CL2012002477A1 - Compuesto modificador del sabor formula (i), composicion ingerible que comprende el compuestos de la formula (i), metodo para mejorar el sabor dulce de una composicion ingerible combinando dicho producto con el compuesto de la formula (i) - Google Patents

Compuesto modificador del sabor formula (i), composicion ingerible que comprende el compuestos de la formula (i), metodo para mejorar el sabor dulce de una composicion ingerible combinando dicho producto con el compuesto de la formula (i)

Info

Publication number
CL2012002477A1
CL2012002477A1 CL2012002477A CL2012002477A CL2012002477A1 CL 2012002477 A1 CL2012002477 A1 CL 2012002477A1 CL 2012002477 A CL2012002477 A CL 2012002477A CL 2012002477 A CL2012002477 A CL 2012002477A CL 2012002477 A1 CL2012002477 A1 CL 2012002477A1
Authority
CL
Chile
Prior art keywords
formula
ingestible composition
compound
compounds
sweet taste
Prior art date
Application number
CL2012002477A
Other languages
English (en)
Inventor
Xiao Qing Tang
Donald S Karanewsky
Xiaodong Li
Feng Zhang
Qing Chen
Hong Zhang
Timothy Davis
Vincent Darmohusodo
Melissa Wong
Victor Selchau
Catherine Tachdjian
Guy Servant
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of CL2012002477A1 publication Critical patent/CL2012002477A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • C07D215/42Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52Adding ingredients
    • A23L2/56Flavouring or bittering agents
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52Adding ingredients
    • A23L2/60Sweeteners
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20Synthetic spices, flavouring agents or condiments
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20Synthetic spices, flavouring agents or condiments
    • A23L27/205Heterocyclic compounds
    • A23L27/2054Heterocyclic compounds having nitrogen as the only hetero atom
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30Artificial sweetening agents
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/88Taste or flavour enhancing agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47064-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60N-oxides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cosmetics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compuestos derivados de quinolina; composición ingerible que comprende a dichos compuestos; método para mejorar el sabor dulce de una composición ingerible; composición ingerible; y formulación saborizante concentrada.
CL2012002477A 2010-04-02 2012-09-06 Compuesto modificador del sabor formula (i), composicion ingerible que comprende el compuestos de la formula (i), metodo para mejorar el sabor dulce de una composicion ingerible combinando dicho producto con el compuesto de la formula (i) CL2012002477A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32052810P 2010-04-02 2010-04-02
US42234110P 2010-12-13 2010-12-13

Publications (1)

Publication Number Publication Date
CL2012002477A1 true CL2012002477A1 (es) 2013-07-19

Family

ID=44710373

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012002477A CL2012002477A1 (es) 2010-04-02 2012-09-06 Compuesto modificador del sabor formula (i), composicion ingerible que comprende el compuestos de la formula (i), metodo para mejorar el sabor dulce de una composicion ingerible combinando dicho producto con el compuesto de la formula (i)

Country Status (22)

