CL2014003462A1 - Uso de compuestos aminotriazolopiridinas sustituidos, en el tratamiento de afecciones inflamatorias, autoinmunitarias, proliferativas, alergias, rechazo de trasplantes, entre otras; composicion farmaceutica que los comprende; combinacion farmaceutica. - Google Patents

Uso de compuestos aminotriazolopiridinas sustituidos, en el tratamiento de afecciones inflamatorias, autoinmunitarias, proliferativas, alergias, rechazo de trasplantes, entre otras; composicion farmaceutica que los comprende; combinacion farmaceutica.

Info

Publication number: CL2014003462A1
Authority: CL; Chile
Prior art keywords: aminotriazolopyridine; allergy; proliferative; autoimmune; inflammatory
Prior art date: 2012-06-22

Application number

CL2014003462A

Other languages

English (en)

Inventor

T Klooster Gerben Albert Eleutherius Van

Reginald Christophe Xavier Brys

Rompaey Luc Juliaan Corina Van

Florence Sylvie Namour

Original Assignee

Galapagos Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-06-22

Filing date

2014-12-19

Publication date

2015-02-27

2014-12-19 Application filed by Galapagos Nv filed Critical Galapagos Nv

2015-02-27 Publication of CL2014003462A1 publication Critical patent/CL2014003462A1/es

Links

KGUHUVQIJHGHLX-UHFFFAOYSA-N 2h-triazolo[4,5-b]pyridin-5-amine Chemical class NC1=CC=C2NN=NC2=N1 KGUHUVQIJHGHLX-UHFFFAOYSA-N 0.000 title 1
206010020751 Hypersensitivity Diseases 0.000 title 1
206010052779 Transplant rejections Diseases 0.000 title 1
208000026935 allergic disease Diseases 0.000 title 1
230000007815 allergy Effects 0.000 title 1
230000001363 autoimmune Effects 0.000 title 1
230000002757 inflammatory effect Effects 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
230000002062 proliferating effect Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Transplantation (AREA)
Pulmonology (AREA)
Oncology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)

CL2014003462A 2012-06-22 2014-12-19 Uso de compuestos aminotriazolopiridinas sustituidos, en el tratamiento de afecciones inflamatorias, autoinmunitarias, proliferativas, alergias, rechazo de trasplantes, entre otras; composicion farmaceutica que los comprende; combinacion farmaceutica. CL2014003462A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201261663520P	2012-06-22	2012-06-22

Publications (1)

Publication Number	Publication Date
CL2014003462A1 true CL2014003462A1 (es)	2015-02-27

Family

ID=48577773

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2014003462A CL2014003462A1 (es)	2012-06-22	2014-12-19	Uso de compuestos aminotriazolopiridinas sustituidos, en el tratamiento de afecciones inflamatorias, autoinmunitarias, proliferativas, alergias, rechazo de trasplantes, entre otras; composicion farmaceutica que los comprende; combinacion farmaceutica.

Country Status (34)

Country	Link
US (2)	US9284311B2 (es)
EP (1)	EP2863950B1 (es)
JP (2)	JP6238975B2 (es)
KR (1)	KR102078069B1 (es)
CN (2)	CN104379173A (es)
AR (1)	AR091395A1 (es)
AU (1)	AU2013279597B2 (es)
BR (1)	BR112014031626A8 (es)
CA (1)	CA2875619C (es)
CL (1)	CL2014003462A1 (es)
CO (1)	CO7160085A2 (es)
CR (1)	CR20140583A (es)
CY (1)	CY1120643T1 (es)
DK (1)	DK2863950T3 (es)
EA (1)	EA029084B1 (es)
ES (1)	ES2685985T3 (es)
HR (1)	HRP20181364T8 (es)
HU (1)	HUE038878T2 (es)
IL (1)	IL235923B (es)
LT (1)	LT2863950T (es)
MA (1)	MA37775A1 (es)
MX (1)	MX368511B (es)
MY (1)	MY177334A (es)
NZ (1)	NZ702480A (es)
PE (1)	PE20150187A1 (es)
PH (1)	PH12014502615B1 (es)
PL (1)	PL2863950T3 (es)
PT (1)	PT2863950T (es)
SG (2)	SG11201408123SA (es)
SI (1)	SI2863950T1 (es)
TW (1)	TWI586352B (es)
UA (1)	UA112804C2 (es)
UY (1)	UY34855A (es)
WO (1)	WO2013189771A1 (es)

