 | Compuestos derivados de oxazol sustituidos, como inhibidores potentes y selectivos de flt-3 y/o inhibidores de syk; composicion farmaceutica que los comprende; y uso en el tratamiento de las malignidades hematologicas, trastorno mieloproliferativo, otros trastornos proliferativos, autoinmunes, entre otros. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8962665B2 (es) |
| EP (1) | EP2523952B1 (es) |
| JP (1) | JP5734313B2 (es) |
| KR (1) | KR101750125B1 (es) |
| CN (1) | CN102812022B (es) |
| AR (1) | AR079993A1 (es) |
| AU (1) | AU2011206621B2 (es) |
| CA (1) | CA2786800C (es) |
| CL (1) | CL2012001938A1 (es) |
| EA (1) | EA022188B1 (es) |
| ES (1) | ES2539170T3 (es) |
| IL (1) | IL220863A (es) |
| MX (1) | MX2012008083A (es) |
| NZ (1) | NZ601143A (es) |
| SG (1) | SG182480A1 (es) |
| TW (1) | TWI523852B (es) |
| WO (1) | WO2011086085A1 (es) |
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| EP2411395B1 (en) | 2009-03-23 | 2013-05-29 | Glenmark Pharmaceuticals S.A. | Furopyrimidinedione derivatives as trpa1 modulators |
| EP2512246B1 (en) | 2009-12-17 | 2015-09-30 | Merck Sharp & Dohme Corp. | Aminopyrimidines as syk inhibitors |
| KR101445012B1 (ko) * | 2009-12-17 | 2014-09-26 | 머크 샤프 앤드 돔 코포레이션 | Ｓｙｋ 억제제로서의 아미노피리미딘 |
| EP2634176A4 (en) * | 2010-10-28 | 2014-04-16 | Nippon Shinyaku Co Ltd | PYRIDINE DERIVATIVE AND MEDICINAL AGENT |
| JP5934782B2 (ja) | 2011-05-04 | 2016-06-15 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | アミノ−ピリジン含有脾臓チロシンキナーゼ（Ｓｙｋ）阻害薬 |
| CA2834062A1 (en) | 2011-05-10 | 2012-11-15 | Merck Sharp & Dohme Corp. | Pyridyl aminopyridines as syk inhibitors |
| US9145391B2 (en) | 2011-05-10 | 2015-09-29 | Merck Sharp & Dohme Corp. | Bipyridylaminopyridines as Syk inhibitors |
| EP2706853B1 (en) | 2011-05-10 | 2017-06-14 | Merck Sharp & Dohme Corp. | Aminopyrimidines as syk inhibitors |
| GB201202027D0 (en) * | 2012-02-06 | 2012-03-21 | Sareum Ltd | Pharmaceutical compounds |
| US9096579B2 (en) | 2012-04-20 | 2015-08-04 | Boehringer Ingelheim International Gmbh | Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments |
| KR20150087400A (ko) | 2012-11-20 | 2015-07-29 | 버텍스 파마슈티칼스 인코포레이티드 | 인돌아민 2,3-디옥시게나제의 억제제로서 유용한 화합물 |
| NZ746607A (en) | 2012-11-21 | 2019-11-29 | Ptc Therapeutics Inc | Substituted reverse pyrimidine bmi-1 inhibitors |
| EP2931281B1 (en) | 2012-12-12 | 2018-01-17 | Merck Sharp & Dohme Corp. | Amino-pyrimidine-containing spleen tyrosine kinase inhibitors |
| EP2934525B1 (en) | 2012-12-21 | 2019-05-08 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors |
| EP2988749B1 (en) | 2013-04-26 | 2019-08-14 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors |
| WO2014176210A1 (en) | 2013-04-26 | 2014-10-30 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
| CN103387569B (zh) * | 2013-07-16 | 2014-09-24 | 浙江医药高等专科学校 | 一类抗肿瘤化合物、其制备方法和用途 |
| CN103420993B (zh) * | 2013-07-16 | 2014-12-17 | 浙江医药高等专科学校 | 含噻吩取代的化合物、其制备方法和用途 |
| CN103387568B (zh) * | 2013-07-16 | 2014-11-05 | 浙江医药高等专科学校 | 一类化合物、其制备方法和用途 |
