CL2012002942A1 - Uso de un derivado sintetico de retinol e hidroxianisol butilado disuelto en aceite de soya para preparar un medicamento util en el tratamiento de un sujeto humano que sufre de la perdida o el deterioro de la vison causado por un trastorno por deficencia de retinol 11-cis producido endogenamente; composicion farmeceutica. - Google Patents

Uso de un derivado sintetico de retinol e hidroxianisol butilado disuelto en aceite de soya para preparar un medicamento util en el tratamiento de un sujeto humano que sufre de la perdida o el deterioro de la vison causado por un trastorno por deficencia de retinol 11-cis producido endogenamente; composicion farmeceutica.

Info

Publication number
CL2012002942A1
CL2012002942A1 CL2012002942A CL2012002942A CL2012002942A1 CL 2012002942 A1 CL2012002942 A1 CL 2012002942A1 CL 2012002942 A CL2012002942 A CL 2012002942A CL 2012002942 A CL2012002942 A CL 2012002942A CL 2012002942 A1 CL2012002942 A1 CL 2012002942A1
Authority
CL
Chile
Prior art keywords
retinol
deterioration
loss
prepare
dissolved
Prior art date
Application number
CL2012002942A
Other languages
English (en)
Inventor
H Andrew Strong
Suzanne Cadden
Original Assignee
Quadra Logic Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quadra Logic Tech Inc filed Critical Quadra Logic Tech Inc
Publication of CL2012002942A1 publication Critical patent/CL2012002942A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Método para tratar la pérdida o deterioro de la visión causado por un trastorno por deficiencia retinoide que comprende administrar una dosis terapéuticamente efectiva de un derivado sintético de retinol en reemplazo del retinol 11-CIS producido endógenamente, suspender el tratamiento por un mes y luego administrar una dosis adicional.
CL2012002942A 2010-04-19 2012-10-19 Uso de un derivado sintetico de retinol e hidroxianisol butilado disuelto en aceite de soya para preparar un medicamento util en el tratamiento de un sujeto humano que sufre de la perdida o el deterioro de la vison causado por un trastorno por deficencia de retinol 11-cis producido endogenamente; composicion farmeceutica. CL2012002942A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32576310P 2010-04-19 2010-04-19
US40743610P 2010-10-27 2010-10-27
US201161447611P 2011-02-28 2011-02-28

Publications (1)

Publication Number Publication Date
CL2012002942A1 true CL2012002942A1 (es) 2013-04-12

Family

ID=44788663

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012002942A CL2012002942A1 (es) 2010-04-19 2012-10-19 Uso de un derivado sintetico de retinol e hidroxianisol butilado disuelto en aceite de soya para preparar un medicamento util en el tratamiento de un sujeto humano que sufre de la perdida o el deterioro de la vison causado por un trastorno por deficencia de retinol 11-cis producido endogenamente; composicion farmeceutica.

Country Status (18)

Country Link
US (3) US9173856B2 (es)
EP (1) EP2563350B1 (es)
JP (4) JP6250389B2 (es)
KR (2) KR20180043846A (es)
CN (2) CN102939081A (es)
AU (3) AU2011244024B2 (es)
BR (1) BR112012026939A2 (es)
CA (1) CA2796991A1 (es)
CL (1) CL2012002942A1 (es)
CO (1) CO6640227A2 (es)
HK (1) HK1246171A1 (es)
IL (1) IL222567A (es)
MX (1) MX339834B (es)
NO (1) NO20121362A1 (es)
NZ (1) NZ603331A (es)
RU (1) RU2622763C2 (es)
SG (2) SG184971A1 (es)
WO (1) WO2011132084A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2546005C2 (ru) 2009-09-15 2015-04-10 Кью Эл Ти ИНК. Фармацевтические составы, содержащие 9-цис-ретиниловые сложные эфиры в липидном наполнителе
US9173856B2 (en) 2010-04-19 2015-11-03 Qlt Inc. Therapeutic regimen and methods for treating or ameliorating visual disorders associated with an endogenous retinoid deficiency
CA2865935C (en) * 2012-03-01 2021-12-14 Qlt Inc. Therapeutic regimens and methods for improving visual function in visual disorders associated with an endogenous retinoid deficiency
WO2015023902A2 (en) * 2013-08-14 2015-02-19 Qlt Inc. Therapeutic regimens and methods for improving visual function in visual disorders associated with impaired dark adaptation and/or impaired low luminance vision
WO2019066549A2 (ko) 2017-09-29 2019-04-04 주식회사 툴젠 망막 기능장애 질환 치료를 위한 유전자 조작
EP4161502A4 (en) * 2020-06-09 2024-07-10 Eluminex Biosciences (Suzhou) Limited Methods of treating visual disorders using daily low dosing of a retinoid compound

