CL2012002477A1 - Compuesto modificador del sabor formula (i), composicion ingerible que comprende el compuestos de la formula (i), metodo para mejorar el sabor dulce de una composicion ingerible combinando dicho producto con el compuesto de la formula (i) - Google Patents

Compuesto modificador del sabor formula (i), composicion ingerible que comprende el compuestos de la formula (i), metodo para mejorar el sabor dulce de una composicion ingerible combinando dicho producto con el compuesto de la formula (i)

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Publication number
CL2012002477A1
CL2012002477A1 CL2012002477A CL2012002477A CL2012002477A1 CL 2012002477 A1 CL2012002477 A1 CL 2012002477A1 CL 2012002477 A CL2012002477 A CL 2012002477A CL 2012002477 A CL2012002477 A CL 2012002477A CL 2012002477 A1 CL2012002477 A1 CL 2012002477A1
Authority
CL
Chile
Prior art keywords
formula
ingestible composition
compound
compounds
sweet taste
Prior art date
Application number
CL2012002477A
Other languages
English (en)
Inventor
Xiao Qing Tang
Donald S Karanewsky
Xiaodong Li
Feng Zhang
Qing Chen
Hong Zhang
Timothy Davis
Vincent Darmohusodo
Melissa Wong
Victor Selchau
Catherine Tachdjian
Guy Servant
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of CL2012002477A1 publication Critical patent/CL2012002477A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/56—Flavouring or bittering agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A23L27/205—Heterocyclic compounds
    • A23L27/2054—Heterocyclic compounds having nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/88—Taste or flavour enhancing agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cosmetics (AREA)

Abstract

Compuestos derivados de quinolina; composición ingerible que comprende a dichos compuestos; método para mejorar el sabor dulce de una composición ingerible; composición ingerible; y formulación saborizante concentrada.
CL2012002477A 2010-04-02 2012-09-06 Compuesto modificador del sabor formula (i), composicion ingerible que comprende el compuestos de la formula (i), metodo para mejorar el sabor dulce de una composicion ingerible combinando dicho producto con el compuesto de la formula (i) CL2012002477A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32052810P 2010-04-02 2010-04-02
US42234110P 2010-12-13 2010-12-13

Publications (1)

Publication Number Publication Date
CL2012002477A1 true CL2012002477A1 (es) 2013-07-19

Family

ID=44710373

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012002477A CL2012002477A1 (es) 2010-04-02 2012-09-06 Compuesto modificador del sabor formula (i), composicion ingerible que comprende el compuestos de la formula (i), metodo para mejorar el sabor dulce de una composicion ingerible combinando dicho producto con el compuesto de la formula (i)

Country Status (22)