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JO3041B1 (ar)	2008-07-25	2016-09-05	Galapagos Nv	مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
TWI462920B (zh)	2009-06-26	2014-12-01	葛萊伯格有限公司	用於治療退化性及發炎疾病之新穎化合物
GB201402071D0 (en)	2014-02-07	2014-03-26	Galapagos Nv	Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
GB201402070D0 (en)	2014-02-07	2014-03-26	Galapagos Nv	Pharmaceutical compositions for the treatment of inflammatory disorders
RS64677B1 (sr) *	2015-04-13	2023-11-30	Galapagos Nv	Metode lečenja kardiovaskularnih poremećaja
JP2018511620A (ja)	2015-04-13	2018-04-26	ガラパゴス・ナムローゼ・フェンノートシャップＧａｌａｐａｇｏｓＮ．Ｖ．	炎症性障害の治療のための方法
AU2016257892A1 (en) *	2015-05-05	2017-11-09	Concert Pharmaceuticals, Inc.	Deuterated filgotinib
CN105061420B (zh) *	2015-06-04	2017-09-05	南京旗昌医药科技有限公司	一种jak抑制剂的晶型及其制备方法和应用
US20170173034A1 (en)	2015-12-17	2017-06-22	Gilead Sciences, Inc.	Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders
WO2017106568A1 (en)	2015-12-17	2017-06-22	Gilead Sciences, Inc.	Combination of a jak inhibitor and a bromodomain inhibitor for treating cancer
WO2017106566A1 (en)	2015-12-17	2017-06-22	Gilead Sciences, Inc.	Combination of a jak inhibitor and an mmp9 binding protein for treating inflammatory disorders
WO2017133423A1 (zh) *	2016-02-02	2017-08-10	深圳市塔吉瑞生物医药有限公司	一种取代的吡啶酰胺类化合物及其应用
WO2018087202A1 (en)	2016-11-10	2018-05-17	Galapagos Nv	Compounds and pharmaceutical compositions thereof for the treatment of inflammatory diseases
GB201702603D0 (en)	2017-02-17	2017-04-05	Galápagos Nv	Novel compositions and pharmaceutical compositions thereof for the treatment of inflammatory disorders
SMT202400019T1 (it)	2017-03-14	2024-03-13	Galapagos Nv	Composizioni farmaceutiche comprendenti un inibitore jak
GB201808575D0 (en) *	2018-05-24	2018-07-11	Galapagos Nv	Methods for the treatment of psoriatic arthrits
US12171764B2 (en)	2018-06-20	2024-12-24	Biora Therapeutics, Inc.	Treatment of a disease of the gastrointestinal tract with a JAK or other kinase inhibitor
CN113677676A (zh) *	2019-03-30	2021-11-19	联合化学实验室有限公司	一种制备非戈替尼及其中间体的新方法
JP7315166B2 (ja) *	2019-06-10	2023-07-26	富士通株式会社	グラフェンナノリボンネットワーク膜の製造方法及び電子装置の製造方法
CN111686106B (zh) *	2020-04-05	2022-07-15	温州医科大学附属第一医院	提高Dicer表达的化合物在制备药物中的应用
CN114409675B (zh) *	2022-01-07	2023-08-04	重庆医科大学	螺环异恶唑酮色满衍生物在制备用于治疗jak1介导的疾病药物中的用途
WO2026027676A1 (en)	2024-07-31	2026-02-05	Alfasigma S.P.A.	Biomarkers for determining treatment of ulcerative colitis with filgotinib
WO2026027669A1 (en)	2024-07-31	2026-02-05	Alfasigma S.P.A.	Biomarkers for determining treatment of ulcerative colitis with filgotinib

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ES2549862T3 (es) *	2006-08-30	2015-11-02	Cellzome Limited	Derivados de triazol como inhibidores de quinasa
TWI453207B (zh) *	2008-09-08	2014-09-21	Signal Pharm Llc	胺基三唑并吡啶，其組合物及使用其之治療方法
NZ597140A (en) *	2009-06-05	2014-01-31	Cephalon Inc	Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives
TWI462920B (zh) *	2009-06-26	2014-12-01	葛萊伯格有限公司	用於治療退化性及發炎疾病之新穎化合物
JO3030B1 (ar) *	2009-06-26	2016-09-05	Galapagos Nv	مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات