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196078A (en) 1962-01-30 1965-07-20 Ortho Pharma Corp Process for combating retinits pigmentosa
US3517067A (en) 1964-02-11 1970-06-23 Eastman Kodak Co Syntheses of quaternary phosphonium salts
DE2300107C2 (de) 1973-01-03 1982-03-11 Basf Ag, 6700 Ludwigshafen Vitamin A-Säureanilid-4-carbonsäureäthylester, Verfahren zu seiner Herstellung und diesen enthaltende Zubereitungen
CH590222A5 (es) 1973-08-21 1977-07-29 Hoffmann La Roche
US4022913A (en) 1973-09-13 1977-05-10 Hoffmann-La Roche Inc. High potency vitamin A compositions
DE2456959A1 (de) 1974-12-03 1976-06-16 Basf Ag 4-(e)- und 4-(z)-7-methyl-9-(2,6,6trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8tetraencarbonsaeure, ihre derivate und diese enthaltende zubereitungen
US4532133A (en) 1983-05-24 1985-07-30 Basf Wyandotte Corporation Low temperature stable, emulsifiable vitamin A concentrates
CA1282326C (en) 1984-12-14 1991-04-02 Paul J. Jarosz Pharmaceutical composition containing 13-cis vitamin a acid as the active ingredient
JPS61275266A (ja) 1985-05-28 1986-12-05 Taisho Pharmaceut Co Ltd レチノイド誘導体
CZ282548B6 (cs) 1992-01-22 1997-08-13 F. Hoffmann-La Roche Ag Farmaceutický přípravek
US5310764A (en) 1992-05-08 1994-05-10 Steven Baranowitz Treatment of age related macular degeneration with beta-carotene
JPH06340525A (ja) 1993-06-02 1994-12-13 Lion Corp 安定な低眼刺激性ビタミンａ類可溶化点眼剤
WO1995026734A1 (en) 1994-04-04 1995-10-12 Freeman William R Use of phosphonylmethoxyalkyl nucleosides for the treatment of raised intraocular pressure
US5425560A (en) 1994-04-21 1995-06-20 Strattec Security Corporation Squeeze latch
RU2106843C1 (ru) 1994-06-29 1998-03-20 Красноярская государственная медицинская академия Способ лечения близорукости
JPH08198746A (ja) 1995-01-18 1996-08-06 Lion Corp 可溶化点眼剤
US5837728A (en) 1995-01-27 1998-11-17 Molecular Design International 9-cis retinoic acid esters and amides and uses thereof
US5489611A (en) 1995-02-10 1996-02-06 Warner-Lambert Company Method for lowering plasma levels of lipoprotein (a)
US5620970A (en) 1995-06-05 1997-04-15 Alcon Laboratories, Inc. Topical ophthalmic carbonic anhydrase inhibitor formulations
EP0839029A1 (en) 1995-07-20 1998-05-06 PHARMACIA & UPJOHN COMPANY Stable clear solutions of non-steroidal anti-inflammatory drugs for incorporation into gelatin capsules
US5716627A (en) 1996-04-25 1998-02-10 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing fatty acid amides, azoles, and retinol or retinyl ester
EP0908179A1 (en) 1997-08-23 1999-04-14 Werner Bollag Treatment of cell-mediated immune diseases
ZA989513B (en) 1997-10-21 1999-04-21 Alcon Lab Inc Compositions containing histamine H2 agonists and methods of use in treating dry eye
US6391924B1 (en) 1997-12-10 2002-05-21 Hampar Karageozian Taurine derivatives useable in the treatment of ophthalmic disorders
US6552009B2 (en) 1998-07-16 2003-04-22 Gentrix Llc Compositions and methods of treating abnormal cell proliferation
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6372463B1 (en) 1999-05-06 2002-04-16 The President & Fellows Of Harvard College Mutations in nucleic acid molecules encoding 11-CIS retinol dehydrogenase, the mutated proteins, and uses thereof
US6300328B1 (en) 1999-08-06 2001-10-09 Alcon Universal Ltd. Selective inhibitors of adenosine monophosphate deaminase for the treatment of optic nerve and retinal damage
US20020028849A1 (en) 2000-04-18 2002-03-07 Godkin James D. Use of retinol in assisted-reproduction protocols
US6696069B2 (en) 2000-06-30 2004-02-24 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Skin care cosmetic compositions containing phosphates and/or sulfates of branched alcohols and/or ethoxylates thereof
US20040077604A1 (en) 2001-12-19 2004-04-22 Lenard Lichtenberger Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity
JP4210115B2 (ja) 2001-01-11 2009-01-14 チェビジェン・インコーポレイテッド 新規レチノール誘導体および製造方法および用途