Country Link
US (4) US8592592B2 (es)
EP (1) EP2552207B1 (es)
JP (1) JP5988506B2 (es)
KR (1) KR101810265B1 (es)
CN (1) CN102933081B (es)
AR (1) AR081814A1 (es)
AU (1) AU2011235069B2 (es)
BR (1) BR112012025167B1 (es)
CA (1) CA2792068A1 (es)
CL (1) CL2012002477A1 (es)
CO (1) CO6630147A2 (es)
ES (1) ES2753523T3 (es)
IL (1) IL222219A0 (es)
MX (1) MX2012011386A (es)
MY (1) MY175079A (es)
NZ (1) NZ603332A (es)
PE (2) PE20130211A1 (es)
PH (1) PH12012501846A1 (es)
RU (1) RU2605549C2 (es)
SG (2) SG184156A1 (es)
TW (1) TWI595838B (es)
WO (1) WO2011123693A1 (es)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9603848B2 (en) 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
MY153622A (en) 2008-07-31 2015-02-27 Senomyx Inc Processes and intermediates for making sweet taste enhancers
WO2010014813A2 (en) 2008-07-31 2010-02-04 Senomyx, Inc. Compositions comrpising sweetness enhancers and methods of making them
NZ603332A (en) 2010-04-02 2014-11-28 Senomyx Inc Sweet flavor modifier
CN106107406B (zh) 2010-08-12 2020-06-09 弗门尼舍公司 提高甜味增强剂的稳定性的方法和包含稳定的甜味增强剂的组合物
EP2742026B1 (en) * 2011-08-12 2016-10-05 Senomyx, Inc. Sweet flavor modifier
JP6196235B2 (ja) * 2011-12-21 2017-09-13 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 抗菌活性化合物としてのシクロヘキサノール誘導体の使用
WO2013158928A2 (en) 2012-04-18 2013-10-24 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
NZ703926A (en) * 2012-08-06 2018-04-27 Senomyx Inc Sweet flavor modifier
GB201222241D0 (en) 2012-12-11 2013-01-23 Morris George J Control of ice formation
JO3155B1 (ar) 2013-02-19 2017-09-20 Senomyx Inc معدِّل نكهة حلوة
CN103497151B (zh) * 2013-10-30 2015-07-15 山东铂源药业有限公司 一种4-氨基-6-甲基烟酸的合成方法
US11339128B2 (en) 2014-11-07 2022-05-24 Firmenich Incorporated Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers
CA3003163A1 (en) 2015-10-29 2017-05-04 Senomyx, Inc. High intensity sweeteners
SG11201811777RA (en) * 2016-07-06 2019-01-30 Mccormick & Co Inc Method of predicting flavor performance
LT3322695T (lt) 2016-09-21 2020-11-10 Celanese International Corporation Kalio acesulfamo kompozicijos ir jų gamybos būdas
PL3319949T3 (pl) 2016-09-21 2021-01-11 Celanese International Corporation Kompozycje acesulfamu potasowego i sposoby ich wytwarzania
RS59840B8 (sr) 2016-09-21 2026-02-27 Celanese Int Corp Kompozicije acesulfam-kalijuma i postupci za njihovu proizvodnju
US10029998B2 (en) 2016-09-21 2018-07-24 Celanese International Corporation Acesulfame potassium compositions and processes for producing same
BR112019023104A2 (pt) 2017-05-03 2020-11-03 Firmenich Incorporated métodos para fazer adoçante de alta intensidade
WO2020033420A1 (en) 2018-08-07 2020-02-13 Firmenich Incorporated 5-substituted 4-amino-1h-benzo[c][1,2,6]thiadiazine 2,2-dioxides and formulations and uses thereof
PT3860998T (pt) 2018-10-05 2024-04-02 Annapurna Bio Inc Compostos e composições para o tratamento de condições associadas à atividade do recetor apj
MX2021005219A (es) 2018-11-07 2021-06-18 Firmenich Incorporated Metodos para hacer edulcorantes de alta intensidad.
US12338476B2 (en) 2018-11-07 2025-06-24 Firmenich Incorporated Methods for making high intensity sweeteners
WO2020161939A1 (ja) * 2019-02-06 2020-08-13 株式会社Ｍｉｚｋａｎ Ｈｏｌｄｉｎｇｓ 甘い風味が増強された乾燥植物粉末および飲食品
BR112021008782A2 (pt) 2019-03-28 2021-11-03 Firmenich S/A Sistema de sabor
