CL2014001060A1 - Compuestos derivados de aril-quinolina; proceso de obtencion; composicion farmaceutica que los comprende y uso en el tratamiento o profilaxis de la diabetes tipo 2, la aterosclerosis, cancer, entre otras enfermedades. - Google Patents
Compuestos derivados de aril-quinolina; proceso de obtencion; composicion farmaceutica que los comprende y uso en el tratamiento o profilaxis de la diabetes tipo 2, la aterosclerosis, cancer, entre otras enfermedades.Info
- Publication number
- CL2014001060A1 CL2014001060A1 CL2014001060A CL2014001060A CL2014001060A1 CL 2014001060 A1 CL2014001060 A1 CL 2014001060A1 CL 2014001060 A CL2014001060 A CL 2014001060A CL 2014001060 A CL2014001060 A CL 2014001060A CL 2014001060 A1 CL2014001060 A1 CL 2014001060A1
- Authority
- CL
- Chile
- Prior art keywords
- prophylaxis
- atherosclerosis
- diabetes
- cancer
- diseases
- Prior art date
Links
- 201000001320 Atherosclerosis Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- -1 aryl quinoline Chemical compound 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 title 1
- 238000011282 treatment Methods 0.000 title 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11187967 | 2011-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014001060A1 true CL2014001060A1 (es) | 2014-11-07 |
Family
ID=47115939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014001060A CL2014001060A1 (es) | 2011-11-04 | 2014-04-25 | Compuestos derivados de aril-quinolina; proceso de obtencion; composicion farmaceutica que los comprende y uso en el tratamiento o profilaxis de la diabetes tipo 2, la aterosclerosis, cancer, entre otras enfermedades. |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9199938B2 (es) |
| EP (1) | EP2773619B1 (es) |
| JP (1) | JP6170060B2 (es) |
| KR (1) | KR20140088194A (es) |
| CN (1) | CN103906735B (es) |
| AR (1) | AR088625A1 (es) |
| AU (1) | AU2012331289B2 (es) |
| BR (1) | BR112014010644A2 (es) |
| CA (1) | CA2849945A1 (es) |
| CL (1) | CL2014001060A1 (es) |
| CO (1) | CO6930359A2 (es) |
| CR (1) | CR20140135A (es) |
| EA (1) | EA201490846A1 (es) |
| ES (1) | ES2609773T3 (es) |
| IL (1) | IL231950B (es) |
| MX (1) | MX343893B (es) |
| MY (1) | MY169267A (es) |
| PE (1) | PE20142282A1 (es) |
| PH (1) | PH12014500814A1 (es) |
| SG (1) | SG11201401937YA (es) |
| TW (1) | TWI616437B (es) |
| WO (1) | WO2013064465A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103906735B (zh) | 2011-11-04 | 2016-12-07 | 霍夫曼-拉罗奇有限公司 | 新芳基-喹啉衍生物 |
| KR20150046056A (ko) * | 2012-08-24 | 2015-04-29 | 에프. 호프만-라 로슈 아게 | 신규한 바이사이클릭피리딘 유도체 |
| CN105294648B (zh) * | 2015-11-30 | 2017-11-28 | 山东罗欣药业集团股份有限公司 | 一种西他沙星的制备方法 |
| WO2017184547A1 (en) | 2016-04-18 | 2017-10-26 | New York University | Quinoline compounds as modulators of rage activity and uses thereof |
| EP3246028A1 (en) * | 2016-05-18 | 2017-11-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Quinoline compounds for increasing insuline release |
| WO2018083051A1 (en) | 2016-11-01 | 2018-05-11 | F. Hoffmann-La Roche Ag | 1,3-dihydro-1,4-benzodiazepine-2-thiones for the treatment of cns related diseases |
| WO2018165120A1 (en) * | 2017-03-06 | 2018-09-13 | Gemphire Therapeutics Inc. | Effect of carboxyalkylethers on obesity symptoms and lipodystropy |