Country Link
US (4) US8592592B2 (es)
EP (1) EP2552207B1 (es)
JP (1) JP5988506B2 (es)
KR (1) KR101810265B1 (es)
CN (1) CN102933081B (es)
AR (1) AR081814A1 (es)
AU (1) AU2011235069B2 (es)
BR (1) BR112012025167B1 (es)
CA (1) CA2792068A1 (es)
CL (1) CL2012002477A1 (es)
CO (1) CO6630147A2 (es)
ES (1) ES2753523T3 (es)
IL (1) IL222219A0 (es)
MX (1) MX2012011386A (es)
MY (1) MY175079A (es)
NZ (1) NZ603332A (es)
PE (2) PE20130211A1 (es)
PH (1) PH12012501846A1 (es)
RU (1) RU2605549C2 (es)
SG (2) SG10201507846YA (es)
TW (1) TWI595838B (es)
WO (1) WO2011123693A1 (es)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9603848B2 (en) 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
KR101577159B1 (ko) 2008-07-31 2015-12-11 세노믹스, 인코포레이티드 단맛 향상제의 제조 방법 및 중간체
ES2525551T3 (es) 2008-07-31 2014-12-26 Senomyx, Inc. Composiciones que comprenden potenciadores de dulzor y métodos de producirlas
CA2792068A1 (en) 2010-04-02 2011-10-06 Senomyx, Inc. Sweet flavor modifier
WO2012021837A2 (en) 2010-08-12 2012-02-16 Senomyx, Inc. Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer
MX336378B (es) 2011-08-12 2016-01-15 Senomyx Inc Modificador del sabor dulce.
WO2013091775A2 (de) 2011-12-21 2013-06-27 Merck Patent Gmbh Verwendung von cyclohexanolderivaten als antimikrobielle wirkstoffe
WO2013158928A2 (en) 2012-04-18 2013-10-24 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
PE20191204A1 (es) * 2012-08-06 2019-09-10 Firmenich Incorporated Modificador del sabor dulce
GB201222241D0 (en) 2012-12-11 2013-01-23 Morris George J Control of ice formation
JO3155B1 (ar) 2013-02-19 2017-09-20 Senomyx Inc معدِّل نكهة حلوة
CN103497151B (zh) * 2013-10-30 2015-07-15 山东铂源药业有限公司 一种4-氨基-6-甲基烟酸的合成方法
CA2963901A1 (en) * 2014-11-07 2016-05-12 Senomyx, Inc. Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers
CA3003163A1 (en) 2015-10-29 2017-05-04 Senomyx, Inc. High intensity sweeteners
RU2019102926A (ru) * 2016-07-06 2020-08-06 Маккормик Энд Компани, Инкорпорейтед Способ прогнозирования характеристик ароматизатора
US10030000B2 (en) 2016-09-21 2018-07-24 Celanese International Corporation Acesulfame potassium compositions and processes for producing same
HUE051396T2 (hu) 2016-09-21 2021-03-01 Celanese Int Corp Aceszulfám-kálium kompozíciók és az elõállításukra szolgáló eljárások
LT3319948T (lt) 2016-09-21 2021-10-11 Celanese International Corporation Kalio acesulfamo kompozicijos ir jų gamybos būdai
EP3623363A1 (en) 2016-09-21 2020-03-18 Celanese International Corporation Acesulfame potassium compositions and processes for producing same
US11060124B2 (en) 2017-05-03 2021-07-13 Firmenich Incorporated Methods for making high intensity sweeteners
JP7453210B2 (ja) 2018-08-07 2024-03-19 フィルメニッヒ インコーポレイテッド 5-置換4-アミノ-1H-ベンゾ[c][1,2,6]チアジアジン2,2-ジオキシド並びにその配合物及び使用
JP7640458B2 (ja) 2018-10-05 2025-03-05 アンナプルナ バイオ インコーポレイテッド Apj受容体活性に関連する状態を処置するための化合物および組成物
JP2022512931A (ja) 2018-11-07 2022-02-07 フィルメニッヒ インコーポレイテッド 高甘味度甘味料の製造方法
CA3118467A1 (en) 2018-11-07 2020-05-14 Firmenich Incorporated Methods for making high intensity sweeteners
WO2020161939A1 (ja) * 2019-02-06 2020-08-13 株式会社Mizkan Holdings 甘い風味が増強された乾燥植物粉末および飲食品