CN113661171B (zh) 2019-04-04 2024-04-12 弗门尼舍有限公司 罗汉果苷化合物及其用途
CN113423287A (zh) 2019-06-28 2021-09-21 弗门尼舍有限公司 脂肪混合物、其乳液和相关用途
EP4025071A1 (en) 2019-09-05 2022-07-13 Firmenich SA Flavanone derivatives and their use as sweetness enhancers
WO2021094268A1 (en) 2019-11-11 2021-05-20 Firmenich Sa Gingerol compounds and their use as flavor modifiers
BR112022009553A2 (pt) 2019-12-13 2022-08-02 Firmenich Incorporated Composições modificadoras de sabor e usos das mesmas
US20230028760A1 (en) 2019-12-13 2023-01-26 Firmenich Incorporated Taste modifying compositions and uses thereof
KR20220114529A (ko) 2019-12-18 2022-08-17 피르메니히 인코포레이티드 맛 개질 조성물 및 이의 용도
WO2021126569A1 (en) 2019-12-18 2021-06-24 Firmenich Incorporated Taste modifying compositions and uses thereof
CN114127084B (zh) 2020-03-05 2024-08-06 弗门尼舍有限公司 11-氧代-葫芦烷及其作为风味改良剂的用途
WO2021198199A1 (en) 2020-03-31 2021-10-07 Firmenich Sa Flavor composition
EP4055006A1 (en) 2020-04-17 2022-09-14 Firmenich SA Amino acid derivatives and their use as flavor modifiers
CN115279414A (zh) 2020-05-22 2022-11-01 弗门尼舍有限公司 用于减少咸味的组合物及其用途
BR112022016411A2 (pt) 2020-06-03 2022-10-11 Firmenich & Cie Composições para reduzir gostos desagradáveis e usos das mesmas
US11691971B2 (en) 2020-06-19 2023-07-04 Incyte Corporation Naphthyridinone compounds as JAK2 V617F inhibitors
WO2021257863A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Pyrrolotriazine compounds as jak2 v617f inhibitors
EP4171266A1 (en) 2020-06-24 2023-05-03 Firmenich SA Sweetening compositions and uses thereof
WO2022006456A1 (en) 2020-07-02 2022-01-06 Incyte Corporation Tricyclic pyridone compounds as jak2 v617f inhibitors
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WO2022013163A1 (en) 2020-07-14 2022-01-20 Firmenich Sa Reduction of undesirable taste notes in oral care products
US20230276835A1 (en) 2020-07-24 2023-09-07 Firmenich Incorporated Savory taste enhancement via transmembrane region binding
US11661422B2 (en) 2020-08-27 2023-05-30 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
EP4125428A1 (en) 2020-09-22 2023-02-08 Firmenich SA Wintergreen flavor compositions free of methyl salicylate
EP4228433A1 (en) 2020-10-13 2023-08-23 Firmenich SA Malonyl steviol glycosides and their comestible use
EP4161292A1 (en) 2020-10-27 2023-04-12 Firmenich SA Conjugated diynes and their use as flavor modifiers
WO2022115837A1 (en) 2020-11-24 2022-06-02 Firmenich Incorporated Kokumi taste enhancement and related screening methods
WO2022112432A1 (en) 2020-11-29 2022-06-02 Firmenich Sa Compositions that reduce peroxide off taste and uses thereof
WO2022140231A1 (en) 2020-12-21 2022-06-30 Incyte Corporation Deazaguaine compounds as jak2 v617f inhibitors
US20230397627A1 (en) 2020-12-23 2023-12-14 Firmenich Sa Uses of fat blends and emulsions thereof
EP4251122B1 (en) 2021-01-13 2025-03-12 Firmenich Incorporated Compositions that enhance the cooling effect
US20240188613A1 (en) 2021-01-15 2024-06-13 Firmenich Incorporated Sweetener compositions comprising mogrosides and uses thereof
US20240065302A1 (en) 2021-01-15 2024-02-29 Firmenich Incorporated Sweetener compositions comprising mogrosides and uses thereof
EP4258895A1 (en) 2021-01-15 2023-10-18 Firmenich Incorporated Sweetener compostions comprising siamenoside i and uses thereof