CA2442670A1 (en) 2001-04-13 2002-10-24 The Trustees Of The University Of Pennsylvania Method of treating or retarding the development of blindness
ITMI20012366A1 (it) 2001-11-09 2003-05-09 Farmatron Ltd Sistemi terapeutici stabilizzati a rilascio immediato e/o modificato per la somministrazione orale di principi attivi e/o eccipienti e/o ali
RU2332996C2 (ru) 2001-11-30 2008-09-10 КьюЭлТи Инк. Производные гидразонпиразола и их применение в качестве лекарственного средства
CA2474154A1 (en) 2002-01-18 2003-07-24 Tatton Technologies, Llc. Methods for treating eye disorders
US20030215413A1 (en) 2002-03-22 2003-11-20 L'oreal Compositions containing stabilized retinoid
US20040097587A1 (en) 2002-03-27 2004-05-20 Arbiser Jack L Compositions and methods of treatment of ulcerating diseases, burns, and related conditions
AU2003220624A1 (en) 2002-03-29 2003-10-13 Maxim Pharmaceuticals, Inc. Use of rom production and release inhibitors to treat and prevent intraocular damage
JP3854524B2 (ja) * 2002-04-01 2006-12-06 ピアス株式会社 油溶性成分安定化組成物及びその組成物を配合した化粧料、並びに油溶性成分の安定化方法
EP1527774A1 (en) 2003-11-03 2005-05-04 Basilea Pharmaceutica AG New formulation for retinoid-containing soft gelatin capsules
US20040242704A1 (en) 2003-03-14 2004-12-02 University Of Washington, Techtransfer - Invention Licensing Stabilized mutant opsin proteins
EP1510133A1 (en) 2003-09-01 2005-03-02 Belovo S.A., Egg Science & Technology Balanced oil composition
ES2600876T3 (es) 2003-09-04 2017-02-13 The Uab Research Foundation Procedimiento y aparato de detección de adaptación a oscuridad deteriorada
US7706863B2 (en) 2004-01-21 2010-04-27 University Of Washington Methods for assessing a physiological state of a mammalian retina
EP1722766A2 (en) 2004-02-17 2006-11-22 President And Fellows Of Harvard College Management of ophthalmologic disorders, including macular degeneration
KR20070011379A (ko) 2004-03-17 2007-01-24 라스 미카엘 라르센 시각 사이클 억제에 의한 망막증의 예방
BRPI0511396B1 (pt) 2004-06-18 2021-07-27 University Of Washington Uso de 9-cis-retinil éster e uso de um derivado de retinal sintético
SI1768657T1 (sl) * 2004-06-23 2009-02-28 Sirion Terapeutics Inc Postopki in sestavki za zdravljenje oftalmičnih obolenj z derivati retinila
US20060240098A1 (en) 2004-07-14 2006-10-26 Aphios Corporation Formulations for hyperforin-enriched hypericum fractions
WO2006033734A2 (en) 2004-08-18 2006-03-30 Sirion Therapeutics, Inc. Combination compositions comprising 13-cis-retinyl derivatives and uses thereof to treat opthalmic disorders
WO2006039551A2 (en) * 2004-09-30 2006-04-13 The Regents Of The University Of California Local administration of retinoids to treat deficiencies in dark adaptation
US20060177392A1 (en) 2005-02-10 2006-08-10 William Walden Oil-based composition for acne
PT1903866E (pt) 2005-11-07 2016-06-09 Murty Pharmaceuticals Inc Distribuição melhorada de tetra-hidrocanabinol
US8202541B2 (en) 2006-02-07 2012-06-19 U.S. Nutraceuticals, LLC Dietary supplement composition for blood lipid health
EP2069390A4 (en) 2006-07-27 2009-12-30 Univ Florida OPSIN STABILIZING COMPOUNDS AND METHODS OF USE
CN113636966B (zh) 2007-01-15 2024-01-12 于崇曦 维生素a酸类和类维生素a酸化合物的前药
EP2187880B1 (en) 2007-09-12 2013-12-18 The Trustees of Columbia University in the City of New York Compositions and methods for treating macular degeneration
JP6022746B2 (ja) 2008-02-11 2016-11-09 ユニヴァーシティ オブ ワシントン 加齢関連性網膜機能不全の治療及び予防方法
RU2546005C2 (ru) 2009-09-15 2015-04-10 Кью Эл Ти ИНК. Фармацевтические составы, содержащие 9-цис-ретиниловые сложные эфиры в липидном наполнителе
US9173856B2 (en) 2010-04-19 2015-11-03 Qlt Inc. Therapeutic regimen and methods for treating or ameliorating visual disorders associated with an endogenous retinoid deficiency
CA2865935C (en) 2012-03-01 2021-12-14 Qlt Inc. Therapeutic regimens and methods for improving visual function in visual disorders associated with an endogenous retinoid deficiency