JP7572357B2 (ja) 2019-03-28 2024-10-23 フイルメニツヒ ソシエテ アノニム フレーバーシステム
JP2022525490A (ja) 2019-04-04 2022-05-17 フイルメニツヒ ソシエテ アノニム モグロシド化合物およびその使用
EP3908126A1 (en) 2019-06-28 2021-11-17 Firmenich SA Fat blends, emulsions thereof, and related uses
CN114364265B (zh) 2019-09-05 2025-01-03 弗门尼舍有限公司 黄烷酮衍生物及其作为甜味增强剂的用途
CN113226058A (zh) 2019-11-11 2021-08-06 弗门尼舍有限公司 姜酚化合物及其作为风味改良剂的用途
EP4040986B1 (en) 2019-12-13 2025-12-24 Firmenich Incorporated Taste modifying compositions and uses thereof
WO2021118864A1 (en) 2019-12-13 2021-06-17 Firmenich Incorporated Taste modifying compositions and uses thereof
WO2021126569A1 (en) 2019-12-18 2021-06-24 Firmenich Incorporated Taste modifying compositions and uses thereof
CN114727636A (zh) 2019-12-18 2022-07-08 弗门尼舍公司 味道改良组合物及其用途
EP4048086A1 (en) 2020-03-05 2022-08-31 Firmenich SA 11-oxo-cucurbitanes and their use as flavor modifiers
EP4125427A1 (en) 2020-03-31 2023-02-08 Firmenich SA Flavor composition
CN114096515B (zh) 2020-04-17 2024-07-26 弗门尼舍有限公司 氨基酸衍生物及其作为风味改良剂的用途
US20230165290A1 (en) 2020-05-22 2023-06-01 Firmenich Sa Compositions for reducing salty taste and uses thereof
BR112022016411A2 (pt) 2020-06-03 2022-10-11 Firmenich & Cie Composições para reduzir gostos desagradáveis e usos das mesmas
WO2021257863A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Pyrrolotriazine compounds as jak2 v617f inhibitors
WO2021257857A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Naphthyridinone compounds as jak2 v617f inhibitors
CN115701912A (zh) 2020-06-24 2023-02-14 弗门尼舍有限公司 赋甜组合物及其用途
SMT202500271T1 (it) 2020-07-02 2025-09-12 Incyte Corp Composti di urea triciclici come inibitori di v617f di jak2
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
EP4110475A1 (en) 2020-07-14 2023-01-04 Firmenich SA Reduction of undesirable taste notes in oral care products
US20230276835A1 (en) 2020-07-24 2023-09-07 Firmenich Incorporated Savory taste enhancement via transmembrane region binding
US11661422B2 (en) 2020-08-27 2023-05-30 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
CN115697082A (zh) 2020-09-22 2023-02-03 弗门尼舍有限公司 不含水杨酸甲酯的鹿蹄草风味剂组合物
EP4228433A1 (en) 2020-10-13 2023-08-23 Firmenich SA Malonyl steviol glycosides and their comestible use
CN114468199A (zh) 2020-10-27 2022-05-13 弗门尼舍有限公司 共轭二炔及其作为风味改良剂的用途
CN116782778A (zh) 2020-11-24 2023-09-19 弗门尼舍公司 浓厚味道的增强和相关筛选方法
CN115988967A (zh) 2020-11-29 2023-04-18 弗门尼舍有限公司 减少过氧化物异味的组合物及其用途
WO2022140231A1 (en) 2020-12-21 2022-06-30 Incyte Corporation Deazaguaine compounds as jak2 v617f inhibitors
EP4213636A1 (en) 2020-12-23 2023-07-26 Firmenich SA Uses of fat blends and emulsions thereof
US20240058238A1 (en) 2021-01-13 2024-02-22 Firmenich Incorporated Compositions that enhance the cooling effect
EP4258895A1 (en) 2021-01-15 2023-10-18 Firmenich Incorporated Sweetener compostions comprising siamenoside i and uses thereof
JP2024503101A (ja) 2021-01-15 2024-01-24 フィルメニッヒ インコーポレイテッド モグロシドを含む甘味料組成物およびその使用
US20240065302A1 (en) 2021-01-15 2024-02-29 Firmenich Incorporated Sweetener compositions comprising mogrosides and uses thereof