US20240074479A1 (en) 2021-02-10 2024-03-07 Firmenich Sa Fiber blends, sweetened fiber blends, and their comestible use
AR125273A1 (es) 2021-02-25 2023-07-05 Incyte Corp Lactamas espirocíclicas como inhibidores de jak2 v617f
EP4258900A1 (en) 2021-03-09 2023-10-18 Firmenich SA Hydroxy- and methoxy-substituted flavonoids and their use
EP4258899A1 (en) 2021-03-09 2023-10-18 Firmenich SA Hydroxy- and methoxy-substituted flavones and their use
WO2022214275A1 (en) 2021-04-06 2022-10-13 Firmenich Sa Use of gingerdiol compounds to enhance flavor
WO2022231908A1 (en) 2021-04-26 2022-11-03 Firmenich Incorporated Amide compounds and their use as flavor modifiers
WO2022231918A1 (en) 2021-04-26 2022-11-03 Firmenich Incorporated Amide compounds and their use as flavor modifiers
EP4307919A2 (en) 2021-05-11 2024-01-24 Firmenich SA Process of making gingerol compounds and their use as flavor modifiers
WO2022248405A1 (en) 2021-05-24 2022-12-01 Firmenich Sa Flavored fiber blends and their comestible use
JP2024522284A (ja) 2021-05-28 2024-06-13 フィルメニッヒ インコーポレイテッド 清涼効果を増強する組成物
BR112023022013A2 (pt) 2021-06-02 2023-12-26 Firmenich & Cie Processo de desacetilação, composições e usos das mesmas
WO2022268875A1 (en) 2021-06-23 2022-12-29 Firmenich Sa Flavor-modifying compositions containing lactase
BR112023026922A2 (pt) 2021-06-28 2024-03-05 Firmenich Incorporated Sais policatiônicos de compostos fenólicos e usos dos mesmos
US20240225066A1 (en) 2021-06-29 2024-07-11 Firmenich Incorporated Mogroside compounds and their comestible use
US20240237690A1 (en) 2021-06-29 2024-07-18 Firmenich Sa Licorice Compounds and Their Use as Flavor Modifiers
US20250075155A1 (en) 2021-09-27 2025-03-06 Firmenich Incorporated Use of Vanillyl Ethers to Modify Flavor of Distilled Spirits
WO2023046914A1 (en) 2021-09-27 2023-03-30 Firmenich Sa Flavor compositions containing iron compounds and their use
WO2023072604A1 (en) 2021-11-01 2023-05-04 Firmenich Sa Composition comprising a nutrient and a taste modulator
EP4404767A2 (en) 2021-11-16 2024-07-31 Firmenich Incorporated Amide compounds and their use as flavor modifiers
US20250052739A1 (en) 2021-12-07 2025-02-13 Firmenich Incorporated Reduction of bitter taste of plant proteins and related assays and screening methods
US20250040583A1 (en) 2021-12-20 2025-02-06 Firmenich Sa Encapsulated metal compounds and comestible uses thereof
WO2023117643A1 (en) 2021-12-23 2023-06-29 Firmenich Sa Antimicrobial composition having encapsulated colorant
WO2023165764A1 (en) 2022-03-04 2023-09-07 Firmenich Sa Purification process for polymethoxylated flavonoids and compositions obtained therefrom
WO2023172415A1 (en) 2022-03-07 2023-09-14 Firmenich Incorporated Sweetener compositions
JP2025507547A (ja) 2022-03-10 2025-03-21 フイルメニツヒ ソシエテ アノニム 甘味料組成物
JP2025509073A (ja) 2022-03-11 2025-04-11 フィルメニッヒ インコーポレイテッド フラバノン化合物およびそれらの風味改変剤としての使用
EP4456737A1 (en) 2022-03-11 2024-11-06 Firmenich Incorporated Amide compounds and their use as flavor modifiers
KR20240163688A (ko) 2022-03-17 2024-11-19 인사이트 코포레이션 Jak2 v617f 억제제로서의 삼환계 우레아 화합물
EP4472442A1 (en) 2022-03-25 2024-12-11 Firmenich SA Fatty acid amides and their use as flavor modifiers
CN119212569A (zh) 2022-03-28 2024-12-27 弗门尼舍有限公司 非动物蛋白组合物及其用途
US20250204564A1 (en) 2022-04-06 2025-06-26 Firmenich Incorporated Taste modifying compositions and uses thereof