| CN103396400B (zh) * | 2013-07-16 | 2014-12-17 | 浙江医药高等专科学校 | 含吡唑酰胺类化合物、其制备方法和用途 |
| CN103382198B (zh) * | 2013-07-16 | 2014-11-19 | 浙江医药高等专科学校 | 吡唑酰胺类化合物、其制备方法和用途 |
| CN103382202B (zh) * | 2013-07-16 | 2014-11-26 | 浙江医药高等专科学校 | 含呋喃取代的化合物、其制备方法和用途 |
| EA034866B1 (ru) | 2013-08-30 | 2020-03-31 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Замещенные пиримидиновые ингибиторы bmi-1 |
| CN104458671A (zh) * | 2013-09-12 | 2015-03-25 | 中国药科大学 | 一种筛选原肌球蛋白相关激酶b抑制剂高通量筛选方法 |
| CN104458676A (zh) * | 2013-09-12 | 2015-03-25 | 中国药科大学 | 一种筛选淋巴细胞特异性激酶抑制剂高通量筛选方法 |
| WO2015076800A1 (en) | 2013-11-21 | 2015-05-28 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine bmi-1 inhibitors |
| WO2015094997A1 (en) * | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
| US9822107B2 (en) | 2013-12-20 | 2017-11-21 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
| WO2015095444A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
| WO2015138273A1 (en) | 2014-03-13 | 2015-09-17 | Merck Sharp & Dohme Corp. | 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors |
| US10053455B2 (en) * | 2014-03-24 | 2018-08-21 | Ab Science | Diazaspiroalkaneone-substituted oxazole derivatives as spleen tyrosine kinase inhibitors |
| ES2796276T3 (es) * | 2015-02-05 | 2020-11-26 | Ab Science | Compuestos con actividad antitumoral |
| EP3144307A1 (en) * | 2015-09-18 | 2017-03-22 | AB Science | Novel oxazole derivatives that inhibit syk |
| WO2018195155A1 (en) | 2017-04-18 | 2018-10-25 | Celgene Quanticel Research, Inc. | Therapeutic compounds |
| CN109666028B (zh) * | 2017-10-16 | 2021-10-12 | 苏州大学 | 具有刺猬通路拮抗剂活性的1,3,4-噻二唑杂环化合物 |
| EP3836932A2 (en) | 2018-08-17 | 2021-06-23 | PTC Therapeutics, Inc. | Method for treating pancreatic cancer |
| JP7615056B2 (ja) * | 2019-02-19 | 2025-01-16 | スーチュアン・コールン－バイオテック・バイオファーマシューティカル・カンパニー・リミテッド | 複素環化合物、これを含む薬物組成物、その製造方法および使用 |
| EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
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| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| US7361665B2 (en) * | 2002-07-09 | 2008-04-22 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases |
| AU2003262642B2 (en) | 2002-08-14 | 2010-06-17 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors and uses thereof |
| EP1539754A4 (en) | 2002-08-23 | 2009-02-25 | Novartis Vaccines & Diagnostic | BENZIMIDAZOCHINOLINONE AND ITS USE |
| EP1566379A4 (en) | 2002-10-29 | 2005-11-09 | Kirin Brewery | CHINOLINE DERIVATIVES AND CHINAZOLINE DERIVATIVES AS INHIBITORS OF FLT3 AUTOPHOSPHORYLATION AND THE MEDICAL COMPOSITIONS CONTAINING THEREOF |
| SG148864A1 (en) | 2002-11-13 | 2009-01-29 | Chiron Corp | Methods of treating cancer and related methods |
| TWI335913B (en) | 2002-11-15 | 2011-01-11 | Vertex Pharma | Diaminotriazoles useful as inhibitors of protein kinases |
| DE60326646D1 (de) | 2002-12-18 | 2009-04-23 | Vertex Pharma | Benzisoxazolderivate, die sich als inhibitoren von proteinkinasen eigen |
| ZA200707227B (en) * | 2005-02-28 | 2009-08-26 | Japan Tobacco Inc | Novel aminopyridine compound with syk inhibitory activity |