| CN107311847B (zh) * | 2017-07-12 | 2020-11-10 | 安徽省诚联医药科技有限公司 | 5-溴-2-氯-4′-乙氧基二苯甲烷的制备方法 |
| CN109280028B (zh) * | 2017-07-19 | 2022-03-25 | 上海医药工业研究院 | 喹啉类化合物及其在dpp-4酶抑制剂的应用 |
| US11572357B2 (en) | 2018-05-09 | 2023-02-07 | Bayer Animal Health Gmbh | Quinoline derivatives |
| WO2020227331A1 (en) * | 2019-05-06 | 2020-11-12 | Inspira, LLC | Chemical entities, pharmaceutical formulations, and methods for treating fibrosis |
| JP2023532888A (ja) | 2020-06-27 | 2023-08-01 | クレセンタ バイオサイエンシズ | 細胞代謝を調節する化合物の組成及び使用方法 |
| US20220313681A1 (en) * | 2020-07-06 | 2022-10-06 | Crescenta Biosciences | Novel cell metabolism modulating compounds and uses thereof for the treatment of viral diseases |
| CN113277978B (zh) * | 2021-06-02 | 2022-06-03 | 河南师范大学 | 一种2，4-双取代喹啉类化合物的制备方法 |
| US12054486B2 (en) | 2021-09-24 | 2024-08-06 | Xenon Pharmaceuticals Inc. | Pyridine derivatives and their use as sodium channel activators |
| US12138243B2 (en) | 2021-12-31 | 2024-11-12 | Crescenta Biosciences | Antiviral use of FABP4 modulating compounds |
| CN116693456A (zh) * | 2022-02-28 | 2023-09-05 | 复旦大学 | 异喹啉酮类化合物及其制备方法和应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2569746B2 (ja) * | 1987-08-20 | 1997-01-08 | 日産化学工業株式会社 | キノリン系メバロノラクトン類 |
| TW205037B (es) * | 1989-10-06 | 1993-05-01 | Takeda Pharm Industry Co Ltd | |
| US5371227A (en) | 1991-10-28 | 1994-12-06 | Synthelabo | Quinoline derivatives, process for their preparation, and their therapeutic applications |
| EP0585913B1 (en) * | 1992-09-04 | 1997-12-29 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
| JP3724818B2 (ja) * | 1992-09-04 | 2005-12-07 | 武田薬品工業株式会社 | 縮合複素環化合物、その製造法および剤 |
| JPH0769890A (ja) * | 1993-06-29 | 1995-03-14 | Takeda Chem Ind Ltd | キノリンまたはキナゾリン誘導体を含んでなる医薬組成物 |
| JPH08225531A (ja) * | 1994-03-08 | 1996-09-03 | Takeda Chem Ind Ltd | キノリンまたはキナゾリン誘導体を含んでなる医薬およびそれに用いる新規誘導体 |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| US6900226B2 (en) | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
| AU2003265382A1 (en) * | 2002-08-23 | 2004-03-11 | Pharmacia & Upjohn Company Llc | Antibacterial benzoic acid derivatives |
| KR101154431B1 (ko) * | 2002-11-29 | 2012-06-15 | 주식회사 씨앤드씨신약연구소 | 치환된 1h-피리딘-2-온 유도체 |
| WO2004063156A1 (en) * | 2003-01-08 | 2004-07-29 | Biovitrum Ab | Novel indole derivates as fabp-4 inhibitors |
| EP1660087A2 (en) * | 2003-07-22 | 2006-05-31 | Janssen Pharmaceutica N.V. | Quinolinone derivatives as inhibitors of c-fms kinase |
| SE0302323D0 (sv) | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
| TW200825054A (en) * | 2006-10-18 | 2008-06-16 | Wyeth Corp | Quinoline compounds |
| PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| CA2699697A1 (en) | 2007-09-27 | 2009-04-02 | F. Hoffmann-La Roche Ag | Quinoline derivatives as 5ht5a receptor antagonists |
| TW200940537A (en) | 2008-02-26 | 2009-10-01 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| GB0818365D0 (en) | 2008-10-07 | 2008-11-12 | Argenta Discovery Ltd | Quinoline compounds |
| WO2010056631A1 (en) * | 2008-11-12 | 2010-05-20 | Schering Corporation | Inhibitors of fatty acid binding protein (fabp) |
| US20100125091A1 (en) * | 2008-11-14 | 2010-05-20 | Gilead Palo Alto, Inc. | Substituted heterocyclic compounds as ion channel modulators |