US20250331542A1 (en) 2022-04-11 2025-10-30 Firmenich Sa Sweetener compositions
WO2023224812A1 (en) 2022-05-16 2023-11-23 Firmenich Incorporated Unsaturated fatty acids and their use to modify taste
EP4492988A1 (en) 2022-05-16 2025-01-22 Firmenich Incorporated Saturated fatty acids and their use to modify taste
WO2023232968A1 (en) 2022-06-03 2023-12-07 Firmenich Sa Fat reduction in non-animal protein compositions
CN119325346A (zh) 2022-06-14 2025-01-17 弗门尼舍有限公司 蛋白质的聚电解质复合物及其用途
EP4507522A1 (en) 2022-06-24 2025-02-19 Firmenich SA Taste modifying compositions and uses thereof
CN119604269A (zh) 2022-07-07 2025-03-11 弗门尼舍公司 增强清凉效果的组合物
WO2024041974A1 (en) 2022-08-22 2024-02-29 Firmenich Sa Gel compositions and their use in seafood analogue products
EP4547034A1 (en) 2022-10-26 2025-05-07 Firmenich SA Extrusion methods and flavored products formed thereby
EP4577059A1 (en) 2022-10-26 2025-07-02 Firmenich Incorporated Taste modifying compositions and uses thereof
EP4580420A1 (en) 2022-11-01 2025-07-09 Firmenich SA Low-calorie composition for flavor modification
EP4601483A1 (en) 2022-12-23 2025-08-20 Firmenich Incorporated Beta-cyclodextrin and its use to modify flavor
CN120513026A (zh) 2023-01-09 2025-08-19 弗门尼舍有限公司 植物纤维用于改善发酵产品风味的用途
EP4665157A1 (en) 2023-02-15 2025-12-24 Firmenich SA Thermoresponsive gel composition and uses thereof
EP4630413A1 (en) 2023-02-25 2025-10-15 Firmenich Incorporated Flavanone compounds and their use as flavor modifiers
WO2024196906A1 (en) 2023-03-23 2024-09-26 Firmenich Incorporated Use of vanillyl ethers to modify flavor
JP2026509602A (ja) 2023-03-24 2026-03-19 フイルメニツヒ ソシエテ アノニム 藻類タンパク質を含有する微粒子およびその使用
EP4687492A1 (en) 2023-03-29 2026-02-11 Firmenich Incorporated Use of fatty acids to modify flavor
WO2024208837A1 (en) 2023-04-04 2024-10-10 Firmenich Sa Polysaccharide compositions and their comestible use
WO2024227789A1 (en) 2023-05-03 2024-11-07 Firmenich Sa Encapsulated phenolic compounds and their comestible use
WO2024251755A1 (en) 2023-06-09 2024-12-12 Dsm-Firmenich Ag Compositions for reducing off notes and uses thereof
EP4480319A1 (en) 2023-06-22 2024-12-25 DSM-Firmenich AG Granola cluster
WO2025067974A1 (en) 2023-09-26 2025-04-03 Firmenich Sa Vegan cheese compositions and methods of making the same
CN122028804A (zh) 2023-10-04 2026-05-12 弗门尼舍有限公司 黄烷酮化合物及其作为风味修饰剂的用途
WO2025125286A1 (en) 2023-12-13 2025-06-19 Firmenich Sa Biopolymer compositions and their use in foamed compositions
WO2025132821A1 (en) 2023-12-19 2025-06-26 Firmenich Sa Comestible products having high fiber and low sugar
WO2025132803A1 (en) 2023-12-20 2025-06-26 Firmenich Sa 3-hydroxybenzoic acid and its use as a flavor modifier
WO2025191050A1 (en) 2024-03-15 2025-09-18 Firmenich Sa Lipid particles and their comestible use
WO2025221883A1 (en) 2024-04-17 2025-10-23 Firmenich Incorporated Taste modifying compositions and uses thereof
WO2025230968A1 (en) 2024-04-30 2025-11-06 Firmenich Incorporated Ketone compounds for enhancing alcohol perception
WO2026064099A1 (en) 2024-09-17 2026-03-26 Firmenich Incorporated Dihydrochalcone compounds for enhancing alcohol perception
WO2026064098A1 (en) 2024-09-17 2026-03-26 Firmenich Incorporated Flavonoid compounds for enhancing alcohol perception