| BRPI0607062A2 (pt) * | 2005-02-28 | 2009-08-04 | Japan Tobacco Inc | composto de aminopiridina com atividade inibidora de syk, composição farmacêutica e agente terapêutico compreendendo os mesmos |
| US20080015193A1 (en) * | 2006-06-20 | 2008-01-17 | Mendoza Jose S | Certain azoles exhibiting ATP-utilizing enzyme inhibitory activity, compositions, and uses thereof |
| US20100016300A1 (en) | 2006-08-02 | 2010-01-21 | Ajami Alfred M | Imidazoacridine Compounds for Treating FLT3-Mediated Disorders |
| WO2009076140A1 (en) * | 2007-12-13 | 2009-06-18 | Smithkline Beecham Corporation | Thiazole and oxazole kinase inhibitors |
| KR101445012B1 (ko) | 2009-12-17 | 2014-09-26 | 머크 샤프 앤드 돔 코포레이션 | Ｓｙｋ 억제제로서의 아미노피리미딘 |
-
2011
- 2011-01-12 ES ES11702802.7T patent/ES2539170T3/es active Active
- 2011-01-12 JP JP2012548414A patent/JP5734313B2/ja not_active Expired - Fee Related
- 2011-01-12 TW TW100101108A patent/TWI523852B/zh not_active IP Right Cessation
- 2011-01-12 SG SG2012051249A patent/SG182480A1/en unknown
- 2011-01-12 CN CN201180013642.XA patent/CN102812022B/zh not_active Expired - Fee Related
- 2011-01-12 AR ARP110100088A patent/AR079993A1/es unknown
- 2011-01-12 EA EA201290600A patent/EA022188B1/ru not_active IP Right Cessation
- 2011-01-12 AU AU2011206621A patent/AU2011206621B2/en not_active Ceased
- 2011-01-12 US US13/521,676 patent/US8962665B2/en active Active
- 2011-01-12 EP EP11702802.7A patent/EP2523952B1/en active Active
- 2011-01-12 WO PCT/EP2011/050312 patent/WO2011086085A1/en not_active Ceased
- 2011-01-12 MX MX2012008083A patent/MX2012008083A/es active IP Right Grant
- 2011-01-12 KR KR1020127018016A patent/KR101750125B1/ko not_active Expired - Fee Related
- 2011-01-12 NZ NZ601143A patent/NZ601143A/en not_active IP Right Cessation
- 2011-01-12 CA CA2786800A patent/CA2786800C/en not_active Expired - Fee Related
-
2012
- 2012-07-10 IL IL220863A patent/IL220863A/en not_active IP Right Cessation
- 2012-07-11 CL CL2012001938A patent/CL2012001938A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2539170T3 (es) | 2015-06-26 |
| US20130035331A1 (en) | 2013-02-07 |
| EP2523952A1 (en) | 2012-11-21 |
| JP5734313B2 (ja) | 2015-06-17 |
| IL220863A (en) | 2017-11-30 |
| TWI523852B (zh) | 2016-03-01 |
| AU2011206621A1 (en) | 2012-08-02 |
| HK1177205A1 (en) | 2013-08-16 |
| CA2786800A1 (en) | 2011-07-21 |
| EP2523952B1 (en) | 2015-03-04 |
| AR079993A1 (es) | 2012-03-07 |
| US8962665B2 (en) | 2015-02-24 |
| CN102812022A (zh) | 2012-12-05 |
| EA022188B1 (ru) | 2015-11-30 |
| KR20120115515A (ko) | 2012-10-18 |
| TW201132635A (en) | 2011-10-01 |
| MX2012008083A (es) | 2012-08-15 |
| KR101750125B1 (ko) | 2017-06-22 |
| SG182480A1 (en) | 2012-08-30 |
| CA2786800C (en) | 2018-02-27 |
| WO2011086085A1 (en) | 2011-07-21 |
| EA201290600A1 (ru) | 2013-01-30 |
| JP2013517244A (ja) | 2013-05-16 |
| NZ601143A (en) | 2014-10-31 |
| CN102812022B (zh) | 2016-02-03 |
| AU2011206621B2 (en) | 2016-04-14 |
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