EP4266904A1 (en) 2021-02-10 2023-11-01 Firmenich SA Fiber blends, sweetened fiber blends, and their comestible use
AR125273A1 (es) 2021-02-25 2023-07-05 Incyte Corp Lactamas espirocíclicas como inhibidores de jak2 v617f
EP4258900A1 (en) 2021-03-09 2023-10-18 Firmenich SA Hydroxy- and methoxy-substituted flavonoids and their use
JP2024509300A (ja) 2021-03-09 2024-02-29 フイルメニツヒ ソシエテ アノニム ヒドロキシおよびメトキシ置換フラボンならびにそれらの使用
US20240099343A1 (en) 2021-04-06 2024-03-28 Firmenich Sa Use of gingerdiol compounds to enhance flavor
BR112023022012A2 (pt) 2021-04-26 2023-12-26 Firmenich Incorporated Compostos de amida e seu uso como modificadores de sabor
JP2024517692A (ja) 2021-04-26 2024-04-23 フィルメニッヒ インコーポレイテッド アミド化合物および風味修飾剤としてのその使用
US20250275560A1 (en) 2021-05-11 2025-09-04 Firmenich Sa Process of making gingerol compounds and their use as flavor modifiers
EP4307910B1 (en) 2021-05-24 2025-12-10 Firmenich SA Flavored fiber blends and their comestible use
EP4304385A1 (en) 2021-05-28 2024-01-17 Firmenich Incorporated Compositions that enhance the cooling effect
JP2024522442A (ja) 2021-06-02 2024-06-21 フイルメニツヒ ソシエテ アノニム 脱アセチル化の方法、組成物、およびその使用
JP2024524266A (ja) 2021-06-23 2024-07-05 フイルメニツヒ ソシエテ アノニム ラクターゼを含むフレーバー修飾組成物
BR112023026922A2 (pt) 2021-06-28 2024-03-05 Firmenich Incorporated Sais policatiônicos de compostos fenólicos e usos dos mesmos
WO2023278226A1 (en) 2021-06-29 2023-01-05 Firmenich Incorporated Mogroside compounds and their comestible use
CN117651498A (zh) 2021-06-29 2024-03-05 弗门尼舍有限公司 甘草化合物及其作为风味修饰剂的用途
EP4362689A1 (en) 2021-09-27 2024-05-08 Firmenich SA Flavor compositions containing iron compounds and their use
JP2024534633A (ja) 2021-09-27 2024-09-20 フィルメニッヒ インコーポレイテッド 蒸留酒のフレーバーを変調するためのバニリルエーテルの使用
AR127359A1 (es) 2021-11-01 2024-01-17 Firmenich & Cie Composición que comprende un nutriente y un modulador del sabor
EP4404767A2 (en) 2021-11-16 2024-07-31 Firmenich Incorporated Amide compounds and their use as flavor modifiers
US20250052739A1 (en) 2021-12-07 2025-02-13 Firmenich Incorporated Reduction of bitter taste of plant proteins and related assays and screening methods
WO2023118002A1 (en) 2021-12-20 2023-06-29 Firmenich Sa Encapsulated metal compounds and comestible uses thereof
EP4415542A1 (en) 2021-12-23 2024-08-21 Firmenich SA Antimicrobial composition having encapsulated colorant
CN118785815A (zh) 2022-03-04 2024-10-15 弗门尼舍有限公司 多甲氧基黄酮类化合物的纯化方法以及由该方法获得的组合物
EP4472947A1 (en) 2022-03-07 2024-12-11 Firmenich Incorporated Sweetener compositions
JP2025507547A (ja) 2022-03-10 2025-03-21 フイルメニツヒ ソシエテ アノニム 甘味料組成物
CN118843399A (zh) 2022-03-11 2024-10-25 弗门尼舍公司 酰胺化合物及其作为风味修饰剂的用途
JP2025509073A (ja) 2022-03-11 2025-04-11 フィルメニッヒ インコーポレイテッド フラバノン化合物およびそれらの風味改変剤としての使用
CN119173514A (zh) 2022-03-17 2024-12-20 因赛特公司 作为jak2 v617f抑制剂的三环脲化合物
US20250194649A1 (en) 2022-03-25 2025-06-19 Firmenich Sa Fatty acid amides and their use as flavor modifiers
CN119212569A (zh) 2022-03-28 2024-12-27 弗门尼舍有限公司 非动物蛋白组合物及其用途
US20250204564A1 (en) 2022-04-06 2025-06-26 Firmenich Incorporated Taste modifying compositions and uses thereof
JP2025510598A (ja) 2022-04-11 2025-04-15 フイルメニツヒ ソシエテ アノニム 甘味料組成物