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2030899A1 (de) * 1970-06-18 1971-12-23 Schering Ag, 1000 Berlin Und 4619 Bergkamen Chinolincarbonsäurederivate
FR2101004B2 (es) * 1970-08-05 1974-02-01 Bellon Labor Sa Roger
JPS5833843B2 (ja) * 1974-10-24 1983-07-22 武田薬品工業株式会社 スイサンヨウ ヤクザイ
JPS52142098A (en) 1976-05-20 1977-11-26 Sumitomo Chem Co Ltd 1-fluoroalkyl-491h)-oxo-3-quinolinecarboxylic acid derivatives
DE3111155A1 (de) * 1981-03-21 1982-09-30 Troponwerke GmbH & Co KG, 5000 Köln 5,6-dimethyl-pyrrolo (2,3-b)pyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4552883A (en) * 1982-06-15 1985-11-12 Ici Americas Inc. Pyrazolo[3,4-b]pyridine carboxylic acid esters and their pharmaceutical use
US4952584A (en) 1986-01-11 1990-08-28 Beecham Group P.L.C. 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity
GB8600651D0 (en) 1986-01-11 1986-02-19 Beecham Group Plc Compounds
GB8610981D0 (en) 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
GB8804447D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
JPH0676401B2 (ja) * 1990-10-19 1994-09-28 エスエス製薬株式会社 キノリン誘導体及びこれを含有する医薬
US5240934A (en) * 1990-10-19 1993-08-31 Ss Pharmaceutical Co., Ltd. Quinoline derivatives
GB9125485D0 (en) 1991-11-29 1992-01-29 Merck Sharp & Dohme Therapeutic agents
GB9127252D0 (en) 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
JPH06199855A (ja) * 1992-12-31 1994-07-19 Nippon Nohyaku Co Ltd ピラゾロピリジン誘導体及びこれを含有する血小板凝集抑制剤
US5776942A (en) 1994-06-17 1998-07-07 Nippon Zoki Pharmaceutical Co., Ltd. Bronchodilating pyrido 2,3-d!pyrimidine derivatives
JPH083046A (ja) * 1994-06-17 1996-01-09 Nippon Zoki Pharmaceut Co Ltd 気管支喘息治療剤
US5593997A (en) * 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
AR016817A1 (es) * 1997-08-14 2001-08-01 Smithkline Beecham Plc Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento
DE19738616A1 (de) * 1997-09-04 1999-03-11 Clariant Gmbh 4-Hydroxychinolin-3-carbonsäure-Derivate als Lichtschutzmittel
YU19302A (sh) * 1999-09-22 2004-11-25 Aventis Pharma Deutschland Gmbh. 4-benzilaminohinolin konjugovan žučnom kiselinom i njegovi heteroanalozi, postupak za njihovu proizvodnju, lekovi koji sadrže ta jedinjenja i njihova primena
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
EP1450802A2 (en) * 2001-10-30 2004-09-01 The General Hospital Corporation Methods for the prevention or treatment of bacterial and fungal infections
EP1451156A4 (en) 2001-11-27 2005-05-25 Merck & Co Inc 4-AMINOCHINOLINVERBINDUNGEN
AU2003248921A1 (en) * 2002-07-09 2004-01-23 Point Therapeutics, Inc. Boroproline compound combination therapy
US20080026077A1 (en) * 2002-11-12 2008-01-31 John Hilfinger Methods and compositions of gene delivery agents for systemic and local therapy
JP2007512227A (ja) * 2003-08-06 2007-05-17 セノミックス、インコーポレイテッド Ｔ１ｒヘテロオリゴマー味覚受容体、この受容体を発現する細胞株、および味覚化合物