2013
- 2013-06-10 HU HUE13727625A patent/HUE038878T2/hu unknown
- 2013-06-10 MY MYPI2014703876A patent/MY177334A/en unknown
- 2013-06-10 AU AU2013279597A patent/AU2013279597B2/en active Active
- 2013-06-10 NZ NZ702480A patent/NZ702480A/en unknown
- 2013-06-10 MX MX2014014800A patent/MX368511B/es active IP Right Grant
- 2013-06-10 DK DK13727625.9T patent/DK2863950T3/en active
- 2013-06-10 HR HRP20181364TT patent/HRP20181364T8/hr unknown
- 2013-06-10 WO PCT/EP2013/061914 patent/WO2013189771A1/en not_active Ceased
- 2013-06-10 KR KR1020157001521A patent/KR102078069B1/ko active Active
- 2013-06-10 SG SG11201408123SA patent/SG11201408123SA/en unknown
- 2013-06-10 BR BR112014031626A patent/BR112014031626A8/pt not_active Application Discontinuation
- 2013-06-10 AR ARP130102033 patent/AR091395A1/es unknown
- 2013-06-10 PL PL13727625T patent/PL2863950T3/pl unknown
- 2013-06-10 CN CN201380032159.5A patent/CN104379173A/zh active Pending
- 2013-06-10 CA CA2875619A patent/CA2875619C/en active Active
- 2013-06-10 UY UY0001034855A patent/UY34855A/es unknown
- 2013-06-10 LT LTEP13727625.9T patent/LT2863950T/lt unknown
- 2013-06-10 PT PT13727625T patent/PT2863950T/pt unknown
- 2013-06-10 US US13/913,597 patent/US9284311B2/en active Active
- 2013-06-10 JP JP2015517666A patent/JP6238975B2/ja active Active
- 2013-06-10 SG SG10201700125VA patent/SG10201700125VA/en unknown
- 2013-06-10 SI SI201331137T patent/SI2863950T1/sl unknown
- 2013-06-10 PE PE2014002472A patent/PE20150187A1/es not_active Application Discontinuation
- 2013-06-10 CN CN201810014031.0A patent/CN107998136A/zh active Pending
- 2013-06-10 MA MA37775A patent/MA37775A1/fr unknown
- 2013-06-10 EP EP13727625.9A patent/EP2863950B1/en active Active
- 2013-06-10 EA EA201590071A patent/EA029084B1/ru unknown
- 2013-06-10 ES ES13727625.9T patent/ES2685985T3/es active Active
- 2013-06-11 TW TW102120793A patent/TWI586352B/zh active
- 2013-10-06 UA UAA201500458A patent/UA112804C2/uk unknown
2014
- 2014-11-24 PH PH12014502615A patent/PH12014502615B1/en unknown
- 2014-11-26 IL IL235923A patent/IL235923B/en active IP Right Grant
- 2014-12-16 CR CR20140583A patent/CR20140583A/es unknown
- 2014-12-19 CO CO14279834A patent/CO7160085A2/es unknown
- 2014-12-19 CL CL2014003462A patent/CL2014003462A1/es unknown
2016
- 2016-03-14 US US15/069,130 patent/US20160296529A1/en not_active Abandoned
2017
- 2017-10-31 JP JP2017210372A patent/JP2018048185A/ja active Pending
2018
- 2018-08-29 CY CY181100902T patent/CY1120643T1/el unknown

Also Published As

Publication number	Publication date
JP2015520198A (ja)	2015-07-16
MX2014014800A (es)	2015-02-12
PT2863950T (pt)	2018-10-10
EP2863950A1 (en)	2015-04-29
HUE038878T2 (hu)	2018-12-28
EA201590071A1 (ru)	2015-04-30
HRP20181364T1 (hr)	2018-10-19
US9284311B2 (en)	2016-03-15
LT2863950T (lt)	2018-09-25
JP6238975B2 (ja)	2017-11-29
IL235923B (en)	2018-11-29
UY34855A (es)	2014-01-31
ES2685985T3 (es)	2018-10-15
CN104379173A (zh)	2015-02-25
BR112014031626A8 (pt)	2021-10-19
SG10201700125VA (en)	2017-02-27
MA37775A1 (fr)	2017-04-28
EA029084B1 (ru)	2018-02-28
UA112804C2 (uk)	2016-10-25
PH12014502615A1 (en)	2015-01-21
CA2875619A1 (en)	2013-12-27
AU2013279597A1 (en)	2015-01-15
HK1208368A1 (en)	2016-03-04
CY1120643T1 (el)	2019-12-11
TW201400114A (zh)	2014-01-01
IL235923A0 (en)	2015-01-29
PL2863950T3 (pl)	2019-02-28
CA2875619C (en)	2020-11-24
HRP20181364T8 (hr)	2018-12-28
PH12014502615B1 (en)	2015-01-21
AU2013279597B2 (en)	2017-04-20
PE20150187A1 (es)	2015-02-27
AR091395A1 (es)	2015-02-04
CO7160085A2 (es)	2015-01-15
JP2018048185A (ja)	2018-03-29
WO2013189771A1 (en)	2013-12-27
US20160296529A1 (en)	2016-10-13
TWI586352B (zh)	2017-06-11
MX368511B (es)	2019-10-07
EP2863950B1 (en)	2018-07-18
SI2863950T1 (sl)	2018-10-30
US20130345209A1 (en)	2013-12-26
KR20150023048A (ko)	2015-03-04
MY177334A (en)	2020-09-12
DK2863950T3 (en)	2018-09-03
CR20140583A (es)	2015-02-10
CN107998136A (zh)	2018-05-08
NZ702480A (en)	2016-11-25
SG11201408123SA (en)	2015-01-29
KR102078069B1 (ko)	2020-02-17
BR112014031626A2 (pt)	2017-06-27

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