CN119212571A (zh) 2022-05-16 2024-12-27 弗门尼舍公司 不饱和脂肪酸及其修饰味道的用途
WO2023224814A1 (en) 2022-05-16 2023-11-23 Firmenich Incorporated Saturated fatty acids and their use to modify taste
WO2023232968A1 (en) 2022-06-03 2023-12-07 Firmenich Sa Fat reduction in non-animal protein compositions
EP4507521A1 (en) 2022-06-14 2025-02-19 Firmenich SA Polyelectrolyte complexes of proteins and uses thereof
EP4507522A1 (en) 2022-06-24 2025-02-19 Firmenich SA Taste modifying compositions and uses thereof
JP2025520966A (ja) 2022-07-07 2025-07-03 フィルメニッヒ インコーポレイテッド 冷却効果を増強する組成物
WO2024041974A1 (en) 2022-08-22 2024-02-29 Firmenich Sa Gel compositions and their use in seafood analogue products
WO2024089025A1 (en) 2022-10-26 2024-05-02 Firmenich Sa Extrusion methods and flavored products formed thereby
EP4577059A1 (en) 2022-10-26 2025-07-02 Firmenich Incorporated Taste modifying compositions and uses thereof
EP4580420A1 (en) 2022-11-01 2025-07-09 Firmenich SA Low-calorie composition for flavor modification
EP4601483A1 (en) 2022-12-23 2025-08-20 Firmenich Incorporated Beta-cyclodextrin and its use to modify flavor
CN120513026A (zh) 2023-01-09 2025-08-19 弗门尼舍有限公司 植物纤维用于改善发酵产品风味的用途
EP4665157A1 (en) 2023-02-15 2025-12-24 Firmenich SA Thermoresponsive gel composition and uses thereof
CN120752224A (zh) 2023-02-25 2025-10-03 弗门尼舍公司 黄烷酮化合物及其作为风味修饰剂的用途
WO2024196906A1 (en) 2023-03-23 2024-09-26 Firmenich Incorporated Use of vanillyl ethers to modify flavor
CN121620296A (zh) 2023-03-24 2026-03-06 弗门尼舍有限公司 含有藻类蛋白的微粒及其用途
EP4687492A1 (en) 2023-03-29 2026-02-11 Firmenich Incorporated Use of fatty acids to modify flavor
WO2024208837A1 (en) 2023-04-04 2024-10-10 Firmenich Sa Polysaccharide compositions and their comestible use
WO2024227789A1 (en) 2023-05-03 2024-11-07 Firmenich Sa Encapsulated phenolic compounds and their comestible use
WO2024251755A1 (en) 2023-06-09 2024-12-12 Dsm-Firmenich Ag Compositions for reducing off notes and uses thereof
EP4480319A1 (en) 2023-06-22 2024-12-25 DSM-Firmenich AG Granola cluster
WO2025067974A1 (en) 2023-09-26 2025-04-03 Firmenich Sa Vegan cheese compositions and methods of making the same
WO2025073683A1 (en) 2023-10-04 2025-04-10 Firmenich Sa Flavanone compounds and their use as flavor modifiers
WO2025125286A1 (en) 2023-12-13 2025-06-19 Firmenich Sa Biopolymer compositions and their use in foamed compositions
WO2025132821A1 (en) 2023-12-19 2025-06-26 Firmenich Sa Comestible products having high fiber and low sugar
WO2025132803A1 (en) 2023-12-20 2025-06-26 Firmenich Sa 3-hydroxybenzoic acid and its use as a flavor modifier
WO2025191050A1 (en) 2024-03-15 2025-09-18 Firmenich Sa Lipid particles and their comestible use
WO2025221883A1 (en) 2024-04-17 2025-10-23 Firmenich Incorporated Taste modifying compositions and uses thereof
WO2025230968A1 (en) 2024-04-30 2025-11-06 Firmenich Incorporated Ketone compounds for enhancing alcohol perception
WO2026064099A1 (en) 2024-09-17 2026-03-26 Firmenich Incorporated Dihydrochalcone compounds for enhancing alcohol perception
WO2026064098A1 (en) 2024-09-17 2026-03-26 Firmenich Incorporated Flavonoid compounds for enhancing alcohol perception