Also Published As

Publication number Publication date
IL222567A (en) 2017-06-29
CO6640227A2 (es) 2013-03-22
AU2017268684A1 (en) 2017-12-21
AU2011244024B2 (en) 2015-12-10
US9987245B2 (en) 2018-06-05
MX339834B (es) 2016-06-14
AU2016201432A1 (en) 2016-03-24
KR20180043846A (ko) 2018-04-30
EP2563350B1 (en) 2020-10-14
SG10201507819VA (en) 2015-10-29
WO2011132084A2 (en) 2011-10-27
US20170087114A1 (en) 2017-03-30
NO20121362A1 (no) 2012-11-19
US9173856B2 (en) 2015-11-03
CN107308143A (zh) 2017-11-03
HK1246171A1 (zh) 2018-09-07
SG184971A1 (en) 2012-11-29
RU2012148812A (ru) 2014-05-27
IL222567A0 (en) 2012-12-31
BR112012026939A2 (pt) 2016-07-12
WO2011132084A3 (en) 2012-02-16
JP2017222721A (ja) 2017-12-21
NZ603331A (en) 2015-02-27
RU2622763C2 (ru) 2017-06-19
EP2563350A4 (en) 2013-09-18
JP2016014047A (ja) 2016-01-28
US20110257266A1 (en) 2011-10-20
CN102939081A (zh) 2013-02-20
US20190029986A1 (en) 2019-01-31
AU2011244024A1 (en) 2012-11-08
KR20130054961A (ko) 2013-05-27
JP2013527844A (ja) 2013-07-04
KR101851249B1 (ko) 2018-06-20
CA2796991A1 (en) 2011-10-27
JP2019178162A (ja) 2019-10-17
JP6250389B2 (ja) 2017-12-20
EP2563350A2 (en) 2013-03-06
MX2012012199A (es) 2013-02-11

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