EP1720856B1 (en) * 2004-02-11 2013-08-14 GlaxoSmithKline LLC Hiv integrase inhibitors
CN1953979A (zh) 2004-03-11 2007-04-25 神经能质公司 经取代的5,12－二吖－苯幷葱类似物
UY28953A1 (es) 2004-06-09 2006-01-31 Avanir Pharmaceuticals Derivados heterocíclicos para el tratamiento de hiperlipidemia y enfermedades relacionadas
CN101891680B (zh) * 2004-06-24 2014-10-29 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的调控剂
JP2006036762A (ja) * 2004-06-25 2006-02-09 Taisho Pharmaceut Co Ltd 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体
UY29016A1 (es) * 2004-07-20 2006-02-24 Boehringer Ingelheim Int Analogos de dipeptidos inhibidores de la hepatitis c
US20060045953A1 (en) 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
GB0425572D0 (en) * 2004-11-19 2004-12-22 Glaxo Group Ltd 1,7-Naphthyridines
MX2007007026A (es) 2004-12-17 2007-07-04 Hoffmann La Roche Derivados de tieno-piridina como intensificadores alostericos de gaba-b.
GB0505621D0 (en) * 2005-03-18 2005-04-27 Glaxo Group Ltd Novel compounds
US7304074B2 (en) * 2005-04-05 2007-12-04 Hoffmann-La Roche Inc. Substituted 1,5-naphthyridine azolinones
WO2006124944A1 (en) * 2005-05-18 2006-11-23 Wyeth 4, 6-diamino-[1,7] naphthyridine-3-carbonitrile inhibitors of tpl2 kinase and methods of making and using the same
WO2006125974A1 (en) * 2005-05-24 2006-11-30 Astrazeneca Ab Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
AR055329A1 (es) 2005-06-15 2007-08-15 Senomyx Inc Amidas bis-aromaticas y sus usos como modificadores de sabor dulce, saborizantes, y realzadores de sabor
EP2007373A4 (en) 2006-03-29 2012-12-19 Foldrx Pharmaceuticals Inc INHIBITION OF ALPHA SYNUCLEINE TOXICITY
DE102006029446A1 (de) * 2006-06-21 2007-12-27 Bayer Schering Pharma Ag Neue 3-substituierte-Chinoline als Kinase-Inhibitoren
US7928111B2 (en) * 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US9603848B2 (en) * 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US8076491B2 (en) 2007-08-21 2011-12-13 Senomyx, Inc. Compounds that inhibit (block) bitter taste in composition and use thereof
JP5565841B2 (ja) * 2007-11-15 2014-08-06 クラノテク・アクチボラグ キノリン誘導体とチロシンキナーゼ阻害剤としてのその使用
DK2247196T3 (en) 2008-02-06 2015-02-16 Senomyx Inc Sweetener FORMATIONS AND PROCESSES FOR PREPARING THEM
WO2011075559A1 (en) * 2009-12-18 2011-06-23 Glaxo Wellcome Manufacturing Pte Ltd. Novel compounds
NZ603332A (en) 2010-04-02 2014-11-28 Senomyx Inc Sweet flavor modifier
CN106107406B (zh) 2010-08-12 2020-06-09 弗门尼舍公司 提高甜味增强剂的稳定性的方法和包含稳定的甜味增强剂的组合物
EP2742026B1 (en) 2011-08-12 2016-10-05 Senomyx, Inc. Sweet flavor modifier
WO2013158928A2 (en) 2012-04-18 2013-10-24 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
US20140272068A1 (en) 2013-03-14 2014-09-18 Indra Prakash Beverages containing rare sugars
JP6055730B2 (ja) 2013-07-17 2016-12-27 株式会社東海理化電機製作所 遠隔操作システム

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