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2030899A1 (de) * 1970-06-18 1971-12-23 Schering Ag, 1000 Berlin Und 4619 Bergkamen Chinolincarbonsäurederivate
FR2101004B2 (es) * 1970-08-05 1974-02-01 Bellon Labor Sa Roger
JPS5833843B2 (ja) * 1974-10-24 1983-07-22 武田薬品工業株式会社 スイサンヨウ ヤクザイ
JPS52142098A (en) 1976-05-20 1977-11-26 Sumitomo Chem Co Ltd 1-fluoroalkyl-491h)-oxo-3-quinolinecarboxylic acid derivatives
DE3111155A1 (de) * 1981-03-21 1982-09-30 Troponwerke GmbH & Co KG, 5000 Köln 5,6-dimethyl-pyrrolo (2,3-b)pyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4552883A (en) 1982-06-15 1985-11-12 Ici Americas Inc. Pyrazolo[3,4-b]pyridine carboxylic acid esters and their pharmaceutical use
GB8600651D0 (en) 1986-01-11 1986-02-19 Beecham Group Plc Compounds
US4952584A (en) 1986-01-11 1990-08-28 Beecham Group P.L.C. 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
GB8804447D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
JPH0676401B2 (ja) * 1990-10-19 1994-09-28 エスエス製薬株式会社 キノリン誘導体及びこれを含有する医薬
US5240934A (en) * 1990-10-19 1993-08-31 Ss Pharmaceutical Co., Ltd. Quinoline derivatives
GB9125485D0 (en) * 1991-11-29 1992-01-29 Merck Sharp & Dohme Therapeutic agents
GB9127252D0 (en) 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
JPH06199855A (ja) * 1992-12-31 1994-07-19 Nippon Nohyaku Co Ltd ピラゾロピリジン誘導体及びこれを含有する血小板凝集抑制剤
US5776942A (en) 1994-06-17 1998-07-07 Nippon Zoki Pharmaceutical Co., Ltd. Bronchodilating pyrido 2,3-d!pyrimidine derivatives
JPH083046A (ja) * 1994-06-17 1996-01-09 Nippon Zoki Pharmaceut Co Ltd 気管支喘息治療剤
US5593997A (en) * 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
AR016817A1 (es) * 1997-08-14 2001-08-01 Smithkline Beecham Plc Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento
DE19738616A1 (de) * 1997-09-04 1999-03-11 Clariant Gmbh 4-Hydroxychinolin-3-carbonsäure-Derivate als Lichtschutzmittel
CZ2002992A3 (cs) * 1999-09-22 2002-06-12 Aventis Pharma Deutschland Gmbh Konjugáty 4-benzylaminochinolinů se ľlučovými kyselinami a jejich heteroanalogy, způsob jejich přípravy, farmaceutické prostředky je obsahující, a jejich pouľití
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
EP1450802A2 (en) * 2001-10-30 2004-09-01 The General Hospital Corporation Methods for the prevention or treatment of bacterial and fungal infections
AU2002352868A1 (en) * 2001-11-27 2003-06-10 Merck & Co., Inc. 4-aminoquinoline compounds
US20050084490A1 (en) * 2002-07-09 2005-04-21 Point Therapeutics, Inc. Boroproline compound combination therapy
US20080026077A1 (en) * 2002-11-12 2008-01-31 John Hilfinger Methods and compositions of gene delivery agents for systemic and local therapy
BRPI0413347A (pt) 2003-08-06 2006-10-10 Senomyx Inc novos sabores, modificadores de sabor, agentes de sabor, realçadores de sabor, agentes de sabor e/ou realçadores umami ou doces, e utilização correspondente