| CN103906735B (zh) | 2011-11-04 | 2016-12-07 | 霍夫曼-拉罗奇有限公司 | 新芳基-喹啉衍生物 |
| JP2015501786A (ja) | 2011-11-04 | 2015-01-19 | アフラクシス・ホールディングス・インコーポレイテッドＡｆｒａｘｉｓ Ｈｏｌｄｉｎｇｓ，Ｉｎｃ． | 脆弱ｘ症候群を治療するためのｐａｋ阻害剤 |
| AU2012331256A1 (en) | 2011-11-04 | 2014-05-22 | Syngenta Participations Ag | Pesticidal compounds |
-
2012
- 2012-10-29 CN CN201280053295.8A patent/CN103906735B/zh not_active Expired - Fee Related
- 2012-10-29 EP EP12780486.2A patent/EP2773619B1/en not_active Not-in-force
- 2012-10-29 BR BR112014010644A patent/BR112014010644A2/pt not_active IP Right Cessation
- 2012-10-29 EA EA201490846A patent/EA201490846A1/ru unknown
- 2012-10-29 AU AU2012331289A patent/AU2012331289B2/en not_active Ceased
- 2012-10-29 JP JP2014539306A patent/JP6170060B2/ja not_active Expired - Fee Related
- 2012-10-29 ES ES12780486.2T patent/ES2609773T3/es active Active
- 2012-10-29 MY MYPI2014701086A patent/MY169267A/en unknown
- 2012-10-29 MX MX2014005373A patent/MX343893B/es active IP Right Grant
- 2012-10-29 PH PH1/2014/500814A patent/PH12014500814A1/en unknown
- 2012-10-29 SG SG11201401937YA patent/SG11201401937YA/en unknown
- 2012-10-29 PE PE2014000640A patent/PE20142282A1/es not_active Application Discontinuation
- 2012-10-29 KR KR1020147014643A patent/KR20140088194A/ko not_active Ceased
- 2012-10-29 WO PCT/EP2012/071398 patent/WO2013064465A1/en not_active Ceased
- 2012-10-29 CA CA2849945A patent/CA2849945A1/en not_active Abandoned
- 2012-10-31 TW TW101140406A patent/TWI616437B/zh not_active IP Right Cessation
- 2012-11-01 US US13/666,202 patent/US9199938B2/en not_active Expired - Fee Related
- 2012-11-02 AR ARP120104109A patent/AR088625A1/es unknown
-
2014
- 2014-03-24 CR CR20140135A patent/CR20140135A/es unknown
- 2014-03-31 CO CO14068491A patent/CO6930359A2/es unknown
- 2014-04-03 IL IL231950A patent/IL231950B/en not_active IP Right Cessation
- 2014-04-25 CL CL2014001060A patent/CL2014001060A1/es unknown
-
2015
- 2015-11-11 US US14/938,005 patent/US9809599B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP6170060B2 (ja) | 2017-07-26 |
| NZ720278A (en) | 2017-08-25 |
| TW201326130A (zh) | 2013-07-01 |
| US9809599B2 (en) | 2017-11-07 |
| CN103906735A (zh) | 2014-07-02 |
| TWI616437B (zh) | 2018-03-01 |
| MX2014005373A (es) | 2014-07-30 |
| PE20142282A1 (es) | 2015-01-08 |
| EP2773619B1 (en) | 2016-11-16 |
| CN103906735B (zh) | 2016-12-07 |
| NZ622717A (en) | 2016-06-24 |
| AU2012331289A1 (en) | 2014-04-10 |
| WO2013064465A1 (en) | 2013-05-10 |
| PH12014500814A1 (en) | 2014-05-19 |
| EA201490846A1 (ru) | 2014-07-30 |
| SG11201401937YA (en) | 2014-05-29 |
| JP2014532681A (ja) | 2014-12-08 |
| MX343893B (es) | 2016-11-28 |
| IL231950B (en) | 2018-02-28 |
| US9199938B2 (en) | 2015-12-01 |
| US20160060270A1 (en) | 2016-03-03 |
| ES2609773T3 (es) | 2017-04-24 |
| CR20140135A (es) | 2014-06-19 |
| EP2773619A1 (en) | 2014-09-10 |
| AR088625A1 (es) | 2014-06-25 |
| BR112014010644A2 (pt) | 2017-04-25 |
| US20130116234A1 (en) | 2013-05-09 |
| MY169267A (en) | 2019-03-20 |
| CA2849945A1 (en) | 2013-05-10 |
| AU2012331289B2 (en) | 2017-07-13 |
| KR20140088194A (ko) | 2014-07-09 |
| CO6930359A2 (es) | 2014-04-28 |
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