CA2555176A1 (en) * 2004-02-11 2005-08-25 Smithkline Beecham Corporation Hiv integrase inhibitors
EP1723145A4 (en) 2004-03-11 2009-12-02 Neurogen Corp SUBSTITUTED 5,12-DIAZENZOANTHRACENANALOGA
MXJL06000069A (es) 2004-06-09 2007-04-10 Avanir Pharmaceuticals Derivados heterociclicos para el tratamiento de hiperlipidemia y enfermedades relacionadas.
RS56037B1 (sr) * 2004-06-24 2017-09-29 Vertex Pharma Modulatori atp-vezujućih kasetnih transportera
JP2006036762A (ja) * 2004-06-25 2006-02-09 Taisho Pharmaceut Co Ltd 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体
UY29016A1 (es) * 2004-07-20 2006-02-24 Boehringer Ingelheim Int Analogos de dipeptidos inhibidores de la hepatitis c
US20060045953A1 (en) * 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
GB0425572D0 (en) * 2004-11-19 2004-12-22 Glaxo Group Ltd 1,7-Naphthyridines
RU2388761C2 (ru) 2004-12-17 2010-05-10 Ф. Хоффманн-Ля Рош Аг Производные тиенопиридина в качестве аллостерических энхансеров гамк-в
GB0505621D0 (en) * 2005-03-18 2005-04-27 Glaxo Group Ltd Novel compounds
US7304074B2 (en) * 2005-04-05 2007-12-04 Hoffmann-La Roche Inc. Substituted 1,5-naphthyridine azolinones
WO2006124944A1 (en) * 2005-05-18 2006-11-23 Wyeth 4, 6-diamino-[1,7] naphthyridine-3-carbonitrile inhibitors of tpl2 kinase and methods of making and using the same
EP1891078A1 (en) * 2005-05-24 2008-02-27 AstraZeneca AB Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
TW200715993A (en) 2005-06-15 2007-05-01 Senomyx Inc Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
CA2647543A1 (en) 2006-03-29 2007-11-08 Foldrx Pharmaceuticals, Inc. Inhibition of alpha-synuclein toxicity
DE102006029446A1 (de) * 2006-06-21 2007-12-27 Bayer Schering Pharma Ag Neue 3-substituierte-Chinoline als Kinase-Inhibitoren
US9603848B2 (en) * 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US7928111B2 (en) * 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US8076491B2 (en) 2007-08-21 2011-12-13 Senomyx, Inc. Compounds that inhibit (block) bitter taste in composition and use thereof
DK2220047T3 (en) * 2007-11-15 2015-06-29 Clanotech Ab Quinoline derivatives, pharmaceutical compositions comprising them and their use
WO2009100333A2 (en) 2008-02-06 2009-08-13 Senomyx, Inc. Sweetener compositions and methods of making them
WO2011075559A1 (en) * 2009-12-18 2011-06-23 Glaxo Wellcome Manufacturing Pte Ltd. Novel compounds
CA2792068A1 (en) 2010-04-02 2011-10-06 Senomyx, Inc. Sweet flavor modifier
WO2012021837A2 (en) 2010-08-12 2012-02-16 Senomyx, Inc. Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer
MX336378B (es) 2011-08-12 2016-01-15 Senomyx Inc Modificador del sabor dulce.
WO2013158928A2 (en) 2012-04-18 2013-10-24 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
US20140272068A1 (en) 2013-03-14 2014-09-18 Indra Prakash Beverages containing rare sugars
JP6055730B2 (ja) 2013-07-17 2016-12-27 株式会社東海理化電機製作所 遠隔操作システム

Also Published As

Publication number Publication date
IL222219A0 (en) 2012-12-31
BR112012025167A2 (pt) 2015-09-08
US8592592B2 (en) 2013-11-26
TWI595838B (zh) 2017-08-21
PE20171345A1 (es) 2017-09-13
PH12012501846A1 (en) 2013-02-04
US20150265711A1 (en) 2015-09-24
MY175079A (en) 2020-06-04
US9902737B2 (en) 2018-02-27
EP2552207A4 (en) 2016-04-06
AR081814A1 (es) 2012-10-24
CO6630147A2 (es) 2013-03-01
SG10201507846YA (en) 2015-10-29
CA2792068A1 (en) 2011-10-06
US9049878B2 (en) 2015-06-09
US20110245353A1 (en) 2011-10-06
PE20130211A1 (es) 2013-03-22
KR20130012584A (ko) 2013-02-04
SG184156A1 (en) 2012-10-30
NZ603332A (en) 2014-11-28
EP2552207A1 (en) 2013-02-06
CN102933081A (zh) 2013-02-13
US20160251372A1 (en) 2016-09-01
BR112012025167B1 (pt) 2024-01-09
AU2011235069B2 (en) 2016-03-17
EP2552207B1 (en) 2019-08-21
JP2013525278A (ja) 2013-06-20
MX2012011386A (es) 2012-11-29
RU2605549C2 (ru) 2016-12-20
TW201141391A (en) 2011-12-01
ES2753523T3 (es) 2020-04-13
WO2011123693A1 (en) 2011-10-06
HK1180900A1 (zh) 2013-11-01
CN102933081B (zh) 2016-04-13
US20140128481A1 (en) 2014-05-08
JP5988506B2 (ja) 2016-09-07
KR101810265B1 (ko) 2017-12-18
RU2012146608A (ru) 2014-05-10

Similar Documents

Publication Publication Date Title
CL2012002477A1 (es) Compuesto modificador del sabor formula (i), composicion ingerible que comprende el compuestos de la formula (i), metodo para mejorar el sabor dulce de una composicion ingerible combinando dicho producto con el compuesto de la formula (i)
JOP20210065A1 (ar) عملية لتحضير 5- فلورو-1h- بيرازولوبيريدينات مستبدلة
GB2499479A (en) Stabilisation of viral particles
MY176814A (en) Compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis
BR112015014753A2 (pt) composições, utilização de uma composição, método para o combate dos fungos fitopatogênicos e semente
PH12015500900A1 (en) A stabilized pemetrexed formulation
WO2014195978A3 (en) PROCESS FOR THE PREPARATION OF (3R,4R)-4-METHYL-3-(METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL-AMINO)-ß-OXO-1-PIPERIDINEPROPANENITRILE AND ITS SALTS
PH12014502567A1 (en) Piperidine derivatives for gpr119 agonist
MY168212A (en) A new therapeutical composition containing apomorphine as active ingredient
GB201117233D0 (en) Stabilisation of polypeptides
PH12014500321A1 (en) Novel substituted cyclohexane compounds
CY1118514T1 (el) Μεθοδος για την παρασκευη πεμετρεξιδης και αλατος λυσινης αυτης
EP4458153A3 (en) Pesticide composition and method
MY164880A (en) Process for the preparation of isoxazolyl-methoxy-nicotinic acids
MX2013004878A (es) N-hetarilmetil pirazolilcarboxamidas.
CY1116500T1 (el) Μεθοδος ενζυματικης συνθεσης toy (7s)-1-(3,4-διμεθοξυδικυκλο[4.2.0] οκτα-1,3,5-τριεν-7-υλ)-ν-μεθυλομεθαναμινης και εφαρμογη στη συνθεση της ιβαβραδινης και των αλατων αυτης
EP4282973A3 (en) Processes for the preparation of pyrimidinylcyclopentane compounds
PH12016500980A1 (en) Amide derivatives for gpr119 agonist
IN2013MU03308A (es)
WO2012150607A3 (en) Oral liquid composition comprising divalproex sodium and process for preparing thereof
WO2012104874A3 (en) Aqueous concentrated formulation of linezolid
MX338818B (es) Derivados de 5-alquenil-2-oxo-tetrahidrofurano como compuestos saborizantes.
WO2011104555A3 (en) Process for the preparation of sunitinib malate form i
IN2013CH04314A (es)
WO2014125233A3 (fr) Procédé de synthèse de 4-piperidin-4-yl-benzène-1,3-diol et de ses sels et nouveau composé 4-(2,4-dihydroxy-phényl)-4-hydroxy-piperidine-1-carboxylate de tert-butyle